PDB: 92137 resultsInfo pagesStatus searchChemie searchBIRD

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8H7X	Crystal structure of EGFR T790M/C797S mutant in complex with brigatinib Descriptor: 5-chloro-N~4~-[2-(dimethylphosphoryl)phenyl]-N~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine, Epidermal growth factor receptor Authors: Kukimoto-Niino, M, Shirouzu, M. Deposit date: 2022-10-21 Release date: 2023-10-25 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (3.404 Å) Cite: A macrocyclic kinase inhibitor overcomes triple resistant mutations in EGFR-positive lung cancer. NPJ Precis Oncol, 8, 2024
6XVN	Crystal structure of c-Src SH3 domain without ATCUN motif: monomer 1 Descriptor: Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A, Plaza-Garrido, M. Deposit date: 2020-01-22 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
6XVM	Crystal structure of c-Src SH3 domain without ATCUN motif: monomer 2 Descriptor: GLYCEROL, Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A, Plaza-Garrido, M. Deposit date: 2020-01-22 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (0.9 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
6XVO	Crystal structure of the intertwined dimer of the c-Src SH3 domain without ATCUN motif Descriptor: DI(HYDROXYETHYL)ETHER, Proto-oncogene tyrosine-protein kinase Src, TRIETHYLENE GLYCOL Authors: Camara-Artigas, A, Plaza-Garrido, M. Deposit date: 2020-01-22 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
6XX4	Crystal structure of the c-Src SH3 domain H122R-Q128E mutant in complex with Ni(II) at pH 7.5 co-crystallized with methyl beta-cyclodextrin Descriptor: Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose, NICKEL (II) ION, Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A. Deposit date: 2020-01-26 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.05 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
6XX5	Crystal structure of the c-Src SH3 domain H122R-Q128K mutant in complex with Ni(II) at pH 7.5 co-crystallized with methyl beta-cyclodextrin Descriptor: Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose, NICKEL (II) ION, Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A. Deposit date: 2020-01-26 Release date: 2020-05-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.3 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
6XX2	Crystal structure of the c-Src SH3 domain H122R-Q128K mutant in complex with Cu(II) at pH 7.5 co-crystallized with methyl beta-cyclodextrin Descriptor: COPPER (II) ION, Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose, Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A. Deposit date: 2020-01-26 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.25 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
6XX3	Crystal structure of the c-Src SH3 domain H122R-Q128E mutant in complex with Cu(II) at pH 6.5 co-crystallized with methyl beta-cyclodextrin Descriptor: COPPER (II) ION, Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose, Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A. Deposit date: 2020-01-26 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.36 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
6WQW	Thermobacillus composti GH10 xylanase Descriptor: Beta-xylanase, beta-D-xylopyranose Authors: Briganti, L, Polikarpov, I. Deposit date: 2020-04-29 Release date: 2021-04-28 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.102 Å) Cite: Transformation of xylan into value-added biocommodities using Thermobacillus composti GH10 xylanase. Carbohydr Polym, 247, 2020
1IOP	INCORPORATION OF A HEMIN WITH THE SHORTEST ACID SIDE-CHAINS INTO MYOGLOBIN Descriptor: 6,7-DICARBOXYL-1,2,3,4,5,8-HEXAMETHYLHEMIN, CYANIDE ION, MYOGLOBIN, ... Authors: Igarashi, N, Neya, S, Funasaki, N, Tanaka, N. Deposit date: 1997-12-12 Release date: 1998-04-08 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure and function of 6,7-dicarboxyheme-substituted myoglobin Biochemistry, 37, 1998
8GDV	Structure of M66I mutant of disulfide stabilized HIV-1 CA hexamer in complex with CPSF6 peptide and IP6 Descriptor: Cleavage and polyadenylation specificity factor subunit 6, Gag polyprotein, INOSITOL HEXAKISPHOSPHATE Authors: Briganti, L, Schope, L, Kvaratskhelia, M. Deposit date: 2023-03-06 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Structure of M66I mutant of disulfide stabilized HIV-1 CA hexamer in complex with CPSF6 peptide and IP6 To Be Published
8AH7	Crystal Structure of the third PDZ domain of PSD-95 protein in the space group P212121 at pH 4.0 Descriptor: SULFATE ION, cDNA FLJ50577, highly similar to Discs large homolog 4 Authors: Camara-Artigas, A, Salinas-Garcia, M.C. Deposit date: 2022-07-20 Release date: 2023-03-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.25 Å) Cite: pH-Driven Polymorphic Behaviour of the Third PDZ Domain of PSD95: The Role of Electrostatic Interactions Crystals, 2023
7X15	Crystal structure of MIGA2 LD targeting domain Descriptor: DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, FORMIC ACID, Mitoguardin 2 Authors: Kim, H, Lee, C. Deposit date: 2022-02-23 Release date: 2022-09-14 Method: X-RAY DIFFRACTION (2.852 Å) Cite: Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites. Nat Commun, 13, 2022
