4P2Z
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![BU of 4p2z by Molmil](/molmil-images/mine/4p2z) | Structure of NavMS T207A/F214A | Descriptor: | DODECAETHYLENE GLYCOL, HEGA-10, Ion transport protein, ... | Authors: | Bagneris, C, Naylor, C.E, Wallace, B.A. | Deposit date: | 2014-03-05 | Release date: | 2014-06-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.08 Å) | Cite: | Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism. Proc.Natl.Acad.Sci.USA, 111, 2014
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1HXR
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![BU of 1hxr by Molmil](/molmil-images/mine/1hxr) | CRYSTAL STRUCTURE OF MSS4 AT 1.65 ANGSTROMS | Descriptor: | GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4, ZINC ION | Authors: | Zhu, Z, Dumas, J.J, Lietzke, S.E, Lambright, D.G. | Deposit date: | 2001-01-16 | Release date: | 2001-02-14 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | A helical turn motif in Mss4 is a critical determinant of Rab binding and nucleotide release. Biochemistry, 40, 2001
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3MPJ
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![BU of 3mpj by Molmil](/molmil-images/mine/3mpj) | Structure of the glutaryl-coenzyme A dehydrogenase | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Glutaryl-CoA dehydrogenase, ... | Authors: | Wischgoll, S, Warkentin, E, Boll, M, Ermler, U. | Deposit date: | 2010-04-27 | Release date: | 2010-08-18 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for promoting and preventing decarboxylation in glutaryl-coenzyme a dehydrogenases. Biochemistry, 49, 2010
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7ZP7
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![BU of 7zp7 by Molmil](/molmil-images/mine/7zp7) | Crystal structure of evolved photoenzyme EnT1.3 (truncated) with bound product | Descriptor: | (1~{R},10~{R},12~{S})-15-oxa-8-azatetracyclo[8.5.0.0^{1,12}.0^{2,7}]pentadeca-2(7),3,5-trien-9-one, 1,2-ETHANEDIOL, EnT1.3 C | Authors: | Hardy, F.J, Levy, C. | Deposit date: | 2022-04-26 | Release date: | 2022-09-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A designed photoenzyme for enantioselective [2+2] cycloadditions. Nature, 611, 2022
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1HRO
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![BU of 1hro by Molmil](/molmil-images/mine/1hro) | |
3HWX
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![BU of 3hwx by Molmil](/molmil-images/mine/3hwx) | |
2BBH
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![BU of 2bbh by Molmil](/molmil-images/mine/2bbh) | X-ray structure of T.maritima CorA soluble domain | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, MAGNESIUM ION, SODIUM ION, ... | Authors: | Lunin, V.V, Dobrovetsky, E, Khutoreskaya, G, Bochkarev, A, Maguire, M.E, Edwards, A.M, Koth, C.M, Structural Genomics Consortium (SGC) | Deposit date: | 2005-10-17 | Release date: | 2005-12-13 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structure of the CorA Mg2+ transporter. Nature, 440, 2006
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6TNQ
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![BU of 6tnq by Molmil](/molmil-images/mine/6tnq) | Crystal structure of the human Arc N-lobe bound to repeat 4 from GKAP | Descriptor: | ACETYL GROUP, Activity-regulated cytoskeleton-associated protein, Chains: B,D,F | Authors: | Hallin, E.I, Bramham, C.R, Kursula, P. | Deposit date: | 2019-12-10 | Release date: | 2021-01-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structural properties and peptide ligand binding of the capsid homology domains of human Arc. Biochem Biophys Rep, 26, 2021
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7KRA
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![BU of 7kra by Molmil](/molmil-images/mine/7kra) | Cryo-EM structure of Saccharomyces cerevisiae ER membrane protein complex bound to Fab-DH4 in lipid nanodiscs | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ER membrane protein complex subunit 1, ER membrane protein complex subunit 2, ... | Authors: | Miller-Vedam, L.E, Schirle Oakdale, N.S, Braeuning, B, Boydston, E.A, Sevillano, N, Popova, K.D, Bonnar, J.L, Shurtleff, M.J, Prabu, J.R, Stroud, R.M, Craik, C.S, Schulman, B.A, Weissman, J.S, Frost, A. | Deposit date: | 2020-11-19 | Release date: | 2020-12-02 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. Elife, 9, 2020
