PDB: 35140 resultsInfo pagesStatus searchChemie searchBIRD

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6D0Q	Structure of a DNA retention-prone PCNA variant Descriptor: Proliferating cell nuclear antigen Authors: Kelch, B.A, Gaubitz, C. Deposit date: 2018-04-10 Release date: 2019-05-15 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.80051017 Å) Cite: Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex. Nucleic Acids Res., 47, 2019
4FTG	The crystal structure of an AHNAK peptide in complex with the S100A10/AnxA2 heterotetramer Descriptor: Annexin A2, ISOPROPYL ALCOHOL, Neuroblast differentiation-associated protein AHNAK, ... Authors: Ozorowski, G, Luecke, H. Deposit date: 2012-06-27 Release date: 2013-01-02 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (2.5054 Å) Cite: Structure of a C-terminal AHNAK peptide in a 1:2:2 complex with S100A10 and an acetylated N-terminal peptide of annexin A2. Acta Crystallogr.,Sect.D, 69, 2013
6D0R	Structure of a DNA retention-prone PCNA variant Descriptor: Proliferating cell nuclear antigen Authors: Kelch, B.A, Gaubitz, C. Deposit date: 2018-04-10 Release date: 2019-05-15 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.85856962 Å) Cite: Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex. Nucleic Acids Res., 47, 2019
6CZQ	A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model Descriptor: CALCIUM ION, Calmodulin-1, SULFATE ION, ... Authors: Nam, Y.W, Zhang, M. Deposit date: 2018-04-09 Release date: 2018-08-01 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: A V-to-F substitution in SK2 channels causes Ca2+hypersensitivity and improves locomotion in a C. elegans ALS model. Sci Rep, 8, 2018
6CIX	Lactam cyclised mimetic of a fragment of p21 Descriptor: p21 Authors: Wegener, K.L. Deposit date: 2018-02-25 Release date: 2018-07-04 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Rational Design of a 310-Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp. Chemistry, 24, 2018
6D6R	Human nuclear exosome-MTR4 RNA complex - composite map after focused reconstruction Descriptor: DNA/RNA (62-MER), Exosome RNA helicase MTR4, Exosome complex component CSL4, ... Authors: Weick, E.-M, Lima, C.D. Deposit date: 2018-04-22 Release date: 2018-06-20 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.45 Å) Cite: Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex. Cell, 173, 2018
1O9G	rRNA methyltransferase aviRa from Streptomyces viridochromogenes at 1.5A Descriptor: RRNA METHYLTRANSFERASE Authors: Mosbacher, T.G, Schulz, G.E. Deposit date: 2002-12-13 Release date: 2003-05-16 Last modified: 2019-07-24 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal Structure of the Avilamycin Resistance-Conferring Methyltransferase Avira from Streptomyces Viridochromogenes J.Mol.Biol., 329, 2003
1PK2	SOLUTION STRUCTURE OF THE TISSUE-TYPE PLASMINOGEN ACTIVATOR KRINGLE 2 DOMAIN COMPLEXED TO 6-AMINOHEXANOIC ACID AN ANTIFIBRINOLYTIC DRUG Descriptor: 6-AMINOHEXANOIC ACID, TISSUE-TYPE PLASMINOGEN ACTIVATOR Authors: Llinas, M, Byeon, I.-J.L. Deposit date: 1991-09-16 Release date: 1994-01-31 Last modified: 2023-11-15 Method: SOLUTION NMR Cite: Solution structure of the tissue-type plasminogen activator kringle 2 domain complexed to 6-aminohexanoic acid an antifibrinolytic drug. J.Mol.Biol., 222, 1991
3RPG	Bmi1/Ring1b-UbcH5c complex structure Descriptor: E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1, Ubiquitin-conjugating enzyme E2 D3, ... Authors: Bentley, M.L, Dong, K.C, Cochran, A.G. Deposit date: 2011-04-26 Release date: 2011-08-17 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.6485 Å) Cite: Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex. Embo J., 30, 2011
