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8R3V
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BU of 8r3v by Molmil
Escherichia coli paused disome complex (non-rotated disome interface)
Descriptor: 1,4-DIAMINOBUTANE, 16S ribosomal RNA, 23S ribosomal RNA, ...
Authors:Fluegel, T, Schacherl, M.
Deposit date:2023-11-10
Release date:2024-03-06
Last modified:2025-03-12
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Transient disome complex formation in native polysomes during ongoing protein synthesis captured by cryo-EM.
Nat Commun, 15, 2024
8G8G
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BU of 8g8g by Molmil
Interaction of H3 tail in LIN28B nucleosome with Oct4
Descriptor: Histone H2A, Histone H2B, Histone H3, ...
Authors:Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M.
Deposit date:2023-02-17
Release date:2023-03-22
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Histone modifications regulate pioneer transcription factor cooperativity.
Nature, 619, 2023
2V22
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BU of 2v22 by Molmil
REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors
Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, N~2~-{[1-(4-CHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOL-3-YL]CARBONYL}-N~5~-(DIAMINOMETHYLIDENE)-L-ORNITHYL-L-LEUCYL-L-ISOLEUCYL-4-FLUORO-L-PHENYLALANINAMIDE
Authors:Andrews, M.J, Kontopidis, G, McInnes, C, Plater, A, Innes, L, Cowan, A, Jewsbury, P, Fischer, P.M.
Deposit date:2007-05-31
Release date:2008-01-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Replace: A Strategy for Iterative Design of Cyclin- Binding Groove Inhibitors
Chembiochem, 7, 2006
8PEG
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BU of 8peg by Molmil
Escherichia coli paused disome complex (queueing 70S non-rotated closed PRE state)
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S1, ...
Authors:Fluegel, T, Schacherl, M.
Deposit date:2023-06-13
Release date:2024-03-06
Last modified:2025-03-12
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Transient disome complex formation in native polysomes during ongoing protein synthesis captured by cryo-EM.
Nat Commun, 15, 2024
5QS6
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BU of 5qs6 by Molmil
PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z44592329
Descriptor: N-phenyl-N'-pyridin-3-ylurea, T-box transcription factor T
Authors:Newman, J.A, Gavard, A.E, Sherestha, L, Fernandez-Cid, A, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-06-19
Release date:2019-08-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:PanDDA analysis group deposition
To Be Published
8G88
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BU of 8g88 by Molmil
Human Oct4 bound to nucleosome with human nMatn1 sequence
Descriptor: Histone H2A, Histone H2B, Histone H3, ...
Authors:Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M.
Deposit date:2023-02-17
Release date:2023-03-22
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Histone modifications regulate pioneer transcription factor cooperativity.
Nature, 619, 2023
8G8B
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BU of 8g8b by Molmil
Nucleosome with human nMatn1 sequence in complex with Human Oct4
Descriptor: Histone H2A, Histone H2B, Histone H3, ...
Authors:Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M.
Deposit date:2023-02-17
Release date:2023-03-22
Last modified:2025-05-14
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Histone modifications regulate pioneer transcription factor cooperativity.
Nature, 619, 2023
8AT6
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BU of 8at6 by Molmil
Cryo-EM structure of yeast Elp456 subcomplex
Descriptor: Elongator complex protein 4, Elongator complex protein 5, Elongator complex protein 6
Authors:Jaciuk, M, Scherf, D, Kaszuba, K, Gaik, M, Koscielniak, A, Krutyholowa, R, Rawski, M, Indyka, P, Biela, A, Dobosz, D, Lin, T.-Y, Abbassi, N, Hammermeister, A, Chramiec-Glabik, A, Kosinski, J, Schaffrath, R, Glatt, S.
Deposit date:2022-08-22
Release date:2022-12-07
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM structure of the fully assembled Elongator complex.
Nucleic Acids Res., 51, 2023
7WU0
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BU of 7wu0 by Molmil
Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-B3
Descriptor: 18S rRNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ...
Authors:Cheng, J, Lau, B, Thoms, M, Ameismeier, M, Berninghausen, O, Hurt, E, Beckmann, R.
Deposit date:2022-02-05
Release date:2022-10-19
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:The nucleoplasmic phase of pre-40S formation prior to nuclear export.
Nucleic Acids Res., 50, 2022
7WTZ
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BU of 7wtz by Molmil
Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-B2
Descriptor: 18S rRNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ...
Authors:Cheng, J, Lau, B, Thoms, M, Ameismeier, M, Berninghausen, O, Hurt, E, Beckmann, R.
Deposit date:2022-02-05
Release date:2022-10-19
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3 Å)
Cite:The nucleoplasmic phase of pre-40S formation prior to nuclear export.
Nucleic Acids Res., 50, 2022
7WTX
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BU of 7wtx by Molmil
Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-B1
Descriptor: 18S rRNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ...
Authors:Cheng, J, Lau, B, Thoms, M, Ameismeier, M, Berninghausen, O, Hurt, E, Beckmann, R.
Deposit date:2022-02-05
Release date:2022-10-19
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:The nucleoplasmic phase of pre-40S formation prior to nuclear export.