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220L
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![BU of 220l by Molmil](/molmil-images/mine/220l) | GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS | Descriptor: | BENZENE, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... | Authors: | Baldwin, E.P, Baase, W.A, Zhang, X.-J, Feher, V, Matthews, B.W. | Deposit date: | 1997-06-25 | Release date: | 1998-03-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Generation of ligand binding sites in T4 lysozyme by deficiency-creating substitutions. J.Mol.Biol., 277, 1998
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225L
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![BU of 225l by Molmil](/molmil-images/mine/225l) | GENERATING LIGAND BINDING SITES IN T4 LYSOZYME USING DEFICIENCY-CREATING SUBSTITUTIONS | Descriptor: | BETA-MERCAPTOETHANOL, PARA-XYLENE, T4 LYSOZYME | Authors: | Baldwin, E.P, Baase, W.A, Zhang, X.-J, Feher, V, Matthews, B.W. | Deposit date: | 1997-06-25 | Release date: | 1998-03-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Generation of ligand binding sites in T4 lysozyme by deficiency-creating substitutions. J.Mol.Biol., 277, 1998
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8A3I
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![BU of 8a3i by Molmil](/molmil-images/mine/8a3i) | X-ray crystal structure of a de novo designed antiparallel coiled-coil homotetramer with 3 heptad repeats, apCC-Tet*3 | Descriptor: | apCC-Tet*3 | Authors: | Naudin, E.A, Mylemans, B, Albanese, K.I, Woolfson, D.N. | Deposit date: | 2022-06-08 | Release date: | 2022-10-05 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | From peptides to proteins: coiled-coil tetramers to single-chain 4-helix bundles. Chem Sci, 13, 2022
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1HQM
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![BU of 1hqm by Molmil](/molmil-images/mine/1hqm) | CRYSTAL STRUCTURE OF THERMUS AQUATICUS CORE RNA POLYMERASE-INCLUDES COMPLETE STRUCTURE WITH SIDE-CHAINS (EXCEPT FOR DISORDERED REGIONS)-FURTHER REFINED FROM ORIGINAL DEPOSITION-CONTAINS ADDITIONAL SEQUENCE INFORMATION | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Minakhin, L, Bhagat, S, Brunning, A, Campbell, E.A, Darst, S.A, Ebright, R.H, Severinov, K. | Deposit date: | 2000-12-18 | Release date: | 2001-02-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Bacterial RNA polymerase subunit omega and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly. Proc.Natl.Acad.Sci.USA, 98, 2001
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4A2D
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![BU of 4a2d by Molmil](/molmil-images/mine/4a2d) | Coriolopsis gallica Laccase T2 Copper Depleted at pH 4.5 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, LACCASE, ... | Authors: | De La Mora, E, Valderrama, B, Horjales, E, Rudino-Pinera, E. | Deposit date: | 2011-09-26 | Release date: | 2011-10-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Changes Caused by Radiation-Induced Reduction and Radiolysis: The Effect of X-Ray Absorbed Dose in a Fungal Multicopper Oxidase Acta Crystallogr.,Sect.D, 68, 2012
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8BSM
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![BU of 8bsm by Molmil](/molmil-images/mine/8bsm) | Human GLS in complex with compound 18 | Descriptor: | 2-phenyl-~{N}-[5-[[(3~{R})-1-[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide, Glutaminase kidney isoform, mitochondrial 65 kDa chain, ... | Authors: | Debreczeni, J.E. | Deposit date: | 2022-11-25 | Release date: | 2023-01-18 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.782 Å) | Cite: | Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models. J Med Chem, 62, 2019
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8BSN
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![BU of 8bsn by Molmil](/molmil-images/mine/8bsn) | Human GLS in complex with compound 27 | Descriptor: | (2~{S})-2-methoxy-2-phenyl-~{N}-[5-[[(3~{R})-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide, Glutaminase kidney isoform, mitochondrial 65 kDa chain, ... | Authors: | Debreczeni, J.E. | Deposit date: | 2022-11-25 | Release date: | 2023-01-18 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.494 Å) | Cite: | Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models. J Med Chem, 62, 2019
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2Q3S
