8X7U
| MCM in complex with dsDNA in presence of ATP. | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, mini-chromosome maintenance complex 3 | Authors: | Ma, J, Yi, G, Ye, M, MacGregor-Chatwin, C, Sheng, Y, Lu, Y, Li, M, Gilbert, R.J.C, Zhang, P. | Deposit date: | 2023-11-25 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | MCM in complex with dsDNA in presence of ATP To Be Published
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8W0E
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8W0G
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8W0F
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8EAL
| SsoMCM hexamer bound to Mg/ADP-BeFx and DNA. Class 1. Merged particles from datasets with 3 different DNA entities | Descriptor: | DNA, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... | Authors: | Meagher, M, Myasnikov, A, Enemark, E.J. | Deposit date: | 2022-08-29 | Release date: | 2022-12-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.34 Å) | Cite: | Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation. Int J Mol Sci, 23, 2022
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8EAI
| SsoMCM hexamer bound to Mg/ADP-BeFx and 16-mer oligo-dT. Class 2 | Descriptor: | 16-mer oligo-dT, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... | Authors: | Meagher, M, Myasnikov, A, Enemark, E.J. | Deposit date: | 2022-08-29 | Release date: | 2022-12-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation. Int J Mol Sci, 23, 2022
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8EAK
| SsoMCM hexamer bound to Mg/ADP-BeFx and 46-mer DNA strand. Class 2 | Descriptor: | 46-mer DNA, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... | Authors: | Meagher, M, Myasnikov, A, Enemark, E.J. | Deposit date: | 2022-08-29 | Release date: | 2022-12-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.67 Å) | Cite: | Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation. Int J Mol Sci, 23, 2022
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8EAM
| SsoMCM hexamer bound to Mg/ADP-BeFx and DNA. Class 2. Merged particles from datasets with 3 different DNA entities | Descriptor: | DNA, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... | Authors: | Meagher, M, Myasnikov, A, Enemark, E.J. | Deposit date: | 2022-08-29 | Release date: | 2022-12-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.59 Å) | Cite: | Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation. Int J Mol Sci, 23, 2022
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8EAJ
| SsoMCM hexamer bound to Mg/ADP-BeFx and 46-mer DNA strand. Class 1 | Descriptor: | 46-mer DNA strand, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... | Authors: | Meagher, M, Myasnikov, A, Enemark, E.J. | Deposit date: | 2022-08-29 | Release date: | 2022-12-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.45 Å) | Cite: | Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation. Int J Mol Sci, 23, 2022
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8EAF
| SsoMCM hexamer bound to Mg/ADP-BeFx and 12-mer oligo-dT. Class 1 | Descriptor: | 12-mer oligo dT, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... | Authors: | Meagher, M, Myasnikov, A, Enemark, E.J. | Deposit date: | 2022-08-29 | Release date: | 2022-12-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.62 Å) | Cite: | Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation. Int J Mol Sci, 23, 2022
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8EAH
| SsoMCM hexamer bound to Mg/ADP-BeFx and 16-mer oligo-dT. Class 1 | Descriptor: | 16-mer oligo-dT, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... | Authors: | Meagher, M, Myasnikov, A, Enemark, E.J. | Deposit date: | 2022-08-29 | Release date: | 2022-12-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.48 Å) | Cite: | Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation. Int J Mol Sci, 23, 2022
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8EAG
| SsoMCM hexamer bound to Mg/ADP-BeFx and 12-mer oligo-dT. Class 2 | Descriptor: | 12-mer oligo-dT, MAGNESIUM ION, Minichromosome maintenance protein MCM, ... | Authors: | Meagher, M, Myasnikov, A, Enemark, E.J. | Deposit date: | 2022-08-29 | Release date: | 2022-12-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Two Distinct Modes of DNA Binding by an MCM Helicase Enable DNA Translocation. Int J Mol Sci, 23, 2022
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8P5E
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8P62
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8P63
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8Q6P
| X. laevis CMG dimer bound to dimeric DONSON - MCM ATPase | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA replication licensing factor mcm2, DNA replication licensing factor mcm4-B, ... | Authors: | Butryn, A, Cvetkovic, M.A, Costa, A. | Deposit date: | 2023-08-14 | Release date: | 2023-10-18 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.53 Å) | Cite: | The structural mechanism of dimeric DONSON in replicative helicase activation. Mol.Cell, 83, 2023
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8Q6O
| X. laevis CMG dimer bound to dimeric DONSON - without ATPase | Descriptor: | Cell division control protein 45 homolog, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... | Authors: | Butryn, A, Cvetkovic, M.A, Costa, A. | Deposit date: | 2023-08-14 | Release date: | 2023-10-18 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | The structural mechanism of dimeric DONSON in replicative helicase activation. Mol.Cell, 83, 2023
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8S94
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8S91
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8S92
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8OUW
| Cryo-EM structure of CMG helicase bound to TIM-1/TIPN-1 and homodimeric DNSN-1 on fork DNA (Caenorhabditis elegans) | Descriptor: | Cell division control protein 45 homolog, DNA Lagging Strand Template, DNA Leading Strand Template, ... | Authors: | Jenkyn-Bedford, M, Yeeles, J.T.P, Labib, K.P.M. | Deposit date: | 2023-04-25 | Release date: | 2023-08-16 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans. Science, 381, 2023
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7PT7
| Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ADP:BeF3, state I | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division control protein 7, ... | Authors: | Saleh, A, Noguchi, Y, Aramayo, R, Ivanova, M.E, Speck, C. | Deposit date: | 2021-09-26 | Release date: | 2022-06-08 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer. Nat Commun, 13, 2022
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7PT6
| Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ATPgS, state III | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 7, DDK kinase regulatory subunit DBF4, ... | Authors: | Saleh, A, Noguchi, Y, Aramayo, R, Ivanova, M.E, Speck, C. | Deposit date: | 2021-09-26 | Release date: | 2022-06-08 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer. Nat Commun, 13, 2022
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5V8F
| Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1 | Descriptor: | Cell division control protein 6, Cell division cycle protein CDT1, DNA (39-MER), ... | Authors: | Yuan, Z, Riera, A, Bai, L, Sun, J, Spanos, C, Chen, Z.A, Barbon, M, Rappsilber, J, Stillman, B, Speck, C, Li, H. | Deposit date: | 2017-03-21 | Release date: | 2017-05-10 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1. Nat. Struct. Mol. Biol., 24, 2017
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8B9D
| Human replisome bound by Pol Alpha | Descriptor: | Cell division control protein 45 homolog, Claspin, DNA Molecule, ... | Authors: | Jones, M.L, Yeeles, J.T.P. | Deposit date: | 2022-10-05 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication. Mol.Cell, 83, 2023
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