PDB: 435 resultsInfo pagesStatus searchChemie searchBIRD

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4XC4	Insulin co-crystallizes in the presence of it beta-cell chaperone sulfatide Descriptor: CHLORIDE ION, Insulin, SODIUM ION, ... Authors: Bracey, A.W, Magis, A.T, Buschard, K, Osterbye, T, Bailey, K.M, Ostrov, D.A. Deposit date: 2014-12-17 Release date: 2015-02-11 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.499 Å) Cite: Insulin co-crystallizes in the presence of it beta-cell chaperone sulfatide To Be Published
1BQT	THREE-DIMENSIONAL STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR-I (IGF-I) DETERMINED BY 1H-NMR AND DISTANCE GEOMETRY, 6 STRUCTURES Descriptor: INSULIN-LIKE GROWTH FACTOR-I Authors: Sato, A, Nishimura, S, Ohkubo, T, Kyogoku, Y, Koyama, S, Kobayashi, M, Yasuda, T, Kobayashi, Y. Deposit date: 1998-08-18 Release date: 1999-05-18 Last modified: 2022-02-16 Method: SOLUTION NMR Cite: Three-dimensional structure of human insulin-like growth factor-I (IGF-I) determined by 1H-NMR and distance geometry. Int.J.Pept.Protein Res., 41, 1993
1CPH	CONFORMATIONAL CHANGES IN CUBIC INSULIN CRYSTALS IN THE PH RANGE 7-11 Descriptor: 1,2-DICHLOROETHANE, INSULIN (PH 10), SODIUM ION Authors: Gursky, O, Badger, J, Li, Y, Caspar, D.L.D. Deposit date: 1992-10-30 Release date: 1993-01-15 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Conformational changes in cubic insulin crystals in the pH range 7-11. Biophys.J., 63, 1992
5VIZ	X-Ray structure of Insulin Glargine Descriptor: Insulin, chain alpha, chain beta Authors: Reyes-Grajeda, J.P, Romero, A. Deposit date: 2017-04-17 Release date: 2017-10-18 Method: X-RAY DIFFRACTION (1.7 Å) Cite: X-Ray structure of Insulin Glargine To Be Published
5WDM	An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein Descriptor: Single-chain insulin analog Authors: Yee, V.C, Aldabbagh, K, Peng, Y. Deposit date: 2017-07-05 Release date: 2017-11-15 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.803 Å) Cite: An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein. J. Biol. Chem., 293, 2018
5WBT	Solution Structure and Dynamics of an Ultra-Stable Single-Chain Insulin Analog STUDIES OF AN ENGINEERED MONOMER AND IMPLICATIONS FOR RECEPTOR BINDING Descriptor: Insulin Authors: Glidden, M.D, Yang, Y, Wickramasinghe, N.P, Weiss, M.A. Deposit date: 2017-06-29 Release date: 2017-11-15 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding. J. Biol. Chem., 293, 2018
6X4X	B24Y DKP insulin Descriptor: Insulin, Insulin chain A Authors: Weiss, M.A, Yang, Y. Deposit date: 2020-05-24 Release date: 2020-08-05 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Evolution of insulin at the edge of foldability and its medical implications. Proc.Natl.Acad.Sci.USA, 117, 2020
4RXW	Crystal Structure of the cobalt human insulin derivative Descriptor: COBALT (II) ION, Insulin A chain, Insulin B chain Authors: Prugovecki, B, Ivetic, N, Matkovic-Calogovic, D. Deposit date: 2014-12-12 Release date: 2015-01-21 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Crystal Structure of the cobalt human insulin derivative TO BE PUBLISHED
7Z5Q	Crystal structure of human insulin, crystallised in the presence of macrophage migration inhibitory factor (MIF) and p-Hydroxyphenylpyruvate (HPP) Descriptor: Insulin, Insulin A chain, SULFATE ION Authors: van den Elsen, J.M.H, Wahid, A.A, Crennell, S.J. Deposit date: 2022-03-09 Release date: 2023-03-22 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Dissociation of Hexameric Insulin Facilitated by Macrophage Migration Inhibitory Factor Indicates a Novel Role in Insulin Signalling To Be Published
7Z5L	Crystal structure of human insulin, crystallised in the presence of macrophage migration inhibitory factor (MIF) and dimethyl sulfoxide (DMSO) Descriptor: GLYCEROL, Insulin A chain, Insulin B chain, ... Authors: van den Elsen, J.M.H, Wahid, A.A, Crennell, C. Deposit date: 2022-03-09 Release date: 2023-03-22 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Dissociation of Hexameric Insulin Facilitated by Macrophage Migration Inhibitory Factor Indicates a Novel Role in Insulin Signalling To Be Published
4UNH	Human insulin B26Gly mutant crystal structure Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION Authors: Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M. Deposit date: 2014-05-28 Release date: 2014-10-15 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex Acta Crystallogr.,Sect.D, 70, 2014
