PDB: 2596 resultsInfo pagesStatus searchChemie searchBIRD

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7RV2	Crystal structure of the BCL6 BTB domain in complex with OICR-8828 Descriptor: B-cell lymphoma 6 protein, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-08-18 Release date: 2022-11-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.29 Å) Cite: Crystal structure of the BCL6 BTB domain in complex with OICR-8828 To Be Published
7RUX	Crystal structure of the BCL6 BTB domain in complex with OICR-8311 Descriptor: B-cell lymphoma 6 protein, FORMIC ACID, N-(3-chloropyridin-4-yl)-2-(3-(cyclopropylmethyl)-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetamide Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-08-18 Release date: 2022-11-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Crystal structure of the BCL6 BTB domain in complex with OICR-8311 To Be Published
7RUW	Crystal structure of the BCL6 BTB domain in complex with OICR-7859 Descriptor: 2-(2-amino-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-N-(3-chloropyridin-4-yl)acetamide, B-cell lymphoma 6 protein, CHLORIDE ION, ... Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-08-18 Release date: 2022-11-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Crystal structure of the BCL6 BTB domain in complex with OICR-7859 To Be Published
7RUZ	Crystal structure of the BCL6 BTB domain in complex with OICR-8445 Descriptor: 2-[2-(benzylamino)-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-N-(3-chloropyridin-4-yl)acetamide, B-cell lymphoma 6 protein, CHLORIDE ION, ... Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-08-18 Release date: 2022-11-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Crystal structure of the BCL6 BTB domain in complex with OICR-8445 To Be Published
7RV1	Crystal structure of the BCL6 BTB domain in complex with OICR-8826 Descriptor: (E)-3-(7-(2-((3-chloropyridin-4-yl)amino)-2-oxoethyl)-3-(3-(1-methyl-1H-pyrazol-4-yl)prop-2-yn-1-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)acrylamide, B-cell lymphoma 6 protein, DIMETHYL SULFOXIDE, ... Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-08-18 Release date: 2022-11-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.17 Å) Cite: Crystal structure of the BCL6 BTB domain in complex with OICR-8826 To Be Published
7RUY	Crystal structure of the BCL6 BTB domain in complex with OICR-8388 Descriptor: B-cell lymphoma 6 protein, FORMIC ACID, N-(3-chloropyridin-4-yl)-2-(2-{[(2,4-dimethoxyphenyl)methyl]amino}-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)acetamide Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-08-18 Release date: 2022-11-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.27 Å) Cite: Crystal structure of the BCL6 BTB domain in complex with OICR-8388 To Be Published
3HUU	Crystal structure of transcription regulator like protein from Staphylococcus haemolyticus Descriptor: Transcription regulator like protein Authors: Agarwal, R, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC) Deposit date: 2009-06-15 Release date: 2009-07-07 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal structure of transcription regulator like protein from Staphylococcus haemolyticus To be Published
7LZR	Crystal structure of the BCL6 BTB domain in complex with OICR-10256 Descriptor: B-cell lymphoma 6 protein, CHLORIDE ION, GLYCEROL, ... Authors: Kuntz, D.A, Prive, G.G. Deposit date: 2021-03-10 Release date: 2022-03-16 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.34 Å) Cite: Crystal structure of the BCL6 BTB domain in complex with OICR-10256 To Be Published
7M4T	Menin bound to M-1121 Descriptor: Menin, methyl {(1S,2R)-2-[(1S)-2-(azetidin-1-yl)-1-(3-fluorophenyl)-1-{1-[(3-methoxy-1-{4-[(1S,4S)-5-propanoyl-2,5-diazabicyclo[2.2.1]heptane-2-sulfonyl]phenyl}azetidin-3-yl)methyl]piperidin-4-yl}ethyl]cyclopentyl}carbamate, praseodymium triacetate Authors: Stuckey, J. Deposit date: 2021-03-22 Release date: 2021-08-11 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.74 Å) Cite: Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression. J.Med.Chem., 64, 2021
7N40	Crystal structure of LIN9-RbAp48-LIN37, a MuvB subcomplex Descriptor: Histone-binding protein RBBP4, Isoform 2 of Protein lin-9 homolog, Protein lin-37 homolog Authors: Asthana, A, Ramanan, P, Tripathi, S.M, Rubin, S.M. Deposit date: 2021-06-02 Release date: 2022-02-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.55 Å) Cite: The MuvB complex binds and stabilizes nucleosomes downstream of the transcription start site of cell-cycle dependent genes. Nat Commun, 13, 2022
7AX1	Crystal structure of the human CCR4-CAF1 complex Descriptor: CCR4-NOT transcription complex subunit 6, CCR4-NOT transcription complex subunit 7, MAGNESIUM ION Authors: Chen, Y, Khazina, E, Weichenrieder, O. Deposit date: 2020-11-09 Release date: 2021-05-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex. Nucleic Acids Res., 49, 2021
7M3X	Crystal Structure of the Apo Form of Human RBBP7 Descriptor: Histone-binding protein RBBP7, UNKNOWN ATOM OR ION Authors: Righetto, G.L, Dong, A, Li, Y, Hutchinson, A, Seitova, A, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) Deposit date: 2021-03-19 Release date: 2021-05-05 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.46 Å) Cite: Crystal Structure of the Apo Form of Human RBBP7 To Be Published
