8HQC
 
 | | Structure of a GPCR-G protein in complex with a natural peptide agonist | | Descriptor: | Antibody fragment, C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, ... | | Authors: | Saha, S, Maharana, J, Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. | | Deposit date: | 2022-12-13 | | Release date: | 2023-10-18 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.89 Å) | | Cite: | Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors.
Cell, 186, 2023
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8Q3B
 | | The closed state of the ASFV apo-RNA polymerase | | Descriptor: | DNA-directed RNA polymerase RPB1 homolog, DNA-directed RNA polymerase RPB10 homolog, DNA-directed RNA polymerase RPB2 homolog, ... | | Authors: | Pilotto, S, Sykora, M, Cackett, G, Werner, F. | | Deposit date: | 2023-08-03 | | Release date: | 2024-02-14 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.69 Å) | | Cite: | Structure of the recombinant RNA polymerase from African Swine Fever Virus.
Nat Commun, 15, 2024
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7DBP
 | | Linker histone defines structure and self-association behaviour of the 177 bp human chromosome | | Descriptor: | DNA (175-MER), Histone H1.0, Histone H2A type 1-B/E, ... | | Authors: | Wang, S, Vogirala, K.V, Soman, A, Liu, Z.B. | | Deposit date: | 2020-10-21 | | Release date: | 2020-12-23 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Linker histone defines structure and self-association behaviour of the 177 bp human chromatosome.
Sci Rep, 11, 2021
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7UN1
 | | 8-nm repeat of the human sperm tip singlet microtubule | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Gui, M, Croft, J.T, Zabeo, D, Acharya, V, Kollman, J.M, Burgoyne, T, Hoog, J.L, Brown, A. | | Deposit date: | 2022-04-08 | | Release date: | 2022-10-05 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (6 Å) | | Cite: | SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.
Proc.Natl.Acad.Sci.USA, 119, 2022
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1914
 | | SIGNAL RECOGNITION PARTICLE ALU RNA BINDING HETERODIMER, SRP9/14 | | Descriptor: | BETA-MERCAPTOETHANOL, PHOSPHATE ION, SIGNAL RECOGNITION PARTICLE 9/14 FUSION PROTEIN | | Authors: | Birse, D, Kapp, U, Strub, K, Cusack, S, Aberg, A. | | Deposit date: | 1997-11-13 | | Release date: | 1998-12-30 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | The crystal structure of the signal recognition particle Alu RNA binding heterodimer, SRP9/14.
EMBO J., 16, 1997
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1BRD
 | | Model for the structure of Bacteriorhodopsin based on high-resolution Electron Cryo-microscopy | | Descriptor: | BACTERIORHODOPSIN PRECURSOR, RETINAL | | Authors: | Henderson, R, Baldwin, J.M, Ceska, T.A, Zemlin, F, Beckmann, E, Downing, K.H. | | Deposit date: | 1990-05-23 | | Release date: | 1991-04-15 | | Last modified: | 2024-04-17 | | Method: | ELECTRON CRYSTALLOGRAPHY (3.5 Å) | | Cite: | Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy.
J.Mol.Biol., 213, 1990
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2CVW
 | | Structures of Yeast Ribonucleotide Reductase I | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large chain 1, ... | | Authors: | Xu, H, Faber, C, Uchiki, T, Fairman, J.W, Racca, J, Dealwis, C. | | Deposit date: | 2005-06-14 | | Release date: | 2006-03-07 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2NPS
 | | Crystal Structure of the Early Endosomal SNARE Complex | | Descriptor: | Syntaxin 13, Syntaxin-6, Vesicle transport through interaction with t-SNAREs homolog 1A, ... | | Authors: | Zwilling, D, Cypionka, A, Pohl, W.H, Fasshauer, D, Walla, P.J, Wahl, M.C, Jahn, R. | | Deposit date: | 2006-10-30 | | Release date: | 2006-12-26 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Early endosomal SNAREs form a structurally conserved SNARE complex and fuse liposomes with multiple topologies
Embo J., 26, 2007
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1BDA
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1CFP
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8AX5
 | | Crystal structure of a CGRP receptor ectodomain heterodimer bound to macrocyclic inhibitor HTL0029881 | | Descriptor: | (1~{R},10~{R},20~{E})-12-methyl-10-[(7-methyl-2~{H}-indazol-5-yl)methyl]-15,18-dioxa-9,12,24,26-tetrazapentacyclo[20.5.2.1^{1,4}.1^{3,7}.0^{25,28}]hentriaconta-3,5,7(30),20,22,24,28-heptaene-8,11,27-trione, Maltose/maltodextrin-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor, TETRAETHYLENE GLYCOL, ... | | Authors: | Southall, S.M, Watson, S.P. | | Deposit date: | 2022-08-30 | | Release date: | 2022-12-07 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode.
