3QWZ
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![BU of 3qwz by Molmil](/molmil-images/mine/3qwz) | Crystal structure of FAF1 UBX-p97N-domain complex | Descriptor: | FAS-associated factor 1, Transitional endoplasmic reticulum ATPase | Authors: | Park, J.K, Jeon, H, Lee, J.J, Kim, K.H, Lee, K.J, Kim, E.E. | Deposit date: | 2011-02-28 | Release date: | 2012-05-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Dissection of the interaction between FAF1 UBX and p97 To be Published
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3QQ7
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![BU of 3qq7 by Molmil](/molmil-images/mine/3qq7) | |
7JY5
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![BU of 7jy5 by Molmil](/molmil-images/mine/7jy5) | Structure of human p97 in complex with ATPgammaS and Npl4/Ufd1 (masked around p97) | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Pan, M, Yu, Y, Liu, L, Zhao, M. | Deposit date: | 2020-08-28 | Release date: | 2021-01-20 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative. Nat Commun, 12, 2021
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6MDO
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![BU of 6mdo by Molmil](/molmil-images/mine/6mdo) | The D1 and D2 domain rings of NSF engaging the SNAP-25 N-terminus within the 20S supercomplex (focused refinement on D1/D2 rings, class 1) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Synaptosomal-associated protein 25, ... | Authors: | White, K.I, Zhao, M, Brunger, A.T. | Deposit date: | 2018-09-04 | Release date: | 2018-09-19 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural principles of SNARE complex recognition by the AAA+ protein NSF. Elife, 7, 2018
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6MDP
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![BU of 6mdp by Molmil](/molmil-images/mine/6mdp) | The D1 and D2 domain rings of NSF engaging the SNAP-25 N-terminus within the 20S supercomplex (focused refinement on D1/D2 rings, class 2) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Synaptosomal-associated protein 25, ... | Authors: | White, K.I, Zhao, M, Brunger, A.T. | Deposit date: | 2018-09-04 | Release date: | 2018-09-19 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural principles of SNARE complex recognition by the AAA+ protein NSF. Elife, 7, 2018
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7Y53
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![BU of 7y53 by Molmil](/molmil-images/mine/7y53) | The cryo-EM structure of human ERAD retro-translocation complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Derlin-1, Transitional endoplasmic reticulum ATPase | Authors: | Cao, Y, Rao, B, Wang, Q, Yao, D, Xia, Y, Li, W, Li, S, Shen, Y. | Deposit date: | 2022-06-16 | Release date: | 2023-10-18 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.61 Å) | Cite: | The cryo-EM structure of the human ERAD retrotranslocation complex. Sci Adv, 9, 2023
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7Y59
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![BU of 7y59 by Molmil](/molmil-images/mine/7y59) | The cryo-EM structure of human ERAD retro-translocation complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Derlin-1, ... | Authors: | Cao, Y, Rao, B, Wang, Q, Yao, D, Xia, Y, Li, W, Li, S, Shen, Y. | Deposit date: | 2022-06-16 | Release date: | 2023-10-18 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (4.51 Å) | Cite: | The cryo-EM structure of the human ERAD retrotranslocation complex. Sci Adv, 9, 2023
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7Y4W
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![BU of 7y4w by Molmil](/molmil-images/mine/7y4w) | The cryo-EM structure of human ERAD retro-translocation complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Derlin-1, Transitional endoplasmic reticulum ATPase | Authors: | Cao, Y, Rao, B, Wang, Q, Yao, D, Xia, Y, Li, W, Li, S, Shen, Y. | Deposit date: | 2022-06-16 | Release date: | 2023-10-18 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | The cryo-EM structure of the human ERAD retrotranslocation complex. Sci Adv, 9, 2023
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6MDN
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![BU of 6mdn by Molmil](/molmil-images/mine/6mdn) | The 20S supercomplex engaging the SNAP-25 N-terminus (class 2) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Alpha-soluble NSF attachment protein, ... | Authors: | White, K.I, Zhao, M, Brunger, A.T. | Deposit date: | 2018-09-04 | Release date: | 2018-09-19 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structural principles of SNARE complex recognition by the AAA+ protein NSF. Elife, 7, 2018
