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3EA1
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Crystal Structure of the Y247S/Y251S Mutant of Phosphatidylinositol-Specific Phospholipase C from Bacillus Thuringiensis
Descriptor: 1-phosphatidylinositol phosphodiesterase, ZINC ION
Authors:Shi, X, Shao, C, Zhang, X, Zambonelli, C, Redfied, A.G, Head, J.F, Seaton, B.A, Roberts, M.F.
Deposit date:2008-08-24
Release date:2009-04-14
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Modulation of bacillus thuringiensis phosphatidylinositol-specific phospholipase C activity by mutations in the putative dimerization interface.
J.Biol.Chem., 284, 2009
3EA3
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Crystal Structure of the Y246S/Y247S/Y248S/Y251S Mutant of Phosphatidylinositol-Specific Phospholipase C from Bacillus Thuringiensis
Descriptor: 1-phosphatidylinositol phosphodiesterase, MANGANESE (II) ION
Authors:Shi, X, Shao, C, Zhang, X, Zambonelli, C, Redfied, A.G, Head, J.F, Seaton, B.A, Roberts, M.F.
Deposit date:2008-08-24
Release date:2009-04-14
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Modulation of Bacillus thuringiensis Phosphatidylinositol-specific Phospholipase C Activity by Mutations in the Putative Dimerization Interface.
J.Biol.Chem., 284, 2009
3EA2
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Crystal Structure of the Myo-inositol bound Y247S/Y251S Mutant of Phosphatidylinositol-Specific Phospholipase C from Bacillus Thuringiensis
Descriptor: 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase, ZINC ION
Authors:Shi, X, Shao, C, Zhang, X, Zambonelli, C, Redfied, A.G, Head, J.F, Seaton, B.A, Roberts, M.F.
Deposit date:2008-08-24
Release date:2009-04-14
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Modulation of bacillus thuringiensis phosphatidylinositol-specific phospholipase C activity by mutations in the putative dimerization interface.
J.Biol.Chem., 284, 2009
3QR0
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Crystal Structure of S. officinalis PLC21
Descriptor: CALCIUM ION, GLYCEROL, phospholipase C-beta (PLC-beta)
Authors:Lyon, A.M, Northup, J.K, Tesmer, J.J.G.
Deposit date:2011-02-16
Release date:2011-08-10
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:An autoinhibitory helix in the C-terminal region of phospholipase C-beta mediates Galphaq activation.
Nat.Struct.Mol.Biol., 18, 2011
3QR1
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Crystal Structure of L. pealei PLC21
Descriptor: CALCIUM ION, PHOSPHOLIPASE C-BETA (PLC-BETA)
Authors:Lyon, A.M, Suddala, K.C, Northup, J.K, Tesmer, J.J.G.
Deposit date:2011-02-16
Release date:2011-08-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:An autoinhibitory helix in the C-terminal region of phospholipase C-beta mediates Galphaq activation.
Nat.Struct.Mol.Biol., 18, 2011
3V1H
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BU of 3v1h by Molmil
Structure of the H258Y mutant of Phosphatidylinositol-specific phospholipase C from Staphylococcus aureus
Descriptor: 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase, ACETATE ION
Authors:Goldstein, R.I, Cheng, J, Stec, B, Roberts, M.F.
Deposit date:2011-12-09
Release date:2012-04-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the S. aureus PI-Specific Phospholipase C Reveals Modulation of Active Site Access by a Titratable PI-Cation Latched Loop
Biochemistry, 51, 2012
3V16
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An intramolecular pi-cation latch in phosphatidylinositol-specific phospholipase C from S.aureus controls substrate access to the active site
Descriptor: 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase, CHLORIDE ION
Authors:Goldstein, R.I, Cheng, J, Stec, B, Roberts, M.F.
Deposit date:2011-12-09
Release date:2012-04-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of the S. aureus PI-Specific Phospholipase C Reveals Modulation of Active Site Access by a Titratable PI-Cation Latched Loop
Biochemistry, 51, 2012
3V18
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Structure of the Phosphatidylinositol-specific phospholipase C from Staphylococcus aureus
Descriptor: 1-phosphatidylinositol phosphodiesterase, ISOPROPYL ALCOHOL, SULFATE ION
Authors:Goldstein, R.I, Cheng, J, Stec, B, Roberts, M.F.
