9F6F
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![BU of 9f6f by Molmil](/molmil-images/mine/9f6f) | Human DNA polymerase epsilon bound to DNA and PCNA (closed conformation) | Descriptor: | 2',3'-dideoxyadenosine triphosphate, DNA nascent strand, DNA polymerase epsilon catalytic subunit A, ... | Authors: | Roske, J.J, Yeeles, J.T.P. | Deposit date: | 2024-05-01 | Release date: | 2024-08-07 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol epsilon. Nat.Struct.Mol.Biol., 2024
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4HK1
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6CX4
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![BU of 6cx4 by Molmil](/molmil-images/mine/6cx4) | V180A Mutant of Yeast PCNA | Descriptor: | Proliferating cell nuclear antigen | Authors: | Powers, K.T. | Deposit date: | 2018-04-02 | Release date: | 2018-04-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.081 Å) | Cite: | Identification of New Mutations at the PCNA Subunit Interface that Block Translesion Synthesis. PLoS ONE, 11, 2016
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6D0Q
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![BU of 6d0q by Molmil](/molmil-images/mine/6d0q) | Structure of a DNA retention-prone PCNA variant | Descriptor: | Proliferating cell nuclear antigen | Authors: | Kelch, B.A, Gaubitz, C. | Deposit date: | 2018-04-10 | Release date: | 2019-05-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.80051017 Å) | Cite: | Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex. Nucleic Acids Res., 47, 2019
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6T7Y
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![BU of 6t7y by Molmil](/molmil-images/mine/6t7y) | Structure of PCNA bound to cPIP motif of DP2 from P. abyssi | Descriptor: | DNA polymerase sliding clamp, cPIP motif from the DP2 large subunit of PolD | Authors: | Madru, C, Raia, P, Hugonneau Beaufet, I, Delarue, M, Carroni, M, Sauguet, L. | Deposit date: | 2019-10-23 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA. Nat Commun, 11, 2020
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6D0R
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![BU of 6d0r by Molmil](/molmil-images/mine/6d0r) | Structure of a DNA retention-prone PCNA variant | Descriptor: | Proliferating cell nuclear antigen | Authors: | Kelch, B.A, Gaubitz, C. | Deposit date: | 2018-04-10 | Release date: | 2019-05-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.85856962 Å) | Cite: | Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex. Nucleic Acids Res., 47, 2019
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6T7X
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![BU of 6t7x by Molmil](/molmil-images/mine/6t7x) | Crystal structure of PCNA from P. abyssi | Descriptor: | DNA polymerase sliding clamp | Authors: | Madru, C, Raia, P, Hugonneau Beaufet, I, Delarue, M, Carroni, M, Sauguet, L. | Deposit date: | 2019-10-23 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA. Nat Commun, 11, 2020
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2IJX
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2IZO
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![BU of 2izo by Molmil](/molmil-images/mine/2izo) | Structure of an Archaeal PCNA1-PCNA2-FEN1 Complex | Descriptor: | DNA POLYMERASE SLIDING CLAMP B, DNA POLYMERASE SLIDING CLAMP C, FLAP STRUCTURE-SPECIFIC ENDONUCLEASE, ... | Authors: | Dore, A.S, Kilkenny, M.L, Roe, S.M, Pearl, L.H. | Deposit date: | 2006-07-25 | Release date: | 2006-09-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of an Archaeal PCNA1-PCNA2-Fen1 Complex: Elucidating PCNA Subunit and Client Enzyme Specificity. Nucleic Acids Res., 34, 2006
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4YHR
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![BU of 4yhr by Molmil](/molmil-images/mine/4yhr) | Crystal Structure of Yeast Proliferating Cell Nuclear Antigen | Descriptor: | Proliferating cell nuclear antigen | Authors: | Litman, J.M, Nguyen, V.Q, Kondratick, C.M, Powers, K.T, Schnieders, M.J, Washington, M.T. | Deposit date: | 2015-02-27 | Release date: | 2015-03-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.9502 Å) | Cite: | Dead-End Elimination with a Polarizable Force Field Repacks PCNA Models from Low-Resolution X-ray Diffraction into Atomic Resolution Structures To be published
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4ZTD
