PDB: 73332 resultsInfo pagesStatus searchChemie searchBIRD

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5GVZ	Crystal structure of Peptidyl-tRNA hydrolase from Vibrio cholerae in space group C2221 at resolution 1.75A. Descriptor: ACETATE ION, Peptidyl-tRNA hydrolase, SULFATE ION Authors: Shahid, S, Kabra, A, Pal, R.K, Arora, A. Deposit date: 2016-09-07 Release date: 2017-09-20 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Crystal structure of Peptidyl-tRNA hydrolase from Vibrio cholerae in space group C2221 at resolution 1.75A. To Be Published
7X09	Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with inhibitors L95 and Halofuginone Descriptor: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, BROMIDE ION, Bifunctional glutamate/proline--tRNA ligase, ... Authors: Manickam, Y, Babbar, P, Pillai, P, Sharma, A. Deposit date: 2022-02-21 Release date: 2023-08-30 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of Homo sapiens Prolyl-tRNA synthetase (HsPRS) with double inhibitors (HF and L95) To Be Published
7X1O	Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with double inhibitors HF and L95 Descriptor: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, BROMIDE ION, Bifunctional glutamate/proline--tRNA ligase, ... Authors: Manickam, Y, Babbar, P, Sharma, A. Deposit date: 2022-02-24 Release date: 2023-08-30 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Crystal structure of Homo sapiens Prolyl-tRNA synthetase (HsPRS) with double inhibitors (HF and L95) To Be Published
7V9D	Plasmodium falciparum Prolyl-tRNA Synthetase (PfPRS) in Complex with inhibitor L95 and azetidine Descriptor: (2S)-azetidine-2-carboxylic acid, 1,2-ETHANEDIOL, 1,4-BUTANEDIOL, ... Authors: Manickam, Y, Malhotra, N, Sharma, A. Deposit date: 2021-08-24 Release date: 2022-09-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.937 Å) Cite: Plasmodium falciparum Prolyl-tRNA Synthetase (PfPRS) in Complex with inhibitor L95 and azetidine To Be Published
1C2Q	SOLUTION STRUCTURE OF A DNA.RNA HYBRID CONTAINING AN ALPHAT-ANOMERIC THYMIDINE AND POLARITY REVERSALS Descriptor: 5'-D(ATGG-3'-3'-(T3P)-5'-5'-GCTC)-3', 5'-R(GAGCACCAU)-3' Authors: Germann, M.W, Aramini, J.M. Deposit date: 1999-07-26 Release date: 1999-11-29 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Solution structure of a DNA.RNA hybrid containing an alpha-anomeric thymidine and polarity reversals: d(ATGG-3'-3'-alphaT-5'-5'-GCTC). r(gagcaccau). Biochemistry, 38, 1999
5E3I	Crystal Structure of a Histidyl-tRNA synthetase from Acinetobacter baumannii with bound L-Histidine and ATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, HISTIDINE, Histidine--tRNA ligase, ... Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2015-10-02 Release date: 2015-11-04 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal Structure of a Histidyl-tRNA synthetase from Acinetobacter baumannii with bound L-Histidine and ATP to be published
6HHV	Structure of T. thermophilus AspRS in Complex with 5'-O-(N-(L-aspartyl)-sulfamoyl)N3-methyluridine Descriptor: 5'-O-(N-(L-aspartyl)-sulfamoyl)N3-methyluridine, Aspartate--tRNA(Asp) ligase Authors: De Graef, S, Pang, L, Strelkov, S.V, Weeks, S.D. Deposit date: 2018-08-29 Release date: 2019-12-18 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases. Acs Chem.Biol., 15, 2020
5F9Y	Crystal Structure of Prolyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-Proline and AMP Descriptor: ADENOSINE MONOPHOSPHATE, Aminoacyl-tRNA synthetase, PHOSPHATE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2015-12-10 Release date: 2016-11-16 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal Structure of Prolyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-Proline and AMP to be published
