4IWQ
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![BU of 4iwq by Molmil](/molmil-images/mine/4iwq) | Crystal structure and mechanism of activation of TBK1 | Descriptor: | N-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide, Serine/threonine-protein kinase TBK1 | Authors: | Panne, D, Larabi, A. | Deposit date: | 2013-01-24 | Release date: | 2013-03-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure and mechanism of activation of TANK-binding kinase 1. Cell Rep, 3, 2013
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4A2W
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![BU of 4a2w by Molmil](/molmil-images/mine/4a2w) | Structure of full-length duck RIG-I | Descriptor: | RETINOIC ACID INDUCIBLE PROTEIN I | Authors: | Kowalinski, E, Lunardi, T, McCarthy, A.A, Cusack, S. | Deposit date: | 2011-09-29 | Release date: | 2011-10-19 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Structural Basis for the Activation of Innate Immune Pattern Recognition Receptor Rig-I by Viral RNA. Cell(Cambridge,Mass.), 147, 2011
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4JLC
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![BU of 4jlc by Molmil](/molmil-images/mine/4jlc) | Crystal structure of mouse TBK1 bound to SU6668 | Descriptor: | 3-{2,4-dimethyl-5-[(Z)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid, Serine/threonine-protein kinase TBK1 | Authors: | Li, P. | Deposit date: | 2013-03-12 | Release date: | 2013-06-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity. Structure, 21, 2013
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4JBM
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![BU of 4jbm by Molmil](/molmil-images/mine/4jbm) | Structure of murine DNA binding protein bound with ds DNA | Descriptor: | DNA (5'-D(*GP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3'), Interferon-inducible protein AIM2 | Authors: | Ru, H, Ni, X, Crowley, C, Zhao, L, Ding, W, Hung, L.-W, Shaw, N, Cheng, G, Liu, Z.-J. | Deposit date: | 2013-02-19 | Release date: | 2013-06-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.218 Å) | Cite: | Structural basis for termination of AIM2-mediated signaling by p202 Cell Res., 23, 2013
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3U3Y
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![BU of 3u3y by Molmil](/molmil-images/mine/3u3y) | Mouse TREX1 D200H mutant | Descriptor: | 1,4-BUTANEDIOL, 5'-D(*GP*AP*CP*G)-3', CALCIUM ION, ... | Authors: | Bailey, S.L, Harvey, S, Perrino, F.W, Hollis, T. | Deposit date: | 2011-10-06 | Release date: | 2011-12-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease. Dna Repair, 11, 2012
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3U6F
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![BU of 3u6f by Molmil](/molmil-images/mine/3u6f) | Mouse TREX1 D200N mutant | Descriptor: | 1,4-BUTANEDIOL, 5'-D(*GP*AP*CP*G)-3', MAGNESIUM ION, ... | Authors: | Bailey, S.L, Harvey, S, Perrino, F.W, Hollis, T. | Deposit date: | 2011-10-12 | Release date: | 2011-12-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease. Dna Repair, 11, 2012
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2YVC
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![BU of 2yvc by Molmil](/molmil-images/mine/2yvc) | |
1OJ4
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![BU of 1oj4 by Molmil](/molmil-images/mine/1oj4) | Ternary complex of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | Descriptor: | 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL, 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE, CHLORIDE ION, ... | Authors: | Miallau, L, Alphey, M.S, Hunter, W.N. | Deposit date: | 2003-06-30 | Release date: | 2003-07-31 | Last modified: | 2019-10-16 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Biosynthesis of Isoprenoids: Crystal Structure of 4-Diphosphocytidyl-2C-Methyl-D-Erythritol Kinase Proc.Natl.Acad.Sci.USA, 100, 2003
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1WUE
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![BU of 1wue by Molmil](/molmil-images/mine/1wue) | Crystal structure of protein GI:29375081, unknown member of enolase superfamily from enterococcus faecalis V583 | Descriptor: | mandelate racemase/muconate lactonizing enzyme family protein | Authors: | Fedorov, A.A, Fedorov, E.V, Yew, W.S, Gerlt, J.A, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2004-12-05 | Release date: | 2004-12-21 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family Proc.Natl.Acad.Sci.USA, 111, 2014
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1WUF
