3DVP
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![BU of 3dvp by Molmil](/molmil-images/mine/3dvp) | Pak1 peptide bound LC8 | Descriptor: | Dynein light chain 1, cytoplasmic, P21 activated Kinase peptide | Authors: | Lightcap, C.M, Williams, J.C. | Deposit date: | 2008-07-18 | Release date: | 2009-01-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Biochemical and structural characterization of the Pak1-LC8 interaction. J.Biol.Chem., 283, 2008
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3N5E
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![BU of 3n5e by Molmil](/molmil-images/mine/3n5e) | Crystal Structure of human thymidylate synthase bound to a peptide inhibitor | Descriptor: | SULFATE ION, Synthetic peptide LR, Thymidylate synthase | Authors: | Pozzi, C, Cardinale, D, Guaitoli, G, Tondi, D, Luciani, R, Myllykallio, H, Ferrari, S, Costi, M.P, Mangani, S. | Deposit date: | 2010-05-25 | Release date: | 2011-06-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase. Proc.Natl.Acad.Sci.USA, 108, 2011
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8T5H
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![BU of 8t5h by Molmil](/molmil-images/mine/8t5h) | Cryo-EM studies of the interplay between uS2 ribosomal protein and leaderless mRNA during bacterial translation initiation | Descriptor: | 16S, 23S, 30S ribosomal protein S10, ... | Authors: | Bhattacharjee, S, Gottesman, M.E, Frank, J. | Deposit date: | 2023-06-13 | Release date: | 2024-08-28 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | How Dedicated Ribosomes Translate a Leaderless mRNA. J.Mol.Biol., 436, 2024
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8T5D
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![BU of 8t5d by Molmil](/molmil-images/mine/8t5d) | Cryo-EM studies of the interplay between uS2 ribosomal protein and leaderless mRNA during bacterial translation initiation | Descriptor: | 16s RNA, 23S RNA, 30S ribosomal protein S10, ... | Authors: | Bhattacharjee, S, Gottesman, M.E, Frank, J. | Deposit date: | 2023-06-13 | Release date: | 2024-08-28 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | How Dedicated Ribosomes Translate a Leaderless mRNA. J.Mol.Biol., 436, 2024
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3KUP
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![BU of 3kup by Molmil](/molmil-images/mine/3kup) | Crystal Structure of the CBX3 Chromo Shadow Domain | Descriptor: | Chromobox protein homolog 3, UNKNOWN ATOM OR ION | Authors: | Tempel, W, Li, Z, Li, Y, Kozieradzki, I, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Ouyang, H, Structural Genomics Consortium (SGC) | Deposit date: | 2009-11-27 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Crystal Structure of the CBX3 Chromo Shadow Domain to be published
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3N5G
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![BU of 3n5g by Molmil](/molmil-images/mine/3n5g) | Crystal Structure of histidine-tagged human thymidylate synthase | Descriptor: | SULFATE ION, Thymidylate synthase | Authors: | Pozzi, C, Cardinale, D, Guaitoli, G, Tondi, D, Luciani, R, Myllykallio, H, Ferrari, S, Costi, M.P, Mangani, S. | Deposit date: | 2010-05-25 | Release date: | 2011-06-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase. Proc.Natl.Acad.Sci.USA, 108, 2011
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5WRN
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![BU of 5wrn by Molmil](/molmil-images/mine/5wrn) | |
6M5W
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![BU of 6m5w by Molmil](/molmil-images/mine/6m5w) | Co-crystal structure of human serine hydroxymethyltransferase 1 in complex with Pyridoxal 5'-phosphate (PLP) and glycodeoxycholic acid | Descriptor: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, GLYCINE, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Ota, T, Senoo, A, Ito, S, Ueno, G, Nagatoishi, S, Tsumoto, K, Sando, S. | Deposit date: | 2020-03-11 | Release date: | 2021-01-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural basis for selective inhibition of human serine hydroxymethyltransferase by secondary bile acid conjugate. Iscience, 24, 2021
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7KD8