6HHW	Structure of T. thermophilus AspRS in Complex with 5'-O-(N-(L-aspartyl)-sulfamoyl)uridine Descriptor: 5'-O-(N-(L-aspartyl)-sulfamoyl)uridine, Aspartate--tRNA(Asp) ligase Authors: De Graef, S, Pang, L, Strelkov, S.V, Weeks, S.D. Deposit date: 2018-08-29 Release date: 2019-12-18 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases. Acs Chem.Biol., 15, 2020
5F9Z	Crystal Structure of Prolyl-tRNA Synthetase from Cryptosporidium parvum complexed with Halofuginone and AMPPNP Descriptor: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, Aminoacyl-tRNA synthetase, GLYCEROL, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2015-12-10 Release date: 2016-11-16 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal Structure of Prolyl-tRNA Synthetase from Cryptosporidium parvum complexed with Halofuginone and AMPPNP to be published
6J93	Crystal structure of Peptidyl-tRNA hydrolase from Acinetobacter baumannii at 0.95 A resolution Descriptor: 1,2-ETHANEDIOL, Peptidyl-tRNA hydrolase Authors: Viswanathan, V, Sharma, P, Singh, P.K, Iqbal, N, Sharma, S, Singh, T.P. Deposit date: 2019-01-21 Release date: 2019-02-06 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (0.95 Å) Cite: Crystal structure of Peptidyl-tRNA hydrolase form apo at 0.95 A resolution. To Be Published
6HHX	Structure of T. thermophilus AspRS in Complex with 5'-O-(N-(L-aspartyl)-sulfamoyl)cytidine Descriptor: 5'-O-(N-(L-aspartyl)-sulfamoyl)cytidine, Aspartate--tRNA(Asp) ligase Authors: De Graef, S, Pang, L, Strelkov, S.V, Weeks, S.D. Deposit date: 2018-08-29 Release date: 2019-12-18 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases. Acs Chem.Biol., 15, 2020
7V8K	Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with L-Proline Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, IMIDAZOLE, ... Authors: Manickam, Y, Malhotra, N, Sharma, A. Deposit date: 2021-08-23 Release date: 2022-09-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.47 Å) Cite: Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with L-Proline To Be Published
7V8J	Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with the reaction intermediates proline-adenylate (Pro-AMP) and pyrophosphate Descriptor: 1,2-ETHANEDIOL, 5'-O-[(R)-hydroxy{[(2S)-pyrrolidin-2-ylcarbonyl]oxy}phosphoryl]adenosine, PROLINE, ... Authors: Manickam, Y, Malhotra, N, Sharma, A. Deposit date: 2021-08-23 Release date: 2022-09-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.519 Å) Cite: Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with the reaction intermediates proline-adenylate (Pro-AMP) and pyrophosphate To Be Published
6NCR	Crystal Structure of Tryptophan-tRNA ligase from Chlamydia trachomatis with bound L-tryptophan Descriptor: 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2018-12-12 Release date: 2018-12-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Crystal Structure of Tryptophan-tRNA ligase from Chlamydia trachomatis with bound L-tryptophan to be published
6JJQ	Crystal structure of peptidyl-tRNA hydrolase from Acinetobacter baumannii at 0.99 A resolution. Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Peptidyl-tRNA hydrolase, ... Authors: Viswanathan, V, Bairagya, H.R, Sharma, P, Sharma, S, Singh, T.P. Deposit date: 2019-02-26 Release date: 2019-03-06 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (0.99 Å) Cite: Crystal structure of peptidyl-tRNA hydrolase from Acinetobacter baumannii at 0.99 A resolution. To Be Published
8TC8	Human asparaginyl-tRNA synthetase bound to adenosine 5'-sulfamate Descriptor: 5'-O-[N-(L-ASPARAGINYL)SULFAMOYL]ADENOSINE, Asparagine--tRNA ligase, cytoplasmic, ... Authors: Dogovski, C, Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. Deposit date: 2023-06-30 Release date: 2024-02-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nat Commun, 15, 2024