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![BU of 1wuf by Molmil](/molmil-images/mine/1wuf) | Crystal structure of protein GI:16801725, member of Enolase superfamily from Listeria innocua Clip11262 | Descriptor: | MAGNESIUM ION, hypothetical protein lin2664 | Authors: | Fedorov, A.A, Fedorov, E.V, Yew, W.S, Gerlt, J.A, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2004-12-07 | Release date: | 2004-12-21 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family Proc.Natl.Acad.Sci.USA, 111, 2014
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1X9I
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![BU of 1x9i by Molmil](/molmil-images/mine/1x9i) | Crystal structure of Crystal structure of phosphoglucose/phosphomannose phosphoglucose/phosphomannoseisomerase from Pyrobaculum aerophilum in complex with glucose 6-phosphate | Descriptor: | GLUCOSE-6-PHOSPHATE, GLYCEROL, glucose-6-phosphate isomerase | Authors: | Swan, M.K, Hansen, T, Schoenheit, P, Davies, C. | Deposit date: | 2004-08-21 | Release date: | 2004-12-07 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.16 Å) | Cite: | Structural basis for phosphomannose isomerase activity in phosphoglucose isomerase from Pyrobaculum aerophilum: a subtle difference between distantly related enzymes. Biochemistry, 43, 2004
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1X9J
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1X9H
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![BU of 1x9h by Molmil](/molmil-images/mine/1x9h) | Crystal structure of phosphoglucose/phosphomannose isomerase from Pyrobaculum aerophilum in complex with fructose 6-phosphate | Descriptor: | FRUCTOSE -6-PHOSPHATE, GLYCEROL, SULFATE ION, ... | Authors: | Swan, M.K, Hansen, T, Schoenheit, P, Davies, C. | Deposit date: | 2004-08-21 | Release date: | 2004-12-07 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural basis for phosphomannose isomerase activity in phosphoglucose isomerase from Pyrobaculum aerophilum: a subtle difference between distantly related enzymes. Biochemistry, 43, 2004
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3B94
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![BU of 3b94 by Molmil](/molmil-images/mine/3b94) | Crystal structure of human GITRL | Descriptor: | Tumor necrosis factor ligand superfamily member 18 | Authors: | Song, X.M, Zhou, Z.C. | Deposit date: | 2007-11-02 | Release date: | 2008-02-12 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of human GITRL TO BE PUBLISHED
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6G3E
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![BU of 6g3e by Molmil](/molmil-images/mine/6g3e) | Crystal structure of EDDS lyase in complex with formate | Descriptor: | Argininosuccinate lyase, FORMIC ACID, SODIUM ION | Authors: | Poddar, H, Thunnissem, A.M.W.H, Poelarends, G.J. | Deposit date: | 2018-03-25 | Release date: | 2018-05-16 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Basis for the Catalytic Mechanism of Ethylenediamine- N, N'-disuccinic Acid Lyase, a Carbon-Nitrogen Bond-Forming Enzyme with a Broad Substrate Scope. Biochemistry, 57, 2018
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6G3G
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![BU of 6g3g by Molmil](/molmil-images/mine/6g3g) | Crystal structure of EDDS lyase in complex with succinate | Descriptor: | Argininosuccinate lyase, DI(HYDROXYETHYL)ETHER, SUCCINIC ACID | Authors: | Poddar, H, Thunnissem, A.M.W.H, Poelarends, G.J. | Deposit date: | 2018-03-25 | Release date: | 2018-05-16 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.606 Å) | Cite: | Structural Basis for the Catalytic Mechanism of Ethylenediamine- N, N'-disuccinic Acid Lyase, a Carbon-Nitrogen Bond-Forming Enzyme with a Broad Substrate Scope. Biochemistry, 57, 2018
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3B93
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![BU of 3b93 by Molmil](/molmil-images/mine/3b93) | crystal structure of human GITRL | Descriptor: | Tumor necrosis factor ligand superfamily member 18 | Authors: | Song, X.M, Zhou, Z.C. | Deposit date: | 2007-11-02 | Release date: | 2008-02-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | crystal structure of human GITRL To be Published
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4RQI
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![BU of 4rqi by Molmil](/molmil-images/mine/4rqi) | Structure of TRF2/RAP1 secondary interaction binding site | Descriptor: | GLYCEROL, MAGNESIUM ION, Telomeric repeat-binding factor 2, ... | Authors: | Miron, S, Guimaraes, B, Gaullier, G, Giraud-Panis, M.-J, Gilson, E, Le Du, M.-H. | Deposit date: | 2014-11-03 | Release date: | 2016-02-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.4405 Å) | Cite: | A higher-order entity formed by the flexible assembly of RAP1 with TRF2. Nucleic Acids Res., 44, 2016
