1WKW
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![BU of 1wkw by Molmil](/molmil-images/mine/1wkw) | Crystal structure of the ternary complex of eIF4E-m7GpppA-4EBP1 peptide | Descriptor: | Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E binding protein 1, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE | Authors: | Tomoo, K, Matsushita, Y, Fujisaki, H, Shen, X, Miyagawa, H, Kitamura, K, Miura, K, Ishida, T. | Deposit date: | 2004-06-10 | Release date: | 2005-06-10 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods Biochim.Biophys.Acta, 1753, 2005
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4DQ7
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4DHX
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![BU of 4dhx by Molmil](/molmil-images/mine/4dhx) | ENY2:GANP complex | Descriptor: | 80 kDa MCM3-associated protein, Enhancer of yellow 2 transcription factor homolog | Authors: | Stewart, M, Jani, D. | Deposit date: | 2012-01-30 | Release date: | 2012-06-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export. Nucleic Acids Res., 40, 2012
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5N6F
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![BU of 5n6f by Molmil](/molmil-images/mine/5n6f) | Crystal structure of TGT in complex with guanine fragment | Descriptor: | DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, GUANINE, ... | Authors: | Hassaan, E, Heine, A, Klebe, G. | Deposit date: | 2017-02-15 | Release date: | 2018-03-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.11909521 Å) | Cite: | Fragments as Novel Starting Points for tRNA-Guanine Transglycosylase Inhibitors Found by Alternative Screening Strategies. Chemmedchem, 15, 2020
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4DQJ
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![BU of 4dqj by Molmil](/molmil-images/mine/4dqj) | Structural Investigation of Bacteriophage Phi6 Lysin (in complex with chitotetraose) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE, Membrane protein Phi6 P5 | Authors: | Dessau, M.A, Modis, Y. | Deposit date: | 2012-02-16 | Release date: | 2013-01-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.23 Å) | Cite: | Selective pressure causes an RNA virus to trade reproductive fitness for increased structural and thermal stability of a viral enzyme. PLoS Genet, 8, 2012
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3BCP
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![BU of 3bcp by Molmil](/molmil-images/mine/3bcp) | Crystal Structure of The Swapped non covalent form of P19A/L28Q/N67D BS-RNase | Descriptor: | Seminal ribonuclease | Authors: | Merlino, A, Ercole, C, Picone, D, Pizzo, E, Mazzarella, L, Sica, F. | Deposit date: | 2007-11-13 | Release date: | 2008-02-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme J.Mol.Biol., 376, 2008
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3AU7
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3BOR
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![BU of 3bor by Molmil](/molmil-images/mine/3bor) | Crystal structure of the DEADc domain of human translation initiation factor 4A-2 | Descriptor: | Human initiation factor 4A-II | Authors: | Dimov, S, Hong, B, Tempel, W, MacKenzie, F, Karlberg, T, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2007-12-17 | Release date: | 2008-01-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Comparative Structural Analysis of Human DEAD-Box RNA Helicases. Plos One, 5, 2010
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3BCO
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![BU of 3bco by Molmil](/molmil-images/mine/3bco) | Crystal Structure of The Swapped FOrm of P19A/L28Q/N67D BS-RNase | Descriptor: | Seminal ribonuclease | Authors: | Merlino, A, Ercole, C, Picone, D, Pizzo, E, Mazzarella, L, Sica, F. | Deposit date: | 2007-11-13 | Release date: | 2008-02-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme J.Mol.Biol., 376, 2008
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2KBP
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4DQ5
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![BU of 4dq5 by Molmil](/molmil-images/mine/4dq5) | Structural Investigation of Bacteriophage Phi6 Lysin (WT) | Descriptor: | 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE, Membrane protein Phi6 P5wt | Authors: | Dessau, M.A, Modis, Y. | Deposit date: | 2012-02-15 | Release date: | 2013-01-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.395 Å) | Cite: | Selective pressure causes an RNA virus to trade reproductive fitness for increased structural and thermal stability of a viral enzyme. PLoS Genet, 8, 2012
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1HS1
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1HS3
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1HS8
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3HXG
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![BU of 3hxg by Molmil](/molmil-images/mine/3hxg) | Crystal structure of Schistsome eIF4E complexed with m7GpppA and 4E-BP | Descriptor: | Eukaryotic Translation Initiation Factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE | Authors: | Liu, W, Zhao, R, Jones, D.N.M, Davis, R.E. | Deposit date: | 2009-06-20 | Release date: | 2009-08-25 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural insights into parasite EIF4E binding specificity for m7G and m2,2,7G mRNA cap. J.Biol.Chem., 284, 2009
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1HS4