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6MDM
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![BU of 6mdm by Molmil](/molmil-images/mine/6mdm) | The 20S supercomplex engaging the SNAP-25 N-terminus (class 1) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Alpha-soluble NSF attachment protein, ... | Authors: | White, K.I, Zhao, M, Brunger, A.T. | Deposit date: | 2018-09-04 | Release date: | 2018-09-19 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structural principles of SNARE complex recognition by the AAA+ protein NSF. Elife, 7, 2018
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7K59
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![BU of 7k59 by Molmil](/molmil-images/mine/7k59) | Structure of apo VCP hexamer generated from bacterially recombinant VCP/p97 | Descriptor: | Transitional endoplasmic reticulum ATPase | Authors: | Yu, G, Bai, Y, Li, K, Jiang, W, Zhang, Z.Y. | Deposit date: | 2020-09-16 | Release date: | 2021-10-13 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Cryo-electron microscopy structures of VCP/p97 reveal a new mechanism of oligomerization regulation. Iscience, 24, 2021
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7K56
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![BU of 7k56 by Molmil](/molmil-images/mine/7k56) | Structure of VCP dodecamer purified from H1299 cells | Descriptor: | Transitional endoplasmic reticulum ATPase | Authors: | Yu, G, Bai, Y, Li, K, Jiang, W, Zhang, Z.Y. | Deposit date: | 2020-09-16 | Release date: | 2021-10-13 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-electron microscopy structures of VCP/p97 reveal a new mechanism of oligomerization regulation. Iscience, 24, 2021
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7K57
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![BU of 7k57 by Molmil](/molmil-images/mine/7k57) | Structure of apo VCP dodecamer generated from bacterially recombinant VCP/p97 | Descriptor: | Transitional endoplasmic reticulum ATPase | Authors: | Yu, G, Bai, Y, Li, K, Jiang, W, Zhang, Z.Y. | Deposit date: | 2020-09-16 | Release date: | 2021-10-13 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-electron microscopy structures of VCP/p97 reveal a new mechanism of oligomerization regulation. Iscience, 24, 2021
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3J99
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![BU of 3j99 by Molmil](/molmil-images/mine/3j99) | Structure of 20S supercomplex determined by single particle cryoelectron microscopy (State IIIb) | Descriptor: | Alpha-soluble NSF attachment protein, Synaptosomal-associated protein 25, Syntaxin-1A, ... | Authors: | Zhao, M, Wu, S, Cheng, Y, Brunger, A.T. | Deposit date: | 2014-12-05 | Release date: | 2015-01-28 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (8.2 Å) | Cite: | Mechanistic insights into the recycling machine of the SNARE complex. Nature, 518, 2015
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4KDL
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![BU of 4kdl by Molmil](/molmil-images/mine/4kdl) | Crystal structure of p97/VCP N in complex with OTU1 UBXL | Descriptor: | Transitional endoplasmic reticulum ATPase, Ubiquitin thioesterase OTU1 | Authors: | Kim, S.J, Kim, E.E. | Deposit date: | 2013-04-25 | Release date: | 2014-03-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structural Basis for Ovarian Tumor Domain-containing Protein 1 (OTU1) Binding to p97/Valosin-containing Protein (VCP). J.Biol.Chem., 289, 2014
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4KLN
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![BU of 4kln by Molmil](/molmil-images/mine/4kln) | Structure of p97 N-D1 A232E mutant in complex with ATPgS | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Xia, D, Tang, W.K. | Deposit date: | 2013-05-07 | Release date: | 2013-11-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants. J.Biol.Chem., 288, 2013
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6OAA
