PDB: 73050 resultsInfo pagesStatus searchChemie searchBIRD

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7ZNA	Crystal structure of the light-driven inward proton pump xenorhodopsin BcXeR in the ground state at pH 5.2 in the presence of sodium at 100K Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, EICOSANE, OLEIC ACID, ... Authors: Kovalev, K, Tsybrov, F, Alekseev, A, Bourenkov, G, Gordeliy, V. Deposit date: 2022-04-20 Release date: 2023-05-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Mechanisms of inward transmembrane proton translocation. Nat.Struct.Mol.Biol., 30, 2023
7ZND	Crystal structure of the light-driven inward proton pump xenorhodopsin BcXeR in the M state at pH 7.6 in the absence of sodium at 100K Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, EICOSANE, OLEIC ACID, ... Authors: Kovalev, K, Tsybrov, F, Alekseev, A, Bourenkov, G, Gordeliy, V. Deposit date: 2022-04-20 Release date: 2023-05-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.985 Å) Cite: Mechanisms of inward transmembrane proton translocation. Nat.Struct.Mol.Biol., 30, 2023
7ZN8	Crystal structure of the light-driven inward proton pump xenorhodopsin BcXeR in the ground state at pH 7.0 in the presence of sodium at 100K Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, EICOSANE, OLEIC ACID, ... Authors: Kovalev, K, Tsybrov, F, Alekseev, A, Bourenkov, G, Gordeliy, V. Deposit date: 2022-04-20 Release date: 2023-05-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Mechanisms of inward transmembrane proton translocation. Nat.Struct.Mol.Biol., 30, 2023
7ZNC	Crystal structure of the light-driven inward proton pump xenorhodopsin BcXeR in the ground state at pH 7.6 in the absence of sodium at 100K Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, EICOSANE, OLEIC ACID, ... Authors: Kovalev, K, Tsybrov, F, Alekseev, A, Bourenkov, G, Gordeliy, V. Deposit date: 2022-04-20 Release date: 2023-05-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Mechanisms of inward transmembrane proton translocation. Nat.Struct.Mol.Biol., 30, 2023
7ZNE	Crystal structure of the light-driven inward proton pump xenorhodopsin BcXeR in the ground state at pH 8.2 at room temperature, 7.5-ms-long snapshots Descriptor: EICOSANE, OLEIC ACID, PHOSPHATE ION, ... Authors: Kovalev, K, Tsybrov, F, Alekseev, A, Bourenkov, G, Gordeliy, V. Deposit date: 2022-04-20 Release date: 2023-05-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Mechanisms of inward transmembrane proton translocation. Nat.Struct.Mol.Biol., 30, 2023
7ZNG	Crystal structure of the light-driven inward proton pump xenorhodopsin BcXeR in the ground state at pH 8.2 at room temperature, 500-mks-long snapshots Descriptor: EICOSANE, OLEIC ACID, PHOSPHATE ION, ... Authors: Kovalev, K, Tsybrov, F, Alekseev, A, Bourenkov, G, Gordeliy, V. Deposit date: 2022-04-20 Release date: 2023-05-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Mechanisms of inward transmembrane proton translocation. Nat.Struct.Mol.Biol., 30, 2023
7ZNH	Crystal structure of the light-driven inward proton pump xenorhodopsin BcXeR in the activated state at pH 8.2 at room temperature, 250-750-mks-snapshot Descriptor: EICOSANE, OLEIC ACID, PHOSPHATE ION, ... Authors: Kovalev, K, Tsybrov, F, Alekseev, A, Bourenkov, G, Gordeliy, V. Deposit date: 2022-04-20 Release date: 2023-05-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Mechanisms of inward transmembrane proton translocation. Nat.Struct.Mol.Biol., 30, 2023
1JIJ	Crystal structure of S. aureus TyrRS in complex with SB-239629 Descriptor: [2-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONYLAMINO]-(1,3,4,5-TETRAHYDROXY-4-HYDROXYMETHYL-PIPERIDIN-2-YL)- ACETIC ACID, tyrosyl-tRNA synthetase Authors: Qiu, X, Janson, C.A, Smith, W.W, Jarvest, R.L. Deposit date: 2001-07-02 Release date: 2001-10-26 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors. Protein Sci., 10, 2001
