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1UIZ	Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis. Descriptor: Macrophage Migration Inhibitory Factor Authors: Suzuki, M, Takamura, Y, Maeno, M, Tochinai, S, Iyaguchi, D, Tanaka, I, Nishihira, J, Ishibashi, T. Deposit date: 2003-07-24 Release date: 2004-05-25 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Xenopus laevis Macrophage Migration Inhibitory Factor Is Essential for Axis Formation and Neural Development. J.Biol.Chem., 279, 2004
1P1G	MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH PRO-1 MUTATED TO GLY-1 Descriptor: PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR) Authors: Lubetsky, J.B, Lolis, E. Deposit date: 1999-03-24 Release date: 1999-06-07 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity. Biochemistry, 38, 1999
5XEJ	Crystal Structure of Macrophage Migration Inhibitory Factor bound to MTX Descriptor: (2~{R})-2-[[4-[[2,4-bis(azanyl)pteridin-6-yl]methyl-methyl-amino]phenyl]carbonylamino]pentanedioic acid, Macrophage migration inhibitory factor, SULFATE ION Authors: Takimoto-Kamimura, M, Fukushima, K. Deposit date: 2017-04-05 Release date: 2018-07-25 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of macrophage migration inhibitory factor in complex with methotrexate. Acta Crystallogr D Struct Biol, 77, 2021
8AP3	Structure of A. thaliana MIF/D-DT-like protein-2 (MDL2) Descriptor: MIF homologue Authors: Manjula, R, Basquin, J, Lolis, E. Deposit date: 2022-08-09 Release date: 2023-08-23 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Structure of A. thaliana MIF/D-DT-like protein-2 (MDL2) To Be Published
1CA7	MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH HYDROXPHENYLPYRUVATE Descriptor: 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR) Authors: Lubetsky, J.B, Lolis, E. Deposit date: 1999-02-25 Release date: 1999-06-30 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity. Biochemistry, 38, 1999
8IMR	Structure of ligand-free human macrophage migration inhibitory factor Descriptor: 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Sugishima, K, Noguchi, K, Yohda, M, Odaka, M, Matsumura, H. Deposit date: 2023-03-07 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Identification of methotrexate as an inhibitor of macrophage migration inhibitory factor by high-resolution crystal structure analysis To Be Published
2GDG	Crystal structure of covalently modified macrophage inhibitory factor Descriptor: Macrophage migration inhibitory factor Authors: Golubkov, P.A, Hackert, M.L. Deposit date: 2006-03-16 Release date: 2006-07-04 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Inactivation of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor by 2-oxo-4-phenyl-3-butynoate. Bioorg.Chem., 34, 2006
5J7Q	Macrophage Migration Inhibitory Factor bound to Inhibitor K664 Derivative Descriptor: 4-(imidazo[1,2-a]pyridin-2-yl)benzene-1,2-diol, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Robertson, M.J, Jorgensen, W.L. Deposit date: 2016-04-06 Release date: 2016-05-04 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Irregularities in enzyme assays: The case of macrophage migration inhibitory factor. Bioorg.Med.Chem.Lett., 26, 2016
4TRF	Crystal structure of Macrophage Migration Inhibitory Factor in complex with N-(pyridin-3-ylmethyl)thioformamide Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2014-06-16 Release date: 2015-09-30 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.63 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
1CGQ	MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH ALANINE INSERTED BETWEEN PRO-1 AND MET-2 Descriptor: PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR) Authors: Lubetsky, J.B, Lolis, E. Deposit date: 1999-03-25 Release date: 1999-06-07 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity. Biochemistry, 38, 1999
4TRU	Crystal structure of Q24A Q25A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2014-06-17 Release date: 2015-09-30 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.81 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
5J7P	Macrophage Migration Inhibitory Factor bound to Covalent Inhibitor RDR03785 Descriptor: 6-{[4-(trifluoromethyl)phenyl]methyl}-2H-1,3-benzodioxol-5-ol, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Robertson, M.J, Jorgensen, W.L. Deposit date: 2016-04-06 Release date: 2016-05-04 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Irregularities in enzyme assays: The case of macrophage migration inhibitory factor. Bioorg.Med.Chem.Lett., 26, 2016
1DPT	D-DOPACHROME TAUTOMERASE Descriptor: D-DOPACHROME TAUTOMERASE Authors: Sugimoto, H, Taniguchi, M, Nakagawa, A, Tanaka, I. Deposit date: 1998-05-11 Release date: 1999-03-30 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.54 Å) Cite: Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution. Biochemistry, 38, 1999