6L53	Structure of SMG1 Descriptor: Serine/threonine-protein kinase SMG1 Authors: Xu, Y, Qi, Y. Deposit date: 2019-10-22 Release date: 2020-04-15 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.63 Å) Cite: Cryo-EM structure of SMG1-SMG8-SMG9 complex. Cell Res., 29, 2019
3HV4	Human p38 MAP Kinase in Complex with RL51 Descriptor: 1-{3-[(6-aminoquinolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mitogen-activated protein kinase 14, ... Authors: Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. Deposit date: 2009-06-15 Release date: 2009-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Displacement assay for the detection of stabilizers of inactive kinase conformations. J.Med.Chem., 53, 2010
3HL7	Crystal Structure of Human p38alpha complexed with SD-0006 Descriptor: 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, 2-{4-[5-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-3-yl]piperidin-1-yl}-2-oxoethanol, Mitogen-activated protein kinase 14 Authors: Shieh, H.-S, Kurumbail, R.G, Stegeman, R.A, Williams, J.M. Deposit date: 2009-05-26 Release date: 2009-07-14 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804. Biochemistry, 48, 2009
3HLL	Crystal Structure of Human p38alpha complexed with PH-797804 Descriptor: 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, 3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1(2H)-yl}-N,4-dimethylbenzamide, HYPOPHOSPHITE, ... Authors: Shieh, H.-S, Williams, J.M, Stegeman, R.A, Kurumbail, R.G. Deposit date: 2009-05-27 Release date: 2009-07-14 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804. Biochemistry, 48, 2009
3HL8	Crystal structure of exonuclease I in complex with inhibitor BCBP Descriptor: (5R)-3-tert-butyl-1-(6-chloro-1,3-benzothiazol-2-yl)-4,5-dihydro-1H-pyrazol-5-ol, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... Authors: Satyshur, K.A. Deposit date: 2009-05-27 Release date: 2010-01-19 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Small-molecule tools for dissecting the roles of SSB/protein interactions in genome maintenance Proc.Natl.Acad.Sci.USA, 107, 2010
1WBT	Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation. Descriptor: 3-FLUORO-5-MORPHOLIN-4-YL-N-[1-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-6-YL]BENZAMIDE, MITOGEN-ACTIVATED PROTEIN KINASE 14 Authors: Tickle, J, Cleasby, A, Devine, L.A, Jhoti, H. Deposit date: 2004-11-05 Release date: 2005-11-03 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2 Å) Cite: Identification of Novel P38Alpha Map Kinase Inhibitors Using Fragment-Based Lead Generation. J.Med.Chem., 48, 2005
1WC8	The crystal structure of mouse bet3p Descriptor: MYRISTIC ACID, TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT3 Authors: Kim, Y.-G, Sacher, M, Oh, B.-H. Deposit date: 2004-11-10 Release date: 2004-12-13 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal Structure of Bet3 Reveals a Novel Mechanism for Golgi Localization of Tethering Factor Trapp Nat.Struct.Mol.Biol., 12, 2005
3HP9	Crystal structure of SSB/Exonuclease I in complex with inhibitor CFAM Descriptor: 1,2-ETHANEDIOL, 2-{[2-chloro-5-(trifluoromethyl)phenyl]amino}-5-methoxybenzoic acid, DIMETHYL SULFOXIDE, ... Authors: Satyshur, K.A. Deposit date: 2009-06-03 Release date: 2010-01-19 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Small-molecule tools for dissecting the roles of SSB/protein interactions in genome maintenance Proc.Natl.Acad.Sci.USA, 107, 2010