7ZNI	Crystal structure of the light-driven inward proton pump xenorhodopsin BcXeR in the activated state at pH 8.2 at room temperature, 7.5-15-ms-snapshot Descriptor: EICOSANE, OLEIC ACID, PHOSPHATE ION, ... Authors: Kovalev, K, Tsybrov, F, Alekseev, A, Bourenkov, G, Gordeliy, V. Deposit date: 2022-04-20 Release date: 2023-05-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Mechanisms of inward transmembrane proton translocation. Nat.Struct.Mol.Biol., 30, 2023
7WHG	Lokiarchaeota gelsolin (2DGel) bound to two molecules of rabbit actin Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... Authors: Robinson, R.C, Akil, C. Deposit date: 2021-12-30 Release date: 2022-09-21 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Structural and biochemical evidence for the emergence of a calcium-regulated actin cytoskeleton prior to eukaryogenesis Commun Biol, 5, 2022
8CK2	MUC2 CysD1 G1352S Descriptor: ACETATE ION, CALCIUM ION, Mucin-2, ... Authors: Khmelnitsky, L, Fass, D. Deposit date: 2023-02-14 Release date: 2024-02-28 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Pulmonary Fibrosis Mutation Undermines Mucin 5B Supramolecular Assembly To Be Published
2W8C	Plastocyanin variant with N-terminal Methionine - closed structure Descriptor: COPPER (II) ION, PLASTOCYANIN, ZINC ION Authors: Crowley, P.B, Matias, P.M, Khan, A.R. Deposit date: 2009-01-15 Release date: 2009-10-27 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Metal-Mediated Self-Assembly of a Beta-Sandwich Protein. Chemistry, 15, 2009
7WHF	Heimdallarchaeota gelsolin (2DGel) bound to rabbit actin Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... Authors: Robinson, R.C, Akil, C. Deposit date: 2021-12-30 Release date: 2022-09-21 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural and biochemical evidence for the emergence of a calcium-regulated actin cytoskeleton prior to eukaryogenesis Commun Biol, 5, 2022
6QIK	Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles Descriptor: 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... Authors: Kargas, V, Warren, A.J. Deposit date: 2019-01-20 Release date: 2019-06-26 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Mechanism of completion of peptidyltransferase centre assembly in eukaryotes. Elife, 8, 2019
7WJV	Crystal structure of human liver FBPase complexed with an covalent inhibitor Descriptor: 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase 1, ... Authors: Cao, H, Huang, Y, Ren, Y, Wan, J. Deposit date: 2022-01-08 Release date: 2022-07-13 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.724 Å) Cite: N -Acylamino Saccharin as an Emerging Cysteine-Directed Covalent Warhead and Its Application in the Identification of Novel FBPase Inhibitors toward Glucose Reduction. J.Med.Chem., 65, 2022
1I5X	HIV-1 GP41 CORE Descriptor: SULFATE ION, TRANSMEMBRANE GLYCOPROTEIN (GP41) Authors: Liu, J, Lu, M. Deposit date: 2001-03-01 Release date: 2002-09-10 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural and functional analysis of interhelical interactions in the human immunodeficiency virus type 1 gp41 envelope glycoprotein by alanine-scanning mutagenesis. J.Virol., 75, 2001
3HLO	Crystal structure of chemically synthesized 'covalent dimer' [Gly51/D-Ala51']HIV-1 protease Descriptor: 'covalent dimer' [Gly51/D-Ala51'] HIV-1 protease, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide Authors: Torbeev, V.Y, Kent, S.B.H. Deposit date: 2009-05-27 Release date: 2011-07-27 Last modified: 2012-12-12 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc.Natl.Acad.Sci.USA, 108, 2011
