4DJW
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1QWQ
| Solution structure of the monomeric N67D mutant of Bovine Seminal Ribonuclease | Descriptor: | Ribonuclease | Authors: | Avitabile, F, Alfano, C, Spadaccini, R, Crescenzi, O, D'Ursi, A.M, D'Alessio, G, Tancredi, T, Picone, D. | Deposit date: | 2003-09-03 | Release date: | 2003-09-16 | Last modified: | 2021-11-10 | Method: | SOLUTION NMR | Cite: | THE SWAPPING OF TERMINAL ARMS IN RIBONUCLEASES: COMPARISON OF THE SOLUTION STRUCTURE OF MONOMERIC BOVINE SEMINAL AND PANCREATIC RIBONUCLEASES Biochemistry, 42, 2003
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4DGM
| Crystal Structure of maize CK2 in complex with the inhibitor apigenin | Descriptor: | 1,2-ETHANEDIOL, 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, Casein kinase II subunit alpha, ... | Authors: | Lolli, G, Mazzorana, M, Battistutta, R. | Deposit date: | 2012-01-26 | Release date: | 2012-08-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight. Biochemistry, 51, 2012
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1QLY
| NMR Study of the SH3 Domain From Bruton's Tyrosine Kinase, 20 Structures | Descriptor: | TYROSINE-PROTEIN KINASE BTK | Authors: | Tzeng, S.R, Lou, Y.C, Pai, M.T, Chen, C, Chen, S.H, Cheng, J.Y. | Deposit date: | 1999-09-20 | Release date: | 1999-12-14 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution Structure of the Human Btk SH3 Domain Complexed with a Proline-Rich Peptide from P120Cbl J.Biomol.NMR, 16, 2000
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1QQN
| D206S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, D206S MUTANT OF BOVINE 70 KILODALTON HEAT SHOCK PROTEIN, ... | Authors: | Johnson, E.R, McKay, D.B. | Deposit date: | 1999-06-07 | Release date: | 1999-09-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Mapping the role of active site residues for transducing an ATP-induced conformational change in the bovine 70-kDa heat shock cognate protein. Biochemistry, 38, 1999
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4DLI
| Human p38 MAP kinase in complex with RL87 | Descriptor: | Mitogen-activated protein kinase 14, N~4~-cyclopropyl-2-phenylquinazoline-4,7-diamine | Authors: | Gruetter, C, Getlik, M, Simard, J.R, Rauh, D. | Deposit date: | 2012-02-06 | Release date: | 2013-01-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Fluorophore labeled kinase detects ligands that bind within the MAPK insert of p38alpha kinase. Plos One, 7, 2012
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4DQ4
| Bovine beta-lactoglobulin complex with linoleic acid | Descriptor: | Beta-lactoglobulin, ETHANOL, GLYCEROL, ... | Authors: | Loch, J.I, Lewinski, K. | Deposit date: | 2012-02-15 | Release date: | 2012-02-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Binding of 18-carbon unsaturated fatty acids to bovine beta-lactoglobulin--structural and thermodynamic studies. Int.J.Biol.Macromol., 57, 2013
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1QSI
| MAGNESIUM(II)-AND ZINC(II)-PROTOPORPHYRIN IX'S STABILIZE THE LOWEST OXYGEN AFFINITY STATE OF HUMAN HEMOGLOBIN EVEN MORE STRONGLY THAN DEOXYHEME | Descriptor: | CARBON MONOXIDE, PROTEIN (HEMOGLOBIN ALPHA CHAIN), PROTEIN (HEMOGLOBIN BETA CHAIN), ... | Authors: | Miyazaki, G, Morimoto, H, Yun, K.-M, Park, S.-Y, Nakagawa, A, Minagawa, H, Shibayama, N. | Deposit date: | 1999-06-22 | Release date: | 1999-07-02 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Magnesium(II) and zinc(II)-protoporphyrin IX's stabilize the lowest oxygen affinity state of human hemoglobin even more strongly than deoxyheme. J.Mol.Biol., 292, 1999
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4DLR