Acs Med.Chem.Lett., 13, 2022
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8AX6
 | | Crystal structure of a CGRP receptor ectodomain heterodimer bound to macrocyclic inhibitor HTL0029882 | | Descriptor: | (1~{S},10~{R},20~{E})-12-methyl-10-[(7-methyl-2~{H}-indazol-5-yl)methyl]-15,18-dioxa-9,12,24,26-tetrazapentacyclo[20.5.2.1^{1,4}.1^{3,7}.0^{25,28}]hentriaconta-3(30),4,6,20,22,24,28-heptaene-8,11,27-trione, Maltose/maltodextrin-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor, TETRAETHYLENE GLYCOL, ... | | Authors: | Southall, S.M, Watson, S.P. | | Deposit date: | 2022-08-30 | | Release date: | 2022-12-07 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode.
Acs Med.Chem.Lett., 13, 2022
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8AX7
 | | Crystal structure of a CGRP receptor ectodomain heterodimer bound to macrocyclic inhibitor HTL0031448 | | Descriptor: | (1~{S},10~{R},20~{E})-10-[(1,7-dimethylindazol-5-yl)methyl]-12-methyl-15,18-dioxa-9,12,24,26-tetrazapentacyclo[20.5.2.1^{1,4}.1^{3,7}.0^{25,28}]hentriaconta-3(30),4,6,20,22,24,28-heptaene-8,11,27-trione, ACETATE ION, Maltose/maltodextrin-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor, ... | | Authors: | Southall, S.M, Watson, S.P. | | Deposit date: | 2022-08-30 | | Release date: | 2022-12-07 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode.
Acs Med.Chem.Lett., 13, 2022
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1CXV
 | | STRUCTURE OF RECOMBINANT MOUSE COLLAGENASE-3 (MMP-13) | | Descriptor: | 2-{4-[4-(4-CHLORO-PHENOXY)-BENZENESULFONYL]-TETRAHYDRO-PYRAN-4-YL}-N-HYDROXY-ACETAMIDE, CALCIUM ION, PROTEIN (COLLAGENASE-3), ... | | Authors: | Botos, I, Meyer, E, Swanson, S.M, Lemaitre, V, Eeckhout, Y, Meyer, E.F. | | Deposit date: | 1999-08-30 | | Release date: | 2000-08-30 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of recombinant mouse collagenase-3 (MMP-13).
J.Mol.Biol., 292, 1999
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3WI2
 | | Crystal structure of PDE10A in complex with inhibitor | | Descriptor: | 2-({[1-phenyl-2-(propan-2-yl)-1H-benzimidazol-6-yl]oxy}methyl)quinoline, MAGNESIUM ION, ZINC ION, ... | | Authors: | Amano, Y. | | Deposit date: | 2013-09-04 | | Release date: | 2013-12-11 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | Design and synthesis of novel benzimidazole derivatives as phosphodiesterase 10A inhibitors with reduced CYP1A2 inhibition.
Bioorg.Med.Chem., 21, 2013
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7YAG
 | | CryoEM structure of SPCA1a in E1-Ca-AMPPCP state subclass 1 | | Descriptor: | CALCIUM ION, Calcium-transporting ATPase type 2C member 1, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | | Authors: | Chen, Z, Watanabe, S, Inaba, K. | | Deposit date: | 2022-06-28 | | Release date: | 2023-03-22 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Cryo-EM structures of human SPCA1a reveal the mechanism of Ca 2+ /Mn 2+ transport into the Golgi apparatus.
Sci Adv, 9, 2023
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7YAH
 | | CryoEM structure of SPCA1a in E1-Ca-AMPPCP state subclass 2 | | Descriptor: | CALCIUM ION, Calcium-transporting ATPase type 2C member 1, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | | Authors: | Chen, Z, Watanabe, S, Inaba, K. | | Deposit date: | 2022-06-28 | | Release date: | 2023-03-22 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | Cryo-EM structures of human SPCA1a reveal the mechanism of Ca 2+ /Mn 2+ transport into the Golgi apparatus.
Sci Adv, 9, 2023
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7YAI
 | | CryoEM structure of SPCA1a in E1-Ca-AMPPCP state subclass 3 | | Descriptor: | CALCIUM ION, Calcium-transporting ATPase type 2C member 1, Nanobody head piece of megabody, ... | | Authors: | Chen, Z, Watanabe, S, Inaba, K. | | Deposit date: | 2022-06-28 | | Release date: | 2023-03-22 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | Cryo-EM structures of human SPCA1a reveal the mechanism of Ca 2+ /Mn 2+ transport into the Golgi apparatus.
