PDB: 250 resultsInfo pagesStatus searchChemie searchBIRD

---

8XPP	Crystal structure of the enterovirus 71 RdRP elongation complex with the nucleoside monophosphate form of compound HNC-1664 at product position -1 (post-translocation state) Descriptor: Genome polyprotein, RNA (17-MER), RNA (35-MER), ... Authors: Zhong, Y, Gong, P. Deposit date: 2024-01-04 Release date: 2024-12-04 Last modified: 2025-01-15 Method: X-RAY DIFFRACTION (3 Å) Cite: An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode. Nat Commun, 15, 2024
3H5X	Crystal Structure of 2'-amino-2'-deoxy-cytidine-5'-triphosphate bound to Norovirus GII RNA polymerase Descriptor: 2'-amino-2'-deoxycytidine 5'-(tetrahydrogen triphosphate), 5'-R(*UP*GP*CP*CP*CP*GP*GP*G)-3', 5'-R(P*UP*GP*CP*CP*CP*GP*GP*GP*C)-3', ... Authors: Zamyatkin, D.F, Parra, F, Machin, A, Grochulski, P, Ng, K.K.S. Deposit date: 2009-04-22 Release date: 2009-05-19 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Binding of 2'-amino-2'-deoxycytidine-5'-triphosphate to norovirus polymerase induces rearrangement of the active site. J.Mol.Biol., 390, 2009
3H5Y	Norovirus polymerase+primer/template+CTP complex at 6 mM MnCl2 Descriptor: 5'-R(*UP*GP*CP*CP*CP*GP*GP*G)-3', 5'-R(P*UP*GP*CP*CP*CP*GP*GP*GP*C)-3', CYTIDINE-5'-TRIPHOSPHATE, ... Authors: Zamyatkin, D.F, Parra, F, Machin, A, Grochulski, P, Ng, K.K.S. Deposit date: 2009-04-22 Release date: 2009-05-19 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Binding of 2'-amino-2'-deoxycytidine-5'-triphosphate to norovirus polymerase induces rearrangement of the active site. J.Mol.Biol., 390, 2009
2CKW	The 2.3 A resolution structure of the Sapporo virus RNA dependant RNA polymerase. Descriptor: RNA-DIRECTED RNA POLYMERASE Authors: Fullerton, S.W.B, Tucker, P.A, Rohayem, J, Coutard, B, Gebhardt, J, Gorbalenya, A, Canard, B. Deposit date: 2006-04-24 Release date: 2006-11-29 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and Functional Characterization of Sapovirus RNA-Dependent RNA Polymerase. J.Virol., 81, 2007
2B43	Crystal structure of the Norwalk virus RNA dependent RNA polymerase from strain Hu/NLV/Dresden174/1997/GE Descriptor: non-structural polyprotein Authors: Hogbom, M, Rohayem, J, Unge, T, Jones, T.A. Deposit date: 2005-09-22 Release date: 2005-10-04 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of the Norwalk virus RNA dependent RNA polymerase from strain Hu/NLV/Dresden174/1997/GE To be Published
5Y3D	Structural insight into the interaction between RNA polymerase and VPg for norovirus replication Descriptor: RNA-dependent RNA polymerase, viral protein genome-linked (VPg) Authors: Kim, K.H, Lee, J.-H, Seok, J.H. Deposit date: 2017-07-28 Release date: 2018-07-18 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.14 Å) Cite: Insight Into the Interaction Between RNA Polymerase and VPg for Murine Norovirus Replication. Front Microbiol, 9, 2018
6S2L	FMDV 3D polymerase crystallized in presence of (F)uridylylated VPg peptide Descriptor: GLYCEROL, Genome polyprotein Authors: Verdaguer, N, Ferrer-Orta, C. Deposit date: 2019-06-21 Release date: 2019-07-03 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.3 Å) Cite: (F)uridylylated Peptides Linked to VPg1 of Foot-and- Mouth Disease Virus (FMDV): Design, Synthesis and X-Ray Crystallography of the Complexes with FMDV RNA-Dependent RNA Polymerase. Molecules, 24, 2019
3UQS	Crystal structures of murine norovirus RNA-dependent RNA polymerase Descriptor: RNA-dependent RNA polymerase, SULFATE ION Authors: Milani, M, Mastrangelo, E, Bolognesi, M. Deposit date: 2011-11-21 Release date: 2012-05-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure-Based Inhibition of Norovirus RNA-Dependent RNA Polymerases. J.Mol.Biol., 419, 2012
