5JHK
 
 | | X-ray structure of neuropilin-1 b1 domain complexed with Arg-6 ligand. | | Descriptor: | N-(benzenecarbonyl)glycyl-L-arginine, Neuropilin-1 | | Authors: | Fotinou, C, Rana, R, Djordjevic, S, Yelland, T. | | Deposit date: | 2016-04-21 | | Release date: | 2017-05-24 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Architecture and hydration of the arginine-binding site of neuropilin-1.
FEBS J., 285, 2018
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5IJR
 | | X-ray structure of neuropilin-1 b1 domain complexed with Arg-1 ligand. | | Descriptor: | DIMETHYL SULFOXIDE, L-HOMOARGININE, Neuropilin-1 | | Authors: | Fotinou, C, Rana, R, Djordjevic, S, Yelland, T. | | Deposit date: | 2016-03-02 | | Release date: | 2017-03-29 | | Last modified: | 2018-07-11 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | Architecture and hydration of the arginine-binding site of neuropilin-1.
FEBS J., 285, 2018
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6FMF
 | | Neuropilin-1 b1 domain in complex with EG01377; 2.8 Angstrom structure | | Descriptor: | (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, Neuropilin-1, trifluoroacetic acid | | Authors: | Yelland, T, Djordjevic, S, Selwood, D, Zachary, I, Frankel, P. | | Deposit date: | 2018-01-31 | | Release date: | 2018-10-17 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.811 Å) | | Cite: | Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells.
J. Med. Chem., 61, 2018
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6TKK
 | | Neuropilin 1-b1 domain in a complex with the C-terminal VEGFB186 peptide | | Descriptor: | 1,2-ETHANEDIOL, ACE-ARG-PRO-GLN-PRO-ARG, Neuropilin-1 | | Authors: | Eldrid, C, Yu, L, Yelland, T, Fotinou, C, Djordjevic, S. | | Deposit date: | 2019-11-28 | | Release date: | 2020-12-16 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.06 Å) | | Cite: | Neuropilin 1-b1 domain in a complex with the C-terminal VEGFB186 peptide
To Be Published
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2QQO
 | | Crystal Structure of the a2b1b2 Domains from Human Neuropilin-2 | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... | | Authors: | Appleton, B.A, Wiesmann, C. | | Deposit date: | 2007-07-26 | | Release date: | 2007-11-20 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
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2QQM
 | | Crystal Structure of the a2b1b2 Domains from Human Neuropilin-1 | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Appleton, B.A, Wiesmann, C. | | Deposit date: | 2007-07-26 | | Release date: | 2007-11-20 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
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2QQJ
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2QQI
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6FMC
 | | Neuropilin1-b1 domain in complex with EG01377, 0.9 Angstrom structure | | Descriptor: | (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, Neuropilin-1 | | Authors: | Yelland, T, Djordjevic, S, Fotinou, K, Selwood, D, Zachary, I, Frankel, P. | | Deposit date: | 2018-01-30 | | Release date: | 2018-10-17 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (0.9 Å) | | Cite: | Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells.
J. Med. Chem., 61, 2018
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2W07
 | | Structural determinants of polymerization reactivity of the P pilus adaptor subunit PapF | | Descriptor: | CHAPERONE PROTEIN PAPD, MINOR PILIN SUBUNIT PAPF, SULFATE ION | | Authors: | Verger, D, Rose, R.J, Paci, E, Costakes, G, Daviter, T, Hultgren, S, Remaut, H, Ashcroft, A.E, Radford, S.E, Waksman, G. | | Deposit date: | 2008-08-12 | | Release date: | 2008-11-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural Determinants of Polymerization Reactivity of the P Pilus Adaptor Subunit Papf.
Structure, 16, 2008
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7BVX
 | | Crystal structure of C-terminal fragment of pilus adhesin SpaC from Lactobacillus rhamnosus GG-Iodide soaked | | Descriptor: | IODIDE ION, Pilus assembly protein | | Authors: | Kant, A, Palva, A, von Ossowski, I, Krishnan, V. | | Deposit date: | 2020-04-12 | | Release date: | 2020-07-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.36 Å) | | Cite: | Crystal structure of lactobacillar SpaC reveals an atypical five-domain pilus tip adhesin: Exposing its substrate-binding and assembly in SpaCBA pili.
J.Struct.Biol., 211, 2020
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5FLU
 | | Structure of a Chaperone-Usher pilus reveals the molecular basis of rod uncoilin | | Descriptor: | PAP FIMBRIAL MAJOR PILIN PROTEIN | | Authors: | Hospenthal, M.K, Redzej, A, Dodson, K, Ukleja, M, Frenz, B, Hultgren, S.J, DiMaio, F, Egelman, E.H, Waksman, G. | | Deposit date: | 2015-10-28 | | Release date: | 2016-01-13 | | Last modified: | 2019-10-23 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling.
Cell(Cambridge,Mass.), 164, 2016
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2UY7
 | | Crystal structure of the P pilus rod subunit PapA | | Descriptor: | PAP FIMBRIAL MAJOR PILIN PROTEIN, PERIPLASMID CHAPERONE PAPD PROTEIN, SULFATE ION | | Authors: | Verger, D, Bullitt, E, Hultgren, S.J, Waksman, G. | | Deposit date: | 2007-04-02 | | Release date: | 2007-05-29 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal Structure of the P Pilus Rod Subunit Papa.