1WI4	Solution structure of the PDZ domain of syntaxin binding protein 4 Descriptor: syntaxin binding protein 4 Authors: Endo, H, Tomizawa, T, Kigawa, T, Yoshida, M, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2004-05-28 Release date: 2005-06-07 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the PDZ domain of syntaxin binding protein 4 To be published
3HUB	Human p38 MAP Kinase in Complex with Scios-469 Descriptor: 2-(6-chloro-5-{[(2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazin-1-yl]carbonyl}-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside Authors: Gruetter, C, Simard, J.R, Rauh, D. Deposit date: 2009-06-13 Release date: 2010-03-09 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations. J.Am.Chem.Soc., 132, 2010
6DLN	Oligomeric Structure of the HIV gp41 MPER-TMD in Phospholipid Bilayers Descriptor: Transmembrane protein gp41 Authors: Kwon, B, Lee, M, Waring, A.J, Hong, M. Deposit date: 2018-06-01 Release date: 2018-08-08 Last modified: 2024-05-01 Method: SOLID-STATE NMR Cite: Oligomeric Structure and Three-Dimensional Fold of the HIV gp41 Membrane-Proximal External Region and Transmembrane Domain in Phospholipid Bilayers. J. Am. Chem. Soc., 140, 2018
3HUF	Structure of the S. pombe Nbs1-Ctp1 complex Descriptor: DNA repair and telomere maintenance protein nbs1, Double-strand break repair protein ctp1, THIOCYANATE ION Authors: Williams, R.S, Guenther, G, Tainer, J.A. Deposit date: 2009-06-13 Release date: 2009-10-13 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair. Cell(Cambridge,Mass.), 139, 2009
3HSU	Functional roles of the 6-s-cysteinyl, 8 alpha-N1-histidyl FAD in Glucooligosaccharide Oxidase from Acremonium strictum Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN-ADENINE DINUCLEOTIDE, ... Authors: Liaw, S.-H, Huang, C.-H. Deposit date: 2009-06-10 Release date: 2009-06-30 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.69 Å) Cite: Functional roles of the 6-S-cysteinyl, 8alpha-N1-histidyl FAD in glucooligosaccharide oxidase from Acremonium strictum J.Biol.Chem., 283, 2008
3HTX	Crystal structure of small RNA methyltransferase HEN1 Descriptor: 5'-R(*GP*AP*UP*UP*UP*CP*UP*CP*UP*CP*UP*GP*CP*AP*AP*GP*CP*GP*AP*AP*AP*G)-3', 5'-R(P*UP*UP*CP*GP*CP*UP*UP*GP*CP*AP*GP*AP*GP*AP*GP*AP*AP*AP*UP*CP*AP*C)-3', HEN1, ... Authors: Huang, Y, Ji, L.-J, Huang, Q.-C, Vassylyev, D.G, Chen, X.-M, Ma, J.-B. Deposit date: 2009-06-12 Release date: 2009-09-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structural insights into mechanisms of the small RNA methyltransferase HEN1. Nature, 461, 2009
1WKQ	Crystal Structure of Bacillus subtilis Guanine Deaminase. The first domain-swapped structure in the cytidine deaminase superfamily Descriptor: Guanine deaminase, IMIDAZOLE, ZINC ION Authors: Liaw, S.H, Chang, Y.J, Lai, C.T. Deposit date: 2004-06-01 Release date: 2004-07-13 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.17 Å) Cite: Crystal Structure of Bacillus subtilis Guanine Deaminase: THE FIRST DOMAIN-SWAPPED STRUCTURE IN THE CYTIDINE DEAMINASE SUPERFAMILY J.Biol.Chem., 279, 2004
1WC9	The crystal structure of truncated mouse bet3p Descriptor: GLYCEROL, MYRISTIC ACID, TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT3 Authors: Kim, Y.-G, Lee, H.-S, Sacher, M, Oh, B.-H. Deposit date: 2004-11-10 Release date: 2004-12-13 Last modified: 2015-04-15 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal Structure of Bet3 Reveals a Novel Mechanism for Golgi Localization of Tethering Factor Trapp Nat.Struct.Mol.Biol., 12, 2005

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