2C36
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![BU of 2c36 by Molmil](/molmil-images/mine/2c36) | Structure of unliganded HSV gD reveals a mechanism for receptor- mediated activation of virus entry | Descriptor: | CHLORIDE ION, GLYCOPROTEIN D HSV-1, ZINC ION, ... | Authors: | Krummenacher, C, Supekar, V.M, Whitbeck, J.C, Lazear, E, Connolly, S.A, Eisenberg, R.J, Cohen, G.H, Wiley, D.C, Carfi, A. | Deposit date: | 2005-10-04 | Release date: | 2005-11-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Structure of unliganded HSV gD reveals a mechanism for receptor-mediated activation of virus entry. EMBO J., 24, 2005
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1NEJ
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![BU of 1nej by Molmil](/molmil-images/mine/1nej) | Crystalline Human Carbonmonoxy Hemoglobin S (Liganded Sickle Cell Hemoglobin) Exhibits The R2 Quaternary State At Neutral pH In The Presence Of Polyethylene Glycol: The 2.1 Angstrom Resolution Crystal Structure | Descriptor: | CARBON MONOXIDE, Hemoglobin alpha chain, Hemoglobin beta chain, ... | Authors: | Patskovska, L.N, Patskovsky, Y.V, Almo, S.C, Hirsch, R.E. | Deposit date: | 2002-12-11 | Release date: | 2003-12-16 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | COHbC and COHbS crystallize in the R2 quaternary state at neutral pH in the presence of PEG 4000. Acta Crystallogr.,Sect.D, 61, 2005
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2C5I
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![BU of 2c5i by Molmil](/molmil-images/mine/2c5i) | N-terminal domain of tlg1 complexed with N-terminus of vps51 in distorted conformation | Descriptor: | SULFATE ION, T-SNARE AFFECTING A LATE GOLGI COMPARTMENT PROTEIN 1, VACUOLAR PROTEIN SORTING PROTEIN 51 | Authors: | Fridmann-Sirkis, Y, Kent, H.M, Lewis, M.J, Evans, P.R, Pelham, H.R.B. | Deposit date: | 2005-10-27 | Release date: | 2006-01-25 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Analysis of the Interaction between the Snare Tlg1 and Vps51. Traffic, 7, 2006
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2BDD
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![BU of 2bdd by Molmil](/molmil-images/mine/2bdd) | Crystal Structure of Holo-ACP-synthase from Plasmodium yoelii | Descriptor: | ACP-synthase | Authors: | Dong, A, Melone, M, Zhao, Y, Lew, J, Koeieradzki, I, Alam, Z, Wasney, G, Vedadi, M, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Amani, M, Structural Genomics Consortium (SGC) | Deposit date: | 2005-10-20 | Release date: | 2005-11-01 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms. Mol.Biochem.Parasitol., 151, 2007
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2BLQ
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![BU of 2blq by Molmil](/molmil-images/mine/2blq) | Elastase After A High Dose X-Ray "Burn" | Descriptor: | CALCIUM ION, ELASTASE 1, SULFATE ION | Authors: | Nanao, M.H, Ravelli, R.B. | Deposit date: | 2005-03-08 | Release date: | 2005-09-07 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Improving Radiation-Damage Substructures for Rip. Acta Crystallogr.,Sect.D, 61, 2005
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1MRZ
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![BU of 1mrz by Molmil](/molmil-images/mine/1mrz) | Crystal structure of a flavin binding protein from Thermotoga Maritima, TM379 | Descriptor: | CITRIC ACID, Riboflavin kinase/FMN adenylyltransferase | Authors: | Wang, W, Kim, R, Jancarik, J, Yokota, H, Kim, S.-H, Berkeley Structural Genomics Center (BSGC) | Deposit date: | 2002-09-19 | Release date: | 2003-09-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of a flavin-binding protein from Thermotoga Maritima Proteins, 52, 2003
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1RI1
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![BU of 1ri1 by Molmil](/molmil-images/mine/1ri1) | Structure and mechanism of mRNA cap (guanine N-7) methyltransferase | Descriptor: | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, S-ADENOSYL-L-HOMOCYSTEINE, mRNA CAPPING ENZYME | Authors: | Fabrega, C, Hausmann, S, Shen, V, Shuman, S, Lima, C.D. | Deposit date: | 2003-11-16 | Release date: | 2004-02-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure and mechanism of mRNA cap (Guanine-n7) methyltransferase Mol.Cell, 13, 2004
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1MQR
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![BU of 1mqr by Molmil](/molmil-images/mine/1mqr) | THE CRYSTAL STRUCTURE OF ALPHA-D-GLUCURONIDASE (E386Q) FROM BACILLUS STEAROTHERMOPHILUS T-6 | Descriptor: | ALPHA-D-GLUCURONIDASE, GLYCEROL | Authors: | Golan, G, Shallom, D, Teplitsky, A, Zaide, G, Shulami, S, Baasov, T, Stojanoff, V, Thompson, A, Shoham, Y, Shoham, G. | Deposit date: | 2002-09-17 | Release date: | 2003-09-17 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structures of Geobacillus stearothermophilus {alpha}-Glucuronidase Complexed with Its Substrate and Products: MECHANISTIC IMPLICATIONS. J.Biol.Chem., 279, 2004
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1R53