4UNE	Human insulin B26Phe mutant crystal structure Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION Authors: Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M. Deposit date: 2014-05-28 Release date: 2014-10-15 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.59 Å) Cite: Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex Acta Crystallogr.,Sect.D, 70, 2014
4UNG	Human insulin B26Asn mutant crystal structure Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION Authors: Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M. Deposit date: 2014-05-28 Release date: 2014-10-15 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex Acta Crystallogr.,Sect.D, 70, 2014
7ELJ	Prion Derived Tetrapeptide Stabilizes Thermolabile Insulin via Conformational Trapping Descriptor: IS1, Insulin A Chain, Insulin B chain Authors: Banerjee, N. Deposit date: 2021-04-11 Release date: 2021-04-28 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Prion-derived tetrapeptide stabilizes thermolabile insulin via conformational trapping. Iscience, 24, 2021
7INS	STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z Descriptor: GENERAL PROTAMINE CHAIN, INSULIN (CHAIN A), INSULIN (CHAIN B), ... Authors: Balschmidt, P, Hansen, F.B, Dodson, E, Dodson, G, Korber, F. Deposit date: 1991-09-03 Release date: 1994-01-31 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure of porcine insulin cocrystallized with clupeine Z. Acta Crystallogr.,Sect.B, 47, 1991
7JP3	Des-B29,B30-insulin Descriptor: CHLORIDE ION, Insulin B chain,Insulin A chain, PHENOL, ... Authors: Yoder, J, Weiss, M.A, DiMarchi, R, Zaykov, A. Deposit date: 2020-08-07 Release date: 2021-10-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Des-B29,B30-insulin To Be Published
7NHU	Crystal structure of desB30 insulin produced by cell free protein synthesis Descriptor: Insulin Authors: Johansson, E. Deposit date: 2021-02-11 Release date: 2021-06-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Cell free protein synthesis versus yeast expression - A comparison using insulin as a model protein. Protein Expr.Purif., 186, 2021
8GSG	T3R3 form of Human insulin with single Zn Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Zhu, Z.L. Deposit date: 2022-09-06 Release date: 2023-03-15 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.05 Å) Cite: T3R3 insulin with single Zn To Be Published
8HSK	Insulin single mutant INS-Q Descriptor: Insulin A chain, Insulin B chain, SULFATE ION Authors: Rao, S.S, Kundapura, S.V, Kulal, A, Ramagopal, U.A. Deposit date: 2022-12-19 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Insulin single mutant INS-Q To Be Published
8HSF	Insulin triple mutant INS-RQD Descriptor: Insulin A chain, Insulin B chain Authors: Kundapura, S.V, Rao, S.S, Kulal, A, Ramagopal, U.A. Deposit date: 2022-12-19 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Insulin triple mutant INS-RQD To Be Published
3P2X	Insulin fibrillation is the Janus face of induced fit. A chiaral clamp stabilizes the native state at the expense of activity Descriptor: CHLORIDE ION, Insulin, PHENOL, ... Authors: Hua, Q.X, Wan, Z.L, Huang, K, Hu, S.Q, Phillip, N.F, Jia, W.H, Whittingham, J, Dodson, G.G, Katsoyannis, P.G, Weiss, M.A. Deposit date: 2010-10-04 Release date: 2011-11-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity To be Published
3P33	Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity Descriptor: CHLORIDE ION, Insulin, PHENOL, ... Authors: Hua, Q.X, Wan, Z.L, Huang, K, Hu, S.Q, Phillip, N.F, Jia, W.H, Whittingham, J, Dodson, G.G, Katsoyannis, P.G, Weiss, M.A. Deposit date: 2010-10-04 Release date: 2011-11-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity To be Published
8HGZ	Crystal structure of insulin Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: DeMirci, H, Ayan, E. Deposit date: 2022-11-16 Release date: 2024-03-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Comparative Study of High-Resolution LysB29(N epsilon-myristoyl) des(B30) Insulin Structures Display Novel Dynamic Causal Interrelations in Monomeric-Dimeric Motions Crystals, 13, 2023
5L3N	D11 bound [N29, S39_PQ]-IGF-II Descriptor: Insulin-like growth factor II Authors: Hexnerova, R. Deposit date: 2016-05-23 Release date: 2016-08-10 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain. J.Biol.Chem., 291, 2016
5L3L	D11 bound IGF-II Descriptor: Insulin-like growth factor II Authors: Hexnerova, R. Deposit date: 2016-05-23 Release date: 2016-08-10 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain. J.Biol.Chem., 291, 2016

 

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