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2XBK
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BU of 2xbk by Molmil
X-ray structure of the substrate-bound cytochrome P450 PimD - a polyene macrolide antibiotic pimaricin epoxidase
Descriptor: 4,5-DE-EPOXYPIMARICIN, PIMD PROTEIN, PROTOPORPHYRIN IX CONTAINING FE
Authors:Kells, P.M, Ouellet, H, Santos-Aberturas, J, Aparicio, J.F, Podust, L.M.
Deposit date:2010-04-12
Release date:2010-08-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of Cytochrome P450 Pimd Suggests Epoxidation of the Polyene Macrolide Pimaricin Occurs Via a Hydroperoxoferric Intermediate.
Chem.Biol., 17, 2010
3K9V
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BU of 3k9v by Molmil
Crystal structure of rat mitochondrial P450 24A1 S57D in complex with CHAPS
Descriptor: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ...
Authors:Annalora, A.J, Goodin, D.B, Hong, W, Zhang, Q, Johnson, E.F, Stout, C.D.
Deposit date:2009-10-16
Release date:2009-12-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of CYP24A1, a mitochondrial cytochrome P450 involved in vitamin D metabolism.
J.Mol.Biol., 396, 2010
3K9Y
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BU of 3k9y by Molmil
Crystal structure of rat mitochondrial P450 24A1 S57D in complex with CYMAL-5
Descriptor: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, ...
Authors:Annalora, A.J, Goodin, D.B, Hong, W, Zhang, Q, Johnson, E.F, Stout, C.D.
Deposit date:2009-10-16
Release date:2009-12-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of CYP24A1, a mitochondrial cytochrome P450 involved in vitamin D metabolism.
J.Mol.Biol., 396, 2010
1JPZ
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BU of 1jpz by Molmil
Crystal structure of a complex of the heme domain of P450BM-3 with N-Palmitoylglycine
Descriptor: BIFUNCTIONAL P-450:NADPH-P450 REDUCTASE, N-PALMITOYLGLYCINE, PROTOPORPHYRIN IX CONTAINING FE
Authors:Haines, D.C, Tomchick, D.R, Machius, M, Peterson, J.A.
Deposit date:2001-08-03
Release date:2001-11-09
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Pivotal role of water in the mechanism of P450BM-3.
Biochemistry, 40, 2001
6FSH
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BU of 6fsh by Molmil
Crystal structure of hybrid P450 OxyBtei(BC/FGvan)
Descriptor: ACETATE ION, OxyB protein, POTASSIUM ION, ...
Authors:Brieke, C, Tarnawski, M, Greule, A, Cryle, M.J.
Deposit date:2018-02-19
Release date:2018-05-23
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Investigating Cytochrome P450 specificity during glycopeptide antibiotic biosynthesis through a homologue hybridization approach.
J. Inorg. Biochem., 185, 2018
4UAX
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BU of 4uax by Molmil
X-ray crystal structure of ligand free CYP142A2 from Mycobacterium smegmatis
Descriptor: P450 heme-thiolate protein, PROTOPORPHYRIN IX CONTAINING FE
Authors:Madrona, Y.
Deposit date:2014-08-11
Release date:2014-09-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Cholesterol ester oxidation by mycobacterial cytochrome p450.
J.Biol.Chem., 289, 2014
3EJE
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BU of 3eje by Molmil
Crystal Structure of P450BioI in complex with octadec-9Z-enoic acid ligated Acyl Carrier Protein
Descriptor: Acyl carrier protein, Biotin biosynthesis cytochrome P450-like enzyme, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Cryle, M.J, Schlichting, I.
Deposit date:2008-09-18
Release date:2008-10-07
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3EJD
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BU of 3ejd by Molmil
Crystal Structure of P450BioI in complex with hexadec-9Z-enoic acid ligated Acyl Carrier Protein
Descriptor: Acyl carrier protein, Biotin biosynthesis cytochrome P450-like enzyme, CHLORIDE ION, ...
Authors:Cryle, M.J, Schlichting, I.
Deposit date:2008-09-18
Release date:2008-10-07
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex.
Proc.Natl.Acad.Sci.Usa, 105, 2008
4KEW
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BU of 4kew by Molmil
structure of the A82F BM3 heme domain in complex with omeprazole
Descriptor: 6-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfanyl}-1H-benzimidazole, Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE
Authors:Leys, D.
