8J07
 
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5KHJ
 | | HCN2 CNBD in complex with uridine-3', 5'-cyclic monophosphate (cUMP) | | Descriptor: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, Uridine-3',5'-cyclic monophosphate | | Authors: | Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A. | | Deposit date: | 2016-06-14 | | Release date: | 2016-09-14 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.
Structure, 24, 2016
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8IUE
 | | RNA polymerase III pre-initiation complex melting complex 1 | | Descriptor: | DNA (74-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | | Authors: | Hou, H, Jin, Q, Ren, Y, Wang, Q, Xu, Y. | | Deposit date: | 2023-03-24 | | Release date: | 2023-05-24 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structure of the SNAPc-bound RNA polymerase III preinitiation complex.
Cell Res., 33, 2023
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8IUH
 | | RNA polymerase III pre-initiation complex open complex 1 | | Descriptor: | DNA (81-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | | Authors: | Hou, H, Jin, Q, Ren, Y, Wang, Q, Xu, Y. | | Deposit date: | 2023-03-24 | | Release date: | 2023-05-24 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structure of the SNAPc-bound RNA polymerase III preinitiation complex.
Cell Res., 33, 2023
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8ITY
 | | human RNA polymerase III pre-initiation complex closed DNA 1 | | Descriptor: | DNA (82-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | | Authors: | Hou, H, Jin, Q, Ren, Y, Wang, Q, Xu, Y. | | Deposit date: | 2023-03-23 | | Release date: | 2023-06-07 | | Last modified: | 2023-07-12 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structure of the SNAPc-bound RNA polymerase III preinitiation complex.
Cell Res., 33, 2023
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4YKL
 | | Hnt3 in complex with DNA and guanosine | | Descriptor: | Aprataxin-like protein, CHLORIDE ION, DNA (5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3'), ... | | Authors: | Jacewicz, A, Chauleau, M, Shuman, S. | | Deposit date: | 2015-03-04 | | Release date: | 2015-06-03 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | DNA3'pp5'G de-capping activity of aprataxin: effect of cap nucleoside analogs and structural basis for guanosine recognition.
Nucleic Acids Res., 43, 2015
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7CVN
 | | The N-arylsulfonyl-indole-2-carboxamide-based inhibitors against fructose-1,6-bisphosphatase | | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, 4-(3-acetamidophenyl)-N-(4-methoxyphenyl)sulfonyl-7-nitro-1H-indole-2-carboxamide, Fructose-1,6-bisphosphatase 1 | | Authors: | Wang, X, Zhou, J, Xu, B. | | Deposit date: | 2020-08-26 | | Release date: | 2020-09-23 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Design,synthesis,biological evaluation and binding mode analysis of 7-nitro-indole-N-acylarylsulfonamide-based fructose-1,6-bisphosphatase inhibitors
Chinese journal of medicinal chemistry, 30, 2020
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6D3K
 | | Crystal structure of unphosphorylated human PKR kinase domain in complex with ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Interferon-induced, double-stranded RNA-activated protein kinase, ... | | Authors: | Erlandsen, H, Mayo, C.B, Robinson, V.L, Cole, J.L. | | Deposit date: | 2018-04-16 | | Release date: | 2019-07-10 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural Basis of Protein Kinase R Autophosphorylation.
Biochemistry, 58, 2019
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5KHG
 | | HCN2 CNBD in complex with cytidine-3', 5'-cyclic monophosphate (cCMP) | | Descriptor: | 4-amino-1-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]pyrimidin-2(1H)-one, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | | Authors: | Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A. | | Deposit date: | 2016-06-14 | | Release date: | 2016-09-14 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.241 Å) | | Cite: | Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.
Structure, 24, 2016
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5KHH
 | | HCN2 CNBD in complex with inosine-3', 5'-cyclic monophosphate (cIMP) | | Descriptor: | Inosine-3',5'-cyclic monophosphate, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | | Authors: | Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A. | | Deposit date: | 2016-06-14 | | Release date: | 2016-09-14 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.
Structure, 24, 2016
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5KKC
 | | l-lactate dehydrogenase from rabbit muscle with the inhibitor 6DHNAD | | Descriptor: | L-lactate dehydrogenase A chain, SULFATE ION, [[(2~{R},3~{S},4~{R},5~{R})-5-(5-aminocarbonyl-2~{H}-pyridin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate | | Authors: | Meneely, K.M, Moran, G.R, Lamb, A.L. | | Deposit date: | 2016-06-21 | | Release date: | 2016-11-02 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.859 Å) | | Cite: | Ligand binding phenomena that pertain to the metabolic function of renalase.
Arch.Biochem.Biophys., 612, 2016
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4ZEM
 | | Crystal structure of eIF2B beta from Chaetomium thermophilum | | Descriptor: | Translation initiation factor eIF2b-like protein,Translation initiation factor eIF2b-like protein | | Authors: | Kuhle, B, Ficner, R. | | Deposit date: | 2015-04-20 | | Release date: | 2015-09-30 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Architecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2.
