6M5W
Co-crystal structure of human serine hydroxymethyltransferase 1 in complex with Pyridoxal 5'-phosphate (PLP) and glycodeoxycholic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine hydroxymethyltransferase, cytosolic | polymer | 503 | 55323.9 | 1 | UniProt (P34896) Pfam (PF00464) | Homo sapiens (Human) | SHMT,Glycine hydroxymethyltransferase,Serine methylase |
| 2 | B (A) | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 1 | Chemie (PLP) PubChem (1051) | |||
| 3 | C (A) | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID | non-polymer | 392.6 | 1 | Chemie (DXC) PubChem (16398945) PubChem (16757991) PubChem (16759977) PubChem (18346235) PubChem (18528829) PubChem (20106101) PubChem (20714831) PubChem (2987) PubChem (176479387) PubChem (176489046) PubChem (71183244) PubChem (23643772) PubChem (6742) PubChem (24106003) PubChem (25749121) PubChem (25749125) PubChem (40469677) PubChem (40469679) PubChem (44372437) PubChem (44725023) PubChem (91449) PubChem (45358122) PubChem (1750955) PubChem (1750952) PubChem (145538113) PubChem (49791913) PubChem (1769282) PubChem (1769279) PubChem (1769277) PubChem (51411346) PubChem (51669127) PubChem (52947316) PubChem (53298648) PubChem (160530) PubChem (222528) PubChem (59032048) PubChem (44724091) PubChem (45050703) PubChem (59373866) PubChem (59603119) PubChem (59877675) PubChem (59963668) PubChem (59997753) PubChem (60103596) PubChem (440355) PubChem (67122254) PubChem (68027121) PubChem (68027124) PubChem (68027246) PubChem (71047569) PubChem (71315440) PubChem (51413969) PubChem (53393577) PubChem (53477694) PubChem (637628) PubChem (56846007) PubChem (57937275) PubChem (58069304) PubChem (59373875) PubChem (60081048) PubChem (86310104) PubChem (67122253) PubChem (87298938) PubChem (2817554) PubChem (5283831) PubChem (5283833) PubChem (5283834) PubChem (5283835) PubChem (5283836) PubChem (89517208) PubChem (89595858) PubChem (91277849) PubChem (3246028) PubChem (5316554) PubChem (90661466) PubChem (5283832) PubChem (99565238) PubChem (118725000) PubChem (7000965) PubChem (7002091) PubChem (7200738) PubChem (124897171) PubChem (124917110) PubChem (125034662) PubChem (9886838) PubChem (126497949) PubChem (126577443) PubChem (131700475) PubChem (97032051) PubChem (6546957) PubChem (6708651) PubChem (6713712) PubChem (99565239) PubChem (100940592) PubChem (7002093) PubChem (102513999) PubChem (134555898) PubChem (117767697) PubChem (118085203) PubChem (118227551) PubChem (7067172) PubChem (7067178) PubChem (7091730) PubChem (71164460) PubChem (9953605) PubChem (12358589) PubChem (71171226) PubChem (124190288) PubChem (140609403) PubChem (124305301) PubChem (124351304) PubChem (124352383) PubChem (124352508) PubChem (124510867) PubChem (124510868) PubChem (124511068) PubChem (141854532) PubChem (11761472) PubChem (11875893) PubChem (11875895) PubChem (11877125) PubChem (11889739) PubChem (11889741) PubChem (11889743) PubChem (124762205) PubChem (12358594) PubChem (12598155) PubChem (124897175) PubChem (124907310) PubChem (124917111) PubChem (124917112) PubChem (125034663) PubChem (125034664) PubChem (125180673) PubChem (125180674) PubChem (125180675) PubChem (155392252) PubChem (162937386) PubChem (162937385) PubChem (126672052) PubChem (126672053) PubChem (175674103) PubChem (175889631) PubChem (129213992) PubChem (129253082) PubChem (130219689) PubChem (133126817) PubChem (133567529) PubChem (133612068) PubChem (134452639) PubChem (134555900) PubChem (139291938) PubChem (144316921) PubChem (144706089) PubChem (145266284) PubChem (145714627) PubChem (146158532) PubChem (148065335) PubChem (155897264) PubChem (162523132) PubChem (162937382) PubChem (162937383) PubChem (162937384) PubChem (162937387) PubChem (162937388) PubChem (162937389) PubChem (166047560) PubChem (166847890) PubChem (170838259) | |||
| 4 | D (A) | GLYCINE | non-polymer | 75.1 | 1 | Chemie (GLY) PubChem (750) |
Sequence modifications
A: 1 - 483 (UniProt: P34896)
| PDB | External Database | Details |
|---|---|---|
| Met -19 | - | initiating methionine |
| Gly -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Ser -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 55323.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 714.8 | |
| All* | Total formula weight | 56038.6 |