6FTO	Crystal structure of the Chp2 chromoshadow domain in complex with N-terminal domain of chromatin remodeler Mit1 Descriptor: Chromatin remodeling factor mit1, Chromo domain-containing protein 2, HEXANE-1,6-DIOL Authors: Leopold, K, Schalch, T. Deposit date: 2018-02-22 Release date: 2019-03-27 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Transcriptional gene silencing requires dedicated interaction between HP1 protein Chp2 and chromatin remodeler Mit1. Genes Dev., 33, 2019
6GKO	Mouse thymidylate synthase cocrystallized with dUMP and soaked in phenolphthalein Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one, DIMETHYL SULFOXIDE, ... Authors: Maj, P, Wilk, P, Jarmula, A, Weiss, M.S, Rode, W. Deposit date: 2018-05-21 Release date: 2019-06-05 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.839 Å) Cite: Thymidylate synthase fragment screening To Be Published
6H1C	Structure of Ferric uptake regulator from Pseudomonas aeruginosa with manganese. Descriptor: Ferric uptake regulation protein, MANGANESE (II) ION, ZINC ION Authors: Nader, S, Perard, J, Carpentier, P, Michaud-Soret, I, Crouzy, S. Deposit date: 2018-07-11 Release date: 2019-07-31 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.34 Å) Cite: Ferric uptake regulator with Mn and Zn form Pseudomonas aeruginosa To Be Published
6GYJ	Mouse thymidylate synthase crystal soaked in phenolphthalein Descriptor: 3,3-bis(4-hydroxyphenyl)-2-benzofuran-1-one, DIMETHYL SULFOXIDE, SULFATE ION, ... Authors: Maj, P, Jarmula, A, Wilk, P, Weiss, M.S, Rode, W. Deposit date: 2018-06-30 Release date: 2019-08-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Thymidylate synthase fragment screening To be published
3ZHO	X-ray structure of E.coli Wrba in complex with FMN at 1.2 A resolution Descriptor: FLAVIN MONONUCLEOTIDE, FLAVOPROTEIN WRBA Authors: Kishko, I, Lapkouski, M, Brynda, J, Kuty, M, Carey, J, Smatanova, I.K, Ettrich, R. Deposit date: 2012-12-23 Release date: 2013-08-28 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.2 Å) Cite: 1.2 A Resolution Crystal Structure of Escherichia Coli Wrba Holoprotein Acta Crystallogr.,Sect.D, 69, 2013
3DVP	Pak1 peptide bound LC8 Descriptor: Dynein light chain 1, cytoplasmic, P21 activated Kinase peptide Authors: Lightcap, C.M, Williams, J.C. Deposit date: 2008-07-18 Release date: 2009-01-20 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Biochemical and structural characterization of the Pak1-LC8 interaction. J.Biol.Chem., 283, 2008
5X5A	Human thymidylate synthase bound with phosphate ion Descriptor: PHOSPHATE ION, Thymidylate synthase Authors: Chen, D, Jansson, A, Larsson, A, Nordlund, P. Deposit date: 2017-02-15 Release date: 2017-06-28 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states J. Biol. Chem., 292, 2017
5X66	Human thymidylate synthase in complex with dUMP and methotrexate Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, METHOTREXATE, Thymidylate synthase Authors: Chen, D, Jansson, A, Larsson, A, Nordlund, P. Deposit date: 2017-02-21 Release date: 2017-06-28 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states J. Biol. Chem., 292, 2017
5X4Y	Mutant human thymidylate synthase M190K crystallized in a sulfate-containing condition Descriptor: SULFATE ION, Thymidylate synthase Authors: Chen, D, Jansson, A, Larsson, A, Nordlund, P. Deposit date: 2017-02-14 Release date: 2017-06-28 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states J. Biol. Chem., 292, 2017
5X5Q	Human thymidylate synthase complexed with dUMP and raltitrexed Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX, Thymidylate synthase Authors: Chen, D, Jansson, A, Larsson, A, Nordlund, P. Deposit date: 2017-02-17 Release date: 2017-06-28 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.79 Å) Cite: Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states J. Biol. Chem., 292, 2017
3CFS	Structural basis of the interaction of RbAp46/RbAp48 with histone H4 Descriptor: ARSENIC, Histone H4, Histone-binding protein RBBP7 Authors: Murzina, N.V, Pei, X.-Y, Pratap, J.V, Sparkes, M, Vicente-Garcia, J, Ben-Shahar, T.R, Verreault, A, Luisi, B.F, Laue, E.D. Deposit date: 2008-03-04 Release date: 2008-06-10 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural Basis for the Recognition of Histone H4 by the Histone-Chaperone RbAp46. Structure, 16, 2008
5X67	Human thymidylate synthase in complex with dUMP and nolatrexed Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-azanyl-6-methyl-5-pyridin-4-ylsulfanyl-3H-quinazolin-4-one, Thymidylate synthase Authors: Chen, D, Jansson, A, Larsson, A, Nordlund, P. Deposit date: 2017-02-21 Release date: 2017-06-28 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.13 Å) Cite: Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states. J. Biol. Chem., 292, 2017
5X4X	Mutant human thymidylate synthase A191K crystallized in a sulfate-containing condition Descriptor: SULFATE ION, Thymidylate synthase Authors: Chen, D, Jansson, A, Larsson, A, Nordlund, P. Deposit date: 2017-02-14 Release date: 2017-06-28 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states J. Biol. Chem., 292, 2017

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