7BGY
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![BU of 7bgy by Molmil](/molmil-images/mine/7bgy) | Cryo-EM Structure of KdpFABC in E2Pi state with MgF4 | Descriptor: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, MAGNESIUM ION, ... | Authors: | Sweet, M.E, Larsen, C, Pedersen, B.P, Stokes, D.L. | Deposit date: | 2021-01-09 | Release date: | 2021-01-27 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis for potassium transport in prokaryotes by KdpFABC. Proc.Natl.Acad.Sci.USA, 118, 2021
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7SWJ
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![BU of 7swj by Molmil](/molmil-images/mine/7swj) | KirBac1.1 mutant - I131C | Descriptor: | Inward rectifier potassium channel | Authors: | Amani, R, Wylie, B.J. | Deposit date: | 2021-11-19 | Release date: | 2022-02-02 | Last modified: | 2024-05-15 | Method: | SOLID-STATE NMR | Cite: | Water Accessibility Refinement of the Extended Structure of KirBac1.1 in the Closed State. Front Mol Biosci, 8, 2021
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8T4Y
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![BU of 8t4y by Molmil](/molmil-images/mine/8t4y) | Human HCN1 F186C S264C C309A bound to cAMP, reconstituted in LMNG + SPL | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Authors: | Burtscher, V, Mount, J, Cowgill, J, Chang, Y, Bickel, K, Yuan, P, Chanda, B. | Deposit date: | 2023-06-12 | Release date: | 2024-06-19 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | Structural basis for hyperpolarization-dependent opening of human HCN1 channel. Nat Commun, 15, 2024
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6GDL
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6GDK
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![BU of 6gdk by Molmil](/molmil-images/mine/6gdk) | Calcium bound form of human calmodulin mutant F141L | Descriptor: | CALCIUM ION, Calmodulin-1 | Authors: | Grachov, O, Holt, C, Overgaard, M.T, Wimmer, R. | Deposit date: | 2018-04-23 | Release date: | 2018-10-17 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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8T50
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![BU of 8t50 by Molmil](/molmil-images/mine/8t50) | Open human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG + SPL | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Authors: | Burtscher, V, Mount, J, Cowgill, J, Chang, Y, Bickel, K, Yuan, P, Chanda, B. | Deposit date: | 2023-06-12 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis for hyperpolarization-dependent opening of human HCN1 channel. Nat Commun, 15, 2024
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4GOW
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![BU of 4gow by Molmil](/molmil-images/mine/4gow) | Crystal Structure of Ca2+/CaM:Kv7.4 (KCNQ4) B helix complex | Descriptor: | CALCIUM ION, Calmodulin, Potassium voltage-gated channel subfamily KQT member 4 | Authors: | Xu, Q, Chang, A, Tolia, A, Minor Jr, D.L. | Deposit date: | 2012-08-20 | Release date: | 2012-12-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of a Ca(2+)/CaM:Kv7.4 (KCNQ4) B-helix complex provides insight into M current modulation. J.Mol.Biol., 425, 2013
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5JON
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![BU of 5jon by Molmil](/molmil-images/mine/5jon) | Crystal structure of the unliganded form of HCN2 CNBD | Descriptor: | Maltose-binding periplasmic protein,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, NITRATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Klenchin, V.A, Chanda, B. | Deposit date: | 2016-05-02 | Release date: | 2016-11-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.042 Å) | Cite: | Structure and dynamics underlying elementary ligand binding events in human pacemaking channels. Elife, 5, 2016
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7WIT
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![BU of 7wit by Molmil](/molmil-images/mine/7wit) | Structure of SUR1 in complex with mitiglinide | Descriptor: | (2S)-4-[(3aR,7aS)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-4-oxidanylidene-2-(phenylmethyl)butanoic acid, ADENOSINE-5'-TRIPHOSPHATE, ATP-sensitive inward rectifier potassium channel 11,ATP-binding cassette sub-family C member 8 isoform X1 | Authors: | Chen, L, Wang, M.M. | Deposit date: | 2022-01-04 | Release date: | 2022-11-16 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Structural Insights Into the High Selectivity of the Anti-Diabetic Drug Mitiglinide Front Pharmacol, 13, 2022
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6DU8
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![BU of 6du8 by Molmil](/molmil-images/mine/6du8) | Human Polycsytin 2-l1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystic kidney disease 2-like 1 protein | Authors: | Hulse, R.E, Clapham, D.E, Li, Z, Huang, R.K, Zhang, J. | Deposit date: | 2018-06-20 | Release date: | 2018-07-25 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | Cryo-EM structure of the polycystin 2-l1 ion channel. Elife, 7, 2018
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4J9V
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![BU of 4j9v by Molmil](/molmil-images/mine/4j9v) | Crystal Structure of the TrkA Gating ring bound to ATP-gamma-S | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Potassium uptake protein TrkA, ... | Authors: | Huang, H, Levin, E.J, Jin, X, Cao, Y, Zhou, M, New York Consortium on Membrane Protein Structure (NYCOMPS) | Deposit date: | 2013-02-17 | Release date: | 2013-04-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.051 Å) | Cite: | Gating of the TrkH ion channel by its associated RCK protein TrkA. Nature, 496, 2013
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3BJ4
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6WTH
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![BU of 6wth by Molmil](/molmil-images/mine/6wth) | Full-length human ENaC ECD | Descriptor: | 10D4 Fab, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Posert, R, Baconguis, I, Noreng, S, Bharadwaj, A, Houser, A. | Deposit date: | 2020-05-02 | Release date: | 2020-08-12 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Molecular principles of assembly, activation, and inhibition in epithelial sodium channel. Elife, 9, 2020
