PDB: 92212 resultsInfo pagesStatus searchChemie searchBIRD

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7OX7	Target-bound SpCas9 complex with TRAC chimeric RNA-DNA guide Descriptor: CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, POTASSIUM ION, ... Authors: Donohoue, P, Pacesa, M, Lau, E, Vidal, B, Irby, M.J, Nyer, D.B, Rotstein, T, Banh, L, Toh, M.T, Gibson, J, Kohrs, B, Baek, K, Owen, A.L.G, Slorach, E.M, van Overbeek, M, Fuller, C.K, May, A.P, Jinek, M, Cameron, P. Deposit date: 2021-06-22 Release date: 2021-09-15 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells. Mol.Cell, 81, 2021
7OX9	Target-bound SpCas9 complex with AAVS1 all-RNA guide Descriptor: AAVS1 non-target DNA strand, AAVS1 target DNA strand, CRISPR-associated endonuclease Cas9/Csn1, ... Authors: Pacesa, M, Donohoue, P, May, A.P, Jinek, M, Cameron, P. Deposit date: 2021-06-22 Release date: 2021-09-15 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells. Mol.Cell, 81, 2021
3GE5	Crystal structure of a putative nad(p)h:fmn oxidoreductase (pg0310) from porphyromonas gingivalis w83 at 1.70 A resolution Descriptor: 1,2-ETHANEDIOL, FLAVIN MONONUCLEOTIDE, SULFATE ION, ... Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2009-02-25 Release date: 2009-03-17 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of putative NAD(P)H:FMN oxidoreductase (NP_904626.1) from PORPHYROMONAS GINGIVALIS W83 at 1.70 A resolution To be published
5KVP	Solution structure of the catalytic domain of zoocin A Descriptor: UNKNOWN LIGAND, ZINC ION, Zoocin A endopeptidase Authors: Timkovich, R, Xing, M, Simmonds, R.S. Deposit date: 2016-07-15 Release date: 2016-10-26 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Solution structure of the Cys74 to Ala74 mutant of the recombinant catalytic domain of Zoocin A. Proteins, 85, 2017
3HOI	Crystal structure of FMN-dependent nitroreductase BF3017 from Bacteroides fragilis NCTC 9343 (YP_212631.1) from Bacteroides fragilis NCTC 9343 at 1.55 A resolution Descriptor: CITRATE ANION, DI(HYDROXYETHYL)ETHER, FLAVIN MONONUCLEOTIDE, ... Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2009-06-02 Release date: 2009-06-23 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Crystal structure of FMN-dependent nitroreductase BF3017 from Bacteroides fragilis NCTC 9343 (YP_212631.1) from Bacteroides fragilis NCTC 9343 at 1.55 A resolution To be published
4LQX	Crystal structure of a TENA/THI-4 domain-containing protein (SSO2700) from Sulfolobus solfataricus P2 at 2.34 A resolution Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ... Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2013-07-19 Release date: 2013-09-04 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (2.34 Å) Cite: Crystal structure of a TENA/THI-4 domain-containing protein (SSO2700) from Sulfolobus solfataricus P2 at 2.34 A resolution To be published
3GBH	CRYSTAL STRUCTURE OF A PUTATIVE NAD(P)H:FMN OXIDOREDUCTASE (SE1966) FROM STAPHYLOCOCCUS EPIDERMIDIS ATCC 12228 AT 2.00 A RESOLUTION Descriptor: CALCIUM ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2009-02-19 Release date: 2009-03-03 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of putative NAD(P)H:FMN oxidoreductase (NP_765521.1) from Staphylococcus epidermidis ATCC 12228 at 2.00 A resolution To be published
3GIW	CRYSTAL STRUCTURE OF a DUF574 family protein (SAV_2177) FROM STREPTOMYCES AVERMITILIS MA-4680 AT 1.45 A RESOLUTION Descriptor: GLYCEROL, Protein of unknown function DUF574, UNKNOWN LIGAND Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2009-03-06 Release date: 2009-04-14 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Crystal structure of Rossmann-fold protein of unknown function (DUF574) (NP_823353.1) from Streptomyces avermitilis MA-4680 at 1.45 A resolution To be published
