6M5W

Co-crystal structure of human serine hydroxymethyltransferase 1 in complex with Pyridoxal 5'-phosphate (PLP) and glycodeoxycholic acid

Summary for 6M5W

• Entry DOI: 10.2210/pdb6m5w/pdb
• Descriptor: Serine hydroxymethyltransferase, cytosolic, PYRIDOXAL-5'-PHOSPHATE, (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 56038.65

Authors

Ota, T.,Senoo, A.,Ito, S.,Ueno, G.,Nagatoishi, S.,Tsumoto, K.,Sando, S. (deposition date: 2020-03-11, release date: 2021-01-20, Last modification date: 2023-11-29)

• Primary citation: Ota, T.,Senoo, A.,Shirakawa, M.,Nonaka, H.,Saito, Y.,Ito, S.,Ueno, G.,Nagatoishi, S.,Tsumoto, K.,Sando, S.; Structural basis for selective inhibition of human serine hydroxymethyltransferase by secondary bile acid conjugate.; Iscience, 24:102036-102036, 2021; PubMed: 33521601; DOI: 10.1016/j.isci.2021.102036

Experimental method

X-RAY DIFFRACTION (3.1 Å)