Sci Adv, 9, 2023
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7YAJ
 | | CryoEM structure of SPCA1a in E1-Mn-AMPPCP state subclass 1 | | Descriptor: | Calcium-transporting ATPase type 2C member 1, MANGANESE (II) ION, Nanobody head piece of megabody, ... | | Authors: | Chen, Z, Watanabe, S, Inaba, K. | | Deposit date: | 2022-06-28 | | Release date: | 2023-03-22 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | Cryo-EM structures of human SPCA1a reveal the mechanism of Ca 2+ /Mn 2+ transport into the Golgi apparatus.
Sci Adv, 9, 2023
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1BY3
 | | FHUA FROM E. COLI | | Descriptor: | N-OCTYL-2-HYDROXYETHYL SULFOXIDE, PROTEIN (FERRICHROME-IRON RECEPTOR PRECURSOR (FHUA)) | | Authors: | Locher, K.P, Rees, B, Koebnik, R, Mitschler, A, Moulinier, L, Rosenbusch, J.P, Moras, D. | | Deposit date: | 1998-10-22 | | Release date: | 1999-01-13 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.74 Å) | | Cite: | Transmembrane signaling across the ligand-gated FhuA receptor: crystal structures of free and ferrichrome-bound states reveal allosteric changes.
Cell(Cambridge,Mass.), 95, 1998
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1C05
 | | SOLUTION STRUCTURE OF RIBOSOMAL PROTEIN S4 DELTA 41, REFINED WITH DIPOLAR COUPLINGS (MINIMIZED AVERAGE STRUCTURE) | | Descriptor: | RIBOSOMAL PROTEIN S4 DELTA 41 | | Authors: | Markus, M.A, Gerstner, R.B, Draper, D.E, Torchia, D.A. | | Deposit date: | 1999-07-14 | | Release date: | 1999-09-29 | | Last modified: | 2024-04-10 | | Method: | SOLUTION NMR | | Cite: | Refining the overall structure and subdomain orientation of ribosomal protein S4 delta41 with dipolar couplings measured by NMR in uniaxial liquid crystalline phases.
J.Mol.Biol., 292, 1999
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2AJO
 | | NMR structure of the in-plane membrane anchor domain [1-28] of the monotopic NonStructural Protein 5A (NS5A) from the Bovine Viral Diarrhea Virus (BVDV) | | Descriptor: | Nonstructural protein 5A | | Authors: | Sapay, N, Montserret, R, Chipot, C, Brass, V, Moradpour, D, Deleage, G, Penin, F. | | Deposit date: | 2005-08-02 | | Release date: | 2005-08-23 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | NMR structure and molecular dynamics of the in-plane membrane anchor of nonstructural protein 5A from bovine viral diarrhea virus.
Biochemistry, 45, 2006
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1BLD
 | | BASIC FIBROBLAST GROWTH FACTOR (FGF-2) MUTANT WITH CYS 78 REPLACED BY SER AND CYS 96 REPLACED BY SER, NMR | | Descriptor: | BASIC FIBROBLAST GROWTH FACTOR | | Authors: | Powers, R, Seddon, A.P, Bohlen, P, Moy, F.J. | | Deposit date: | 1996-05-20 | | Release date: | 1996-11-08 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | High-resolution solution structure of basic fibroblast growth factor determined by multidimensional heteronuclear magnetic resonance spectroscopy.
Biochemistry, 35, 1996
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2AJM
 | | NMR structure of the in-plane membrane anchor domain [1-28] of the monotopic NonStructural Protein 5A (NS5A) from the Bovine Viral Diarrhea Virus (BVDV) | | Descriptor: | Nonstructural protein 5A | | Authors: | Sapay, N, Montserret, R, Chipot, C, Brass, V, Moradpour, D, Deleage, G, Penin, F. | | Deposit date: | 2005-08-02 | | Release date: | 2005-08-23 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | NMR structure and molecular dynamics of the in-plane membrane anchor of nonstructural protein 5A from bovine viral diarrhea virus.
Biochemistry, 45, 2006
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7WHW
 | | Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in detergent with AMPPCP (E1-ATP state) | | Descriptor: | Alkylphosphocholine resistance protein LEM3, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | | Authors: | Xu, J, He, Y, Wu, X, Li, L. | | Deposit date: | 2021-12-31 | | Release date: | 2022-03-23 | | Last modified: | 2022-03-30 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Conformational changes of a phosphatidylcholine flippase in lipid membranes.
Cell Rep, 38, 2022
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