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![BU of 1hs4 by Molmil](/molmil-images/mine/1hs4) | |
2FCA
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![BU of 2fca by Molmil](/molmil-images/mine/2fca) | The structure of BsTrmB | Descriptor: | POTASSIUM ION, tRNA (guanine-N(7)-)-methyltransferase | Authors: | Zegers, I, Van Vliet, F, Bujnicki, J, Kosinski, J, Gigot, D, Droogmans, L. | Deposit date: | 2005-12-12 | Release date: | 2006-08-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of Bacillus subtilis TrmB, the tRNA (m7G46) methyltransferase. Nucleic Acids Res., 34, 2006
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3D80
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![BU of 3d80 by Molmil](/molmil-images/mine/3d80) | Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase with NADPH and a Ternary Complex wtih the Potent and Selective Inhibitor 2,4-Diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine | Descriptor: | (4aS)-5-[(2,4-diaminopteridin-6-yl)methyl]-4a,5-dihydro-2H-dibenzo[b,f]azepin-8-ol, Dihydrofolate reductase, GLYCEROL, ... | Authors: | Cody, V. | Deposit date: | 2008-05-22 | Release date: | 2008-09-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural analysis of a holoenzyme complex of mouse dihydrofolate reductase with NADPH and a ternary complex with the potent and selective inhibitor 2,4-diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine. Acta Crystallogr.,Sect.D, 64, 2008
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3BCM
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![BU of 3bcm by Molmil](/molmil-images/mine/3bcm) | Crystal Structure of The Unswapped Form of P19A/L28Q/N67D BS-RNase | Descriptor: | PHOSPHATE ION, Seminal ribonuclease | Authors: | Merlino, A, Ercole, C, Picone, D, Pizzo, E, Mazzarella, L, Sica, F. | Deposit date: | 2007-11-13 | Release date: | 2008-02-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme J.Mol.Biol., 376, 2008
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3LD0
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![BU of 3ld0 by Molmil](/molmil-images/mine/3ld0) | Crystal structure of B.licheniformis Anti-TRAP protein, an antagonist of TRAP-RNA interactions | Descriptor: | Inhibitor of TRAP, regulated by T-BOX (Trp) sequence RtpA, MAGNESIUM ION, ... | Authors: | Shevtsov, M.B, Chen, Y, Isupov, M.N, Gollnick, P, Antson, A.A. | Deposit date: | 2010-01-12 | Release date: | 2010-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Bacillus licheniformis Anti-TRAP can assemble into two types of dodecameric particles with the same symmetry but inverted orientation of trimers. J.Struct.Biol., 170, 2010
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3D1D
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![BU of 3d1d by Molmil](/molmil-images/mine/3d1d) | Hexagonal crystal structure of Tas3 C-terminal alpha motif | Descriptor: | RNA-induced transcriptional silencing complex protein tas3 | Authors: | Li, H, Patel, D.J. | Deposit date: | 2008-05-05 | Release date: | 2009-04-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | An alpha motif at Tas3 C terminus mediates RITS cis spreading and promotes heterochromatic gene silencing. Mol.Cell, 34, 2009
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3IMQ
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![BU of 3imq by Molmil](/molmil-images/mine/3imq) | Crystal structure of the NusB101-S10(delta loop) complex | Descriptor: | 30S ribosomal protein S10, N utilization substance protein B, POTASSIUM ION | Authors: | Luo, X, Wahl, M.C. | Deposit date: | 2009-08-11 | Release date: | 2009-11-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Fine tuning of the E. coli NusB:NusE complex affinity to BoxA RNA is required for processive antitermination. Nucleic Acids Res., 38, 2010
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6RKT
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![BU of 6rkt by Molmil](/molmil-images/mine/6rkt) | Crystal Structure of TGT in complex with N2-methyl-1H,7H,8H-imidazo[4,5-g]quinazoline-2,6-diamine | Descriptor: | DIMETHYL SULFOXIDE, GLYCEROL, Queuine tRNA-ribosyltransferase, ... | Authors: | Hassaan, E, Heine, A, Klebe, G. | Deposit date: | 2019-04-30 | Release date: | 2020-06-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.746 Å) | Cite: | Fragment Screening Hit Draws Attention to a Novel Transient Pocket Adjacent to the Recognition Site of the tRNA-Modifying Enzyme TGT. J.Med.Chem., 63, 2020
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7D8T
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![BU of 7d8t by Molmil](/molmil-images/mine/7d8t) | MITF bHLHLZ complex with M-box DNA | Descriptor: | DNA (5'-D(*TP*GP*TP*AP*AP*CP*AP*TP*GP*TP*GP*TP*CP*CP*CP*C)-3'), DNA (5'-D(P*GP*GP*GP*AP*CP*AP*CP*AP*TP*GP*TP*TP*AP*CP*AP*G)-3'), Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit | Authors: | Guo, M, Fang, P, Wang, J. | Deposit date: | 2020-10-09 | Release date: | 2021-10-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.201 Å) | Cite: | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023
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7D8R
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![BU of 7d8r by Molmil](/molmil-images/mine/7d8r) | MITF HLHLZ structure | Descriptor: | Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit | Authors: | Guo, M, Fang, P, Wang, J. | Deposit date: | 2020-10-09 | Release date: | 2021-10-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023
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