8KG8
 
 | | Yeast replisome in state II | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, DNA (61-mer), ... | | Authors: | Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. | | Deposit date: | 2023-08-17 | | Release date: | 2023-12-06 | | Method: | ELECTRON MICROSCOPY (4.23 Å) | | Cite: | Synergism between CMG helicase and leading strand DNA polymerase at replication fork.
Nat Commun, 14, 2023
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8OJB
 | | HSV-1 DNA polymerase-processivity factor complex in exonuclease state active site | | Descriptor: | CALCIUM ION, DNA (47-MER), DNA polymerase catalytic subunit | | Authors: | Gustavsson, E, Grunewald, K, Elias, P, Hallberg, B.M. | | Deposit date: | 2023-03-24 | | Release date: | 2024-04-03 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (1.9 Å) | | Cite: | Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM.
Nucleic Acids Res., 2024
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8OJA
 | | HSV-1 DNA polymerase-processivity factor complex in exonuclease state | | Descriptor: | CALCIUM ION, DNA (47-MER), DNA (68-MER), ... | | Authors: | Gustavsson, E, Grunewald, K, Elias, P, Hallberg, B.M. | | Deposit date: | 2023-03-24 | | Release date: | 2024-04-03 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (1.87 Å) | | Cite: | Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM.
Nucleic Acids Res., 2024
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8OJD
 | | HSV-1 DNA polymerase beta-hairpin loop | | Descriptor: | CALCIUM ION, DNA (47-MER), DNA (68-MER), ... | | Authors: | Gustavsson, E, Grunewald, K, Elias, P, Hallberg, B.M. | | Deposit date: | 2023-03-24 | | Release date: | 2024-04-03 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.46 Å) | | Cite: | Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM.
Nucleic Acids Res., 2024
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8OJ6
 | | HSV-1 DNA polymerase-processivity factor complex in pre-translocation state | | Descriptor: | DNA (22-MER), DNA (48-MER), DNA polymerase catalytic subunit, ... | | Authors: | Gustavsson, E, Grunewald, K, Elias, P, Hallberg, B.M. | | Deposit date: | 2023-03-24 | | Release date: | 2024-04-03 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.41 Å) | | Cite: | Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM.
Nucleic Acids Res., 2024
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8OJC
 | | HSV-1 DNA polymerase active site in alternative exonuclease state | | Descriptor: | CALCIUM ION, DNA (47-MER), DNA polymerase catalytic subunit | | Authors: | Gustavsson, E, Grunewald, K, Elias, P, Hallberg, B.M. | | Deposit date: | 2023-03-24 | | Release date: | 2024-04-03 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.08 Å) | | Cite: | Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM.
Nucleic Acids Res., 2024
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8OJ7
 | | HSV-1 DNA polymerase-processivity factor complex in halted elongation state | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (53-MER), DNA (67-MER), ... | | Authors: | Gustavsson, E, Grunewald, K, Elias, P, Hallberg, B.M. | | Deposit date: | 2023-03-24 | | Release date: | 2024-04-03 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.46 Å) | | Cite: | Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM.
Nucleic Acids Res., 2024
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8KG9
 | | Yeast replisome in state III | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, DNA (61-mer), ... | | Authors: | Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. | | Deposit date: | 2023-08-17 | | Release date: | 2023-12-06 | | Method: | ELECTRON MICROSCOPY (4.52 Å) | | Cite: | Synergism between CMG helicase and leading strand DNA polymerase at replication fork.
Nat Commun, 14, 2023
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8FOJ
 | | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the post RNA handoff state | | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | | Deposit date: | 2022-12-30 | | Release date: | 2023-05-31 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
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8FOK
 | | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the DNA elongation state | | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | | Deposit date: | 2022-12-30 | | Release date: | 2023-05-31 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.56 Å) | | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
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8FOH
 | | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the RNA synthesis state | | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | | Deposit date: | 2022-12-30 | | Release date: | 2023-05-31 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
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8FOC
 | | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase in Apo state conformation I | | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | | Deposit date: | 2022-12-30 | | Release date: | 2023-05-31 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
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8FOE
 | | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex bound to a template DNA | | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | | Deposit date: | 2022-12-30 | | Release date: | 2023-05-31 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (5.6 Å) | | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
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8FOD
 | | Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in Apo state conformation II | | Descriptor: | DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ... | | Authors: | Yuan, Z, Georgescu, R, Li, H, O'Donnell, M. | | Deposit date: | 2022-12-30 | | Release date: | 2023-05-31 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
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8G9L
 | | DNA initiation subcomplex of Xenopus laevis DNA polymerase alpha-primase | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA primase large subunit, ... | | Authors: | Mullins, E.A, Durie, C.L, Ohi, M.D, Chazin, W.J, Eichman, B.F. | | Deposit date: | 2023-02-21 | | Release date: | 2023-04-12 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Nat.Struct.Mol.Biol., 31, 2024
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8G9F
 | | Complete auto-inhibitory complex of Xenopus laevis DNA polymerase alpha-primase | | Descriptor: | DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase, ... | | Authors: | Mullins, E.A, Chazin, W.J, Eichman, B.F. | | Deposit date: | 2023-02-21 | | Release date: | 2023-04-12 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Nat.Struct.Mol.Biol., 31, 2024
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4DU1
 | | RB69 DNA Polymerase Ternary Complex with dATP Opposite dT | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase, ... | | Authors: | Xia, S, Wang, J, Konigsberg, W.H. | | Deposit date: | 2012-02-21 | | Release date: | 2012-05-23 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Probing minor groove hydrogen bonding interactions between RB69 DNA polymerase and DNA.