Plos Pathog., 3, 2007
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2UY6
 | | Crystal structure of the P pilus rod subunit PapA | | Descriptor: | PAP FIMBRIAL MAJOR PILIN PROTEIN, PERIPLASMID CHAPERONE PAPD PROTEIN | | Authors: | Verger, D, Bullitt, E, Hultgren, S.J, Waksman, G. | | Deposit date: | 2007-04-02 | | Release date: | 2007-05-29 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure of the P Pilus Rod Subunit Papa.
Plos Pathog., 3, 2007
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6M3Y
 | | Crystal structure of pilus adhesin, SpaC from Lactobacillus rhamnosus GG - open conformation | | Descriptor: | MAGNESIUM ION, Pilus assembly protein | | Authors: | Kant, A, Palva, A, von Ossowski, I, Krishnan, V. | | Deposit date: | 2020-03-04 | | Release date: | 2020-07-29 | | Last modified: | 2021-09-15 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Crystal structure of lactobacillar SpaC reveals an atypical five-domain pilus tip adhesin: Exposing its substrate-binding and assembly in SpaCBA pili.
J.Struct.Biol., 211, 2020
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1DZO
 | | Truncated PAK pilin from Pseudomonas aeruginosa | | Descriptor: | TYPE IV PILIN | | Authors: | Hazes, B, Read, R.J. | | Deposit date: | 2000-03-06 | | Release date: | 2000-06-11 | | Last modified: | 2019-05-08 | | Method: | X-RAY DIFFRACTION (1.63 Å) | | Cite: | Crystal Structure of Pseudomonas Aeruginosa Pak Pilin Suggests a Main-Chain-Dominated Mode of Receptor Binding
J.Mol.Biol., 299, 2000
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8PIZ
 | | Neisseria meningitidis Type IV pilus SB-DATDH variant bound to the C24 nanobody | | Descriptor: | 2,4-bisacetamido-2,4,6-trideoxy-beta-D-glucopyranose, C24 nanobody, Pilin, ... | | Authors: | Fernandez-Martinez, D, Dumenil, G. | | Deposit date: | 2023-06-22 | | Release date: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (2.75 Å) | | Cite: | Cryo-EM structures of type IV pili complexed with nanobodies reveal immune escape mechanisms.
Nat Commun, 15, 2024
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8PIJ
 | | Neisseria meningitidis Type IV pilus SB-GATDH variant bound to the C24 nanobody | | Descriptor: | (2~{R})-~{N}-[(2~{R},3~{S},4~{S},5~{R},6~{R})-5-acetamido-2-methyl-4,6-bis(oxidanyl)oxan-3-yl]-2,3-bis(oxidanyl)propanamide, C24 nanobody, Pilin, ... | | Authors: | Fernandez-Martinez, D, Dumenil, G. | | Deposit date: | 2023-06-21 | | Release date: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Cryo-EM structures of type IV pili complexed with nanobodies reveal immune escape mechanisms.
Nat Commun, 15, 2024
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5LEG
 | | Structure of the bacterial sex F pilus (pED208) | | Descriptor: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, Pilin | | Authors: | Costa, T.R.D, Ilangovan, I, Ukleja, M, Redzej, A, Santini, J.M, Smith, T.K, Egelman, E.H, Waksman, G. | | Deposit date: | 2016-06-29 | | Release date: | 2016-09-28 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structure of the Bacterial Sex F Pilus Reveals an Assembly of a Stoichiometric Protein-Phospholipid Complex.
Cell, 166, 2016
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2CO7
 | | Salmonella enterica SafA pilin in complex with the SafB chaperone (Type II) | | Descriptor: | PUTATIVE FIMBRIAE ASSEMBLY CHAPERONE, SAFA PILUS SUBUNIT, SULFATE ION | | Authors: | Remaut, H, Rose, R.J, Hannan, T.J, Hultgren, S.J, Radford, S.E, Ashcroft, A.E, Waksman, G. | | Deposit date: | 2006-05-25 | | Release date: | 2006-06-27 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Donor-Strand Exchange in Chaperone-Assisted Pilus Assembly Proceeds Through a Concerted Beta-Strand Displacement Mechanism
Mol.Cell, 22, 2006
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3JC8
 | | Architectural model of the type IVa pilus machine in a piliated state | | Descriptor: | LysM domain protein, PilA, PilN, ... | | Authors: | Chang, Y.-W, Rettberg, L.A, Jensen, G.J. | | Deposit date: | 2015-11-24 | | Release date: | 2016-03-16 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY | | Cite: | Architecture of the type IVa pilus machine.
Science, 351, 2016
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3KLQ
 | | Crystal Structure of the Minor Pilin FctB from Streptococcus pyogenes 90/306S | | Descriptor: | GLYCEROL, Putative pilus anchoring protein | | Authors: | Linke, C, Young, P.G, Bunker, R.D, Caradoc-Davies, T.T, Baker, E.N. | | Deposit date: | 2009-11-08 | | Release date: | 2010-04-28 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of the minor pilin FctB reveals determinants of Group A streptococcal pilus anchoring
J.Biol.Chem., 285, 2010
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2J2Z
 | | X-Ray Structure of the Chaperone PapD in complex with the Pilus terminator subunit PapH at 2.3 Angstrom resolution | | Descriptor: | CHAPERONE PROTEIN PAPD, COBALT (II) ION, PAP FIMBRIAL MINOR PILIN PROTEIN, ... | | Authors: | Verger, D, Miller, E, Remaut, H, Waksman, G, Hultgren, S. | | Deposit date: | 2006-08-17 | | Release date: | 2006-11-08 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Molecular Mechanism of P Pilus Termination in Uropathogenic Escherichia Coli.
Embo Rep., 7, 2006
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3S0T
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8UHF
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