6X48	Sortilin-Progranulin Interaction With Compound 17 Descriptor: GLYCEROL, N-(3,5-dichlorobenzene-1-carbonyl)-5,5-dimethyl-L-norleucine, Sortilin, ... Authors: Parthasarathy, G, Soisson, S.M. Deposit date: 2020-05-22 Release date: 2020-08-12 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Identification of potent inhibitors of the sortilin-progranulin interaction. Bioorg.Med.Chem.Lett., 30, 2020
1Q7X	Solution structure of the alternatively spliced PDZ2 domain (PDZ2b) of PTP-Bas (hPTP1E) Descriptor: PDZ2b domain of PTP-Bas (hPTP1E) Authors: Kachel, N, Erdmann, K.S, Kremer, W, Wolff, P, Gronwald, W, Heumann, R, Kalbitzer, H.R, Structural Proteomics in Europe (SPINE) Deposit date: 2003-08-20 Release date: 2003-12-02 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Structure determination and ligand interactions of the PDZ2b domain of PTP-Bas (hPTP1E): Splicing induced modulation of ligand specificity. J.Mol.Biol., 334, 2003
1EXT	EXTRACELLULAR DOMAIN OF THE 55KDA TUMOR NECROSIS FACTOR RECEPTOR. CRYSTALLIZED AT PH3.7 IN P 21 21 21. Descriptor: MAGNESIUM ION, SULFATE ION, TUMOR NECROSIS FACTOR RECEPTOR Authors: Naismith, J.H, Sprang, S.R. Deposit date: 1996-07-03 Release date: 1997-01-11 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structures of the extracellular domain of the type I tumor necrosis factor receptor. Structure, 4, 1996
2OEJ	Crystal structure of a rubisco-like protein from Geobacillus kaustophilus (tetramutant form), liganded with phosphate ions Descriptor: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase, PHOSPHATE ION Authors: Fedorov, A.A, Imker, H.J, Fedorov, E.V, Almo, S.C, Gerlt, J.A. Deposit date: 2006-12-30 Release date: 2007-03-20 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Mechanistic Diversity in the RuBisCO Superfamily: The "Enolase" in the Methionine Salvage Pathway in Geobacillus kaustophilus. Biochemistry, 46, 2007
5L3I	Re-refinement of 4dd6; cisplatin coordination chemistry determination at hen egg white lysozyme His15 Descriptor: AMMONIA, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Helliwell, J.R. Deposit date: 2016-05-06 Release date: 2016-06-15 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Cisplatin coordination chemistry determination at hen egg white lysozyme His15 with ligand distances and angles, and their standard uncertainties, and also reporting a split occupancy effect ArXiv, 2016
2FXS	Yeast HSP82 in complex with the novel HSP90 Inhibitor Radamide Descriptor: ATP-dependent molecular chaperone HSP82, GLYCEROL, METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE Authors: Immormino, R.M, Gewirth, D.T. Deposit date: 2006-02-06 Release date: 2007-02-06 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2 Å) Cite: Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design. J.Mol.Biol., 388, 2009
1EEF	HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH BOUND LIGAND PEPG Descriptor: 2-PHENETHYL-2,3-DIHYDRO-PHTHALAZINE-1,4-DIONE, PROTEIN (HEAT-LABILE ENTEROTOXIN B CHAIN), alpha-D-galactopyranose Authors: Merritt, E.A, Hol, W.G.J. Deposit date: 2000-01-31 Release date: 2000-02-16 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives. Acta Crystallogr.,Sect.D, 57, 2001
3H51	Crystal structure of Putative calcium/calmodulin dependent protein kinase II association domain (NP_636218.1) from XANTHOMONAS CAMPESTRIS at 1.70 A resolution Descriptor: DI(HYDROXYETHYL)ETHER, Putative calcium/calmodulin dependent protein kinase II association domain, TETRAETHYLENE GLYCOL, ... Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2009-04-21 Release date: 2009-05-05 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of Putative calcium/calmodulin dependent protein kinase II association domain (NP_636218.1) from XANTHOMONAS CAMPESTRIS at 1.70 A resolution To be published
3GPT	Crystal structure of the yeast 20S proteasome in complex with Salinosporamide derivatives: slow substrate ligand Descriptor: (2R,3S,4R)-2-[(S)-(1S)-cyclohex-2-en-1-yl(hydroxy)methyl]-4-(2-fluoroethyl)-3-hydroxy-3-methyl-5-oxopyrrolidine-2-carbaldehyde, Proteasome component C1, Proteasome component C11, ... Authors: Groll, M, Macherla, V.R, Manam, R.R, Arthur, K.A.M, Potts, C.B. Deposit date: 2009-03-23 Release date: 2009-09-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition J.Med.Chem., 52, 2009
