7CR7
| human KCNQ2-CaM in complex with retigabine | Descriptor: | Calmodulin-3, Potassium voltage-gated channel subfamily KQT member 2, ethyl N-[2-azanyl-4-[(4-fluorophenyl)methylamino]phenyl]carbamate | Authors: | Li, X, Lv, D, Wang, J, Ye, S, Guo, J. | Deposit date: | 2020-08-12 | Release date: | 2020-09-16 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res., 31, 2021
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7CUY
| Crystal structure of Primo-1 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Low molecular weight phosphotyrosine protein phosphatase 1 | Authors: | Lee, H.S, Kim, S.J, Ku, B. | Deposit date: | 2020-08-25 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.081 Å) | Cite: | Structural and Biochemical Characterization of the Two Drosophila Low Molecular Weight-Protein Tyrosine Phosphatases DARP and Primo-1. Mol.Cells, 43, 2020
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3T08
| E. coli (LacZ) beta-galactosidase (S796A) IPTG complex | Descriptor: | 1-methylethyl 1-thio-beta-D-galactopyranoside, Beta-galactosidase, DIMETHYL SULFOXIDE, ... | Authors: | Jancewicz, L.J, Wheatley, R.W, Sutendra, G, Lee, M, Fraser, M, Huber, R.E. | Deposit date: | 2011-07-19 | Release date: | 2012-01-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Ser-796 of Beta-Galactosidase (E. coli) Plays a Key Role in Maintaining an Optimum Balance between the Opened and Closed Conformations of the Catalytically Important Active Site Loop Arch.Biochem.Biophys., 517, 2012
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2A2E
| Crystal structure of the RNA subunit of Ribonuclease P. Bacterial A-type. | Descriptor: | OSMIUM ION, RNA subunit of RNase P | Authors: | Torres-Larios, A, Swinger, K.K, Krasilnikov, A.S, Pan, T, Mondragon, A. | Deposit date: | 2005-06-22 | Release date: | 2005-09-06 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.85 Å) | Cite: | Crystal structure of the RNA component of bacterial ribonuclease P. Nature, 437, 2005
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7CQH
| Complex of TRP_CBS2 and Calmodulin_Clobe | Descriptor: | AT15141p, CALCIUM ION, Transient receptor potential protein | Authors: | Shen, Z.S. | Deposit date: | 2020-08-10 | Release date: | 2021-06-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Calmodulin binds to Drosophila TRP with an unexpected mode. Structure, 29, 2021
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7CRF
| Crystal structure of human TLR8 in complex with CU-CPD107 | Descriptor: | 1-[2-(ethoxymethyl)-4-iodanyl-5-phenyl-imidazol-1-yl]-2-methyl-propan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ... | Authors: | Sakaniwa, K, Tanji, H, Ohto, U, Shimizu, T. | Deposit date: | 2020-08-13 | Release date: | 2021-06-23 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists. Nat Commun, 12, 2021
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7CQV
| Complex of TRP_CBS1 and Calmodulin_Nlobe | Descriptor: | AT15141p, CALCIUM ION, Transient receptor potential protein | Authors: | Shen, Z.S. | Deposit date: | 2020-08-11 | Release date: | 2021-06-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Calmodulin binds to Drosophila TRP with an unexpected mode. Structure, 29, 2021
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7CIX
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7CIW
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7CIU
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3T2P
| E. coli (lacZ) beta-galactosidase (S796D) in complex with IPTG | Descriptor: | 1-methylethyl 1-thio-beta-D-galactopyranoside, Beta-galactosidase, DIMETHYL SULFOXIDE, ... | Authors: | Jancewicz, L.J, Wheatley, R.W, Sutendra, G, Lee, M, Fraser, M, Huber, R.E. | Deposit date: | 2011-07-22 | Release date: | 2012-01-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Ser-796 of Beta-Galactosidase (E. coli) Plays a Key Role in Maintaining an Optimum Balance between the Opened and Closed Conformations of the Catalytically Important Active Site Loop Arch.Biochem.Biophys., 517, 2012
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7DPT
| Structural basis for ligand binding modes of CTP synthase | Descriptor: | 6-DIAZENYL-5-OXO-L-NORLEUCINE, ADENOSINE-5'-DIPHOSPHATE, CTP synthase, ... | Authors: | Liu, J.L, Zhou, X, Guo, C.J, Chang, C.C. | Deposit date: | 2020-12-21 | Release date: | 2021-09-15 | Method: | ELECTRON MICROSCOPY (2.48 Å) | Cite: | Structural basis for ligand binding modes of CTP synthase. Proc.Natl.Acad.Sci.USA, 118, 2021
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7DPW
| Structural basis for ligand binding modes of CTP synthase | Descriptor: | CTP synthase, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION | Authors: | Liu, J.L, Zhou, X, Guo, C.J, Chang, C.C. | Deposit date: | 2020-12-21 | Release date: | 2021-09-15 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.65 Å) | Cite: | Structural basis for ligand binding modes of CTP synthase. Proc.Natl.Acad.Sci.USA, 118, 2021
