7ZJE
| C16-2 | Descriptor: | Transient receptor potential cation channel subfamily V member 2,Enhanced green fluorescent protein | Authors: | Zhang, L, Gourdon, P, Zygmunt, P.M. | Deposit date: | 2022-04-10 | Release date: | 2023-01-18 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function. Nat Commun, 13, 2022
|
|
7ZJG
| Probenecid | Descriptor: | Transient receptor potential cation channel subfamily V member 2 | Authors: | Zhang, L, Gourdon, P, Zygmunt, P.M. | Deposit date: | 2022-04-11 | Release date: | 2023-01-18 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function. Nat Commun, 13, 2022
|
|
7ZJI
| |
7ZJH
| TRPV2-C16+Pro-2 | Descriptor: | Transient receptor potential cation channel subfamily V member 2 | Authors: | Zhang, L, Gourdon, P, Zygmunt, P.M. | Deposit date: | 2022-04-11 | Release date: | 2023-01-18 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function. Nat Commun, 13, 2022
|
|
7ZJD
| |
3GB7
| Potassium Channel KcsA-Fab complex in Li+ | Descriptor: | DIACYL GLYCEROL, NICKEL (II) ION, Voltage-gated potassium channel, ... | Authors: | Thompson, A.N, Ilsoo, K, Panosian, T.D, Iverson, T.M, Allen, T.W, Nimigean, C.M. | Deposit date: | 2009-02-18 | Release date: | 2009-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore. Nat.Struct.Mol.Biol., 16, 2009
|
|
3HPL
| KcsA E71H-F103A mutant in the closed state | Descriptor: | Antibody Fab heavy chain, Antibody fab light chain, POTASSIUM ION, ... | Authors: | Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E. | Deposit date: | 2009-06-04 | Release date: | 2010-06-23 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis for the coupling between activation and inactivation gates in K(+) channels. Nature, 466, 2010
|
|
3IGA
| Potassium Channel KcsA-Fab complex in Li+ and K+ | Descriptor: | Antibody Fab Fragment heavy chain, Antibody Fab fragment light chain, DIACYL GLYCEROL, ... | Authors: | Thompson, A.N, Ilsoo, K, Panosian, T.D, Iverson, T.M, Allen, T.W, Nimigean, C.M. | Deposit date: | 2009-07-27 | Release date: | 2009-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore. Nat.Struct.Mol.Biol., 16, 2009
|
|
8BDC
| Human apo TRPM8 in a closed state (composite map) | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL HEMISUCCINATE, SODIUM ION, ... | Authors: | Palchevskyi, S, Czarnocki-Cieciura, M, Vistoli, G, Gervasoni, S, Nowak, E, Beccari, A.R, Nowotny, M, Talarico, C. | Deposit date: | 2022-10-19 | Release date: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (2.65 Å) | Cite: | Structure of human TRPM8 channel. Commun Biol, 6, 2023
|
|
3FB8
| KcsA Potassium channel in the open-conductive state with 20 A opening at T112 in the presence of Rb+ ion | Descriptor: | RUBIDIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ... | Authors: | Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E. | Deposit date: | 2008-11-18 | Release date: | 2010-05-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | KcsA Potassium channel in the open-conductive state
with 20 A opening at T112 in the presence of Rb+ ion TO BE PUBLISHED
|
|
3F7V
| KcsA Potassium channel in the open-inactivated state with 23 A opening at T112 | Descriptor: | POTASSIUM ION, Voltage-gated potassium channel, antibody fab fragment Heavy chain, ... | Authors: | Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E. | Deposit date: | 2008-11-10 | Release date: | 2010-05-19 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | KcsA Potassium channel in the open-inactivated state with 23 A opening at T112 TO BE PUBLISHED
|
|
3IFX
| Crystal structure of the Spin-labeled KcsA mutant V48R1 | Descriptor: | POTASSIUM ION, S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate, TETRABUTYLAMMONIUM ION, ... | Authors: | Cieslak, J.A, Focia, P.J, Gross, A. | Deposit date: | 2009-07-26 | Release date: | 2010-02-09 | Last modified: | 2023-09-06 | Method: | EPR (3.56 Å), X-RAY DIFFRACTION | Cite: | Electron Spin-Echo Envelope Modulation (ESEEM) Reveals Water and Phosphate Interactions with the KcsA Potassium Channel Biochemistry, 49, 2010
|
|
3F7Y
| KcsA Potassium channel in the partially open state with 17 A opening at T112 | Descriptor: | POTASSIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ... | Authors: | Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E. | Deposit date: | 2008-11-10 | Release date: | 2010-05-19 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | KcsA Potassium channel in the partially open state with 17 A opening at T112 TO BE PUBLISHED
|
|
6W0A
