3WI2

Crystal structure of PDE10A in complex with inhibitor

Summary for 3WI2

Entry DOI	10.2210/pdb3wi2/pdb
Descriptor	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	phosphodiesterase, cgmp binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q9Y233
Total number of polymer chains	2
Total formula weight	80179.25
Authors	Amano, Y. (deposition date: 2013-09-04, release date: 2013-12-11, Last modification date: 2022-08-24)
Primary citation	Hamaguchi, W.,Masuda, N.,Isomura, M.,Miyamoto, S.,Kikuchi, S.,Amano, Y.,Honbou, K.,Mihara, T.,Watanabe, T. Design and synthesis of novel benzimidazole derivatives as phosphodiesterase 10A inhibitors with reduced CYP1A2 inhibition. Bioorg.Med.Chem., 21:7612-7623, 2013 Cited by PubMed: 24238902 DOI: 10.1016/j.bmc.2013.10.035 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.26 Å)

Structure validation