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![BU of 7kd8 by Molmil](/molmil-images/mine/7kd8) | TtgR C137I I141W M167L F168Y mutant in complex with resveratrol | Descriptor: | HTH-type transcriptional regulator TtgR, MAGNESIUM ION, RESVERATROL | Authors: | Bingman, C.A, Nishikawa, K.K, Smith, R.W, Raman, S. | Deposit date: | 2020-10-08 | Release date: | 2021-10-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Epistasis shapes the fitness landscape of an allosteric specificity switch. Nat Commun, 12, 2021
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7K1A
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![BU of 7k1a by Molmil](/molmil-images/mine/7k1a) | TtgR quadruple mutant (C137I I141W M167L F168Y) | Descriptor: | HTH-type transcriptional regulator TtgR, MAGNESIUM ION | Authors: | Bingman, C.A, Nishikawa, K.K, Smith, R.W, Raman, S. | Deposit date: | 2020-09-07 | Release date: | 2021-10-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Epistasis shapes the fitness landscape of an allosteric specificity switch. Nat Commun, 12, 2021
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7K1C
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![BU of 7k1c by Molmil](/molmil-images/mine/7k1c) | TtgR in complex with resveratrol | Descriptor: | HTH-type transcriptional regulator TtgR, MAGNESIUM ION, RESVERATROL | Authors: | Bingman, C.A, Nishikawa, K.K, Smith, R.W, Raman, S. | Deposit date: | 2020-09-07 | Release date: | 2021-10-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Epistasis shapes the fitness landscape of an allosteric specificity switch. Nat Commun, 12, 2021
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6MRK
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![BU of 6mrk by Molmil](/molmil-images/mine/6mrk) | |
6MRJ
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![BU of 6mrj by Molmil](/molmil-images/mine/6mrj) | |
3QQA
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![BU of 3qqa by Molmil](/molmil-images/mine/3qqa) | Crystal structures of CmeR-bile acid complexes from Campylobacter jejuni | Descriptor: | CmeR, TAUROCHOLIC ACID | Authors: | Lei, H.T, Routh, M.D, Shen, Z, Su, C.-C, Zhang, Q, Yu, E.W. | Deposit date: | 2011-02-15 | Release date: | 2011-03-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of CmeR-bile acid complexes from Campylobacter jejuni. Protein Sci., 20, 2011
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4UP1
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![BU of 4up1 by Molmil](/molmil-images/mine/4up1) | |
6OJU
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![BU of 6oju by Molmil](/molmil-images/mine/6oju) | Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-D-glutamic acid | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, N-{4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}-D-glutamic acid, Thymidylate synthase,Thymidylate synthase | Authors: | Czyzyk, D.J, Anderson, K.S, Valhondo, M, Jorgensen, W.L. | Deposit date: | 2019-04-12 | Release date: | 2019-06-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.884 Å) | Cite: | Understanding the structural basis of species selective, stereospecific inhibition for Cryptosporidium and human thymidylate synthase. Febs Lett., 593, 2019
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6OJV
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![BU of 6ojv by Molmil](/molmil-images/mine/6ojv) | Crystal structure of human thymidylate synthase delta(7-29) in complex with dUMP and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-L-glutamic acid | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, N-{4-[(2-amino-4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzoyl}-L-glutamic acid, Thymidylate synthase,Thymidylate synthase | Authors: | Czyzyk, D.J, Anderson, K.S, Valhondo, M, Jorgensen, W.L. | Deposit date: | 2019-04-12 | Release date: | 2019-06-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.593 Å) | Cite: | Understanding the structural basis of species selective, stereospecific inhibition for Cryptosporidium and human thymidylate synthase. Febs Lett., 593, 2019
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3QPS
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![BU of 3qps by Molmil](/molmil-images/mine/3qps) | Crystal structures of CmeR-bile acid complexes from Campylobacter jejuni | Descriptor: | CHOLIC ACID, CmeR | Authors: | Lei, H.T, Routh, M.D, Shen, Z, Su, C.C, Zhang, Q, Yu, E.W. | Deposit date: | 2011-02-14 | Release date: | 2011-03-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.351 Å) | Cite: | Crystal structures of CmeR-bile acid complexes from Campylobacter jejuni. Protein Sci., 20, 2011
