6HGY
CRYSTAL STRUCTURE OF CATHEPSIN K WITH N-DESMETHYL THALASSOSPIRAMIDE C
Summary for 6HGY
Entry DOI | 10.2210/pdb6hgy/pdb |
Descriptor | Cathepsin K, THALASSOSPIRAMIDE C (3 entities in total) |
Functional Keywords | protease, cathepsin k, proteros biostructures gmbh, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 24315.45 |
Authors | Zakarian, A.,Buckman, B.O.,Adler, M.,Griessner, A.,Blaesse, M. (deposition date: 2018-08-23, release date: 2019-06-26, Last modification date: 2024-01-17) |
Primary citation | Fournier, J.,Chen, K.,Mailyan, A.K.,Jackson, J.J.,Buckman, B.O.,Emayan, K.,Yuan, S.,Rajagopalan, R.,Misialek, S.,Adler, M.,Blaesse, M.,Griessner, A.,Zakarian, A. Total Synthesis of Covalent Cysteine Protease Inhibitor N-Desmethyl Thalassospiramide C and Crystallographic Evidence for Its Mode of Action. Org.Lett., 21:508-512, 2019 Cited by PubMed: 30628449DOI: 10.1021/acs.orglett.8b03821 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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