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5MKE
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![BU of 5mke by Molmil](/molmil-images/mine/5mke) | cryoEM Structure of Polycystin-2 in complex with cations and lipids | Descriptor: | 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wilkes, M, Madej, M.G, Ziegler, C. | Deposit date: | 2016-12-04 | Release date: | 2017-01-18 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2. Nat. Struct. Mol. Biol., 24, 2017
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5MKF
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![BU of 5mkf by Molmil](/molmil-images/mine/5mkf) | cryoEM Structure of Polycystin-2 in complex with calcium and lipids | Descriptor: | 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wilkes, M, Madej, M.G, Ziegler, C. | Deposit date: | 2016-12-04 | Release date: | 2017-01-18 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2. Nat. Struct. Mol. Biol., 24, 2017
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2MUB
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1SXM
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![BU of 1sxm by Molmil](/molmil-images/mine/1sxm) | SCORPION TOXIN (NOXIUSTOXIN) WITH HIGH AFFINITY FOR VOLTAGE DEPENDENT POTASSIUM CHANNEL AND LOW AFFINITY FOR CALCIUM DEPENDENT POTASSIUM CHANNEL (NMR AT 20 DEGREES, PH3.5, 39 STRUCTURES) | Descriptor: | NOXIUSTOXIN | Authors: | Dauplais, M, Gilquin, B, Possani, L.D, Gurrola-Briones, G, Roumestand, C, Menez, A. | Deposit date: | 1995-09-07 | Release date: | 1996-01-29 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Determination of the three-dimensional solution structure of noxiustoxin: analysis of structural differences with related short-chain scorpion toxins. Biochemistry, 34, 1995
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7UHF
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![BU of 7uhf by Molmil](/molmil-images/mine/7uhf) | Human L-type voltage-gated calcium channel Cav1.3 in the presence of cinnarizine at 3.1 Angstrom resolution | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gao, S, Yao, X, Yan, N. | Deposit date: | 2022-03-26 | Release date: | 2022-05-11 | Last modified: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for pore blockade of human voltage-gated calcium channel Ca v 1.3 by motion sickness drug cinnarizine. Cell Res., 32, 2022
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7UHG
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![BU of 7uhg by Molmil](/molmil-images/mine/7uhg) | Human L-type voltage-gated calcium channel Cav1.3 at 3.0 Angstrom resolution | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gao, S, Yao, X, Yan, N. | Deposit date: | 2022-03-26 | Release date: | 2022-05-11 | Last modified: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis for pore blockade of human voltage-gated calcium channel Ca v 1.3 by motion sickness drug cinnarizine. Cell Res., 32, 2022
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4KL1
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![BU of 4kl1 by Molmil](/molmil-images/mine/4kl1) | HCN4 CNBD in complex with cGMP | Descriptor: | ACETATE ION, CYCLIC GUANOSINE MONOPHOSPHATE, GLYCEROL, ... | Authors: | Lolicato, M, Arrigoni, C, Zucca, S, Nardini, M, Bucchi, A, Schroeder, I, Simmons, K, Bolognesi, M, DiFrancesco, D, Schwede, F, Fishwick, C.W.G, Johnson, A.P.K, Thiel, G, Moroni, A. | Deposit date: | 2013-05-07 | Release date: | 2014-04-30 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness. Nat.Chem.Biol., 10, 2014
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6FIZ
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![BU of 6fiz by Molmil](/molmil-images/mine/6fiz) | Crystal Structure of CNG mimicking NaK-EAPP mutant (T67A) cocrystallized with K+ | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCINE, POTASSIUM ION, ... | Authors: | Napolitano, L.M.R, De March, M, Steiner, R.A, Onesti, S. | Deposit date: | 2018-01-19 | Release date: | 2019-03-06 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Crystal Structure of CNG mimicking NaK-EAPP mutant (T67A) cocrystallized with K+ To Be Published
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6C3P
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![BU of 6c3p by Molmil](/molmil-images/mine/6c3p) | Cryo-EM structure of human KATP bound to ATP and ADP in propeller form | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | Authors: | Lee, K.P.K, Chen, J, MacKinnon, R. | Deposit date: | 2018-01-10 | Release date: | 2018-01-24 | Method: | ELECTRON MICROSCOPY (5.6 Å) | Cite: | Molecular structure of human KATP in complex with ATP and ADP. Elife, 6, 2017
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1S8K
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![BU of 1s8k by Molmil](/molmil-images/mine/1s8k) | Solution Structure of BmKK4, A Novel Potassium Channel Blocker from Scorpion Buthus martensii Karsch, 25 structures | Descriptor: | Toxin BmKK4 | Authors: | Zhang, N, Chen, X, Li, M, Cao, C, Wang, Y, Hu, G, Wu, H. | Deposit date: | 2004-02-02 | Release date: | 2005-02-08 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Solution structure of BmKK4, the first member of subfamily alpha-KTx 17 of scorpion toxins Biochemistry, 43, 2004
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8GHF
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![BU of 8ghf by Molmil](/molmil-images/mine/8ghf) | cryo-EM structure of hSlo1 in plasma membrane vesicles | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL, ... | Authors: | Tao, X, Zhao, C, MacKinnon, R. | Deposit date: | 2023-03-10 | Release date: | 2023-05-10 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Membrane protein isolation and structure determination in cell-derived membrane vesicles. Proc.Natl.Acad.Sci.USA, 120, 2023
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8GHG
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![BU of 8ghg by Molmil](/molmil-images/mine/8ghg) | |