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![BU of 2q3s by Molmil](/molmil-images/mine/2q3s) | Ensemble refinement of the protein crystal structure of gene product from Arabidopsis thaliana At5g06450 | Descriptor: | Protein At5g06450 | Authors: | Levin, E.J, Kondrashov, D.A, Wesenberg, G.E, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2007-05-30 | Release date: | 2007-06-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Ensemble refinement of protein crystal structures: validation and application. Structure, 15, 2007
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8BSL
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![BU of 8bsl by Molmil](/molmil-images/mine/8bsl) | Human GLS in complex with compound 12 | Descriptor: | Glutaminase kidney isoform, mitochondrial, ~{N}-[5-[[(3~{R})-1-(5-azanyl-1,3,4-thiadiazol-2-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]-2-phenyl-ethanamide | Authors: | Debreczeni, J.E. | Deposit date: | 2022-11-25 | Release date: | 2023-01-18 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models. J Med Chem, 62, 2019
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6TTO
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![BU of 6tto by Molmil](/molmil-images/mine/6tto) | N-terminally truncated hyoscyamine 6-hydroxylase (tH6H) in complex with 2-oxoglutarate | Descriptor: | 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, FORMIC ACID, ... | Authors: | Kluza, A, Mrugala, B, Porebski, P.J, Kurpiewska, K, Niedzialkowska, E, Weiss, M.S, Borowski, T. | Deposit date: | 2019-12-29 | Release date: | 2020-03-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Regioselectivity of hyoscyamine 6 beta-hydroxylase-catalysed hydroxylation as revealed by high-resolution structural information and QM/MM calculations. Dalton Trans, 49, 2020
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2AKY
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![BU of 2aky by Molmil](/molmil-images/mine/2aky) | |
8BSH
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![BU of 8bsh by Molmil](/molmil-images/mine/8bsh) | COPII inner coat | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Protein transport protein SEC23, ... | Authors: | Zanetti, G, Pyle, E.W. | Deposit date: | 2022-11-25 | Release date: | 2023-01-18 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | A Bayesian approach to single-particle electron cryo-tomography in RELION-4.0. Elife, 11, 2022
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8B58
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![BU of 8b58 by Molmil](/molmil-images/mine/8b58) | |
3HT0
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![BU of 3ht0 by Molmil](/molmil-images/mine/3ht0) | Crystal structure of E. coli HPPK(F123A) in complex with MgAMPCPP | Descriptor: | CHLORIDE ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, HPPK, ... | Authors: | Blaszczyk, J, Li, Y, Yan, H, Ji, X. | Deposit date: | 2009-06-11 | Release date: | 2010-06-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Pterin-binding site mutation Y53A, N55A or F123A and activity of E. coli HPPK To be Published
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6TR3
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![BU of 6tr3 by Molmil](/molmil-images/mine/6tr3) | Ruminococcus gnavus GH29 fucosidase E1_10125 in complex with fucose | Descriptor: | CALCIUM ION, F5/8 type C domain-containing protein, MAGNESIUM ION, ... | Authors: | Owen, C.D, Wu, H, Crost, E, Colvile, A, Juge, N, Walsh, M.A. | Deposit date: | 2019-12-17 | Release date: | 2020-10-28 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Fucosidases from the human gut symbiont Ruminococcus gnavus. Cell.Mol.Life Sci., 78, 2021
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1HKU
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![BU of 1hku by Molmil](/molmil-images/mine/1hku) | CtBP/BARS: a dual-function protein involved in transcription corepression and Golgi membrane fission | Descriptor: | C-TERMINAL BINDING PROTEIN 3, FORMIC ACID, GLYCEROL, ... | Authors: | Nardini, M, Spano, S, Cericola, C, Pesce, A, Massaro, A, Millo, E, Luini, A, Corda, D, Bolognesi, M. | Deposit date: | 2003-03-11 | Release date: | 2003-06-19 | Last modified: | 2016-12-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Ctbp/Bars: A Dual-Function Protein Involved in Transcription Co-Repression and Golgi Membrane Fission Embo J., 22, 2003
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