4WRB	Macrophage Migration Inhibitory Factor in complex with a biaryltriazole inhibitor (3b-190) Descriptor: 4-{4-[6-(2-methoxyethoxy)quinolin-2-yl]-1H-1,2,3-triazol-1-yl}phenol, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Robertson, M.J, Baxter, R.H.G, Jorgensen, W.L. Deposit date: 2014-10-23 Release date: 2015-03-11 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Design, synthesis, and protein crystallography of biaryltriazoles as potent tautomerase inhibitors of macrophage migration inhibitory factor. J.Am.Chem.Soc., 137, 2015
4WR8	Macrophage Migration Inhibitory Factor in complex with a biaryltriazole inhibitor (3b-180) Descriptor: 4-[4-(quinolin-2-yl)-1H-1,2,3-triazol-1-yl]phenol, Macrophage migration inhibitory factor, SODIUM ION, ... Authors: Robertson, M.J, Baxter, R.H.G, Jorgensen, W.L. Deposit date: 2014-10-23 Release date: 2015-03-11 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Design, synthesis, and protein crystallography of biaryltriazoles as potent tautomerase inhibitors of macrophage migration inhibitory factor. J.Am.Chem.Soc., 137, 2015
7XTX	High resolution crystal structure of human macrophage migration inhibitory factor in complex with methotrexate Descriptor: 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Sugishima, K, Noguchi, K, Yohda, M, Odaka, M, Matsumura, H. Deposit date: 2022-05-18 Release date: 2023-05-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.28 Å) Cite: Identification of methotrexate as an inhibitor of macrophage migration inhibitory factor by high-resolution crystal structure analysis To Be Published
7XVX	Neutron crystal structure of human macrophage migration inhibitory factor Descriptor: Macrophage migration inhibitory factor Authors: Ezawa, T, Tamada, T, Odaka, M, Matsumura, H. Deposit date: 2022-05-25 Release date: 2023-05-31 Last modified: 2024-04-03 Method: NEUTRON DIFFRACTION (1.6 Å), X-RAY DIFFRACTION Cite: Neutron crystal structure of human macrophage migration inhibitory factor To Be Published
6FVE	Macrophage Migration Inhibitory Factor (MIF) with Covalently Bound FITC Descriptor: 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-5-[(E)-(sulfanylmethylidene)amino]benzoic acid, Macrophage migration inhibitory factor, SULFATE ION Authors: Samygina, V.R, Bourenkov, G, Sokolov, A.V. Deposit date: 2018-03-02 Release date: 2018-06-06 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.41 Å) Cite: Structural Study of the Complex Formed by Ceruloplasmin and Macrophage Migration Inhibitory Factor. Biochemistry Mosc., 83, 2018
6FVH	Macrophage Migration Inhibitory Factor (MIF) with Covalently Bound PITC Descriptor: Macrophage migration inhibitory factor, N-phenylthioformamide, SULFATE ION Authors: Samygina, V.R, Bourenkov, G, Sokolov, A.V. Deposit date: 2018-03-02 Release date: 2018-06-06 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Structural Study of the Complex Formed by Ceruloplasmin and Macrophage Migration Inhibitory Factor. Biochemistry Mosc., 83, 2018
6LR3	Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum Descriptor: Macrophage migration inhibitory factor, SULFATE ION Authors: Su, Z.M, Tian, X.Y, Li, H.J, Wei, Z.M, Chen, L.F, Ren, H.X, Peng, W.F, Tang, C.T. Deposit date: 2020-01-15 Release date: 2020-07-22 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum. Biochem.J., 477, 2020
6LKV	Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor, SULFATE ION Authors: Su, Z.M, Tian, X.Y, Li, H.J, Wei, Z.M, Chen, L.F, Ren, H.X, Peng, W.F, Tang, C.T. Deposit date: 2019-12-20 Release date: 2020-07-22 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum. Biochem.J., 477, 2020
6LKW	Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor Authors: Su, Z.M, Tian, X.Y, Li, H.J, Wei, Z.M, Chen, L.F, Ren, H.X, Peng, W.F, Tang, C.T. Deposit date: 2019-12-20 Release date: 2020-07-22 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum. Biochem.J., 477, 2020
6ICE	Crystal structure of Hamster MIF Descriptor: Macrophage migration inhibitory factor Authors: Sundaram, R, Vasudevan, D. Deposit date: 2018-09-05 Release date: 2019-09-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Macrophage migration inhibitory factor of Syrian golden hamster shares structural and functional similarity with human counterpart and promotes pancreatic cancer. Sci Rep, 9, 2019
2WKF	Crystal Structure of Macrophage Migration Inhibitory Factor from Plasmodium falciparum Descriptor: GLYCEROL, MACROPHAGE MIGRATION INHIBITORY FACTOR Authors: Dobson, S.E, Augustijn, K.D, Brannigan, J.A, Dodson, E.J, Waters, A.P, Wilkinson, A.J. Deposit date: 2009-06-11 Release date: 2009-10-27 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: The crystal structures of macrophage migration inhibitory factor from Plasmodium falciparum and Plasmodium berghei. Protein Sci., 18, 2009
8CA0	Macrophage inhibitory factor (MIF) in complex with small molecule PAV174 Descriptor: 1-ethyl-9-methyl-3,7-dipyrrolidin-1-yl-phenothiazine, Macrophage migration inhibitory factor Authors: Mueller, A, Torres, F, Roland, R, Korth, C. Deposit date: 2023-01-24 Release date: 2024-02-07 Method: SOLUTION NMR Cite: Oxidized MIF is a drug target at the molecular intersection between immune activation and tau cellular pathology To Be Published

 

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