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3NOV
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BU of 3nov by Molmil
Crystal Structure of D17E Isocyanide Hydratase from Pseudomonas fluorescens
Descriptor: ACETATE ION, ThiJ/PfpI family protein
Authors:Lakshminarasimhan, M, Madzelan, P, Nan, R, Milkovic, N.M, Wilson, M.A.
Deposit date:2010-06-25
Release date:2010-07-07
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Evolution of New Enzymatic Function by Structural Modulation of Cysteine Reactivity in Pseudomonas fluorescens Isocyanide Hydratase.
J.Biol.Chem., 285, 2010
3NOO
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BU of 3noo by Molmil
Crystal Structure of C101A Isocyanide Hydratase from Pseudomonas fluorescens
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, ThiJ/PfpI family protein
Authors:Lakshminarasimhan, M, Madzelan, P, Nan, R, Milkovic, N.M, Wilson, M.A.
Deposit date:2010-06-25
Release date:2010-07-07
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.03 Å)
Cite:Evolution of New Enzymatic Function by Structural Modulation of Cysteine Reactivity in Pseudomonas fluorescens Isocyanide Hydratase.
J.Biol.Chem., 285, 2010
5MAJ
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BU of 5maj by Molmil
CATHEPSIN L IN COMPLEX WITH 4-[cyclopentyl(imidazo[1,2-a]pyridin-2-ylmethyl)amino]-6-morpholino-1,3,5-triazine-2-carbonitrile
Descriptor: 1,2-ETHANEDIOL, Cathepsin L1, ~{N}-cyclopentyl-~{N}-(imidazo[1,2-a]pyridin-2-ylmethyl)-4-(iminomethyl)-6-morpholin-4-yl-1,3,5-triazin-2-amine
Authors:Kuglstatter, A, Stihle, M, Benz, J.
Deposit date:2016-11-03
Release date:2017-01-11
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1 Å)
Cite:Inhibition of the Cysteine Protease Human Cathepsin L by Triazine Nitriles: AmideHeteroarene pi-Stacking Interactions and Chalcogen Bonding in the S3 Pocket.
ChemMedChem, 12, 2017
6HGY
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BU of 6hgy by Molmil
CRYSTAL STRUCTURE OF CATHEPSIN K WITH N-DESMETHYL THALASSOSPIRAMIDE C
Descriptor: Cathepsin K, THALASSOSPIRAMIDE C
Authors:Zakarian, A, Buckman, B.O, Adler, M, Griessner, A, Blaesse, M.
Deposit date:2018-08-23
Release date:2019-06-26
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Total Synthesis of Covalent Cysteine Protease Inhibitor N-Desmethyl Thalassospiramide C and Crystallographic Evidence for Its Mode of Action.
Org.Lett., 21, 2019
5MAE
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BU of 5mae by Molmil
CATHEPSIN L IN COMPLEX WITH (2S,4R)-4-(2-Chloro-4-methoxy-benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]-pyrrolidine-2-car boxylic acid (1-cyano-cyclopropyl)-amide
Descriptor: 1,2-ETHANEDIOL, Cathepsin L1, [4-[cyclopentyl(pyrazin-2-ylmethyl)amino]-6-morpholin-4-yl-1,3,5-triazin-2-yl]methylideneazanide
Authors:Kuglstatter, A, Stihle, M, Benz, J.
Deposit date:2016-11-03
Release date:2017-01-11
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1 Å)
Cite:Inhibition of the Cysteine Protease Human Cathepsin L by Triazine Nitriles: AmideHeteroarene pi-Stacking Interactions and Chalcogen Bonding in the S3 Pocket.
ChemMedChem, 12, 2017
3UEY
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BU of 3uey by Molmil
Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase Cdelta
Descriptor: PHOSPHATE ION, Protein kinase C delta type, ZINC ION
Authors:Shanmugasundararaj, S, Stehle, T, Miller, K.W.
Deposit date:2011-10-31
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.301 Å)
Cite:Structural and Functional Characterization of an Anesthetic Binding Site in the Second Cysteine-Rich Domain of Protein Kinase Cdelta
Biophys.J., 103, 2012
6B2M
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BU of 6b2m by Molmil
LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase in complex with coenzyme A
Descriptor: ATP-utilizing enzyme of the PP-loopsuperfamily, COENZYME A, PHOSPHATE ION
Authors:Fellner, M, Hausinger, R.P, Hu, J.
Deposit date:2017-09-20
Release date:2018-09-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.088 Å)
Cite:Analysis of the Active Site Cysteine Residue of the Sacrificial Sulfur Insertase LarE from Lactobacillus plantarum.
Biochemistry, 57, 2018
3UEJ
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BU of 3uej by Molmil
Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase Cdelta
Descriptor: PHOSPHATE ION, Protein kinase C delta type, ZINC ION
Authors:Shanmugasundararaj, S, Stehle, T, Miller, K.W.
