Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5ZQI
DownloadVisualize
BU of 5zqi by Molmil
Alginate lyase AlgAT5 from Polysaccharide Lyase family 7
Descriptor: Alginate lyase AlgAT5, SULFATE ION
Authors:Su, H, Dong, S, Feng, Y.G, Ji, S.Q, Lu, M, Li, F.L.
Deposit date:2018-04-19
Release date:2019-04-24
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Alginate lyase AlgAT5 from Polysaccharide Lyase family 7
To Be Published
7VL3
DownloadVisualize
BU of 7vl3 by Molmil
The complex structure of beta-1,2-glucosyltransferase from Ignavibacterium album with phenyl alpha-D-glucoside
Descriptor: (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-phenoxy-oxane-3,4,5-triol, CALCIUM ION, beta-1,2-glucosyltransferase
Authors:Kobayashi, K, Shimizu, H, Tanaka, N, Kuramochi, K, Nakai, H, Nakajima, M, Taguchi, H.
Deposit date:2021-10-01
Release date:2022-03-09
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Characterization and structural analyses of a novel glycosyltransferase acting on the beta-1,2-glucosidic linkages.
J.Biol.Chem., 298, 2022
8PDI
DownloadVisualize
BU of 8pdi by Molmil
The phosphatase and C2 domains of SHIP1 with covalent Z1763271112
Descriptor: (5-phenyl-1,3,4-thiadiazol-2-yl)methanimine, DIMETHYL SULFOXIDE, Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
Authors:Bradshaw, W.J, Moreira, T, Pascoa, T.C, Bountra, C, Chalk, R, von Delft, F, Brennan, P.E, Gileadi, O.
Deposit date:2023-06-12
Release date:2023-07-26
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2.
Structure, 32, 2024
7SI5
DownloadVisualize
BU of 7si5 by Molmil
CRYSTAL STRUCTURE OF EED WITH MRTX-1919
Descriptor: (4R)-8-(1,3-dimethyl-1H-pyrazol-5-yl)-5-{[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]amino}imidazo[1,2-c]pyrimidine-2-carbonitrile, 1,2-ETHANEDIOL, FORMIC ACID, ...
Authors:Gunn, R.J, Burns, A.C, Lawson, J.D, Marx, M.A.
Deposit date:2021-10-12
Release date:2022-11-09
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:CRYSTAL STRUCTURE OF EED WITH MRTX-1919
TO BE PUBLISHED
6U0D
DownloadVisualize
BU of 6u0d by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor ZL0590
Descriptor: Bromodomain-containing protein 4, DIMETHYL SULFOXIDE, N-[4-({(2S)-2-[(morpholin-4-yl)methyl]pyrrolidin-1-yl}sulfonyl)phenyl]-N'-[4-(trifluoromethyl)phenyl]urea
Authors:Leonard, P.G, Joseph, S.
Deposit date:2019-08-14
Release date:2020-08-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site
J. Med. Chem., 2022
5ZQP
DownloadVisualize
BU of 5zqp by Molmil
Tankyrase-2 in complex with compound 12
Descriptor: 1'-(4-oxo-3,4,5,6,7,8-hexahydroquinazolin-2-yl)-2H-spiro[1-benzofuran-3,4'-piperidin]-2-one, GLYCEROL, PHOSPHATE ION, ...
Authors:Niwa, H, Shirai, F, Sato, S, Yoshimoto, N, Tsumura, T, Okue, M, Shirouzu, M, Seimiya, H, Umehara, T.
Deposit date:2018-04-19
Release date:2019-04-03
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
J. Med. Chem., 62, 2019
6OBR
DownloadVisualize
BU of 6obr by Molmil
PP1 Y134A in complex with Microcystin LR
Descriptor: CHLORIDE ION, MANGANESE (II) ION, Microcystin LR, ...
Authors:Choy, M.S, Moon, T.M, Bray, J.A, Archuleta, T.L, Shi, W, Peti, W, Page, R.
Deposit date:2019-03-21
Release date:2019-09-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:SDS22 selectively recognizes and traps metal-deficient inactive PP1.
Proc.Natl.Acad.Sci.USA, 116, 2019
7VL0
DownloadVisualize
BU of 7vl0 by Molmil
The complex structure of beta-1,2-glucosyltransferase from Ignavibacterium album with p-nitrophenyl-alpha-D-glucopyranoside
Descriptor: 4-nitrophenyl alpha-D-glucopyranoside, Beta-galactosidase, CALCIUM ION
Authors:Kobayashi, K, Shimizu, H, Tanaka, N, Kuramochi, K, Nakai, H, Nakajima, M, Taguchi, H.