Deposit date:2013-04-26
Release date:2013-07-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Key Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate Bias.
J.Biol.Chem., 288, 2013
1WIY
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BU of 1wiy by Molmil
Crystal Structure Analysis of a 6-coordinated Cytochorome P450 from Thermus thermophilus HB8
Descriptor: Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE
Authors:Kousumi, Y, Nakagawa, N, Kaneko, M, Yamamoto, H, Masui, R, Kuramitsu, S, Ueyama, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2004-05-28
Release date:2004-11-28
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure Analysis of Cytochrome P450 from Thermus thermophilus HB8
To be Published
3EJB
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BU of 3ejb by Molmil
Crystal Structure of P450BioI in complex with tetradecanoic acid ligated Acyl Carrier Protein
Descriptor: Acyl carrier protein, Biotin biosynthesis cytochrome P450-like enzyme, CHLORIDE ION, ...
Authors:Cryle, M.J, Schlichting, I.
Deposit date:2008-09-18
Release date:2008-10-07
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2FDU
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BU of 2fdu by Molmil
Microsomal P450 2A6 with the inhibitor N,N-Dimethyl(5-(pyridin-3-yl)furan-2-yl)methanamine bound
Descriptor: Cytochrome P450 2A6, N,N-DIMETHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Yano, J.K, Stout, C.D, Johnson, E.F.
Deposit date:2005-12-14
Release date:2006-11-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Synthetic Inhibitors of Cytochrome P-450 2A6: Inhibitory Activity, Difference Spectra, Mechanism of Inhibition, and Protein Cocrystallization.
J.Med.Chem., 49, 2006
8CKN
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BU of 8ckn by Molmil
Cytochrome P450 CYP143A1 (Rv1785c) from Mycobacterium tuberculosis
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Selvam, I.R.
Deposit date:2023-02-16
Release date:2024-02-28
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:1.54 Angstrom structure of cytochrome P450 CYP143A1 (Rv1785c) from Mycobacterium tuberculosis
To Be Published
5WK9
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BU of 5wk9 by Molmil
R186AP450cam with CN and camphor
Descriptor: CAMPHOR, CYANIDE ION, Camphor 5-monooxygenase, ...
Authors:Poulos, T.L, Batabyal, D.
Deposit date:2017-07-24
Release date:2017-09-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.983 Å)
Cite:Effect of Redox Partner Binding on Cytochrome P450 Conformational Dynamics.
J. Am. Chem. Soc., 139, 2017
5WK7
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BU of 5wk7 by Molmil
P450cam mutant R186A
Descriptor: 5-EXO-HYDROXYCAMPHOR, Camphor 5-monooxygenase, POTASSIUM ION, ...
Authors:Batabyal, D, Poulos, T.L.
Deposit date:2017-07-24
Release date:2017-09-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.983 Å)
Cite:Effect of Redox Partner Binding on Cytochrome P450 Conformational Dynamics.
J. Am. Chem. Soc., 139, 2017
7SNM
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BU of 7snm by Molmil
Lanosterol-bound P450 domain of the CYP51-ferredoxin fusion protein from Methylococcus capsulatus
Descriptor: Cytochrome P450 51, LANOSTEROL, PROTOPORPHYRIN IX CONTAINING FE
Authors:Lepesheva, G.I, Hargrove, T, Wawrzak, Z.
Deposit date:2021-10-28
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Unravelling the role of transient redox partner complexes in P450 electron transfer mechanics.
Sci Rep, 12, 2022
8HGT
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BU of 8hgt by Molmil
Crystal structure of the CYP153A mutant V456A from Marinobacter aquaeolei
Descriptor: Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE
Authors:Jiang, Y, Tian, X, Cong, Z.
Deposit date:2022-11-15
Release date:2023-08-16
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Enabling Peroxygenase Activity in Cytochrome P450 Monooxygenases by Engineering Hydrogen Peroxide Tunnels.
J.Am.Chem.Soc., 145, 2023
2C7X
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BU of 2c7x by Molmil
Crystal structure of narbomycin-bound cytochrome P450 PikC (CYP107L1)
Descriptor: CYTOCHROME P450 MONOOXYGENASE, NARBOMYCIN, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sherman, D.H, Li, S, Yermalitskaya, L.V, Kim, Y, Smith, J.A, Waterman, M.R, Podust, L.M.
