Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6FX7
DownloadVisualize
BU of 6fx7 by Molmil
Crystal structure of in vitro evolved Af1521
Descriptor: [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, [Protein ADP-ribosylglutamate] hydrolase AF_1521
Authors:Karlberg, T, Thorsell, A.G, Nowak, K, Hottiger, M.O, Schuler, H.
Deposit date:2018-03-08
Release date:2019-09-25
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins.
Nat Commun, 11, 2020
2VRI
DownloadVisualize
BU of 2vri by Molmil
Structure of the NSP3 X-domain of human coronavirus NL63
Descriptor: 1,2-ETHANEDIOL, NON-STRUCTURAL PROTEIN 3
Authors:Piotrowski, Y, Mesters, J.R, Moll, R, Hilgenfeld, R.
Deposit date:2008-04-08
Release date:2009-06-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the Nsp3 X-Domain of Human Coronavirus Nl63
To be Published
9AZX
DownloadVisualize
BU of 9azx by Molmil
Crystal structure of SARS-CoV-2 (Covid-19) Nsp3 macrodomain in complex with NDPr
Descriptor: Non-structural protein 3, {(2R,3S,4R,5R)-5-[(8S)-4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl]-5-cyano-3,4-dihydroxyoxolan-2-yl}methyl [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl dihydrogen diphosphate
Authors:Wallace, S.D, Bagde, S.R, Fromme, J.C.
Deposit date:2024-03-11
Release date:2024-05-01
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.395 Å)
Cite:GS-441524-Diphosphate-Ribose Derivatives as Nanomolar Binders and Fluorescence Polarization Tracers for SARS-CoV-2 and Other Viral Macrodomains.
Acs Chem.Biol., 19, 2024
8ERS
DownloadVisualize
BU of 8ers by Molmil
PanDDA analysis -- Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with Z4718398507 - (R,S) isomer
Descriptor: (1R,2S)-1-[(4-amino-2-hydroxybenzoyl)oxy]-2,3-dihydro-1H-indene-2-carboxylic acid, Non-structural protein 3
Authors:Correy, G.J, Fraser, J.S.
Deposit date:2022-10-12
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Ligand screen against SARS-CoV-2 NSP3 macrodomain
To be published
3JZT
DownloadVisualize
BU of 3jzt by Molmil
Structure of a cubic crystal form of X (ADRP) domain from FCoV with ADP-ribose
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, CHLORIDE ION, SODIUM ION, ...
Authors:Wojdyla, J.A, Manolaridis, I, Tucker, P.A.
Deposit date:2009-09-24
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.91 Å)
Cite:Structure of the X (ADRP) domain of nsp3 from feline coronavirus
Acta Crystallogr.,Sect.D, 65, 2009
1HJZ
DownloadVisualize
BU of 1hjz by Molmil
Crystal structure of AF1521 protein containing a macroH2A domain
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, HYPOTHETICAL PROTEIN AF1521
Authors:Allen, M.D, Buckle, A.M, Cordell, S.C, Lowe, J, Bycroft, M.
Deposit date:2003-03-05
Release date:2003-07-10
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structure of Af1521 a Protein from Archaeoglobus Fulgidus with Homology to the Non-Histone Domain of Macroh2A
J.Mol.Biol., 330, 2003
5AIL
DownloadVisualize
BU of 5ail by Molmil
Human PARP9 2nd macrodomain
Descriptor: 1,2-ETHANEDIOL, PHOSPHATE ION, POLY [ADP-RIBOSE] POLYMERASE 9, ...
Authors:Sieg, C, Shrestha, L, Talon, R, Sorrell, F, Williams, E, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A.M, Knapp, S, Elkins, J.M.
Deposit date:2015-02-15
Release date:2015-02-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of Parp9 2Nd Macrodomain
To be Published
8GIA
DownloadVisualize
BU of 8gia by Molmil
Crystal structure of SARS-CoV-2 (Covid-19) Nsp3 macrodomain in complex with TFMU-ADPr
Descriptor: Non-structural protein 3, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [(2R,3S,4R,5R)-3,4-dihydroxy-5-{[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]oxy}oxolan-2-yl]methyl dihydrogen diphosphate
Authors:Wallace, S.D, Bagde, S.R, Fromme, J.C.
Deposit date:2023-03-13
Release date:2023-05-17
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain.
Acs Chem.Biol., 18, 2023
1SPV
DownloadVisualize
BU of 1spv by Molmil
Crystal Structure of the Putative Phosphatase of Escherichia coli, Northeast Structural Genomoics Target ER58
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, putative polyprotein/phosphatase
Authors:Forouhar, F, Lee, I, Vorobiev, S.M, Xiao, R, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG)
Deposit date:2004-03-17
Release date:2004-04-06
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Putative Phosphatase of Escherichia coli, Northeast Structural Genomoics Target ER58
To be Published
6FY5
DownloadVisualize
BU of 6fy5 by Molmil
Crystal structure of the macro domain of human macroh2a2
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Core histone macro-H2A.2
Authors:Hothorn, M.