5ZIT	Crystal structure of human Enterovirus D68 RdRp in complex with NADPH Descriptor: DI(HYDROXYETHYL)ETHER, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, RdRp Authors: Wang, M.L, Li, L, Chen, Y.P, Jiang, H, Zhang, Y, Su, D. Deposit date: 2018-03-17 Release date: 2019-04-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.196 Å) Cite: Structure of the enterovirus D68 RNA-dependent RNA polymerase in complex with NADPH implicates an inhibitor binding site in the RNA template tunnel. J.Struct.Biol., 2020
5ZIU	Crystal structure of human Entervirus D68 RdRp Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, RdRp Authors: Wang, M.L, Zhang, Y, Chen, Y.P, Lu, D.R, Jiang, H, Chen, Y.J, Li, L, Zhang, C.H, Shi, Q.L, Su, D. Deposit date: 2018-03-17 Release date: 2019-04-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.147 Å) Cite: Crystal structure of human Entervirus D68 RdRp in complex with NADPH To Be Published
6R1I	Structure of porcine Aichi virus polymerase Descriptor: Genome polyprotein Authors: Dubankova, A, Boura, E. Deposit date: 2019-03-14 Release date: 2019-10-09 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.634 Å) Cite: Structures of kobuviral and siciniviral polymerases reveal conserved mechanism of picornaviral polymerase activation. J.Struct.Biol., 208, 2019
6QWT	Sicinivirus 3Dpol RNA dependent RNA polymerase Descriptor: Genome polyprotein Authors: Dubankova, A, Boura, E. Deposit date: 2019-03-06 Release date: 2019-10-09 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structures of kobuviral and siciniviral polymerases reveal conserved mechanism of picornaviral polymerase activation. J.Struct.Biol., 208, 2019
3UR0	Crystal structures of murine norovirus RNA-dependent RNA polymerase in complex with Suramin Descriptor: 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID, RNA-dependent RNA polymerase, SULFATE ION Authors: Milani, M, Mastrangelo, E, Bolognesi, M. Deposit date: 2011-11-21 Release date: 2012-05-02 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Structure-Based Inhibition of Norovirus RNA-Dependent RNA Polymerases. J.Mol.Biol., 419, 2012
3UPF	Crystal structure of murine norovirus RNA-dependent RNA polymerase bound to NF023 Descriptor: 8-({3-[({3-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)amino]benzoyl}amino)naphthalene-1,3,5-trisulfonic acid, RNA-dependent RNA polymerase, SULFATE ION Authors: Milani, M, Mastrangelo, E, Bolognesi, M. Deposit date: 2011-11-18 Release date: 2012-05-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure-Based Inhibition of Norovirus RNA-Dependent RNA Polymerases. J.Mol.Biol., 419, 2012
6KWR	Crystal structure of enterovirus 71 polymerase elongation complex (ddCTP form) Descriptor: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, MAGNESIUM ION, RNA (31-MER), ... Authors: Shi, W, Gong, P. Deposit date: 2019-09-08 Release date: 2019-12-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability. Nucleic Acids Res., 48, 2020
6KWQ	Crystal structure of enterovirus 71 polymerase elongation complex (native form) Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, MAGNESIUM ION, ... Authors: Shi, W, Gong, P. Deposit date: 2019-09-08 Release date: 2019-12-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.76 Å) Cite: A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability. Nucleic Acids Res., 48, 2020