7X14	Crystal structure of phospho-FFAT motif of MIGA2 bound to VAPB Descriptor: MIGA2 phospho FFAT motif, SULFATE ION, Vesicle-associated membrane protein-associated protein B Authors: Kim, H, Lee, C. Deposit date: 2022-02-23 Release date: 2022-09-14 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.675 Å) Cite: Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites. Nat Commun, 13, 2022
5LTV	LIGAND BINDING DOMAIN OF PSEUDOMONAS AERUGINOSA PAO1 AMINO ACID CHEMORECPETOR PCTC IN COMPLEX WITH GABA Descriptor: ACETATE ION, Chemotactic transducer PctC, GAMMA-AMINO-BUTANOIC ACID, ... Authors: Gavira, J.A, Rico-Jimenez, M, Conejero-Muriel, M, Krell, T. Deposit date: 2016-09-07 Release date: 2017-09-20 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.31 Å) Cite: How Bacterial Chemoreceptors Evolve Novel Ligand Specificities Mbio, 2020
8AH5	Crystal Structure of the third PDZ domain of PSD-95 protein in the space group P212121 at pH 4.6 Descriptor: ACETATE ION, cDNA FLJ50577, highly similar to Discs large homolog 4 Authors: Camara-Artigas, A, Salinas Garcia, M.C. Deposit date: 2022-07-20 Release date: 2023-03-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.25 Å) Cite: pH-Driven Polymorphic Behaviour of the Third PDZ Domain of PSD95: The Role of Electrostatic Interactions Crystals, 2023
5LTX	LIGAND BINDING DOMAIN OF PSEUDOMONAS AERUGINOSA PAO1 AMINO ACID CHEMORECEPTOR PCTA IN COMPLEX WITH L-MET Descriptor: ACETATE ION, Chemotaxis protein, FORMIC ACID, ... Authors: Gavira, J.A, Rico-Gimenez, M, Ortega, A, Conejero-Muriel, M, Zhulin, I, Krell, T. Deposit date: 2016-09-07 Release date: 2017-09-20 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.02 Å) Cite: How Bacterial Chemoreceptors Evolve Novel Ligand Specificities Mbio, 2020
8AH6	Crystal Structure of the third PDZ domain of PSD-95 protein in the space group P21 at pH 4.0 Descriptor: ACETATE ION, cDNA FLJ50577, highly similar to Discs large homolog 4 Authors: Camara-Artigas, A, Salinas Garcia, M.C. Deposit date: 2022-07-20 Release date: 2023-03-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.63 Å) Cite: pH-Driven Polymorphic Behaviour of the Third PDZ Domain of PSD95: The Role of Electrostatic Interactions Crystals, 2023
8AH8	Crystal Structure of the third PDZ domain of PSD-95 protein in the space group P3121 at pH 3.7 Descriptor: cDNA FLJ50577, highly similar to Discs large homolog 4 Authors: Camara-Artigas, A, Salinas Garcia, M.C. Deposit date: 2022-07-20 Release date: 2023-03-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.5 Å) Cite: pH-Driven Polymorphic Behaviour of the Third PDZ Domain of PSD95: The Role of Electrostatic Interactions Crystals, 2023
8AH4	Crystal Structure of the third PDZ domain of PSD-95 protein in the space group P3112 at pH 4.0 Descriptor: ACETATE ION, cDNA FLJ50577, highly similar to Discs large homolog 4 Authors: Camara-Artigas, A, Salinas Garcia, M.C. Deposit date: 2022-07-20 Release date: 2023-03-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.48 Å) Cite: pH-Driven Polymorphic Behaviour of the Third PDZ Domain of PSD95: The Role of Electrostatic Interactions Crystals, 2023
6S7N	Crystal structure of orthorhombic lysozyme grown at pH 5.5 with a 26% of solvent content Descriptor: Lysozyme C, SULFATE ION Authors: Camara-Artigas, A, Plaza-Garrido, M, Salinas-Garcia, M.C. Deposit date: 2019-07-05 Release date: 2019-11-20 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Major conformational changes in the structure of lysozyme obtained from a crystal with a very low solvent content. Acta Crystallogr.,Sect.F, 75, 2019
5MTW	Mycobacterium tuberculosis Rv1957 SecB-like chaperone in complex with a ChAD peptide from Rv1956 HigA1 antitoxin Descriptor: Antitoxin HigA1, CALCIUM ION, DIMETHYL SULFOXIDE, ... Authors: Guillet, V, Mourey, L. Deposit date: 2017-01-10 Release date: 2018-10-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Structural insights into chaperone addiction of toxin-antitoxin systems. Nat Commun, 10, 2019
6QDB	Leishmania major N-myristoyltransferase in complex with thienopyrimidine inhibitor IMP-0000081 Descriptor: 3-[methyl-[2-[methyl(piperidin-4-yl)amino]thieno[3,2-d]pyrimidin-4-yl]amino]propanenitrile, Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, ... Authors: Brannigan, J.A. Deposit date: 2019-01-01 Release date: 2020-05-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. J.Med.Chem., 63, 2020
6QDA	Leishmania major N-myristoyltransferase in complex with quinazoline inhibitor IMP-0000811 Descriptor: 3-[methyl-[2-[methyl-(1-methylpiperidin-4-yl)amino]quinazolin-4-yl]amino]propanenitrile, Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, ... Authors: Brannigan, J.A. Deposit date: 2019-01-01 Release date: 2020-05-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. J.Med.Chem., 63, 2020
6QDG	Leishmania major N-myristoyltransferase in complex with quinazoline inhibitor IMP-0000169 Descriptor: 3-[[6-bromanyl-2-[3-(dimethylamino)propyl-methyl-amino]quinazolin-4-yl]-methyl-amino]propanenitrile, Glycylpeptide N-tetradecanoyltransferase, MAGNESIUM ION, ... Authors: Brannigan, J.A. Deposit date: 2019-01-01 Release date: 2020-05-06 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Novel Thienopyrimidine Inhibitors of Leishmania N -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. J.Med.Chem., 63, 2020

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