Deposit date:2018-03-10
Release date:2018-04-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms.
EMBO Rep., 19, 2018
6Z6I
DownloadVisualize
BU of 6z6i by Molmil
SARS-CoV-2 Macrodomain in complex with ADP-HPD
Descriptor: 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, ...
Authors:Zorzini, V, Rack, J, Ahel, I.
Deposit date:2020-05-28
Release date:2020-12-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential.
Open Biology, 10, 2020
7NY7
DownloadVisualize
BU of 7ny7 by Molmil
Crystal structure of the Capsaspora owczarzaki macroH2A macrodomain in complex with ADP-ribose
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5-DIPHOSPHORIBOSE, Histone macroH2A1.1
Authors:Guberovic, I, Knobloch, G, Basquin, J, Buschbeck, M, Ladurner, A.G.
Deposit date:2021-03-21
Release date:2021-11-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Evolution of a histone variant involved in compartmental regulation of NAD metabolism.
Nat.Struct.Mol.Biol., 28, 2021
7NY6
DownloadVisualize
BU of 7ny6 by Molmil
Crystal structure of the Capsaspora owczarzaki macroH2A macrodomain
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Histone macroH2A1.1
Authors:Knobloch, G, Guberovic, I, Basquin, J, Buschbeck, M, Ladurner, A.G.
Deposit date:2021-03-21
Release date:2021-11-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Evolution of a histone variant involved in compartmental regulation of NAD metabolism.
Nat.Struct.Mol.Biol., 28, 2021
6YWM
DownloadVisualize
BU of 6ywm by Molmil
Crystal structure of SARS-CoV-2 (Covid-19) NSP3 macrodomain in complex with MES
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, ...
Authors:Ni, X, Schroeder, M, Olieric, V, Sharpe, E.M, Wojdyla, J.A, Wang, M, Knapp, S, Chaikuad, A, Structural Genomics Consortium (SGC)
Deposit date:2020-04-29
Release date:2020-05-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain.
Acs Med.Chem.Lett., 12, 2021
5O2D
DownloadVisualize
BU of 5o2d by Molmil
PARP14 Macrodomain 2 with inhibitor
Descriptor: Poly [ADP-ribose] polymerase 14, ~{N}-[2-(9~{H}-carbazol-1-yl)phenyl]methanesulfonamide
Authors:Uth, K, Schuller, M, Sieg, C, Wang, J, Krojer, T, Knapp, S, Riedels, K, Bracher, F, Edwards, A.M, Arrowsmith, C, Bountra, C, Elkins, J.M, Structural Genomics Consortium (SGC)
Deposit date:2017-05-20
Release date:2017-11-08
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14.
ACS Chem. Biol., 12, 2017
2L8R
DownloadVisualize
BU of 2l8r by Molmil
Solution structure of human protein C6orf130 in complex with ADP-ribose
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, Uncharacterized protein C6orf130
Authors:Lytle, B.L, Peterson, F.C, Volkman, B.F, Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2011-01-22
Release date:2011-02-23
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Orphan Macrodomain Protein (Human C6orf130) Is an O-Acyl-ADP-ribose Deacylase: SOLUTION STRUCTURE AND CATALYTIC PROPERTIES.
J.Biol.Chem., 286, 2011
2LGR
DownloadVisualize
BU of 2lgr by Molmil
Solution structure of human protein C6orf130, a putative macro domain
Descriptor: Uncharacterized protein C6orf130
Authors:Volkman, B.F, Lytle, B.L, Peterson, F.C, Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2011-08-01
Release date:2011-08-17
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Orphan Macrodomain Protein (Human C6orf130) Is an O-Acyl-ADP-ribose Deacylase: SOLUTION STRUCTURE AND CATALYTIC PROPERTIES.
J.Biol.Chem., 286, 2011
8P0C
DownloadVisualize
BU of 8p0c by Molmil
Rubella virus p150 macro domain (apo)
Descriptor: Non-structural polyprotein p200
Authors:Stoll, G.A, Modis, Y.
Deposit date:2023-05-10
Release date:2024-01-17
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Crystal structure and biochemical activity of the macrodomain from rubella virus p150.
J.Virol., 98, 2024
8P0E
DownloadVisualize
BU of 8p0e by Molmil
Rubella virus p150 macro domain in complex with ADP-ribose
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, Non-structural polyprotein p200
Authors:Stoll, G.A, Modis, Y.
