6M5W

Co-crystal structure of human serine hydroxymethyltransferase 1 in complex with Pyridoxal 5'-phosphate (PLP) and glycodeoxycholic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Serine hydroxymethyltransferase, cytosolic	polymer	503	55323.9	1	UniProt (P34896) Pfam (PF00464) In PDB	Homo sapiens (Human)	SHMT,Glycine hydroxymethyltransferase,Serine methylase
2	A	PYRIDOXAL-5'-PHOSPHATE	non-polymer		247.1	1	Chemie (PLP)
3	A	(3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID	non-polymer		392.6	1	Chemie (DXC)
4	A	GLYCINE	non-polymer		75.1	1	Chemie (GLY)

Sequence modifications

A: 1 - 483 (UniProt: P34896)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	55323.9
Non-Polymers*	Number of molecules	3
	Total formula weight	714.8
All*	Total formula weight	56038.6

*Water molecules are not included.