Biochemistry, 51, 2012
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8G99
 | | Partial auto-inhibitory complex of Xenopus laevis DNA polymerase alpha-primase | | Descriptor: | DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase large subunit, ... | | Authors: | Mullins, E.A, Chazin, W.J, Eichman, B.F. | | Deposit date: | 2023-02-21 | | Release date: | 2023-04-12 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Nat.Struct.Mol.Biol., 31, 2024
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8G9N
 | | Partial DNA elongation subcomplex of Xenopus laevis DNA polymerase alpha-primase | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA template, ... | | Authors: | Mullins, E.A, Durie, C.L, Ohi, M.D, Chazin, W.J, Eichman, B.F. | | Deposit date: | 2023-02-21 | | Release date: | 2023-04-12 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Nat.Struct.Mol.Biol., 31, 2024
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8G9O
 | | Complete DNA elongation subcomplex of Xenopus laevis DNA polymerase alpha-primase | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA primase large subunit, ... | | Authors: | Mullins, E.A, Durie, C.L, Ohi, M.D, Chazin, W.J, Eichman, B.F. | | Deposit date: | 2023-02-21 | | Release date: | 2023-04-12 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Nat.Struct.Mol.Biol., 31, 2024
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4DTM
 | | RB69 DNA Polymerase Ternary Complex with dCTP Opposite an Abasic Site and ddG/dC as the Penultimate Base-pair | | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase, ... | | Authors: | Xia, S, Wang, J, Konigsberg, W.H. | | Deposit date: | 2012-02-21 | | Release date: | 2012-06-06 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Contribution of Partial Charge Interactions and Base Stacking to the Efficiency of Primer Extension at and beyond Abasic Sites in DNA.
Biochemistry, 51, 2012
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4DTN
 | | RB69 DNA Polymerase Ternary Complex with dATP Opposite an Abasic Site and ddA/dT as the Penultimate Base-pair | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase, ... | | Authors: | Xia, S, Wang, J, Konigsberg, W.H. | | Deposit date: | 2012-02-21 | | Release date: | 2012-06-06 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Contribution of Partial Charge Interactions and Base Stacking to the Efficiency of Primer Extension at and beyond Abasic Sites in DNA.
Biochemistry, 51, 2012
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4DTU
 | | RB69 DNA Polymerase Ternary Complex with dGTP Opposite an Abasic Site and ddC/dG as the Penultimate Base-pair | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase, ... | | Authors: | Xia, S, Wang, J, Konigsberg, W.H. | | Deposit date: | 2012-02-21 | | Release date: | 2012-06-06 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Contribution of Partial Charge Interactions and Base Stacking to the Efficiency of Primer Extension at and beyond Abasic Sites in DNA.
Biochemistry, 51, 2012
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8HG1
 | | The structure of MPXV polymerase holoenzyme in replicating state | | Descriptor: | DNA (25-MER), DNA (38-MER), DNA polymerase, ... | | Authors: | Peng, Q, Xie, Y.F, Kuai, L, Wang, H, Qi, J.X, Gao, F, Shi, Y. | | Deposit date: | 2022-11-13 | | Release date: | 2022-12-21 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structure of monkeypox virus DNA polymerase holoenzyme.
Science, 379, 2023
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4B08
 | | Yeast DNA polymerase alpha, Selenomethionine protein | | Descriptor: | DNA POLYMERASE ALPHA CATALYTIC SUBUNIT A | | Authors: | Perera, R.L, Torella, R, Klinge, S, Kilkenny, M.L, Maman, J.D, Pellegrini, L. | | Deposit date: | 2012-06-29 | | Release date: | 2013-02-27 | | Last modified: | 2013-05-01 | | Method: | X-RAY DIFFRACTION (2.67 Å) | | Cite: | Mechanism for Priming DNA Synthesis by Yeast DNA Polymerase Alpha
Elife, 2, 2013
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