Deposit date:2021-10-01
Release date:2022-03-09
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Characterization and structural analyses of a novel glycosyltransferase acting on the beta-1,2-glucosidic linkages.
J.Biol.Chem., 298, 2022
8OU1
DownloadVisualize
BU of 8ou1 by Molmil
Crystal structure of the SPOC domain of mouse SPOCD1
Descriptor: CITRATE ANION, SPOC domain-containing protein 1
Authors:Heep, M, Cook, A.G, O'Carroll, D.
Deposit date:2023-04-21
Release date:2024-02-21
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line.
Mol.Cell, 84, 2024
4ZX5
DownloadVisualize
BU of 4zx5 by Molmil
X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10q
Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
Authors:Drinkwater, N, McGowan, S.
Deposit date:2015-05-20
Release date:2016-03-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.
Eur.J.Med.Chem., 110, 2016
7NFQ
DownloadVisualize
BU of 7nfq by Molmil
Fujian capmidlink domain in complex with Nb8193
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, Nb8193, ...
Authors:Keown, J.R, Grimes, J.M, Fodor, E.
Deposit date:2021-02-07
Release date:2021-12-01
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.
Nat Commun, 13, 2022
6OB6
DownloadVisualize
BU of 6ob6 by Molmil
Human equilibrative nucleoside transporter-1, S-(4-nitrobenzyl)-6-thioinosine bound, merohedrally twinned
Descriptor: 6-{[(4-nitrophenyl)methyl]sulfanyl}-9-beta-D-ribofuranosyl-9H-purine, Equilibrative nucleoside transporter 1
Authors:Wright, N.J, Lee, S.-Y.
Deposit date:2019-03-19
Release date:2019-07-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of human ENT1 in complex with adenosine reuptake inhibitors.
Nat.Struct.Mol.Biol., 26, 2019
7NIZ
DownloadVisualize
BU of 7niz by Molmil
Human 14-3-3 sigma in complex with human Estrogen Receptor alpha peptide and ligands Fusicoccin-A and WR-1065
Descriptor: 14-3-3 protein sigma, Estrogen receptor, FUSICOCCIN, ...
Authors:Roversi, P, Falcicchio, M, Doveston, R.
Deposit date:2021-02-14
Release date:2021-12-01
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Cooperative stabilisation of 14-3-3 sigma protein-protein interactions via covalent protein modification.
Chem Sci, 12, 2021
8OT8
DownloadVisualize
BU of 8ot8 by Molmil
Alditol oxidase from Actinomycetota bacterium in complex with D-xylulose
Descriptor: D-XYLULOSE, FAD-binding protein, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Rotilio, L, Mattevi, A.
Deposit date:2023-04-20
Release date:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery and biochemical characterization of thermostable glycerol oxidases.
Appl.Microbiol.Biotechnol., 108, 2024
7VDP
DownloadVisualize
BU of 7vdp by Molmil
The structure of cyclin-dependent kinase 5 (CDK5) in complex with p25 and Compound 1
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Cyclin-dependent kinase 5 activator 1, ...
Authors:Malojcic, G, Clugston, S.L, Daniels, M, Harmange, J.C, Ledeborer, M.
Deposit date:2021-09-07
Release date:2022-03-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Discovery and Optimization of Highly Selective Inhibitors of CDK5.
J.Med.Chem., 65, 2022
6LQB
DownloadVisualize
BU of 6lqb by Molmil
A third intermediate state of L,D-transpeptidase LdtMt2-ertapenem adduct
Descriptor: (2S,3R,4S)-4-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-2-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, ACETIC ACID, GLYCEROL, ...
Authors:Li, D.F, Qin, Y.L.
Deposit date:2020-01-13
Release date:2021-01-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A New State I-plus Observed for the L,D-transpeptidase LdtMt2-ertapenem Adduct
Prog.Biochem.Biophys., 47, 2020
7RYW
DownloadVisualize
BU of 7ryw by Molmil
Crystal structure of Ferritin grown by the microbatch method in the presence of Agarose
Descriptor: CADMIUM ION, Ferritin light chain, SULFATE ION
Authors:Aditya, S, Priyadharshine, R, Maham, I, Miller, D.J, Stojanoff, V.