8COP	Mycobacterium tuberculosis dihydrofolate reductase in complex with N-(4-(2,6-diamino-5-(cyclopropylethynyl)pyrimidin-4-yl)phenyl)methanesulfonamide Descriptor: COBALT (II) ION, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Kirkman, T.J, Dias, M.V.B. Deposit date: 2023-02-28 Release date: 2024-03-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Expansion of a series of pyrimidine derivatives utilising fragment-based merging showcasing anleads to increased affinity with to Mycobacterium tuberculosis dihydrofolate reductase To Be Published
7UVB	CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN S (LIGANDED SICKLE CELL HEMOGLOBIN) COMPLEXED WITH GBT021601 Descriptor: 2-hydroxy-6-({(3S)-4-[2-(2-hydroxyethyl)pyridine-3-carbonyl]morpholin-3-yl}methoxy)benzaldehyde, FORMYL GROUP, Hemoglobin subunit alpha, ... Authors: Partridge, J.R, Kaya, E, Xu, Q, Li, Z, Strutt, S.C, Cathers, B.E. Deposit date: 2022-04-29 Release date: 2023-04-05 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.05 Å) Cite: GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model. Br.J.Haematol., 202, 2023
2VZP	Atomic Resolution Structure of the C-terminal CBM35 from Amycolatopsis orientalis exo-chitosanase CsxA Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, EXO-BETA-D-GLUCOSAMINIDASE Authors: Lammerts van Bueren, A, Boraston, A.B. Deposit date: 2008-08-05 Release date: 2009-01-13 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.05 Å) Cite: Evidence that Family 35 Carbohydrate Binding Modules Display Conserved Specificity But Divergent Function. Proc.Natl.Acad.Sci.USA, 106, 2009
7ZNR	Inactive D62N mutant of BT1760 Endo-acting levanase from Bacteroides thetaiotaomicron VPI-5482 Descriptor: SULFATE ION, Sucrose-6-phosphate hydrolase, beta-D-fructofuranose-(2-6)-beta-D-fructofuranose, ... Authors: Basle, A, Bolam, D. Deposit date: 2022-04-21 Release date: 2023-06-21 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Outer membrane utilisomes mediate glycan uptake in gut Bacteroidetes. Nature, 618, 2023
7ZNS	Inactive D62N mutant of BT1760 Endo-acting levanase from Bacteroides thetaiotaomicron VPI-5482 Descriptor: Glycoside hydrolase family 32, SULFATE ION, beta-D-fructofuranose-(2-6)-beta-D-fructofuranose, ... Authors: Basle, A, Bolam, D. Deposit date: 2022-04-21 Release date: 2023-06-21 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Outer membrane utilisomes mediate glycan uptake in gut Bacteroidetes. Nature, 618, 2023
3HRF	Crystal structure of Human PDK1 kinase domain in complex with an allosteric activator bound to the PIF-pocket Descriptor: (2Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid, 3-phosphoinositide-dependent protein kinase 1, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Hindie, V, Alzari, P.M, Biondi, R.M. Deposit date: 2009-06-09 Release date: 2009-09-15 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat.Chem.Biol., 5, 2009
3HVH	Rat catechol O-methyltransferase in complex with a catechol-type, N6-methyladenine-containing bisubstrate inhibitor Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, CHLORIDE ION, Catechol O-methyltransferase, ... Authors: Ehler, A, Schlatter, D, Stihle, M, Benz, J, Rudolph, M.G. Deposit date: 2009-06-16 Release date: 2009-10-13 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Molecular recognition at the active site of catechol-o-methyltransferase: energetically favorable replacement of a water molecule imported by a bisubstrate inhibitor. Angew.Chem.Int.Ed.Engl., 48, 2009
6QIP	Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the albumin-biniding side chain of the human growth hormone derivative somapacitan Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BETA-MERCAPTOETHANOL, Beta-2-microglobulin, ... Authors: Johansson, E. Deposit date: 2019-01-21 Release date: 2020-02-05 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Identification of Binding Sites on Human Serum Albumin for Somapacitan, a Long-Acting Growth Hormone Derivative. Biochemistry, 59, 2020

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