3DBP
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![BU of 3dbp by Molmil](/molmil-images/mine/3dbp) | Crystal Structure of Human Orotidine 5'-Monophosphate Decarboxylase Complexed with 6-NH2-UMP | Descriptor: | 6-AMINOURIDINE 5'-MONOPHOSPHATE, Orotidine 5'-phosphate decarboxylase, SULFATE ION | Authors: | Liu, Y, To, T, Bello, A.M, Kotra, L.P, Pai, E.F. | Deposit date: | 2008-06-02 | Release date: | 2009-06-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal Structure of Human Orotidine 5'-Monophosphate Decarboxylase Complexed with 6-NH2-UMP To be Published
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4YCJ
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![BU of 4ycj by Molmil](/molmil-images/mine/4ycj) | Structure of Acetobacter aceti PurE Y154F | Descriptor: | 1,2-ETHANEDIOL, N5-carboxyaminoimidazole ribonucleotide mutase, SULFATE ION | Authors: | Kappock, T.J, Sullivan, K.L. | Deposit date: | 2015-02-20 | Release date: | 2016-02-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.845 Å) | Cite: | Structure of a single tryptophan mutant of Acetobacter aceti PurE To Be Published
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4RV4
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![BU of 4rv4 by Molmil](/molmil-images/mine/4rv4) | 2.65 Angstrom Resolution Crystal Structure of an orotate phosphoribosyltransferase from Bacillus anthracis str. 'Ames Ancestor' in complex with 5-phospho-alpha-D-ribosyl diphosphate (PRPP) | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, DI(HYDROXYETHYL)ETHER, Orotate phosphoribosyltransferase | Authors: | Halavaty, A.S, Minasov, G, Shuvalova, L, Winsor, J, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2014-11-24 | Release date: | 2014-12-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | 2.65 Angstrom resolution crystal structure of an orotate phosphoribosyltransferase from Bacillus anthracis str. 'Ames Ancestor' in complex with 5-phospho-alpha-D-ribosyl diphosphate (PRPP) To be Published
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4U72
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![BU of 4u72 by Molmil](/molmil-images/mine/4u72) | Crystal structure of 4-phenylimidazole bound form of human indoleamine 2,3-dioxygenase (A260G mutant) | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 4-PHENYL-1H-IMIDAZOLE, Indoleamine 2,3-dioxygenase 1, ... | Authors: | Sugimoto, H, Horitani, M, Kometani, E, Shiro, Y. | Deposit date: | 2014-07-30 | Release date: | 2015-09-02 | Last modified: | 2020-01-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Conformation and Mobility of Active Site Loop is Critical for Substrate Binding and Inhibition in Human Indoleamine 2,3-Dioxygenase to be published
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4ZC8
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![BU of 4zc8 by Molmil](/molmil-images/mine/4zc8) | Structure of Acetobacter aceti PurE-S57T | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, N5-carboxyaminoimidazole ribonucleotide mutase, ... | Authors: | Kappock, T.J, Sullivan, K.L. | Deposit date: | 2015-04-15 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.754 Å) | Cite: | Mutation of the conserved serine in two PurE classes To Be Published
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3GZ3
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![BU of 3gz3 by Molmil](/molmil-images/mine/3gz3) | |
4S1N
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![BU of 4s1n by Molmil](/molmil-images/mine/4s1n) | The crystal structure of phosphoribosylglycinamide formyltransferase from Streptococcus pneumoniae TIGR4 | Descriptor: | CHLORIDE ION, Phosphoribosylglycinamide formyltransferase | Authors: | Tan, K, Zhou, M, Kwon, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2015-01-14 | Release date: | 2015-01-28 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The crystal structure of phosphoribosylglycinamide formyltransferase from Streptococcus pneumoniae TIGR4 To be Published
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3GZH
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![BU of 3gzh by Molmil](/molmil-images/mine/3gzh) | |
3E2P
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![BU of 3e2p by Molmil](/molmil-images/mine/3e2p) | |
4U74
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![BU of 4u74 by Molmil](/molmil-images/mine/4u74) | Crystal structure of 4-phenylimidazole bound form of human indoleamine 2,3-dioxygenase (G262A mutant) | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 4-PHENYL-1H-IMIDAZOLE, Indoleamine 2,3-dioxygenase 1, ... | Authors: | Sugimoto, H, Horitani, M, Kometani, E, Shiro, Y. | Deposit date: | 2014-07-30 | Release date: | 2015-09-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Conformation and Mobility of Active Site Loop is Critical for Substrate Binding and Inhibition in Human Indoleamine 2,3-Dioxygenase to be published