2M41	Solution Structure of the AXH domain of Ataxin-1 in complex with ligand peptide from Capicua Descriptor: Ataxin-1, Protein capicua homolog Authors: de Chiara, C, Kelly, G, Pastore, A. Deposit date: 2013-01-28 Release date: 2013-12-11 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Protein-Protein Interactions as a Strategy towards Protein-Specific Drug Design: The Example of Ataxin-1. Plos One, 8, 2013
4K75	CFTR Associated Ligand (CAL) PDZ domain bound to peptide iCAL36-QDTRL (ANSRWQDTRL) Descriptor: Golgi-associated PDZ and coiled-coil motif-containing protein, iCAL36-QDTRL peptide Authors: Amacher, J.F, Madden, D.R. Deposit date: 2013-04-16 Release date: 2014-01-22 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Stereochemical Preferences Modulate Affinity and Selectivity among Five PDZ Domains that Bind CFTR: Comparative Structural and Sequence Analyses. Structure, 22, 2014
3HRG	Crystal structure of Bacteroides thetaiotaomicron BT_3980, protein with actin-like ATPase fold and unknown function (NP_812891.1) from BACTEROIDES THETAIOTAOMICRON VPI-5482 at 1.85 A resolution Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, UNKNOWN LIGAND, ... Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2009-06-09 Release date: 2009-06-23 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal structure of Bacteroides thetaiotaomicron BT_3980, protein with actin-like ATPase fold and unknown function (NP_812891.1) from BACTEROIDES THETAIOTAOMICRON VPI-5482 at 1.85 A resolution To be Published
2OEL	Crystal structure of a rubisco-like protein from Geobacillus kaustophilus liganded with Mg2+ and HCO3- ions Descriptor: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase, CARBONATE ION, MAGNESIUM ION Authors: Fedorov, A.A, Imker, H.J, Fedorov, E.V, Almo, S.C, Gerlt, J.A. Deposit date: 2006-12-30 Release date: 2007-03-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Mechanistic Diversity in the RuBisCO Superfamily: The "Enolase" in the Methionine Salvage Pathway in Geobacillus kaustophilus. Biochemistry, 46, 2007
6A1I	Crystal structure of a synthase 1 from Santalum album Descriptor: CARBONATE ION, GLYCEROL, NICKEL (II) ION, ... Authors: Han, X, Ko, T.P, Liu, W.D, Chen, C.C, Guo, R.T. Deposit date: 2018-06-07 Release date: 2019-06-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal structure of a synthase 1 from Santalum album in complex with ligand To Be Published
3KMZ	Crystal structure of RARalpha ligand binding domain in complex with the inverse agonist BMS493 and a corepressor fragment Descriptor: 4-{(E)-2-[5,5-dimethyl-8-(phenylethynyl)-5,6-dihydronaphthalen-2-yl]ethenyl}benzoic acid, GLYCEROL, Nuclear receptor corepressor 1, ... Authors: Bourguet, W, le Maire, A. Deposit date: 2009-11-11 Release date: 2010-06-02 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor. Nat.Struct.Mol.Biol., 17, 2010
2PY6	Crystal structure of Methyltransferase FkbM (YP_546752.1) from Methylobacillus flagellatus KT at 2.20 A resolution Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2007-05-15 Release date: 2007-05-29 Last modified: 2023-01-25 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal structure of Methyltransferase FkbM (YP_546752.1) from Methylobacillus flagellatus KT at 2.20 A resolution To be published
2OH1	Crystal structure of acetyltransferase GNAT family (YP_013287.1) from Listeria monocytogenes 4b F2365 at 1.46 A resolution Descriptor: 1,2-ETHANEDIOL, Acetyltransferase, GNAT family, ... Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2007-01-09 Release date: 2007-02-13 Last modified: 2023-01-25 Method: X-RAY DIFFRACTION (1.46 Å) Cite: Crystal structure of acetyltransferase GNAT family (YP_013287.1) from Listeria monocytogenes 4b F2365 at 1.46 A resolution To be published

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