8BR9
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4Z4E
| Human Argonaute2 Bound to t1-U Target RNA | Descriptor: | ISOPROPYL ALCOHOL, MAGNESIUM ION, PHENOL, ... | Authors: | Schirle, N.T, MacRae, I.J. | Deposit date: | 2015-04-02 | Release date: | 2015-09-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets. Elife, 4, 2015
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4Z4G
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7D98
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6QB8
| Human CCT:mLST8 complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, ... | Authors: | Cuellar, J, Santiago, C, Ludlam, W.G, Bueno-Carrasco, M.T, Valpuesta, J.M, Willardson, B.M. | Deposit date: | 2018-12-20 | Release date: | 2019-07-03 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.97 Å) | Cite: | Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly. Nat Commun, 10, 2019
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3K1F
| Crystal structure of RNA Polymerase II in complex with TFIIB | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | Authors: | Kostrewa, D, Zeller, M.E, Armache, K.-J, Seizl, M, Leike, K, Thomm, M, Cramer, P. | Deposit date: | 2009-09-27 | Release date: | 2009-11-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (4.3 Å) | Cite: | RNA polymerase II-TFIIB structure and mechanism of transcription initiation. Nature, 462, 2009
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4Z4H
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5Y7L
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8A1Z
| Crystal structure of Phosphoserine phosphatase SerB from Mycobacterium avium in complex with 1-(2,4-dichlorophenyl)-3-hydroxyurea | Descriptor: | 1-(2,4-dichlorophenyl)-3-oxidanyl-urea, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Haufroid, M, Wouters, J. | Deposit date: | 2022-06-02 | Release date: | 2022-11-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Targeting the phosphoserine phosphatase MtSerB2 for tuberculosis drug discovery, an hybrid knowledge based /fragment based approach. Eur.J.Med.Chem., 245, 2022
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6R0Z
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6R0Y
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6QZP
| High-resolution cryo-EM structure of the human 80S ribosome | Descriptor: | (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 18S rRNA (1740-MER), 28S rRNA (3773-MER), ... | Authors: | Natchiar, S.K, Myasnikov, A.G, Kratzat, H, Hazemann, I, Klaholz, B.P. | Deposit date: | 2019-03-12 | Release date: | 2019-04-24 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Visualization of chemical modifications in the human 80S ribosome structure. Nature, 551, 2017
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4Z4I
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6R10
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8BTY
| Structure of the active form of ScpB, the C5a-peptidase from Streptococcus agalactiae. | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, C5a peptidase, CALCIUM ION, ... | Authors: | Kagawa, T.F, Cooney, J.C, Miclot, T, Cullen, R. | Deposit date: | 2022-11-30 | Release date: | 2023-11-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The 1.7 angstrom crystal structure of the C5a peptidase from Streptococcus agalactiae (ScpB) reveals an active site competent for catalysis. Proteins, 92, 2024
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3CP4
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5WUD
| Structural basis for conductance through TRIC cation channels | Descriptor: | MAGNESIUM ION, Uncharacterized protein | Authors: | Su, M, Gao, F, Mao, Y, Li, D.L, Guo, Y.Z, Wang, X.H, Bruni, R, Kloss, B, Hendrickson, W.A, Chen, Y.H, New York Consortium on Membrane Protein Structure (NYCOMPS) | Deposit date: | 2016-12-17 | Release date: | 2017-06-21 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for conductance through TRIC cation channels. Nat Commun, 8, 2017
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4IAD
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4IAZ
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6S03
| Carbonic Anhydrase CAIX mimic in complex with inhibitor I39LT379 | Descriptor: | 4-[[4-[5,5-dimethyl-2-(6-methylpyridin-2-yl)-4,6-dihydropyrrolo[1,2-b]pyrazol-3-yl]pyridin-2-yl]amino]benzenesulfonamide, Carbonic anhydrase 2, ZINC ION | Authors: | Kugler, M, Brynda, J, Rezacova, P. | Deposit date: | 2019-06-13 | Release date: | 2020-06-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Identification of Novel Carbonic Anhydrase IX Inhibitors Using High-Throughput Screening of Pooled Compound Libraries by DNA-Linked Inhibitor Antibody Assay (DIANA). SLAS Discov, 25, 2020
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8BP0
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8BP1
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5WLC
| The complete structure of the small subunit processome | Descriptor: | 18S pre-rRNA, 5' ETS, Bms1, ... | Authors: | Barandun, J, Chaker-Margot, M, Hunziker, M, Klinge, S. | Deposit date: | 2017-07-26 | Release date: | 2017-09-27 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | The complete structure of the small-subunit processome. Nat. Struct. Mol. Biol., 24, 2017
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5WM8
| Structure of the 10R (+)-cis-BP-dG modified Rev1 ternary complex | Descriptor: | 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE, 1,2-ETHANEDIOL, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, ... | Authors: | Rechkoblit, O, Kolbanovsky, A, Landes, H, Geacintov, N.E, Aggarwal, A.K. | Deposit date: | 2017-07-28 | Release date: | 2017-10-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase. Nat Commun, 8, 2017
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5WUE
| Structural basis for conductance through TRIC cation channels | Descriptor: | SULFATE ION, Uncharacterized protein | Authors: | Su, M, Gao, F, Mao, Y, Li, D.L, Guo, Y.Z, Wang, X.H, Bruni, R, Kloss, B, Hendrickson, W.A, Chen, Y.H, New York Consortium on Membrane Protein Structure (NYCOMPS) | Deposit date: | 2016-12-17 | Release date: | 2017-06-21 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for conductance through TRIC cation channels. Nat Commun, 8, 2017
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