Deposit date:2011-10-30
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.301 Å)
Cite:Structural and Functional Characterization of an Anesthetic Binding Site in the Second Cysteine-Rich Domain of Protein Kinase Cdelta
Biophys.J., 103, 2012
3W55
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BU of 3w55 by Molmil
The structure of ERK2 in complex with FR148083
Descriptor: (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione, Mitogen-activated protein kinase 1
Authors:Ohori, M, Kinoshita, T.
Deposit date:2013-01-21
Release date:2013-02-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Role of a cysteine residue in the active site of ERK and the MAPKK family
Biochem.Biophys.Res.Commun., 353, 2007
5VSL
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BU of 5vsl by Molmil
Crystal structure of viperin with bound [4Fe-4S] cluster and S-adenosylhomocysteine (SAH)
Descriptor: IRON/SULFUR CLUSTER, Radical S-adenosyl methionine domain-containing protein 2, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Fenwick, M.K, Li, Y, Cresswell, P, Modis, Y, Ealick, S.E.
Deposit date:2017-05-11
Release date:2017-06-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.972 Å)
Cite:Structural studies of viperin, an antiviral radical SAM enzyme.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
1JF9
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BU of 1jf9 by Molmil
Crystal Structure of selenocysteine lyase
Descriptor: PYRIDOXAL-5'-PHOSPHATE, SELENOCYSTEINE LYASE
Authors:Lima, C.D, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2001-06-20
Release date:2001-07-04
Last modified:2025-03-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Analysis of the E. coli NifS CsdB Protein at 2.0A Reveals the Structural Basis for Perselenide and Persulfide Intermediate Formation
J.Mol.Biol., 315, 2002
2VU2
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BU of 2vu2 by Molmil
Biosynthetic thiolase from Z. ramigera. Complex with S-pantetheine-11- pivalate.
Descriptor: (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl 2,2-dimethylpropanoate, ACETYL-COA ACETYLTRANSFERASE, SULFATE ION
Authors:Kursula, P, Merilainen, G, Schmitz, W, Wierenga, R.K.
Deposit date:2008-05-19
Release date:2008-10-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The Sulfur Atoms of the Substrate Coa and the Catalytic Cysteine are Required for a Productive Mode of Substrate Binding in Bacterial Biosynthetic Thiolase, a Thioester-Dependent Enzyme.
FEBS J., 275, 2008
3P7X
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BU of 3p7x by Molmil
Crystal structure of an atypical two-cysteine peroxiredoxin (SAOUHSC_01822) from Staphylococcus aureus NCTC8325
Descriptor: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, Probable thiol peroxidase, ...
Authors:Bhattacharyya, S, Dutta, D, Ghosh, A.K, Das, A.K.
Deposit date:2010-10-13
Release date:2011-10-19
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal structure of an atypical two-cysteine peroxiredoxin (SAOUHSC_01822) from Staphylococcus aureus NCTC8325
To be Published
8BVC
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BU of 8bvc by Molmil
Solution structure of Metridium senile toxin Ms13-1 with the unique fold
Descriptor: Ms13-1
Authors:Mineev, K.S, Arseniev, A.S, Andreev, Y.A, Osmakov, D.I, Khasanov, T.A.
Deposit date:2022-12-06
Release date:2023-12-20
Last modified:2025-07-09
Method:SOLUTION NMR
Cite:Sea anemone Cys-ladder peptide Ms13-1 induces a pain response as a positive modulator of acid-sensing ion channel 1a.
Febs J., 292, 2025
5LQ6
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BU of 5lq6 by Molmil
Salmonella effector SpvD - R161 variant
Descriptor: SODIUM ION, Virulence protein vsdE
Authors:Zhang, Y, Grabe, G.J, Rolhion, N, Yang, Y, Holden, D.W, Hare, S.A.
Deposit date:2016-08-16
Release date:2016-11-02
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:The Salmonella Effector SpvD Is a Cysteine Hydrolase with a Serovar-specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses, and Bacterial Virulence.
J. Biol. Chem., 291, 2016
5LQ7
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BU of 5lq7 by Molmil
Salmonella effector SpvD - G161 variant
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Przydacz, M, Grabe, G.J, Holden, D.W, Hare, S.A.
Deposit date:2016-08-16
Release date:2016-11-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The Salmonella Effector SpvD Is a Cysteine Hydrolase with a Serovar-specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses, and Bacterial Virulence.
J. Biol. Chem., 291, 2016
5CGH
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BU of 5cgh by Molmil
Yeast 20S proteasome beta5-G48C mutant in complex with alpha-chloroacetamide 5
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Dubiella, C, Groll, M.