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![BU of 6oaa by Molmil](/molmil-images/mine/6oaa) | Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ADP-BeFx, state 1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division control protein 48, ... | Authors: | Twomey, E.C, Ji, Z, Wales, T.E, Bodnar, N.O, Engen, J.R, Rapoport, T.A. | Deposit date: | 2019-03-15 | Release date: | 2019-07-03 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding. Science, 365, 2019
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6OA9
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![BU of 6oa9 by Molmil](/molmil-images/mine/6oa9) | Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ATP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 48, ... | Authors: | Twomey, E.C, Ji, Z, Wales, T.E, Bodnar, N.O, Engen, J.R, Rapoport, T.A. | Deposit date: | 2019-03-15 | Release date: | 2019-07-03 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding. Science, 365, 2019
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6OMB
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![BU of 6omb by Molmil](/molmil-images/mine/6omb) | Cdc48 Hexamer (Subunits A to E) with substrate bound to the central pore | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division control protein 48, ... | Authors: | Cooney, I, Han, H, Stewart, M, Carson, R.H, Hansen, D, Price, J.C, Hill, C.P, Shen, P.S. | Deposit date: | 2019-04-18 | Release date: | 2019-07-17 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure of the Cdc48 segregase in the act of unfolding an authentic substrate. Science, 365, 2019
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8RS9
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![BU of 8rs9 by Molmil](/molmil-images/mine/8rs9) | p97 (VCP) double mutant - F266A F539A | Descriptor: | Transitional endoplasmic reticulum ATPase | Authors: | Arie, M, Matzov, D, Karmona, R, Szenkier, N, Stanhill, A, Navon, A. | Deposit date: | 2024-01-24 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | p97 (VCP) double mutant - F266A F539A To Be Published
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8RSB
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![BU of 8rsb by Molmil](/molmil-images/mine/8rsb) | p97 (VCP) mutant - F539A ADP state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | Authors: | Arie, M, Matzov, D, Karmona, R, Szenkier, N, Stanhill, A, Navon, A. | Deposit date: | 2024-01-24 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | p97 (VCP) mutant - F539A ADP state To Be Published
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8R0E
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![BU of 8r0e by Molmil](/molmil-images/mine/8r0e) | p97 (VCP) mutant - F266A | Descriptor: | Transitional endoplasmic reticulum ATPase | Authors: | Arie, M, Matzov, D, Karmona, R, Szenkier, N, Stanhill, A, Navon, A. | Deposit date: | 2023-10-31 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | p97 (VCP) mutant - F266A To Be Published
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8RSC
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![BU of 8rsc by Molmil](/molmil-images/mine/8rsc) | p97 (VCP) mutant - F539A | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | Authors: | Arie, M, Matzov, D, Karmona, R, Szenkier, N, Stanhill, A, Navon, A. | Deposit date: | 2024-01-24 | Release date: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | p97 (VCP) mutant - F539A To Be Published
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6OAB
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![BU of 6oab by Molmil](/molmil-images/mine/6oab) | Cdc48-Npl4 complex processing poly-ubiquitinated substrate in the presence of ADP-BeFx, state 2 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division control protein 48, ... | Authors: | Twomey, E.C, Ji, Z, Wales, T.E, Bodnar, N.O, Engen, J.R, Rapoport, T.A. | Deposit date: | 2019-03-15 | Release date: | 2019-07-03 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding. Science, 365, 2019
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6OPC
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![BU of 6opc by Molmil](/molmil-images/mine/6opc) | Cdc48 Hexamer in a complex with substrate and Shp1(Ubx Domain) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division control protein 48, ... | Authors: | Cooney, I, Han, H, Stewart, M, Carson, R.H, Hansen, D, Price, J.C, Hill, C.P, Shen, P.S. | Deposit date: | 2019-04-24 | Release date: | 2019-07-10 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure of the Cdc48 segregase in the act of unfolding an authentic substrate. Science, 365, 2019
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