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3T0B
| E. coli (LacZ) beta-galactosidase (S796T) IPTG complex | Descriptor: | 1-methylethyl 1-thio-beta-D-galactopyranoside, Beta-galactosidase, DIMETHYL SULFOXIDE, ... | Authors: | Jancewicz, L.J, Wheatley, R.W, Sutendra, G, Lee, M, Fraser, M, Huber, R.E. | Deposit date: | 2011-07-19 | Release date: | 2012-01-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | er-796 of Beta-Galactosidase (E. coli) Plays a Key Role in Maintaining an Optimum Balance between the Opened and Closed Conformations of the Catalytically Important Active Site Loop Arch.Biochem.Biophys., 517, 2012
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7CPR
| glutamine synthetase from Drosophila | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Glutamine synthetase 2 cytoplasmic | Authors: | Yin, H.S, Chen, W.T. | Deposit date: | 2020-08-07 | Release date: | 2021-08-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Structural Insight into the Contributions of the N-Terminus and Key Active-Site Residues to the Catalytic Efficiency of Glutamine Synthetase 2. Biomolecules, 10, 2020
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7CIV
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7EDR
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7B1C
| Cryo-EM of Aedes Aegypti Toll5A trimer bound to Spz1C | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AAEL013433-PA, ... | Authors: | Gangloff, M, Hardwick, S.W, Chirgadze, D.Y. | Deposit date: | 2020-11-24 | Release date: | 2022-07-13 | Last modified: | 2023-01-25 | Method: | ELECTRON MICROSCOPY (3.74 Å) | Cite: | Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti. Nat Commun, 13, 2022
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7B1D
| Cryo-EM of Aedes Aegypti Toll5A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor | Authors: | Gangloff, M, Hardwick, S.W, Chirgadze, D.Y. | Deposit date: | 2020-11-24 | Release date: | 2022-07-13 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.41 Å) | Cite: | Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti. Nat Commun, 13, 2022
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7BPR
| Crystal structure of human TEX101 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PLATINUM (II) ION, Testis-expressed protein 101 | Authors: | Masutani, M, Sakurai, S, Shimizu, T, Ohto, U. | Deposit date: | 2020-03-23 | Release date: | 2020-07-15 | Last modified: | 2020-12-23 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of TEX101, a glycoprotein essential for male fertility, reveals the presence of tandemly arranged Ly6/uPAR domains. Febs Lett., 594, 2020
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7B6X
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7B6Z
| TRAPPC11 subunit (1-716) | Descriptor: | Trafficking protein particle complex subunit 11 | Authors: | Galindo, A, Munro, S, Planelles-Herrero, V.J. | Deposit date: | 2020-12-08 | Release date: | 2022-01-12 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (5.5 Å) | Cite: | Structural insights into the metazoan TRAPP complexes that activate Rab1 and
Rab11. To Be Published
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7B6Y
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7AMA
| IL-17A in complex with small molecule modulators | Descriptor: | Interleukin-17A, ~{N}-[(2~{S})-1,1-dicyclopropyl-3-[[4-(3,5-dimethyl-1~{H}-pyrazol-4-yl)phenyl]amino]-3-oxidanylidene-propan-2-yl]-2-propan-2-yl-pyrazole-3-carboxamide | Authors: | Hakansson, M, Kimbung, R, Logan, D, Walse, U.B, de Groot, M.J, Andrews, M.D, Dack, K.N, Lambert, M. | Deposit date: | 2020-10-08 | Release date: | 2022-04-20 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein-Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases. J.Med.Chem., 65, 2022
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7AMG
| IL-17A in complex with small molecule modulators | Descriptor: | (3~{R})-4-[4-[[(2~{S})-2-[[2,2-bis(fluoranyl)-2-phenyl-ethanoyl]amino]-3-(2-chlorophenyl)propanoyl]amino]phenyl]-3-[[(2~{S})-3-methyl-2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethanoylamino]butanoyl]amino]butanoic acid, Interleukin-17A | Authors: | Hakansson, M, Kimbung, R, Logan, D, Walse, U.B, de Groot, M.J, Andrews, M.D, Dack, K.N, Lambert, M. | Deposit date: | 2020-10-08 | Release date: | 2022-04-20 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (3.18 Å) | Cite: | Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein-Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases. J.Med.Chem., 65, 2022
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