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6G3D
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![BU of 6g3d by Molmil](/molmil-images/mine/6g3d) | Crystal structure of Native EDDS lyase | Descriptor: | Argininosuccinate lyase | Authors: | Poddar, H, Thunnissem, A.M.W.H, Poelarends, G.J. | Deposit date: | 2018-03-25 | Release date: | 2018-05-16 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.221 Å) | Cite: | Structural Basis for the Catalytic Mechanism of Ethylenediamine- N, N'-disuccinic Acid Lyase, a Carbon-Nitrogen Bond-Forming Enzyme with a Broad Substrate Scope. Biochemistry, 57, 2018
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6FXN
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![BU of 6fxn by Molmil](/molmil-images/mine/6fxn) | Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab | Descriptor: | Tumor necrosis factor ligand superfamily member 13B, belimumab heavy chain, belimumab light chain | Authors: | Lammens, A, Maskos, K, Willen, L, Jiang, X, Schneider, P. | Deposit date: | 2018-03-09 | Release date: | 2018-04-04 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors. Nat Commun, 9, 2018
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1ZLP
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![BU of 1zlp by Molmil](/molmil-images/mine/1zlp) | Petal death protein PSR132 with cysteine-linked glutaraldehyde forming a thiohemiacetal adduct | Descriptor: | 5-HYDROXYPENTANAL, MAGNESIUM ION, petal death protein | Authors: | Teplyakov, A, Liu, S, Lu, Z, Howard, A, Dunaway-Mariano, D, Herzberg, O. | Deposit date: | 2005-05-08 | Release date: | 2006-01-03 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal Structure of the Petal Death Protein from Carnation Flower. Biochemistry, 44, 2005
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6G3I
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![BU of 6g3i by Molmil](/molmil-images/mine/6g3i) | Crystal structure of EDDS lyase in complex with N-(2-aminoethyl)aspartic acid (AEAA) | Descriptor: | (2~{S})-2-(2-azanylethylamino)butanedioic acid, Argininosuccinate lyase, FUMARIC ACID | Authors: | Poddar, H, Thunnissem, A.M.W.H, Poelarends, G.J. | Deposit date: | 2018-03-25 | Release date: | 2018-05-16 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Structural Basis for the Catalytic Mechanism of Ethylenediamine- N, N'-disuccinic Acid Lyase, a Carbon-Nitrogen Bond-Forming Enzyme with a Broad Substrate Scope. Biochemistry, 57, 2018
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6G3F
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![BU of 6g3f by Molmil](/molmil-images/mine/6g3f) | Crystal structure of EDDS lyase in complex with fumarate | Descriptor: | Argininosuccinate lyase, DI(HYDROXYETHYL)ETHER, FUMARIC ACID | Authors: | Poddar, H, Thunnissem, A.M.W.H, Poelarends, G.J. | Deposit date: | 2018-03-25 | Release date: | 2018-05-16 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.222 Å) | Cite: | Structural Basis for the Catalytic Mechanism of Ethylenediamine- N, N'-disuccinic Acid Lyase, a Carbon-Nitrogen Bond-Forming Enzyme with a Broad Substrate Scope. Biochemistry, 57, 2018
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6G3H
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![BU of 6g3h by Molmil](/molmil-images/mine/6g3h) | Crystal structure of EDDS lyase in complex with SS-EDDS | Descriptor: | (2~{S})-2-[2-[[(2~{S})-1,4-bis(oxidanyl)-1,4-bis(oxidanylidene)butan-2-yl]amino]ethylamino]butanedioic acid, Argininosuccinate lyase | Authors: | Poddar, H, Thunnissem, A.M.W.H, Poelarends, G.J. | Deposit date: | 2018-03-25 | Release date: | 2018-05-16 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.269 Å) | Cite: | Structural Basis for the Catalytic Mechanism of Ethylenediamine- N, N'-disuccinic Acid Lyase, a Carbon-Nitrogen Bond-Forming Enzyme with a Broad Substrate Scope. Biochemistry, 57, 2018
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4JBK
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![BU of 4jbk by Molmil](/molmil-images/mine/4jbk) | Molecular basis for abrogation of activation of pro-inflammatory cytokines | Descriptor: | DNA (5'-D(P*GP*GP*AP*AP*TP*TP*AP*TP*AP*AP*TP*TP*CP*C)-3'), Interferon-activable protein 202 | Authors: | Ru, H, Ni, X, Crowley, C, Zhao, L, Ding, W, Hung, L.-W, Shaw, N, Cheng, G, Liu, Z.-J. | Deposit date: | 2013-02-19 | Release date: | 2013-06-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.963 Å) | Cite: | Structural basis for termination of AIM2-mediated signaling by p202 Cell Res., 23, 2013
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