PDB Search results for query - Protein Data Bank Japan

PDB: 3 results

SYK catalytic domain complexed with a potent orally bioavailable thiazole inhibitor
Descriptor:	(4R)-4-[(1R)-1-{[6-(3,4-dimethoxyphenyl)[1,3]thiazolo[5,4-c]pyridin-4-yl]oxy}ethyl]pyrrolidin-2-one, Tyrosine-protein kinase SYK
Authors:	Lee, C.C.
Deposit date:	2015-07-29
Release date:	2015-09-23
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Orally bioavailable Syk inhibitors with activity in a rat PK/PD model. Bioorg.Med.Chem.Lett., 25, 2015

SYK catalytic domain complexed with a potent and orally bioavailable benzisothiazole inhibitor
Descriptor:	(5R)-5-[(1R)-1-{[6-(1-methyl-1H-pyrazol-4-yl)-2,1-benzothiazol-4-yl]oxy}ethyl]-1,3-oxazolidin-2-one, Tyrosine-protein kinase SYK
Authors:	Lee, C.C.
Deposit date:	2015-07-30
Release date:	2015-09-23
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (1.76 Å)
Cite:	Orally bioavailable Syk inhibitors with activity in a rat PK/PD model. Bioorg.Med.Chem.Lett., 25, 2015

SYK catalytic domain complexed with naphthyridine inhibitor
Descriptor:	CHLORIDE ION, GLYCEROL, N-{7-[4-(dimethylamino)phenyl]-1,6-naphthyridin-5-yl}propane-1,3-diamine, ...
Authors:	Thoma, G, Veenstra, S, Strang, R, Blanz, J, Vangrevelinghe, E, Berghausen, J, Lee, C.C, Zerwes, H.-G.
Deposit date:	2015-07-29
Release date:	2015-09-16
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Orally bioavailable Syk inhibitors with activity in a rat PK/PD model. Bioorg.Med.Chem.Lett., 25, 2015