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![BU of 1r53 by Molmil](/molmil-images/mine/1r53) | Crystal structure of the bifunctional chorismate synthase from Saccharomyces cerevisiae | Descriptor: | Chorismate synthase | Authors: | Quevillon-Cheruel, S, Leulliot, N, Meyer, P, Graille, M, Bremang, M, Blondeau, K, Sorel, I, Poupon, A, Janin, J, van Tilbeurgh, H. | Deposit date: | 2003-10-09 | Release date: | 2003-12-23 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the bifunctional chorismate synthase from Saccharomyces cerevisiae J.Biol.Chem., 279, 2004
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1MQQ
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![BU of 1mqq by Molmil](/molmil-images/mine/1mqq) | THE CRYSTAL STRUCTURE OF ALPHA-D-GLUCURONIDASE FROM BACILLUS STEAROTHERMOPHILUS T-1 COMPLEXED WITH GLUCURONIC ACID | Descriptor: | ALPHA-D-GLUCURONIDASE, GLYCEROL, alpha-D-glucopyranuronic acid | Authors: | Golan, G, Shallom, D, Teplitsky, A, Zaide, G, Shulami, S, Baasov, T, Stojanoff, V, Thompson, A, Shoham, Y, Shoham, G. | Deposit date: | 2002-09-17 | Release date: | 2003-09-17 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal structures of Geobacillus stearothermophilus alpha-glucuronidase complexed with its substrate and products: mechanistic implications. J.Biol.Chem., 279, 2004
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1MS1
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![BU of 1ms1 by Molmil](/molmil-images/mine/1ms1) | Monoclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA) | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, GLYCEROL, trans-sialidase | Authors: | Buschiazzo, A, Amaya, M.F, Cremona, M.L, Frasch, A.C, Alzari, P.M. | Deposit date: | 2002-09-19 | Release date: | 2003-03-25 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis Mol.Cell, 10, 2002
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1R22
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![BU of 1r22 by Molmil](/molmil-images/mine/1r22) | Crystal structure of the cyanobacterial metallothionein repressor SmtB (C14S/C61S/C121S mutant) in the Zn2alpha5-form | Descriptor: | Transcriptional repressor smtB, ZINC ION | Authors: | Eicken, C, Pennella, M.A, Chen, X, Koshlap, K.M, VanZile, M.L, Sacchettini, J.C, Giedroc, D.P. | Deposit date: | 2003-09-25 | Release date: | 2004-05-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A metal-ligand-mediated intersubunit allosteric switch in related SmtB/ArsR zinc sensor proteins. J.Mol.Biol., 333, 2003
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1MZ5
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![BU of 1mz5 by Molmil](/molmil-images/mine/1mz5) | Trypanosoma rangeli sialidase | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, sialidase | Authors: | Buschiazzo, A, Tavares, G.A, Campetella, O, Spinelli, S, Cremona, M.L, Paris, G, Amaya, M.F, Frasch, A.C.C, Alzari, P.M. | Deposit date: | 2002-10-05 | Release date: | 2002-10-16 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis of sialyltransferase activity in trypanosomal sialidases Embo J., 19, 2000
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1MV8
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![BU of 1mv8 by Molmil](/molmil-images/mine/1mv8) | 1.55 A crystal structure of a ternary complex of GDP-mannose dehydrogenase from Psuedomonas aeruginosa | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETIC ACID, GDP-mannose 6-dehydrogenase, ... | Authors: | Snook, C.F, Tipton, P.A, Beamer, L.J. | Deposit date: | 2002-09-24 | Release date: | 2003-05-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | The crystal structure of GDP-mannose
dehydrogenase: A key enzyme in alginate
biosynthesis of P. aeruginosa Biochemistry, 42, 2003
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1RGX
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![BU of 1rgx by Molmil](/molmil-images/mine/1rgx) | Crystal Structure of resisitin | Descriptor: | Resistin | Authors: | Patel, S.D, Rajala, M.W, Scherer, P.E, Shapiro, L, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2003-11-13 | Release date: | 2004-06-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.787 Å) | Cite: | Disulfide-dependent multimeric assembly of resistin family hormones Science, 304, 2004
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1MZO
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![BU of 1mzo by Molmil](/molmil-images/mine/1mzo) | Crystal structure of pyruvate formate-lyase with pyruvate | Descriptor: | PYRUVIC ACID, Pyruvate formate-lyase, TRIETHYLENE GLYCOL | Authors: | Lehtio, L, Leppanen, V.-M, Kozarich, J.W, Goldman, A. | Deposit date: | 2002-10-09 | Release date: | 2002-12-11 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of Escherichia coli pyruvate formate-lyase with pyruvate. Acta Crystallogr.,Sect.D, 58, 2002
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1MR5
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![BU of 1mr5 by Molmil](/molmil-images/mine/1mr5) | Orthorhombic form of Trypanosoma cruzi trans-sialidase | Descriptor: | trans-sialidase | Authors: | Buschiazzo, A, Amaya, M.F, Cremona, M.L, Frasch, A.C, Alzari, P.M. | Deposit date: | 2002-09-18 | Release date: | 2003-03-18 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis Mol.Cell, 10, 2002