Deposit date:2011-12-09
Release date:2012-04-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Structure of the S. aureus PI-Specific Phospholipase C Reveals Modulation of Active Site Access by a Titratable PI-Cation Latched Loop
Biochemistry, 51, 2012
4F2B
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BU of 4f2b by Molmil
Modulation of S.Aureus Phosphatidylinositol-Specific Phospholipase C Membrane Binding
Descriptor: 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase
Authors:Cheng, J, Goldstein, R, Stec, B, Gershenson, A, Roberts, M.F.
Deposit date:2012-05-07
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Competition between Anion Binding and Dimerization Modulates Staphylococcus aureus Phosphatidylinositol-specific Phospholipase C Enzymatic Activity.
J.Biol.Chem., 287, 2012
4F2U
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Structure of the N254Y/H258Y double mutant of the Phosphatidylinositol-Specific Phospholipase C from S.aureus
Descriptor: 1-phosphatidylinositol phosphodiesterase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SULFATE ION
Authors:Cheng, J, Goldstein, R, Stec, B, Gershenson, A, Roberts, M.F.
Deposit date:2012-05-08
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Competition between Anion Binding and Dimerization Modulates Staphylococcus aureus Phosphatidylinositol-specific Phospholipase C Enzymatic Activity.
J.Biol.Chem., 287, 2012
4F2T
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Modulation of S.aureus Phosphatidylinositol-Specific Phospholipase C Membrane Binding.
Descriptor: 1-phosphatidylinositol phosphodiesterase, ACETATE ION
Authors:Cheng, J, Goldstein, R, Stec, B, Gershenson, A, Roberts, M.F.
Deposit date:2012-05-08
Release date:2012-12-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Competition between Anion Binding and Dimerization Modulates Staphylococcus aureus Phosphatidylinositol-specific Phospholipase C Enzymatic Activity.
J.Biol.Chem., 287, 2012
4GNK
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BU of 4gnk by Molmil
Crystal structure of Galphaq in complex with full-length human PLCbeta3
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Lyon, A.M, Tesmer, J.J.G.
Deposit date:2012-08-17
Release date:2013-02-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (4 Å)
Cite:Full-length G alpha (q)-phospholipase C-beta 3 structure reveals interfaces of the C-terminal coiled-coil domain.
Nat.Struct.Mol.Biol., 20, 2013
4I8Y
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BU of 4i8y by Molmil
Structure of the unliganded N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus
Descriptor: 1-phosphatidylinositol phosphodiesterase, ACETATE ION, CHLORIDE ION
Authors:Goldstein, R.I, Cheng, J, Stec, B, Gershenson, A, Roberts, M.F.
Deposit date:2012-12-04
Release date:2013-04-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The cation-pi box is a specific phosphatidylcholine membrane targeting motif.
J.Biol.Chem., 288, 2013
4I90
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BU of 4i90 by Molmil
Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus bound to choline
Descriptor: 1-phosphatidylinositol phosphodiesterase, ACETATE ION, CHLORIDE ION, ...
Authors:Goldstein, R.I, Cheng, J, Stec, B, Gershenson, A, Roberts, M.F.
Deposit date:2012-12-04
Release date:2013-04-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The cation-pi box is a specific phosphatidylcholine membrane targeting motif.
J.Biol.Chem., 288, 2013
4I9J
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BU of 4i9j by Molmil
Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from S. aureus bound to diC4PC
Descriptor: (4S,7R)-7-(heptanoyloxy)-4-hydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphahexadecan-1-aminium 4-oxide, 1-phosphatidylinositol phosphodiesterase, ACETATE ION
Authors:Goldstein, R.I, Cheng, J, Stec, B, Gershenson, A, Roberts, M.F.
Deposit date:2012-12-05
Release date:2013-04-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The cation-pi box is a specific phosphatidylcholine membrane targeting motif.