Deposit date:2015-07-09
Release date:2015-12-02
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Selective Inhibition of the Immunoproteasome by Structure-Based Targeting of a Non-catalytic Cysteine.
Angew.Chem.Int.Ed.Engl., 54, 2015
5B82
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BU of 5b82 by Molmil
Crystal structure of the cyanobacterial heme-protein Tll0287
Descriptor: CHLORIDE ION, HEME C, Tll0287 protein
Authors:Suga, M, Motomura, T, Shen, J.R.
Deposit date:2016-06-12
Release date:2017-05-03
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure and redox properties of a novel cyanobacterial heme protein with a His/Cys heme axial ligation and a Per-Arnt-Sim (PAS)-like domain
J. Biol. Chem., 292, 2017
1LDR
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BU of 1ldr by Molmil
SECOND REPEAT OF THE LDL RECEPTOR LIGAND-BINDING DOMAIN
Descriptor: LOW-DENSITY LIPOPROTEIN RECEPTOR
Authors:Daly, N.L, Djordjevic, J.T, Kroon, P.A, Smith, R.
Deposit date:1995-08-17
Release date:1996-03-08
Last modified:2024-11-06
Method:SOLUTION NMR
Cite:Three-dimensional structure of the second cysteine-rich repeat from the human low-density lipoprotein receptor.
Biochemistry, 34, 1995
6J76
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BU of 6j76 by Molmil
Structure of 3,6-anhydro-L-galactose Dehydrogenase in Complex with NAP
Descriptor: Aldehyde dehydrogenase A, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Li, P.Y, Wang, Y, Chen, X.L, Zhang, Y.Z.
Deposit date:2019-01-17
Release date:2020-01-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.368 Å)
Cite:3,6-Anhydro-L-Galactose Dehydrogenase VvAHGD is a Member of a New Aldehyde Dehydrogenase Family and Catalyzes by a Novel Mechanism with Conformational Switch of Two Catalytic Residues Cysteine 282 and Glutamate 248.
J.Mol.Biol., 432, 2020
5LAC
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BU of 5lac by Molmil
SeMet Labeled Derivative of Cavally Virus 3CL Protease
Descriptor: 3Cl Protease, GLYCEROL
Authors:Kanitz, M, Heine, A, Diederich, W.E.
Deposit date:2016-06-14
Release date:2017-07-12
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structural basis for catalysis and substrate specificity of a 3C-like cysteine protease from a mosquito mesonivirus.
Virology, 533, 2019
6J75
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BU of 6j75 by Molmil
Structure of 3,6-anhydro-L-galactose Dehydrogenase
Descriptor: Aldehyde dehydrogenase A
Authors:Li, P.Y, Wang, Y, Chen, X.L, Zhang, Y.Z.
Deposit date:2019-01-17
Release date:2020-01-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.695 Å)
Cite:3,6-Anhydro-L-Galactose Dehydrogenase VvAHGD is a Member of a New Aldehyde Dehydrogenase Family and Catalyzes by a Novel Mechanism with Conformational Switch of Two Catalytic Residues Cysteine 282 and Glutamate 248.
J.Mol.Biol., 432, 2020
207L
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BU of 207l by Molmil
MUTANT HUMAN LYSOZYME C77A
Descriptor: LYSOZYME, N-ACETYL-L-CYSTEINE
Authors:Matsushima, M, Song, H.
Deposit date:1996-03-26
Release date:1996-10-14
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A role of PDI in the reductive cleavage of mixed disulfides.
J.Biochem.(Tokyo), 120, 1996
1XDJ
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BU of 1xdj by Molmil
Crystal Structure of T. maritima Cobalamin-Independent Methionine Synthase complexed with Zn2+ and Homocysteine
Descriptor: 2-AMINO-4-MERCAPTO-BUTYRIC ACID, 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, MESO-ERYTHRITOL, ...
Authors:Pejchal, R, Ludwig, M.L.
Deposit date:2004-09-06
Release date:2005-03-01
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication
Plos Biol., 3, 2005
1XU1
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BU of 1xu1 by Molmil
The crystal structure of APRIL bound to TACI
Descriptor: NICKEL (II) ION, Tumor necrosis factor ligand superfamily member 13, Tumor necrosis factor receptor superfamily member 13B
Authors:Hymowitz, S.G, Patel, D.R, Wallweber, H.J.A, Runyon, S, Yan, M, Yin, J, Shriver, S.K, Gordon, N.C, Pan, B, Skelton, N.J, Kelley, R.F, Starovasnik, M.A.
Deposit date:2004-10-25
Release date:2004-11-09
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of APRIL-receptor complexes: Like BCMA, TACI employs only a single cysteine-rich domain for high-affinity ligand binding
J.Biol.Chem., 280, 2005

238582

數據於2025-07-09公開中

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