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6WEX	Crystal Structure of Broadly Neutralizing Antibody 3I14-D93N Mutant Bound to the Influenza A H6 Hemagglutinin Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, Hemagglutinin HA2 chain, ... Authors: Harshbarger, W.D, Lockbaum, G.J, Deming, D.T, Attatippaholkun, N, Schiffer, C.A, Marasco, W.A. Deposit date: 2020-04-03 Release date: 2020-11-25 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (3.49 Å) Cite: Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses. Nat Commun, 12, 2021
6WXB	Cryo-EM Structure of Influenza Hemagglutinin (HA) Trimer Vitrified Using Back-it-up Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, beta-D-mannopyranose Authors: Tan, Y.Z, Rubinstein, J.L. Deposit date: 2020-05-10 Release date: 2020-05-20 Last modified: 2020-11-18 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Through-grid wicking enables high-speed cryoEM specimen preparation. Acta Crystallogr D Struct Biol, 76, 2020
6WCR	Crystal structure of the A/Puerto Rico/8/1934 (H1N1) influenza virus hemagglutinin in complex with small molecule F0045(S) Descriptor: (2,4-dichlorophenyl)[(2S)-2-phenylmorpholin-4-yl]methanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: kadam, R.U, Wilson, I.A. Deposit date: 2020-03-31 Release date: 2020-08-05 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.68 Å) Cite: An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen. Proc.Natl.Acad.Sci.USA, 117, 2020
8D21	Cryo-EM structure of the VRC321 clinical trial, vaccine-elicited, human antibody 1B06 in complex with a stabilized NC99 HA trimer Descriptor: 1B06 Heavy Chain, 1B06 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Gorman, J, Kwong, P.D. Deposit date: 2022-05-27 Release date: 2023-04-12 Last modified: 2024-11-06 Method: ELECTRON MICROSCOPY (3.96 Å) Cite: An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans. Sci Transl Med, 15, 2023
8IUY	H7N9 HA-1H9 Fab Descriptor: 1H9 Fab heavy chain, 1H9 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Zhao, B.B, Sun, Z.Z. Deposit date: 2023-03-25 Release date: 2024-04-24 Last modified: 2024-10-16 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: H7N9 HA-1H9 Fab To Be Published
8IUZ	H7N9 HA-2D7 Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2D7 Fab heavy chain, 2D7 Fab light chain, ... Authors: Zhao, B.B, Sun, Z.Z. Deposit date: 2023-03-25 Release date: 2024-04-24 Last modified: 2024-10-16 Method: ELECTRON MICROSCOPY (3 Å) Cite: H7N9 HA-2D7 Fab To Be Published
8IUX	The cryoEM structure of H7N9-HA protein Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin Authors: Zhao, B.B, Sun, Z.Z. Deposit date: 2023-03-25 Release date: 2024-04-24 Last modified: 2024-10-16 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: The cryoEM structure of H7N9-HA protein To Be Published
8IV0	H7N9 HA-C4H4 Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, C4H4 Fab heavy chain, C4H4 Fab light chain, ... Authors: Zhao, B.B, Sun, Z.Z. Deposit date: 2023-03-25 Release date: 2024-04-24 Last modified: 2024-10-23 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: H7N9 HA-C4H4 Fab To Be Published
7DEA	Structure of an avian influenza H5 hemagglutinin from the influenza virus A/duck Northern China/22/2017 (H5N6) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin Authors: Sun, H, Sun, H, Song, J, Zhang, W, Wei, X, Qi, J, Gao, G.F, Liu, J. Deposit date: 2020-11-03 Release date: 2021-11-03 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.84 Å) Cite: Haemagglutinin and neuraminidase acid stability in H5N6 avian influenza virus confers infection adaptation in mammals To Be Published
7DEB	Structure of an avian influenza H5 hemagglutinin from the influenza virus A/duck/Eastern China/L0230/2010 (H5N2) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... Authors: Sun, H, Sun, H, Song, J, Zhang, W, Qi, J, Gao, G.F, Liu, J. Deposit date: 2020-11-03 Release date: 2021-11-03 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Haemagglutinin and neuraminidase acid stability in H5N6 avian influenza virus confers infection adaptation in mammals To Be Published
7DKJ	Hemagglutinin Influenza A virus (A/Okuda/1957(H2N2) bound with a neutralizing antibody Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fv-clasp heavy chain, Fv-clasp light chain, ... Authors: Shirouzu, M. Deposit date: 2020-11-24 Release date: 2021-11-24 Last modified: 2023-06-14 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Hemagglutinin Influenza A virus (A/Okuda/1957(H2N2) bound with a neutralizing antibody To Be Published
8DIM	CryoEM structure of Influenza A virus A/Ohio/09/2015 hemagglutinin bound to CR6261 Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CR6261 Fab heavy chain, CR6261 Fab light chain, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2022-06-29 Release date: 2022-11-16 Last modified: 2024-10-23 Method: ELECTRON MICROSCOPY (2.62 Å) Cite: CryoEM structure of Influenza A virus A/Ohio/09/2015 hemagglutinin bound to CR6261 Fab To Be Published
8DIU	Cryo-EM structure of influenza A virus A/Bayern/7/1995 hemagglutinin bound to CR6261 Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CR6261 Fab heavy chain, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2022-06-29 Release date: 2022-12-14 Last modified: 2024-10-23 Method: ELECTRON MICROSCOPY (2.61 Å) Cite: CryoEM structure of influenza A virus A/Bayern/7/1995 hemagglutinin bound to CR6261 Fab To be published