| Open-gate KcsA soaked in 1 mM BaCl2 | Descriptor: | BARIUM ION, Fab Heavy Chain, Fab Light Chain, ... | Authors: | Rohaim, A, Gong, L, Li, J. | Deposit date: | 2020-02-29 | Release date: | 2020-07-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.237 Å) | Cite: | Open and Closed Structures of a Barium-Blocked Potassium Channel. J.Mol.Biol., 432, 2020
|
|
6W0I
| Closed-gate KcsA soaked in 10mM KCl/5mM BaCl2 | Descriptor: | Fab Heavy Chain, Fab Light Chain, POTASSIUM ION, ... | Authors: | Rohaim, A, Gong, L, Li, J. | Deposit date: | 2020-02-29 | Release date: | 2020-07-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.328 Å) | Cite: | Open and Closed Structures of a Barium-Blocked Potassium Channel. J.Mol.Biol., 432, 2020
|
|
6W6O
| NaChBac-Nav1.7VSDII chimera and HWTX-IV complex | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Huwentoxin-IV, NaChBac-Nav1.7VSDII chimera | Authors: | Yan, N, Gao, S. | Deposit date: | 2020-03-17 | Release date: | 2020-06-24 | Last modified: | 2021-01-13 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na + channels in nanodisc. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6W0F
| Closed-gate KcsA soaked in 0mM KCl/5mM BaCl2 | Descriptor: | Fab Heavy Chain, Fab Light Chain, POTASSIUM ION, ... | Authors: | Rohaim, A, Gong, L, Li, J. | Deposit date: | 2020-02-29 | Release date: | 2020-07-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Open and Closed Structures of a Barium-Blocked Potassium Channel. J.Mol.Biol., 432, 2020
|
|
6WKN
| PL-bound rat TRPV2 in nanodiscs | Descriptor: | Transient receptor potential cation channel subfamily V member 2, piperlongumine | Authors: | Pumroy, R.P, Moiseenkova-Bell, V.Y. | Deposit date: | 2020-04-16 | Release date: | 2021-04-21 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression. Acs Cent.Sci., 7, 2021
|
|
6W0E
| Open-gate KcsA soaked in 10 mM BaCl2 | Descriptor: | BARIUM ION, Fab Heavy Chain, Fab Light Chain, ... | Authors: | Rohaim, A, Gong, L, Li, J. | Deposit date: | 2020-02-29 | Release date: | 2020-07-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.512 Å) | Cite: | Open and Closed Structures of a Barium-Blocked Potassium Channel. J.Mol.Biol., 432, 2020
|
|
7SJ1
| Structure of shaker-W434F | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel protein Shaker | Authors: | Tan, X, Bae, C, Stix, R, Fernandez, A.I, Huffer, K, Chang, T, Jiang, J, Faraldo-Gomez, J.D, Swartz, K.J. | Deposit date: | 2021-10-15 | Release date: | 2022-03-30 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure of the Shaker Kv channel and mechanism of slow C-type inactivation. Sci Adv, 8, 2022
|
|
7SIP
| Structure of shaker-IR | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel protein Shaker | Authors: | Tan, X, Bae, C, Stix, R, Fernandez, A.I, Huffer, K, Chang, T, Jiang, J, Faraldo-Gomez, J.D, Swartz, K.J. | Deposit date: | 2021-10-14 | Release date: | 2022-03-30 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure of the Shaker Kv channel and mechanism of slow C-type inactivation. Sci Adv, 8, 2022
|
|
7SX3
| Human NALCN-FAM155A-UNC79-UNC80 channelosome with CaM bound, conformation 1/2 | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Kschonsak, M, Chua, H.C, Weidling, C, Chakouri, N, Noland, C.L, Schott, K, Chang, T, Tam, C, Patel, N, Arthur, C.P, Leitner, A, Ben-Johny, M, Ciferri, C, Pless, S.A, Payandeh, J. | Deposit date: | 2021-11-22 | Release date: | 2021-12-29 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural architecture of the human NALCN channelosome. Nature, 603, 2022
|
|
7SX4
| Human NALCN-FAM155A-UNC79-UNC80 channelosome with CaM bound, conformation 2/2 | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Kschonsak, M, Chua, H.C, Weidling, C, Chakouri, N, Noland, C.L, Schott, K, Chang, T, Tam, C, Patel, N, Arthur, C.P, Leitner, A, Ben-Johny, M, Ciferri, C, Pless, S.A, Payandeh, J. | Deposit date: | 2021-11-22 | Release date: | 2021-12-29 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural architecture of the human NALCN channelosome. Nature, 603, 2022
|
|
7SQ7
| Cryo-EM structure of mouse PI(3,5)P2-bound TRPML1 channel at 2.41 Angstrom resolution | Descriptor: | (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, ... | Authors: | Gan, N, Han, Y, Jiang, Y. | Deposit date: | 2021-11-04 | Release date: | 2022-02-02 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (2.41 Å) | Cite: | Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7SQ8
| Cryo-EM structure of mouse apo TRPML1 channel at 2.598 Angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION | Authors: | Gan, N, Han, Y, Jiang, Y. | Deposit date: | 2021-11-04 | Release date: | 2022-02-02 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (2.598 Å) | Cite: | Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|