| H-Ras PEG 400/Ca(OAc)2, ordered off | Descriptor: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, CALCIUM ION, GTPase HRas, ... | Authors: | Holzapfel, G, Mattos, C. | Deposit date: | 2012-02-06 | Release date: | 2012-08-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.319 Å) | Cite: | Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition. Biochemistry, 51, 2012
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4DLY
| Set 1 CaCl2/DTT, ordered off | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CALCIUM ION, GTPase HRas, ... | Authors: | Holzapfel, G, Mattos, C. | Deposit date: | 2012-02-06 | Release date: | 2012-08-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition. Biochemistry, 51, 2012
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1QMT
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1ZZ2
| Two Classes of p38alpha MAP Kinase Inhibitors Having a Common Diphenylether Core but Exhibiting Divergent Binding Modes | Descriptor: | Mitogen-activated protein kinase 14, N-[3-(4-FLUOROPHENOXY)PHENYL]-4-[(2-HYDROXYBENZYL)AMINO]PIPERIDINE-1-SULFONAMIDE, octyl beta-D-glucopyranoside | Authors: | Michelotti, E.L, Moffett, K.K, Springman, E.B, Karpusas, M. | Deposit date: | 2005-06-13 | Release date: | 2005-10-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes. Bioorg.Med.Chem.Lett., 15, 2005
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1ZZJ
| Structure of the third KH domain of hnRNP K in complex with 15-mer ssDNA | Descriptor: | 5'-D(*TP*TP*CP*CP*CP*CP*TP*CP*CP*CP*CP*AP*TP*TP*T)-3', Heterogeneous nuclear ribonucleoprotein K | Authors: | Backe, P.H, Messias, A.C, Ravelli, R.B, Sattler, M, Cusack, S. | Deposit date: | 2005-06-14 | Release date: | 2005-08-09 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | X-Ray Crystallographic and NMR Studies of the Third KH Domain of hnRNP K in Complex with Single-Stranded Nucleic Acids STRUCTURE, 13, 2005
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1ZR8
| Crystal Structure of the complex formed between group II phospholipase A2 and a plant alkaloid ajmaline at 2.0A resolution | Descriptor: | ACETIC ACID, AJMALINE, Phospholipase A2 VRV-PL-VIIIa, ... | Authors: | Mahendra, M, Singh, N, Kaur, P, Sharma, S, Singh, T.P. | Deposit date: | 2005-05-19 | Release date: | 2005-06-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Crystal Structure of the complex formed between group II phospholipase A2 and a plant alkaloid ajmaline at 2.0A resolution To be Published
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1ZTL
| Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with N-[4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-2-{6-oxo-5-[(quinolin-8-ylmethyl)-amino]-2-m-tolyl-6H-pyrimidin-1-yl}-acetamide | Descriptor: | Coagulation factor XI, N-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYL]-2-{6-OXO-5-[(QUINOLIN-8-YLMETHYL)-AMINO]-2-M-TOLYL-6H-PYRIMIDIN-1-YL}-ACETAMIDE, SULFATE ION | Authors: | Nagafuji, P, Jin, L, Rynkiewicz, M, Quinn, J, Bibbins, F, Meyers, H, Babine, R, Strickler, J.E, Abdel-Meguid, S.S. | Deposit date: | 2005-05-27 | Release date: | 2006-05-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Pyrimidinone Inhibitors of a Thrombolytic Protease To be Published
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1ZW6
| Crystal Structure of the GTP-bound form of RasQ61G | Descriptor: | CALCIUM ION, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | Authors: | Ford, B, Hornak, V, Kleinman, H, Nassar, N. | Deposit date: | 2005-06-03 | Release date: | 2006-03-14 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure of a transient intermediate for GTP hydrolysis by ras. Structure, 14, 2006
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1ZSJ