8DIS	CryoEM structure of Influenza A virus A/Melbourne/1/1946 (H1N1) hemagglutinin bound to CR6261 Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CR6261 Fab heavy chain, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2022-06-29 Release date: 2023-06-07 Last modified: 2024-11-06 Method: ELECTRON MICROSCOPY (2.62 Å) Cite: CryoEM structure of Influenza A virus A/Melbourne/1/1946 (H1N1) hemagglutinin bound to CR6261 Fab To be published
7FAH	Immune complex of head region of CA09 HA and neutralizing antibody 12H5 Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... Authors: Li, T.T, Xue, W.H, Gu, Y, Li, S.W. Deposit date: 2021-07-06 Release date: 2022-07-06 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (3.151 Å) Cite: Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza viruses. Nat Commun, 13, 2022
7QA4	Crystal structure of stabilized H3N2 A/Hong Kong/1/1968 Hemagglutinin at 2.2 Angstrom Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... Authors: Milder, F.J, Langedijk, J.P.M. Deposit date: 2021-11-16 Release date: 2022-02-02 Last modified: 2022-03-30 Method: X-RAY DIFFRACTION (2.19 Å) Cite: Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions. Proc.Natl.Acad.Sci.USA, 119, 2022
7RCR	Crystal Structure of the refolded Hemagglutinin head domain of Influenza A virus A/Ohio/09/2015 Descriptor: 1,2-ETHANEDIOL, Hemagglutinin Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2021-07-08 Release date: 2021-08-04 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal Structure of the refolded Hemagglutinin head domain of Influenzavirus A Influenza A virus A/Ohio/09/2015 to be published
7RDH	Crystal structure of the de novo designed binding protein H3mb in complex with the 1968 influenza A virus hemagglutinin Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, De novo designed protein H3mb, ... Authors: Kadam, R.U, Wilson, I.A. Deposit date: 2021-07-09 Release date: 2022-05-04 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Design of protein-binding proteins from the target structure alone. Nature, 605, 2022
7SCO	Structure of H1 influenza hemagglutinin bound to Fab 310-39G10 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 310-39G10 Fab, ... Authors: Torrents de la Pena, A, Ward, A.B. Deposit date: 2021-09-28 Release date: 2022-08-24 Last modified: 2022-09-28 Method: ELECTRON MICROSCOPY (3.37 Å) Cite: Allelic polymorphism controls autoreactivity and vaccine elicitation of human broadly neutralizing antibodies against influenza virus. Immunity, 55, 2022
7SCN	Structure of H1 NC99 influenza hemagglutinin bound to Fab 310-63E6 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 310-63E6 Fab, Heavy Chain, ... Authors: Ward, A, Torrents de la Pena, A. Deposit date: 2021-09-28 Release date: 2022-08-24 Last modified: 2024-11-06 Method: ELECTRON MICROSCOPY (3.02 Å) Cite: Allelic polymorphism controls autoreactivity and vaccine elicitation of human broadly neutralizing antibodies against influenza virus. Immunity, 55, 2022
6CF7	Crystal structure of the A/Solomon Islands/3/2006(H1N1) influenza virus hemagglutinin in complex with small molecule JNJ4796 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... Authors: Kadam, R.U, Wilson, I.A. Deposit date: 2018-02-13 Release date: 2019-02-13 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.719 Å) Cite: A small-molecule fusion inhibitor of influenza virus is orally active in mice. Science, 363, 2019
6D0U	Crystal structure of C05 V110P/A117E mutant bound to H3 influenza hemagglutinin, HA1 subunit Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody C05 V110P/A117E mutant, heavy chain, ... Authors: Wu, N.C, Wilson, I.A. Deposit date: 2018-04-11 Release date: 2019-01-16 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Multistate design of influenza antibodies improves affinity and breadth against seasonal viruses. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6CEX	Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin in complex with small molecule N-Cyclohexyltaurine Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: wilson, I.A, Kadam, R.U. Deposit date: 2018-02-12 Release date: 2018-04-04 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.57 Å) Cite: A small-molecule fragment that emulates binding of receptor and broadly neutralizing antibodies to influenza A hemagglutinin. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6Q0H	Inferred intermediate I-7 (I-7-0) of the human antibody lineage 652 in complex with influenza hemagglutinin head domain of A/Beijing/262/95(H1N1) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, Fab lambda chain, ... Authors: McCarthy, K.R, Harrison, S.C. Deposit date: 2019-08-01 Release date: 2019-12-18 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Affinity maturation in a human humoral response to influenza hemagglutinin. Proc.Natl.Acad.Sci.USA, 2019
6Q18	Human antibody H1244 in complex with the influenza hemagglutinin head domain of A/Beijing/262/95(H1N1) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, H1244 Fab heavy chain, ... Authors: McCarthy, K.R, Harrison, S.C. Deposit date: 2019-08-03 Release date: 2019-12-18 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Affinity maturation in a human humoral response to influenza hemagglutinin. Proc.Natl.Acad.Sci.USA, 2019

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