6L4R	Crystal structure of Enterovirus D68 RdRp Descriptor: RdRp Authors: Wang, M.L, Li, L, Zhang, Y, Chen, Y.P, Su, D. Deposit date: 2019-10-21 Release date: 2020-06-10 Last modified: 2025-03-05 Method: X-RAY DIFFRACTION (2.147 Å) Cite: Structure of the enterovirus D68 RNA-dependent RNA polymerase in complex with NADPH implicates an inhibitor binding site in the RNA template tunnel. J.Struct.Biol., 211, 2020
2ILZ	Crystal structure of poliovirus polymerase complexed with GTP and Mn2+ Descriptor: ACETIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... Authors: Thompson, A.A, Peersen, O.B. Deposit date: 2006-10-03 Release date: 2006-12-12 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Stabilization of Poliovirus Polymerase by NTP Binding and Fingers-Thumb Interactions. J.Mol.Biol., 366, 2007
2IJF	Crystal Structure of the Poliovirus RNA-Dependent RNA Polymerase Fidelity Mutant 3Dpol G64S Descriptor: RNA-directed RNA polymerase Authors: Marcotte, L.L, Gohara, D.G, Filman, D.J, Hogle, J.M. Deposit date: 2006-09-29 Release date: 2007-02-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal structure of poliovirus 3CD: virally-encoded protease and precursor to the RNA-dependent RNA polymerase. J.Virol., 81, 2007
2IM0	Crystal structure of poliovirus polymerase complexed with CTP and Mg2+ Descriptor: ACETIC ACID, CYTIDINE-5'-TRIPHOSPHATE, SODIUM ION, ... Authors: Thompson, A.A, Peersen, O.B. Deposit date: 2006-10-03 Release date: 2006-12-12 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Stabilization of Poliovirus Polymerase by NTP Binding and Fingers-Thumb Interactions. J.Mol.Biol., 366, 2007
6LSE	Crystal structure of the enterovirus 71 polymerase elongation complex (C3S6A/C3S6B form) Descriptor: Genome polyprotein, PYROPHOSPHATE 2-, RNA (35-MER), ... Authors: Wang, M, Shu, B, Jing, X, Gong, P. Deposit date: 2020-01-17 Release date: 2020-04-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures. Nat Commun, 11, 2020
3BSN	Norwalk Virus polymerase bound to 5-nitrocytidine triphosphate and primer-template RNA Descriptor: 5-nitrocytidine 5'-(tetrahydrogen triphosphate), GLYCEROL, MANGANESE (II) ION, ... Authors: Zamyatkin, D.F, Ng, K.K.S. Deposit date: 2007-12-26 Release date: 2008-01-08 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural insights into mechanisms of catalysis and inhibition in norwalk virus polymerase. J.Biol.Chem., 283, 2008
3BSO	Norwalk Virus polymerase bound to cytidine 5'-triphosphate and primer-template RNA Descriptor: CYTIDINE-5'-TRIPHOSPHATE, GLYCEROL, MANGANESE (II) ION, ... Authors: Zamyatkin, D.F, Ng, K.K.S. Deposit date: 2007-12-26 Release date: 2008-01-08 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Structural insights into mechanisms of catalysis and inhibition in norwalk virus polymerase. J.Biol.Chem., 283, 2008
3CDU	Crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase (3Dpol) in complex with a pyrophosphate Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ... Authors: Gruez, A, Selisko, B, Roberts, M, Bricogne, G, Bussetta, C, Canard, B. Deposit date: 2008-02-27 Release date: 2008-07-22 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases J.Virol., 82, 2008
3CDW	Crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase (3Dpol) in complex with protein primer VPg and a pyrophosphate Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ... Authors: Gruez, A, Selisko, B, Roberts, M, Bricogne, G, Bussetta, C, Canard, B. Deposit date: 2008-02-27 Release date: 2008-07-22 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases J.Virol., 82, 2008

<12345678910>