J.Biol.Chem., 288, 2013
4I9M
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BU of 4i9m by Molmil
Structure of the N254Y/H258Y mutant of the phosphatidylinositol-specific phospholipase C from Staphylococcus aureus bound to HEPES
Descriptor: 1-phosphatidylinositol phosphodiesterase, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SULFATE ION
Authors:Goldstein, R.I, Cheng, J, Stec, B, Gershenson, A, Roberts, M.F.
Deposit date:2012-12-05
Release date:2013-04-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The cation-pi box is a specific phosphatidylcholine membrane targeting motif.
J.Biol.Chem., 288, 2013
4I9T
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BU of 4i9t by Molmil
Structure of the H258Y mutant of the phosphatidylinositol-specific phospholipase C from Staphylococcus aureus
Descriptor: 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase, SULFATE ION, ...
Authors:Goldstein, R.I, Cheng, J, Stec, B, Gershenson, A, Roberts, M.F.
Deposit date:2012-12-05
Release date:2013-04-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:The cation-pi box is a specific phosphatidylcholine membrane targeting motif.
J.Biol.Chem., 288, 2013
4QJ4
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BU of 4qj4 by Molmil
Structure of a fragment of human phospholipase C-beta3 delta472-569, bound to IP3 and in complex with Galphaq
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ...
Authors:Lyon, A.M, Tesmer, J.J.G.
Deposit date:2014-06-03
Release date:2014-10-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Molecular mechanisms of phospholipase C beta 3 autoinhibition.
Structure, 22, 2014
4QJ3
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Structure of a fragment of human phospholipase C-beta3 delta472-559, in complex with Galphaq
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Lyon, A.M, Tesmer, J.J.G.
Deposit date:2014-06-03
Release date:2014-10-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Molecular mechanisms of phospholipase C beta 3 autoinhibition.
Structure, 22, 2014
4QJ5
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BU of 4qj5 by Molmil
Structure of a fragment of human phospholipase C-beta3 delta472-581, bound to IP3 and in complex with Galphaq
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ...
Authors:Lyon, A.M, Tesmer, J.J.G.
Deposit date:2014-06-03
Release date:2014-10-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:Molecular mechanisms of phospholipase C beta 3 autoinhibition.
Structure, 22, 2014
4RV3
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BU of 4rv3 by Molmil
Crystal structure of a pentafluoro-Phe incorporated Phosphatidylinositol-specific phospholipase C (H258X)from Staphylococcus aureus
Descriptor: 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase, ACETATE ION
Authors:He, T, Gershenson, A, Eyles, S.J, Gao, J, Roberts, M.F.
Deposit date:2014-11-24
Release date:2015-07-01
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Fluorinated Aromatic Amino Acids Distinguish Cation-pi Interactions from Membrane Insertion.
J.Biol.Chem., 290, 2015
4S3G
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BU of 4s3g by Molmil
Structure of the F249X mutant of Phosphatidylinositol-specific phospholipase C from Staphylococcus aureus
Descriptor: 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase, ACETATE ION
Authors:He, T, Gershenson, A, Eyles, S.J, Gao, J, Roberts, M.F.
Deposit date:2015-01-26
Release date:2015-07-01
Last modified:2015-08-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Fluorinated Aromatic Amino Acids Distinguish Cation-pi Interactions from Membrane Insertion.
J.Biol.Chem., 290, 2015
6PBC
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BU of 6pbc by Molmil
Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, SODIUM ION
Authors:Hajicek, N, Sondek, J.
Deposit date:2019-06-13
Release date:2020-01-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations.
Elife, 8, 2019
6S2A
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BU of 6s2a by Molmil
PI PLC mutant H82A
Descriptor: 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase
Authors:Eisenreichova, A, Boura, E.
Deposit date:2019-06-20
Release date:2019-07-31
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:PI PLC mutant H82A
To Be Published
6PMP
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Crystal structure of a fragment of rat phospholipase Cepsilon EF3-RA1
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1, CALCIUM ION
Authors:Rugema, N.Y, Lyon, A.M.
Deposit date:2019-07-02
Release date:2020-07-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Structure of phospholipase C epsilon reveals an integrated RA1 domain and previously unidentified regulatory elements.
Commun Biol, 3, 2020

226707

數據於2024-10-30公開中

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