| Crystal Structure of the Catalytic Domain of Coagulation Factor XI in complex with N-(7-Carbamimidoyl-naphthalen-1-yl)-3-hydroxy-2-methyl-benzamide | Descriptor: | BICARBONATE ION, Coagulation factor XI, N-(7-CARBAMIMIDOYL-NAPHTHALEN-1-YL)-3-HYDROXY-2-METHYL-BENZAMIDE, ... | Authors: | Guo, Z, Bannister, T, Noll, R, Jin, L, Rynkiewicz, M, Bibbins, F, Magee, S, Gorga, J, Babine, R.E, Strickler, J.E, Meyers, H.V, Abdel-Meguid, S.S. | Deposit date: | 2005-05-24 | Release date: | 2006-05-23 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Synthesis and Optimization of Potent and Selective Inhibitors for Human Factor XIa: Substituted Naphthamidine Series To be Published
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1ZTW
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1ZY4
| Crystal Structure of eIF2alpha Protein Kinase GCN2: R794G Hyperactivating Mutant in Apo Form. | Descriptor: | GLYCEROL, Serine/threonine-protein kinase GCN2 | Authors: | Padyana, A.K, Qiu, H, Roll-Mecak, A, Hinnebusch, A.G, Burley, S.K. | Deposit date: | 2005-06-09 | Release date: | 2005-06-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural Basis for Autoinhibition and Mutational Activation of Eukaryotic Initiation Factor 2{alpha} Protein Kinase GCN2 J.Biol.Chem., 280, 2005
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1ZUK
| Yeast BBC1 Sh3 domain complexed with a peptide from Las17 | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Myosin tail region-interacting protein MTI1, ... | Authors: | Kursula, P, Kursula, I, Lehmann, F, Zou, P, Song, Y.H, Wilmanns, M. | Deposit date: | 2005-05-31 | Release date: | 2006-08-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural genomics of yeast SH3 domains To be Published
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1ZVH
| Crystal structure of the VHH domain D2-L24 in complex with hen egg white lysozyme | Descriptor: | Immunoglobulin heavy chain antibody variable domain, Lysozyme C | Authors: | De Genst, E, Silence, K, Decanniere, K, Conrath, K, Loris, R, Kinne, J, Muyldermans, S, Wyns, L. | Deposit date: | 2005-06-02 | Release date: | 2006-04-04 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies. Proc.Natl.Acad.Sci.Usa, 103, 2006
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1ZWO
| NMR structure of murine gamma-S crystallin | Descriptor: | Gamma crystallin S | Authors: | Wu, Z, Delaglio, F, Wyatt, K, Wistow, G, Bax, A. | Deposit date: | 2005-06-04 | Release date: | 2005-07-05 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of (gamma)S-crystallin by molecular fragment replacement NMR. Protein Sci., 14, 2005
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1ZYC
| Crystal Structure of eIF2alpha Protein Kinase GCN2: Wild-Type in Apo Form. | Descriptor: | Serine/threonine-protein kinase GCN2 | Authors: | Padyana, A.K, Qiu, H, Roll-Mecak, A, Hinnebusch, A.G, Burley, S.K. | Deposit date: | 2005-06-09 | Release date: | 2005-06-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Basis for Autoinhibition and Mutational Activation of Eukaryotic Initiation Factor 2{alpha} Protein Kinase GCN2 J.Biol.Chem., 280, 2005
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207L
| MUTANT HUMAN LYSOZYME C77A | Descriptor: | LYSOZYME, N-ACETYL-L-CYSTEINE | Authors: | Matsushima, M, Song, H. | Deposit date: | 1996-03-26 | Release date: | 1996-10-14 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A role of PDI in the reductive cleavage of mixed disulfides. J.Biochem.(Tokyo), 120, 1996
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1ZRY
| NMR structural analysis of apo chicken liver bile acid binding protein | Descriptor: | Fatty acid-binding protein, liver | Authors: | Ragona, L, Catalano, M, Luppi, M, Cicero, D, Eliseo, T, Foote, J, Fogolari, F, Zetta, L, Molinari, H. | Deposit date: | 2005-05-23 | Release date: | 2006-01-31 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | NMR Dynamic Studies Suggest that Allosteric Activation Regulates Ligand Binding in Chicken Liver Bile Acid-binding Protein J.Biol.Chem., 281, 2006
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