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3EX1
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![BU of 3ex1 by Molmil](/molmil-images/mine/3ex1) | human orotidyl-5'-monophosphate decarboxylase soaked with 6-cyano-UMP, converted to UMP | Descriptor: | 6-cyanouridine 5'-phosphate, GLYCEROL, Orotidine-5'-phosphate decarboxylase, ... | Authors: | Heinrich, D, Diederichsen, U, Rudolph, M. | Deposit date: | 2008-10-16 | Release date: | 2009-04-07 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase Chemistry, 15, 2009
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3EWY
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![BU of 3ewy by Molmil](/molmil-images/mine/3ewy) | K314A mutant of human orotidyl-5'-monophosphate decarboxylase soaked with OMP, decarboxylated to UMP | Descriptor: | GLYCEROL, Orotidine-5'-phosphate decarboxylase, URIDINE-5'-MONOPHOSPHATE | Authors: | Heinrich, D, Diederichsen, U, Rudolph, M. | Deposit date: | 2008-10-16 | Release date: | 2009-04-07 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase Chemistry, 15, 2009
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4ZK2
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![BU of 4zk2 by Molmil](/molmil-images/mine/4zk2) | |
3EX2
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![BU of 3ex2 by Molmil](/molmil-images/mine/3ex2) | |
3EWW
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![BU of 3eww by Molmil](/molmil-images/mine/3eww) | D312N mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-cyano-UMP, covalent adduct | Descriptor: | 6-[(E)-iminomethyl]uridine 5'-phosphate, GLYCEROL, Orotidine-5'-phosphate decarboxylase | Authors: | Heinrich, D, Wittmann, J, Diederichsen, U, Rudolph, M. | Deposit date: | 2008-10-16 | Release date: | 2009-04-07 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase Chemistry, 15, 2009
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3EWZ
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![BU of 3ewz by Molmil](/molmil-images/mine/3ewz) | |
3F1Q
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![BU of 3f1q by Molmil](/molmil-images/mine/3f1q) | Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 1 | Descriptor: | (2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide, ACETIC ACID, Dihydroorotate dehydrogenase, ... | Authors: | Heikkila, T, Davies, M, McConkey, G.A, Fishwick, C.W.G, Parsons, M.R, Johnson, A.P. | Deposit date: | 2008-10-28 | Release date: | 2009-06-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52, 2009
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3EX6
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![BU of 3ex6 by Molmil](/molmil-images/mine/3ex6) | D312N mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-UMP, covalent adduct | Descriptor: | CHLORIDE ION, GLYCEROL, Orotidine-5'-phosphate decarboxylase, ... | Authors: | Heinrich, D, Diederichsen, U, Rudolph, M. | Deposit date: | 2008-10-16 | Release date: | 2009-04-07 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase Chemistry, 15, 2009
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3FJL
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![BU of 3fjl by Molmil](/molmil-images/mine/3fjl) | |
3GYE
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![BU of 3gye by Molmil](/molmil-images/mine/3gye) | |
6VCU
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![BU of 6vcu by Molmil](/molmil-images/mine/6vcu) | Homo sapiens FKBP12 protein bound with APX879 in P32 space group | Descriptor: | ACETATE ION, N'-[(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-1,20,21-trioxo-8-(prop-2-en-1-yl)-1,3,4,5,6,8,11,12,13,14,15,16,17,18,19,20,21,23,24,25,26,26a-docosahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosin-7-ylidene]acetohydrazide, Peptidyl-prolyl cis-trans isomerase FKBP1A | Authors: | Gobeil, S, Spicer, L. | Deposit date: | 2019-12-23 | Release date: | 2020-12-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs. Mbio, 12, 2021
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6V52
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![BU of 6v52 by Molmil](/molmil-images/mine/6v52) | IDO1 IN COMPLEX WITH COMPOUND 1 | Descriptor: | 3-chloro-N-{4-[1-(propylcarbamoyl)cyclobutyl]phenyl}benzamide, Indoleamine 2,3-dioxygenase 1 | Authors: | Lesburg, C.A, Koenig, K.V, Augustin, M.A. | Deposit date: | 2019-12-03 | Release date: | 2020-04-08 | Last modified: | 2020-04-29 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase-1 (IDO1). Acs Med.Chem.Lett., 11, 2020
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3KIZ
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![BU of 3kiz by Molmil](/molmil-images/mine/3kiz) | |
6VTY
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![BU of 6vty by Molmil](/molmil-images/mine/6vty) | |
6VTN
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![BU of 6vtn by Molmil](/molmil-images/mine/6vtn) | |