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3G3H	Crystal structure of the GluR6 ligand binding domain dimer K665R I749L Q753K mutant with glutamate and NaCl at 1.5 Angstrom resolution Descriptor: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... Authors: Chaudhry, C, Mayer, M.L. Deposit date: 2009-02-02 Release date: 2009-06-02 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
3G3K	Crystal structure of the GluR6 ligand binding domain dimer I442H K494E K665R I749L Q753K E757Q mutant with glutamate and NaCl at 1.24 Angstrom resolution Descriptor: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... Authors: Chaudhry, C, Mayer, M.L. Deposit date: 2009-02-02 Release date: 2009-06-02 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (1.24 Å) Cite: Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
3G3J	Crystal structure of the GluR6 ligand binding domain dimer I442H K494E K665R I749L Q753K mutant with glutamate and NaCl at 1.32 Angstrom resolution Descriptor: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... Authors: Chaudhry, C, Mayer, M.L. Deposit date: 2009-02-02 Release date: 2009-06-02 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (1.321 Å) Cite: Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
3G3G	Crystal structure of the GluR6 ligand binding domain dimer K665R mutant with glutamate and NaCl at 1.3 Angstrom resolution Descriptor: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... Authors: Chaudhry, C, Mayer, M.L. Deposit date: 2009-02-02 Release date: 2009-06-02 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (1.303 Å) Cite: Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
3G3I	Crystal structure of the GluR6 ligand binding domain dimer I442H K494E I749L Q753K mutant with glutamate and NaCl at 1.37 Angstrom resolution Descriptor: CHLORIDE ION, GLUTAMIC ACID, Glutamate receptor, ... Authors: Chaudhry, C, Mayer, M.L. Deposit date: 2009-02-02 Release date: 2009-06-02 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (1.371 Å) Cite: Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. Embo J., 28, 2009
3GBA	X-ray structure of iGluR5 ligand-binding core (S1S2) in complex with dysiherbaine at 1.35A resolution Descriptor: (2R,3aR,6S,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6-hydroxy-7-(methylamino)hexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, CHLORIDE ION, GLYCEROL, ... Authors: Frydenvang, K, Naur, P, Gajhede, M, Kastrup, J.S. Deposit date: 2009-02-19 Release date: 2009-03-17 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine J.Biol.Chem., 284, 2009
3GBB	X-ray structure of iGluR5 ligand-binding core (S1S2) in complex with MSVIII-19 at 2.10A resolution Descriptor: (2R,3aR,7aR)-2-[(2S)-2-amino-3-hydroxy-3-oxo-propyl]-3,3a,5,6,7,7a-hexahydrofuro[4,5-b]pyran-2-carboxylic acid, Glutamate receptor, ionotropic kainate 1 Authors: Frydenvang, K, Naur, P, Gajhede, M, Kastrup, J.S. Deposit date: 2009-02-19 Release date: 2009-03-17 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine J.Biol.Chem., 284, 2009
3H06	Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 Descriptor: 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid, Glutamate receptor 2 Authors: Ahmed, A.H, Oswald, R.E. Deposit date: 2009-04-08 Release date: 2009-05-05 Last modified: 2017-08-23 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain. Biochemistry, 48, 2009
3H03	Crystal structure of the binding domain of the AMPA subunit GluR2 bound to UBP277 Descriptor: 3-[3-(2-carboxyethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]-L-alanine, Glutamate receptor 2, ZINC ION Authors: Ahmed, A.H, Oswald, R.E. Deposit date: 2009-04-08 Release date: 2009-05-05 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain. Biochemistry, 48, 2009
3H6W	Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5217 at 1.50 A resolution Descriptor: (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ... Authors: Hald, H, Gajhede, M, Kastrup, J.S. Deposit date: 2009-04-24 Release date: 2009-07-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J.Mol.Biol., 391, 2009
3H6U	Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS1493 at 1.85 A resolution Descriptor: (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, CITRATE ANION, GLUTAMIC ACID, ... Authors: Hald, H, Gajhede, M, Kastrup, J.S. Deposit date: 2009-04-24 Release date: 2009-07-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J.Mol.Biol., 391, 2009
3H6T	Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and cyclothiazide at 2.25 A resolution Descriptor: ACETATE ION, CACODYLATE ION, CYCLOTHIAZIDE, ... Authors: Hald, H, Gajhede, M, Kastrup, J.S. Deposit date: 2009-04-24 Release date: 2009-07-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J.Mol.Biol., 391, 2009
3H6V	Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5206 at 2.10 A resolution Descriptor: (3R)-3-cyclopentyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ... Authors: Hald, H, Gajhede, M, Kastrup, J.S. Deposit date: 2009-04-24 Release date: 2009-07-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J.Mol.Biol., 391, 2009