Nucleic Acids Res., 43, 2015
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4ZEO
 | | Crystal structure of eIF2B delta from Chaetomium thermophilum | | Descriptor: | Translation initiation factor eif-2b-like protein | | Authors: | Kuhle, B, Ficner, R. | | Deposit date: | 2015-04-20 | | Release date: | 2015-09-30 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Architecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2.
Nucleic Acids Res., 43, 2015
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7DE3
 | | Human adenylate kinase 1 (hAK1) mutant-R128W | | Descriptor: | Adenylate kinase isoenzyme 1 | | Authors: | Lin, W. | | Deposit date: | 2020-11-01 | | Release date: | 2021-11-10 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.197 Å) | | Cite: | Structure of human adenylate kinase 1 mutant-R128W.
To Be Published
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5ERQ
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5ERV
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7Q5I
 | | A glucose-based molecular rotor probes the catalytic site of glycogen phosphorylase. | | Descriptor: | 2-cyano-3-[4-(dimethylamino)phenyl]-~{N}-[(2~{R},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]propanamide, BETA-MERCAPTOETHANOL, CARBONATE ION, ... | | Authors: | Neofytos, D.D, Chrysina, E.D. | | Deposit date: | 2021-11-03 | | Release date: | 2022-03-02 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | A glucose-based molecular rotor inhibitor of glycogen phosphorylase as a probe of cellular enzymatic function.
Org.Biomol.Chem., 20, 2022
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5ERU
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5ERT
 | | GephE in complex with Mn(2+) - ADP | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Kasaragod, V.B, Schindelin, H. | | Deposit date: | 2015-11-15 | | Release date: | 2016-05-04 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Framework for Metal Incorporation during Molybdenum Cofactor Biosynthesis.
Structure, 24, 2016
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5ERR
 | | GephE in complex with Mg(2+) - ADP | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Kasaragod, V.B, Schindelin, H. | | Deposit date: | 2015-11-15 | | Release date: | 2016-05-04 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structural Framework for Metal Incorporation during Molybdenum Cofactor Biosynthesis.
Structure, 24, 2016
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5AWE
 | | Crystal structure of a hypothetical protein, TTHA0829 from Thermus thermophilus HB8, composed of cystathionine-beta-synthase (CBS) and aspartate-kinase chorismate-mutase tyrA (ACT) domains | | Descriptor: | Putative acetoin utilization protein, acetoin dehydrogenase | | Authors: | Nakabayashi, M, Shibata, N, Kanagawa, M, Nakagawa, N, Kuramitsu, S, Higuchi, Y. | | Deposit date: | 2015-07-03 | | Release date: | 2016-05-18 | | Last modified: | 2020-02-26 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Crystal structure of a hypothetical protein, TTHA0829 from Thermus thermophilus HB8, composed of cystathionine-beta-synthase (CBS) and aspartate-kinase chorismate-mutase tyrA (ACT) domains.
Extremophiles, 20, 2016
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5FOL
 | | Crystal structure of the Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain complex with a post-transfer editing analogue of isoeucine (Ile2AA) | | Descriptor: | 2'-(L-ISOLEUCYL)AMINO-2'-DEOXYADENOSINE, LEUCYL-TRNA SYNTHETASE, PHOSPHATE ION | | Authors: | Palencia, A, Liu, R.J, Lukarska, M, Gut, J, Bougdour, A, Touquet, B, Wang, E.D, Alley, M.R.K, Rosenthal, P.J, Hakimi, M.A, Cusack, S. | | Deposit date: | 2015-11-24 | | Release date: | 2016-08-03 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
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7QPS
 | | Structure of Mn-free SpoT | | Descriptor: | ACT domain protein, ADENOSINE MONOPHOSPHATE | | Authors: | Garcia-Pino, A, Tamman, H. | | Deposit date: | 2022-01-05 | | Release date: | 2023-01-18 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.79 Å) | | Cite: | Structure of Mn-free SpoT
To Be Published
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7RGE
 | | Crystal structure of phosphoadenylyl-sulfate (PAPS) reductase from Candida auris, phosphate complex | | Descriptor: | 3'-phosphoadenylylsulfate reductase, GLYCEROL, PHOSPHATE ION | | Authors: | Stogios, P.J, Evdokimova, E, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2021-07-15 | | Release date: | 2021-07-28 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.38 Å) | | Cite: | Crystal structure of phosphoadenylyl-sulfate (PAPS) reductase from Candida auris, phosphate complex
To Be Published
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8TV8
 | | Crystal structure of nontypeable Haemophilus influenzae SapA | | Descriptor: | ABC-type transport system, periplasmic component, involved in antimicrobial peptide resistance | | Authors: | Tanaka, K.J, Buechel, E.R, Rivera, K.G, Pinkett, H.W. | | Deposit date: | 2023-08-17 | | Release date: | 2024-01-17 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Antimicrobial Peptide Recognition Motif of the Substrate Binding Protein SapA from Nontypeable Haemophilus influenzae .
Biochemistry, 63, 2024
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