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![BU of 4ztd by Molmil](/molmil-images/mine/4ztd) | Crystal Structure of Human PCNA in complex with a TRAIP peptide | Descriptor: | ALA-GLY-ALA-GLY-ALA, ALA-PHE-GLN-ALA-LYS-LEU-ASP-THR-PHE-LEU-TRP-SER, Proliferating cell nuclear antigen | Authors: | Montoya, G, Mortuza, G.B, Blanco, F.J, Ibanez de Opakua, A. | Deposit date: | 2015-05-14 | Release date: | 2015-12-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.199 Å) | Cite: | TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress. J.Cell Biol., 212, 2016
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7KQ1
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![BU of 7kq1 by Molmil](/molmil-images/mine/7kq1) | PCNA bound to truncated peptide mimetic | Descriptor: | LYS-ARG-ARG-GLN-THR-SER-MET-THR-ASP-PHE-TYR-HIS-SER-LYS-ARG, Proliferating cell nuclear antigen | Authors: | Vandborg, B.A, Bruning, J.B. | Deposit date: | 2020-11-13 | Release date: | 2021-05-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Unlocking the PIP-box: A peptide library reveals interactions that drive high-affinity binding to human PCNA. J.Biol.Chem., 296, 2021
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7KQ0
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![BU of 7kq0 by Molmil](/molmil-images/mine/7kq0) | PCNA bound to peptide mimetic | Descriptor: | LYS-ARG-ARG-GLN-THR-SER-MET-THR-ASP-TYR-TYR-HIS-SER-LYS-ARG, Proliferating cell nuclear antigen | Authors: | Vandborg, B.A, Bruning, J.B. | Deposit date: | 2020-11-13 | Release date: | 2021-05-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Unlocking the PIP-box: A peptide library reveals interactions that drive high-affinity binding to human PCNA. J.Biol.Chem., 296, 2021
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4L60
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![BU of 4l60 by Molmil](/molmil-images/mine/4l60) | |
5A6D
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![BU of 5a6d by Molmil](/molmil-images/mine/5a6d) | Proliferating Cell Nuclear Antigen, PCNA, from Thermococcus gammatolerans | Descriptor: | DNA POLYMERASE SLIDING CLAMP | Authors: | Venancio-Landeros, A, Cardona-Felix, C.S, Rudino-Pinera, E. | Deposit date: | 2015-06-25 | Release date: | 2016-07-06 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Cloning, recombinant production and crystallographic structure of Proliferating Cell Nuclear Antigen from radioresistant archaeon Thermococcus gammatolerans. Biochem Biophys Rep, 8, 2016
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4L6P
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3AIZ
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3AIX
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![BU of 3aix by Molmil](/molmil-images/mine/3aix) | |
7NV1
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![BU of 7nv1 by Molmil](/molmil-images/mine/7nv1) | Human Pol Kappa holoenzyme with Ub-PCNA | Descriptor: | DNA Primer, DNA Template, DNA polymerase kappa, ... | Authors: | Lancey, C, De Biasio, A, Hamdan, S.M. | Deposit date: | 2021-03-15 | Release date: | 2021-11-03 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Cryo-EM structure of human Pol kappa bound to DNA and mono-ubiquitylated PCNA. Nat Commun, 12, 2021
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7NV0
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![BU of 7nv0 by Molmil](/molmil-images/mine/7nv0) | Human Pol Kappa holoenzyme with wt PCNA | Descriptor: | DNA Primer, DNA Template, DNA polymerase kappa, ... | Authors: | Lancey, C, De Biasio, A, Hamdan, S.M. | Deposit date: | 2021-03-15 | Release date: | 2021-11-10 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structure of human Pol kappa bound to DNA and mono-ubiquitylated PCNA. Nat Commun, 12, 2021
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6K2M
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7O1F
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![BU of 7o1f by Molmil](/molmil-images/mine/7o1f) | |
7O1E
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![BU of 7o1e by Molmil](/molmil-images/mine/7o1e) | Crystal structure of PCNA from Chaetomium thermophilum | Descriptor: | Proliferating cell nuclear antigen | Authors: | Alphey, M.A, MacNeill, S, Yang, D. | Deposit date: | 2021-03-29 | Release date: | 2022-04-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Non-canonical binding of the Chaetomium thermophilum PolD4 N-terminal PIP motif to PCNA involves Q-pocket and compact 2-fork plug interactions but no 3 10 helix. Febs J., 290, 2023
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6K3A
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3P91
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![BU of 3p91 by Molmil](/molmil-images/mine/3p91) | |