Deposit date:2005-11-29
Release date:2006-07-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The Structural Basis for Substrate Anchoring, Active Site Selectivity, and Product Formation by P450 Pikc from Streptomyces Venezuelae.
J.Biol.Chem., 281, 2006
6KZS
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BU of 6kzs by Molmil
Crystal structure of cytochrome P450mel 107F1 in complex with heme and imidazole
Descriptor: Cytochrome P-450, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE
Authors:Hou, X.D, Rao, Y.J, Icyishaka, P, Li, C.X, Lou, J.L.
Deposit date:2019-09-25
Release date:2020-09-23
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Crystallization and X-ray analysis of cytochrome P450mel 107F1 with biaryl coupling reactivity
To Be Published
6KZT
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BU of 6kzt by Molmil
Crystal structure of cytochrome P450mel 107F1 with biaryl coupling reactivity
Descriptor: Cytochrome P-450, PROTOPORPHYRIN IX CONTAINING FE
Authors:Hou, X.D, Rao, Y.J, Icyishaka, P, Li, C.X, Lou, J.L.
Deposit date:2019-09-25
Release date:2020-09-23
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystallization and X-ray analysis of cytochrome P450mel 107F1 with biaryl coupling reactivity
To Be Published
2VZM
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BU of 2vzm by Molmil
Crystal structure of the narbomycin-bound PikC D50N mutant
Descriptor: CYTOCHROME P450 MONOOXYGENASE, NARBOMYCIN, PROTOPORPHYRIN IX CONTAINING FE
Authors:Li, S, Sherman, D.H, Podust, L.M.
Deposit date:2008-08-01
Release date:2008-08-12
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Analysis of Transient and Catalytic Desosamine Binding Pockets in Cytochrome P450 Pikc from Streptomyces Venezuelae.
J.Biol.Chem., 284, 2009
4FIA
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BU of 4fia by Molmil
Crystal Structure of Human CYP46A1 P450 with bicalutamide Bound
Descriptor: Cholesterol 24-hydroxylase, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Stout, C.D, Pikuleva, I.A, Mast, N.
Deposit date:2012-06-08
Release date:2013-01-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1: unusual features and spectral response.
J.Biol.Chem., 288, 2013
6MI0
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BU of 6mi0 by Molmil
Crystal structure of the P450 domain of the CYP51-ferredoxin fusion protein from Methylococcus capsulatus, ligand-free state
Descriptor: Cytochrome P450 51, PROTOPORPHYRIN IX CONTAINING FE
Authors:Hargrove, T, Wawrzak, Z, Lamb, D.C, Lepesheva, G.I.
Deposit date:2018-09-18
Release date:2019-07-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Concerning P450 evolution: Structural Analyses Support Bacterial Origin of Sterol 14 alpha-Demethylases.
Mol.Biol.Evol., 2020
3ABB
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BU of 3abb by Molmil
Crystal structure of CYP105D6
Descriptor: Cytochrome P450 hydroxylase, PROTOPORPHYRIN IX CONTAINING FE
Authors:Xu, L.H, Fushinobu, S, Takamatsu, S, Wakagi, T, Ikeda, H, Shoun, H.
Deposit date:2009-12-04
Release date:2010-04-07
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Regio- and stereospecificity of filipin hydroxylation sites revealed by crystal structures of cytochrome P450 105P1 and 105D6 from Streptomyces avermitilis
J.Biol.Chem., 285, 2010
1T2B
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BU of 1t2b by Molmil
Crystal Structure of cytochrome P450cin complexed with its substrate 1,8-cineole
Descriptor: 1,3,3-TRIMETHYL-2-OXABICYCLO[2.2.2]OCTANE, P450cin, PROTOPORPHYRIN IX CONTAINING FE
Authors:Meharenna, Y.T, Li, H, Hawkes, D.B, Pearson, A.G, De Voss, J, Poulos, T.L.
Deposit date:2004-04-20
Release date:2005-04-26
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of P450cin in a complex with its substrate, 1,8-cineole, a close structural homologue to D-camphor, the substrate for P450cam
Biochemistry, 43, 2004

225681

數據於2024-10-02公開中

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