Deposit date:2023-05-10
Release date:2024-01-17
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Crystal structure and biochemical activity of the macrodomain from rubella virus p150.
J.Virol., 98, 2024
3V2B
DownloadVisualize
BU of 3v2b by Molmil
Human poly(adp-ribose) polymerase 15 (ARTD7, BAL3), macro domain 2 in complex with adenosine-5-diphosphoribose
Descriptor: Poly [ADP-ribose] polymerase 15, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Authors:Karlberg, T, Moche, M, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Kallas, A, Kotenyova, T, Kotzcsh, A, Kraulis, P, Nielsen, T.K, Nordlund, P, Nyman, T, Persson, C, Roos, A.K, Schutz, P, Siponen, M.I, Thorsell, A.G, Tresaugues, L, Van den berg, S, Weigelt, J, Welin, M, Wisniewska, M, Schuler, H, Structural Genomics Consortium (SGC)
Deposit date:2011-12-12
Release date:2011-12-21
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Recognition of Mono-ADP-Ribosylated ARTD10 Substrates by ARTD8 Macrodomains.
Structure, 21, 2013
3Q6Z
DownloadVisualize
BU of 3q6z by Molmil
HUman PARP14 (ARTD8)-Macro domain 1 in complex with adenosine-5-diphosphoribose
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, Poly [ADP-ribose] polymerase 14
Authors:Karlberg, T, Siponen, M.I, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Ekblad, T, Flodin, S, Flores, A, Graslund, S, Kotenyova, T, Kouznetsova, E, Moche, M, Nordlund, P, Nyman, T, Persson, C, Sehic, A, Thorsell, A.G, Tresaugues, L, Wahlberg, E, Weigelt, J, Welin, M, Schuler, H, Structural Genomics Consortium (SGC)
Deposit date:2011-01-04
Release date:2011-02-09
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Recognition of Mono-ADP-Ribosylated ARTD10 Substrates by ARTD8 Macrodomains.
Structure, 21, 2013
3Q71
DownloadVisualize
BU of 3q71 by Molmil
Human parp14 (artd8) - macro domain 2 in complex with adenosine-5-diphosphoribose
Descriptor: Poly [ADP-ribose] polymerase 14, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Authors:Karlberg, T, Siponen, M.I, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Ekblad, T, Flodin, S, Flores, A, Graslund, S, Kotenyova, T, Kouznetsova, E, Moche, M, Nordlund, P, Nyman, T, Persson, C, Sehic, A, Thorsell, A.G, Tresaugues, L, Wahlberg, E, Weigelt, J, Welin, M, Schuler, H, Structural Genomics Consortium (SGC)
Deposit date:2011-01-04
Release date:2011-01-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Recognition of Mono-ADP-Ribosylated ARTD10 Substrates by ARTD8 Macrodomains.
Structure, 21, 2013
4UML
DownloadVisualize
BU of 4uml by Molmil
Crystal structure of ganglioside induced differentiation associated protein 2 (GDAP2) macro domain
Descriptor: GANGLIOSIDE-INDUCED DIFFERENTIATION-ASSOCIATED PROTEIN 2
Authors:Elkins, J.M, Wang, J, Kopec, J, Wang, D, Strain-Damerell, C, Shrestha, L, Sieg, C, Tallant, C, Newman, J.A, von Delft, F, Bountra, C, Edwards, A, Knapp, S.
Deposit date:2014-05-19
Release date:2014-05-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of Gdap2
To be Published
4TU0
DownloadVisualize
BU of 4tu0 by Molmil
CRYSTAL STRUCTURE OF CHIKUNGUNYA VIRUS NSP3 MACRO DOMAIN IN COMPLEX WITH A 2'-5' OLIGOADENYLATE TRIMER
Descriptor: 2'-5' OLIGOADENYLATE TRIMER, DI(HYDROXYETHYL)ETHER, Non-structural polyprotein 3
Authors:Morin, B, Ferron, f.p, Malet, h, Coutard, b, Canard, b.
Deposit date:2014-06-23
Release date:2014-07-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:CRYSTAL STRUCTURE OF CHIKUNGUNYA VIRUS NSP3 MACRO DOMAIN IN COMPLEX WITH A 2'-5' OLIGOADENYLATE TRIMER
TO BE PUBLISHED
1VHU
DownloadVisualize
BU of 1vhu by Molmil
Crystal structure of a putative phosphoesterase
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Hypothetical protein AF1521
Authors:Structural GenomiX
Deposit date:2003-12-01
Release date:2003-12-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Structural analysis of a set of proteins resulting from a bacterial genomics project
Proteins, 60, 2005

221716

數據於2024-06-26公開中

PDB statisticsPDBj update infoContact PDBjnumon