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1MS8
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![BU of 1ms8 by Molmil](/molmil-images/mine/1ms8) | Triclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA) | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, trans-sialidase | Authors: | Buschiazzo, A, Amaya, M.F, Cremona, M.L, Frasch, A.C, Alzari, P.M. | Deposit date: | 2002-09-19 | Release date: | 2003-03-25 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis Mol.Cell, 10, 2002
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2C5K
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![BU of 2c5k by Molmil](/molmil-images/mine/2c5k) | N-terminal domain of tlg1 complexed with N-terminus of vps51 | Descriptor: | SULFATE ION, T-SNARE AFFECTING A LATE GOLGI COMPARTMENT PROTEIN 1, VACUOLAR PROTEIN SORTING PROTEIN 51 | Authors: | Fridmann-Sirkis, Y, Kent, H.M, Lewis, M.J, Evans, P.R, Pelham, H.R.B. | Deposit date: | 2005-10-27 | Release date: | 2006-01-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural Analysis of the Interaction between the Snare Tlg1 and Vps51. Traffic, 7, 2006
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2BEO
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![BU of 2beo by Molmil](/molmil-images/mine/2beo) | PrfA, Transcriptional Regulator In Listeria Monocytogenes | Descriptor: | ACETAMIDE, CHLORIDE ION, GLUTAMINE, ... | Authors: | Eiting, M, Hagelueken, G, Schubert, W.-D, Heinz, D.W. | Deposit date: | 2004-11-26 | Release date: | 2005-04-14 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The Mutation G145S in Prfa, a Key Virulence Regulator of Listeria Monocytogenes, Increases DNA-Binding Affinity by Stabilizing the Hth Motif Mol.Microbiol., 56, 2005
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1MQP
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![BU of 1mqp by Molmil](/molmil-images/mine/1mqp) | THE CRYSTAL STRUCTURE OF ALPHA-D-GLUCURONIDASE FROM BACILLUS STEAROTHERMOPHILUS T-6 | Descriptor: | GLYCEROL, alpha-D-glucuronidase | Authors: | Golan, G, Shallom, D, Teplitsky, A, Zaide, G, Shulami, S, Baasov, T, Stojanoff, V, Thompson, A, Shoham, Y, Shoham, G. | Deposit date: | 2002-09-17 | Release date: | 2003-09-23 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structures of Geobacillus stearothermophilus alpha-glucuronidase complexed with its substrate and products: mechanistic implications. J.Biol.Chem., 279, 2004
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2BSM
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![BU of 2bsm by Molmil](/molmil-images/mine/2bsm) | Novel, potent small molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design | Descriptor: | 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE, HEAT SHOCK PROTEIN HSP90-ALPHA | Authors: | Dymock, B.W, Barril, X, Brough, P.A, Cansfield, J.E, Massey, A, McDonald, E, Hubbard, R.E, Surgenor, A, Roughley, S.D, Webb, P, Workman, P, Wright, L, Drysdale, M.J. | Deposit date: | 2005-05-23 | Release date: | 2005-06-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design. J. Med. Chem., 48, 2005
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1N2N
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![BU of 1n2n by Molmil](/molmil-images/mine/1n2n) | Crystal structure of cyanide complex of the oxygenase domain of inducible nitric oxide synthase. | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, ARGININE, CYANIDE ION, ... | Authors: | Fedorov, R, Ghosh, D.K, Schlichting, I. | Deposit date: | 2002-10-23 | Release date: | 2003-02-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structures of cyanide complexes of P450cam and the oxygenase domain of inducible nitric oxide synthase-structural models of the short-lived oxygen complexes Arch.Biochem.Biophys., 409, 2003
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2BFF
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![BU of 2bff by Molmil](/molmil-images/mine/2bff) | Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch | Descriptor: | 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, ... | Authors: | Machius, M, Wynn, R.M, Chuang, J.L, Tomchick, D.R, Brautigam, C.A, Chuang, D.T. | Deposit date: | 2004-12-06 | Release date: | 2006-02-16 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain Alpha-Ketoacid Dehydrogenase. Structure, 14, 2006
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2BZS
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![BU of 2bzs by Molmil](/molmil-images/mine/2bzs) | Binding of anti-cancer prodrug CB1954 to the activating enzyme NQO2 revealed by the crystal structure of their complex. | Descriptor: | 5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE, FLAVIN-ADENINE DINUCLEOTIDE, NRH DEHYDROGENASE [QUINONE] 2, ... | Authors: | Abu Khader, M.M, Heap, J.T, De Matteis, C, Kellam, B, Doughty, S.W, Minton, N, Paoli, M. | Deposit date: | 2005-08-22 | Release date: | 2005-09-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Binding of the Anticancer Prodrug Cb1954 to the Activating Enzyme Nqo2 Revealed by the Crystal Structure of Their Complex. J.Med.Chem., 48, 2005
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