5BMU	The crystal structure of the GST-like domains complex of AIMP3-EPRS mutant C92SC105SC123S Descriptor: Eukaryotic translation elongation factor 1 epsilon-1, Glutamate--tRNA ligase Authors: Cho, H.J, Kang, B.S. Deposit date: 2015-05-23 Release date: 2015-10-21 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Assembly of Multi-tRNA Synthetase Complex via Heterotetrameric Glutathione Transferase-homology Domains J.Biol.Chem., 290, 2015
8IU6	Crystal structure of peptidyl-tRNA hydrolase mutant from Enterococcus faecium Descriptor: GLYCEROL, Peptidyl-tRNA hydrolase Authors: Pandey, R, Tripathi, S, Lanka, A.K, Zohib, M, Pal, R.K, Arora, A. Deposit date: 2023-03-23 Release date: 2024-04-03 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Crystal structure of peptidyl-tRNA hydrolase mutant from Enterococcus faecium To Be Published
1RRD	DNA/RNA HYBRID DUPLEX CONTAINING A PURINE-RICH RNA STRAND, NMR, 10 STRUCTURES Descriptor: DNA (5'-D(*GP*CP*TP*TP*CP*TP*CP*TP*TP*C)-3'), RNA (5'-R(*GP*AP*AP*GP*AP*GP*AP*AP*GP*C)-3') Authors: Gyi, J.I, Lane, A.N, Conn, G.L, Brown, T. Deposit date: 1997-10-21 Release date: 1998-04-22 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Solution structures of DNA.RNA hybrids with purine-rich and pyrimidine-rich strands: comparison with the homologous DNA and RNA duplexes. Biochemistry, 37, 1998
6MES	Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 1907) Descriptor: 1-[(1H-benzimidazol-2-yl)methyl]-4-[(2,4-dichlorophenyl)methyl]-1,3-dihydro-2H-imidazol-2-one, GLYCEROL, METHIONINE, ... Authors: Barros-Alvarez, X, Hol, W.G.J. Deposit date: 2018-09-07 Release date: 2019-09-18 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei Rsc Med Chem, 2020
6IX6	Crystal structure of the complex of peptidyl-tRNA hydrolase with N-propanol at 1.43 A resolution Descriptor: N-PROPANOL, Peptidyl-tRNA hydrolase Authors: Viswanathan, V, Sharma, P, Chaudhary, A, Sharma, S, Singh, T.P. Deposit date: 2018-12-09 Release date: 2018-12-26 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.43 Å) Cite: Crystal structure of the complex of peptidyl-tRNA hydrolase with N-propanol at 1.43 A resolution To Be Published
6NAB	Crystal structure of prolyl-tRNA synthetase from Naegleria fowleri in complex with proline and adenosine monophophsphate (AMP) Descriptor: 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2018-12-05 Release date: 2019-01-30 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of prolyl-tRNA synthetase from Naegleria fowleri in complex with proline and adenosine monophophsphate (AMP) TO BE PUBLISHED
6JKX	Crystal structure of peptidyl-tRNA hydrolase with multiple sodium and chloride ions at 1.08 A resolution. Descriptor: CHLORIDE ION, METHANOL, Peptidyl-tRNA hydrolase, ... Authors: Viswanathan, V, Sharma, P, Bhushan, A, Sharma, S, Singh, T.P. Deposit date: 2019-03-03 Release date: 2019-03-13 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.08 Å) Cite: Crystal structure of peptidyl-tRNA hydrolase with multiple sodium and chloride ions at 1.08 A resolution. To Be Published
6JJ1	Crystal structure of peptidyl-tRNA hydrolase from Acinetobacter baumannii at 0.97 A resolution with disordered five N-terminal residues Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Peptidyl-tRNA hydrolase Authors: Iqbal, N, Sharma, P, Chaudhary, A, Sharma, S, Singh, T.P. Deposit date: 2019-02-24 Release date: 2019-03-13 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (0.97 Å) Cite: Crystal structure of peptidyl-tRNA hydrolase from Acinetobacter baumannii at 0.97 A resolution with disordered five N-terminal residues To Be Published

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