2WKY	Crystal structure of the ligand-binding core of GluR5 in complex with the agonist 4-AHCP Descriptor: 3-(3-HYDROXY-7,8-DIHYDRO-6H-CYCLOHEPTA[D]ISOXAZOL-4-YL)-L-ALANINE, CHLORIDE ION, GLUTAMATE RECEPTOR, ... Authors: Naur, P, Gajhede, M, Kastrup, J.S. Deposit date: 2009-06-18 Release date: 2009-07-21 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The Glutamate Receptor Glur5 Agonist (S)-2-Amino-3-(3-Hydroxy-7,8-Dihydro-6H-Cyclohepta[D]Isoxazol-4-Yl)Propionic Acid and the 8-Methyl Analogue: Synthesis, Molecular Pharmacology, and Biostructural Characterization J.Med.Chem., 52, 2009
3IJO	Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, althiazide Descriptor: (3S)-6-chloro-3-[(prop-2-en-1-ylsulfanyl)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... Authors: Ptak, C.P, Ahmed, A.H, Oswald, R.E. Deposit date: 2009-08-04 Release date: 2009-09-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.003 Å) Cite: Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
3IK6	Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, chlorothiazide Descriptor: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... Authors: Ptak, C.P, Ahmed, A.H, Oswald, R.E. Deposit date: 2009-08-05 Release date: 2009-09-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.101 Å) Cite: Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
3IJX	Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydrochlorothiazide Descriptor: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... Authors: Ptak, C.P, Ahmed, A.H, Oswald, R.E. Deposit date: 2009-08-05 Release date: 2009-09-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.881 Å) Cite: Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
3IL1	Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, IDRA-21 Descriptor: (3S)-7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... Authors: Ahmed, A.H, Ptak, C.P, Oswald, R.E. Deposit date: 2009-08-06 Release date: 2009-09-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.998 Å) Cite: Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
3ILT	Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, trichlormethiazide Descriptor: 6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE, GLUTAMIC ACID, Glutamate receptor 2, ... Authors: Ahmed, A.H, Ptak, C.P, Oswald, R.E. Deposit date: 2009-08-07 Release date: 2009-09-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.107 Å) Cite: Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
3ILU	Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydroflumethiazide Descriptor: 6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... Authors: Ahmed, A.H, Ptak, C.P, Oswald, R.E. Deposit date: 2009-08-07 Release date: 2009-09-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.003 Å) Cite: Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
3KEI	Crystal Structure of the GluA4 Ligand-Binding domain L651V mutant in complex with glutamate Descriptor: GLUTAMIC ACID, Glutamate receptor 4 Authors: Gill, A, Madden, D.R. Deposit date: 2009-10-26 Release date: 2010-02-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Enhanced efficacy without further cleft closure: reevaluating twist as a source of agonist efficacy in AMPA receptors. J.Neurosci., 30, 2010
3KFM	Crystal Structure of the GluA4 Ligand-Binding domain L651V mutant in complex with kainate Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 4 Authors: Gill, A, Madden, D.R. Deposit date: 2009-10-27 Release date: 2010-02-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Enhanced efficacy without further cleft closure: reevaluating twist as a source of agonist efficacy in AMPA receptors. J.Neurosci., 30, 2010
3KG2	AMPA subtype ionotropic glutamate receptor in complex with competitive antagonist ZK 200775 Descriptor: Glutamate receptor 2, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Sobolevsky, A.I, Rosconi, M.P, Gouaux, E. Deposit date: 2009-10-28 Release date: 2009-12-08 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.6 Å) Cite: X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature, 462, 2009
3KGC	Isolated ligand binding domain dimer of GluA2 ionotropic glutamate receptor in complex with glutamate, LY 404187 and ZK 200775 Descriptor: GLUTAMIC ACID, Glutamate receptor 2, N-[(2S)-2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide, ... Authors: Sobolevsky, A.I, Rosconi, M.P, Gouaux, E. Deposit date: 2009-10-28 Release date: 2009-12-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.55 Å) Cite: X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor Nature, 462, 2009
3LSF	Piracetam bound to the ligand binding domain of GluA2 Descriptor: 2-(2-oxopyrrolidin-1-yl)acetamide, GLUTAMIC ACID, Glutamate receptor 2, ... Authors: Ahmed, A.H, Ptak, C.P, Oswald, R.E. Deposit date: 2010-02-12 Release date: 2010-03-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.851 Å) Cite: Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors. J.Med.Chem., 53, 2010

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