Deposit date:2021-08-26
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystal structure of Ferritin grown by microbatch method in the presence of agarose
To Be Published
7N43
DownloadVisualize
BU of 7n43 by Molmil
Alpha-conotoxin OmIA with unusual pharmacological properties at alpha7 nicotinic receptors
Descriptor: Acetylcholine-binding protein, Alpha-conotoxin OmIA
Authors:Ho, T.N.T, Abraham, N, Lewis, R.J.
Deposit date:2021-06-03
Release date:2021-12-01
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Unique Pharmacological Properties of alpha-Conotoxin OmIA at alpha 7 nAChRs.
Front Pharmacol, 12, 2021
6OB7
DownloadVisualize
BU of 6ob7 by Molmil
Human equilibrative nucleoside transporter-1, dilazep bound
Descriptor: (1,4-diazepane-1,4-diyl)di(propane-3,1-diyl) bis(3,4,5-trimethoxybenzoate), (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Equilibrative nucleoside transporter 1
Authors:Wright, N.J, Lee, S.-Y.
Deposit date:2019-03-19
Release date:2019-07-03
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of human ENT1 in complex with adenosine reuptake inhibitors.
Nat.Struct.Mol.Biol., 26, 2019
6U6L
DownloadVisualize
BU of 6u6l by Molmil
BRD4-BD2 in complex with the cyclic peptide 3.1_2
Descriptor: AMINO GROUP, Bromodomain-containing protein 4, Cyclic peptide 3.1_2, ...
Authors:Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P.
Deposit date:2019-08-30
Release date:2020-08-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Cyclic peptides can engage a single binding pocket through highly divergent modes.
Proc.Natl.Acad.Sci.USA, 117, 2020
7S6V
DownloadVisualize
BU of 7s6v by Molmil
Leishmania infantum Glycogen Synthase Kinase 3 beta bound to CGP60474
Descriptor: 1,2-ETHANEDIOL, 3-({4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl}amino)propan-1-ol, Glycogen synthase kinase 3, ...
Authors:dos Reis, C.V, Ramos, P.Z, Counago, R.M.
Deposit date:2021-09-15
Release date:2022-11-09
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Leishmania infantum Glycogen Synthase Kinase 3 beta bound to CGP60474
To Be Published
7RZX
DownloadVisualize
BU of 7rzx by Molmil
Crystal Structure of Ferritin grown by microbatch method in presence of agarose and electric field 4.3KV
Descriptor: CADMIUM ION, Ferritin light chain, SULFATE ION
Authors:Aditya, S, Priyadharshine, R, Maham, I, Miller, J.D, Stojanoff, V.
Deposit date:2021-08-27
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Crystal Structure of Ferritin grown by microbatch method in presence of agarose and electric field 4.3KV
To Be Published
6OC7
DownloadVisualize
BU of 6oc7 by Molmil
HMP42 Fab in complex with Protein G
Descriptor: Heavy chain of HMP42 Fab, Immunoglobulin G-binding protein G, Light chain for HMP42 Fab
Authors:Bernard, S.M, Wilson, I.A.
Deposit date:2019-03-22
Release date:2020-02-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.296 Å)
Cite:A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses.
Science, 366, 2019
4ZRW
DownloadVisualize
BU of 4zrw by Molmil
Structure of cow mincle complexed with trehalose
Descriptor: CALCIUM ION, alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose, mincle protein
Authors:Feinberg, H, Rambaruth, N.D.S, Taylor, M.E, Drickamer, K, Weis, W.I.
Deposit date:2015-05-12
Release date:2016-05-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Binding Sites for Acylated Trehalose Analogs of Glycolipid Ligands on an Extended Carbohydrate Recognition Domain of the Macrophage Receptor Mincle.
J.Biol.Chem., 291, 2016
7SDC
DownloadVisualize
BU of 7sdc by Molmil
Structure of the SARS-CoV-2 main protease in complex with inhibitor MI-09
Descriptor: (1R,2S,5S)-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-{[4-(trifluoromethoxy)phenoxy]acetyl}-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase
Authors:Yang, K.S, Liu, W.R.
Deposit date:2021-09-29
Release date:2022-11-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A Systematic Survey of Reversibly Covalent Dipeptidyl Inhibitors of the SARS-CoV-2 Main Protease.
J.Med.Chem., 66, 2023

224004

數據於2024-08-21公開中

PDB statisticsPDBj update infoContact PDBjnumon