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3CFS
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![BU of 3cfs by Molmil](/molmil-images/mine/3cfs) | Structural basis of the interaction of RbAp46/RbAp48 with histone H4 | Descriptor: | ARSENIC, Histone H4, Histone-binding protein RBBP7 | Authors: | Murzina, N.V, Pei, X.-Y, Pratap, J.V, Sparkes, M, Vicente-Garcia, J, Ben-Shahar, T.R, Verreault, A, Luisi, B.F, Laue, E.D. | Deposit date: | 2008-03-04 | Release date: | 2008-06-10 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Basis for the Recognition of Histone H4 by the Histone-Chaperone RbAp46. Structure, 16, 2008
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4YBB
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![BU of 4ybb by Molmil](/molmil-images/mine/4ybb) | High-resolution structure of the Escherichia coli ribosome | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, ... | Authors: | Noeske, J, Wasserman, M.R, Terry, D.S, Altman, R.B, Blanchard, S.C, Cate, J.H.D. | Deposit date: | 2015-02-18 | Release date: | 2015-03-18 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | High-resolution structure of the Escherichia coli ribosome. Nat.Struct.Mol.Biol., 22, 2015
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1A53
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![BU of 1a53 by Molmil](/molmil-images/mine/1a53) | COMPLEX OF INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE FROM SULFOLOBUS SOLFATARICUS WITH INDOLE-3-GLYCEROLPHOSPHATE AT 2.0 A RESOLUTION | Descriptor: | INDOLE-3-GLYCEROL PHOSPHATE, INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE | Authors: | Hennig, M, Darimont, B, Kirschner, K, Jansonius, J.N. | Deposit date: | 1998-02-19 | Release date: | 1999-03-23 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The catalytic mechanism of indole-3-glycerol phosphate synthase: crystal structures of complexes of the enzyme from Sulfolobus solfataricus with substrate analogue, substrate, and product. J.Mol.Biol., 319, 2002
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1AN7
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![BU of 1an7 by Molmil](/molmil-images/mine/1an7) | |
3E2B
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![BU of 3e2b by Molmil](/molmil-images/mine/3e2b) | Crystal structure of Dynein Light chain LC8 in complex with a peptide derived from Swallow | Descriptor: | ACETATE ION, Dynein light chain 1, cytoplasmic, ... | Authors: | Benison, G, Barbar, E, Karplus, P.A. | Deposit date: | 2008-08-05 | Release date: | 2008-08-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The interplay of ligand binding and quaternary structure in the diverse interactions of dynein light chain LC8. J.Mol.Biol., 384, 2008
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4WQO
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![BU of 4wqo by Molmil](/molmil-images/mine/4wqo) | Structure of VHL-EloB-EloC-Cul2 | Descriptor: | Cullin-2, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ... | Authors: | Nguyen, H.C, Xiong, Y. | Deposit date: | 2014-10-22 | Release date: | 2015-03-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Insights into Cullin-RING E3 Ubiquitin Ligase Recruitment: Structure of the VHL-EloBC-Cul2 Complex. Structure, 23, 2015
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2W3B
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![BU of 2w3b by Molmil](/molmil-images/mine/2w3b) | HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR MYCOBACTERIUM AVIUM DHFR, 6-((2,5- DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D) PYRIMIDINE (SRI-8686) | Descriptor: | 6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE, DIHYDROFOLATE REDUCTASE, FOLIC ACID, ... | Authors: | Leung, A.K.W, Reynolds, R.C, Borhani, D.W. | Deposit date: | 2008-11-11 | Release date: | 2009-11-17 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.27 Å) | Cite: | Structural Basis for Selective Inhibition of Mycobacterium Avium Dihydrofolate Reductase by a Lipophilic Antifolate To be Published
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