Nucleic Acids Res., 50, 2022
4UUS
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BU of 4uus by Molmil
CRYSTAL STRUCTURE OF A UBX-EXD-DNA COMPLEX INCLUDING THE UBDA MOTIF
Descriptor: 5'-D(*AP*CP*GP*TP*GP*AP*TP*TP*TP*AP*TP*GP*GP*CP*G)-3', 5'-D(*GP*TP*CP*GP*CP*CP*AP*TP*AP*AP*AP*TP*CP*AP*C)-3', HOMEOTIC PROTEIN EXTRADENTICLE, ...
Authors:Foos, N, Mate, M.J, Ortiz-Lombardia, M.
Deposit date:2014-07-31
Release date:2015-02-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:A Flexible Extension of the Drosophila Ultrabithorax Homeodomain Defines a Novel Hox/Pbc Interaction Mode.
Structure, 23, 2015
4UUT
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BU of 4uut by Molmil
Crystal structure of the Ultrabithorax protein
Descriptor: CHLORIDE ION, HOMEOTIC PROTEIN ULTRABITHORAX, SULFATE ION
Authors:Foos, N, Mate, M.J, Ortiz-Lombardia, M.
Deposit date:2014-07-31
Release date:2015-02-18
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A Flexible Extension of the Drosophila Ultrabithorax Homeodomain Defines a Novel Hox/Pbc Interaction Mode.
Structure, 23, 2015
9N3R
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BU of 9n3r by Molmil
Crystal structure of PRMT5:MEP50 in complex with MTA and TNG462
Descriptor: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, ...
Authors:Whittington, D.A.
Deposit date:2025-01-31
Release date:2025-03-12
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion.
J.Med.Chem., 68, 2025
9N3N
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BU of 9n3n by Molmil
Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 3
Descriptor: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, ...
Authors:Whittington, D.A.
Deposit date:2025-01-31
Release date:2025-03-12
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion.
J.Med.Chem., 68, 2025
9N3O
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BU of 9n3o by Molmil
Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 14
Descriptor: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, ...
Authors:Whittington, D.A.
Deposit date:2025-01-31
Release date:2025-03-12
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion.
J.Med.Chem., 68, 2025
9N3Q
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BU of 9n3q by Molmil
Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 51
Descriptor: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein 50, ...
Authors:Whittington, D.A.
Deposit date:2025-01-31
Release date:2025-03-12
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion.
J.Med.Chem., 68, 2025
9N3P
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BU of 9n3p by Molmil
Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 30
Descriptor: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, ...
Authors:Whittington, D.A.
Deposit date:2025-01-31
Release date:2025-03-12
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion.
J.Med.Chem., 68, 2025
8R1G
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BU of 8r1g by Molmil
Dimeric ternary structure of E6AP-E6-p53
Descriptor: Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ...
Authors:Sandate, C.R, Chakrabory, D, Kater, L, Kempf, G, Thoma, N.H.
Deposit date:2023-11-01
Release date:2023-12-06
Last modified:2025-07-09
Method:ELECTRON MICROSCOPY (3.99 Å)
Cite:Structural insights into viral hijacking of p53 by E6 and E6AP
Biorxiv, 2023
9MRE
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BU of 9mre by Molmil
From DNA-Encoded Library Screening to AM-9747 - an MTA-Cooperative PRMT5 Inhibitor with Potent Oral in vivo Efficacy
Descriptor: 2-amino-3-methyl-N-[(1R)-1-(pyrimidin-2-yl)ethyl]-N-{[5-(trifluoromethyl)pyridin-2-yl]methyl}quinoline-6-carboxamide, 5'-DEOXY-5'-METHYLTHIOADENOSINE, DI(HYDROXYETHYL)ETHER, ...
Authors:GhimireRijal, S, Mukund, S.
Deposit date:2025-01-07
Release date:2025-03-26
Last modified:2025-04-02
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:From DNA-Encoded Library Screening to AM-9747 : An MTA-Cooperative PRMT5 Inhibitor with Potent Oral In Vivo Efficacy.
J.Med.Chem., 68, 2025
3DDQ
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BU of 3ddq by Molmil
Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor roscovitine
Descriptor: Cell division protein kinase 2, Cyclin-A2, MONOTHIOGLYCEROL, ...
Authors:Echalier, A, Endicott, J.A.
Deposit date:2008-06-06
Release date:2008-07-22
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases.
Oncogene, 27, 2008
8R1F
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BU of 8r1f by Molmil
Monomeric E6AP-E6-p53 ternary complex
Descriptor: Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ...
Authors:Sandate, C.R, Chakraborty, D, Kater, L, Kempf, G, Thoma, N.H.
Deposit date:2023-11-01
Release date:2023-12-06
Last modified:2025-07-09
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Structural insights into viral hijacking of p53 by E6 and E6AP
Biorxiv, 2023
5XQM
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BU of 5xqm by Molmil
NMR solution structure of SMO1, Sumo homologue in Caenorhabditis elegans
Descriptor: Small ubiquitin-related modifier
Authors:Gowda, C.M, Surana, P, Das, R.
Deposit date:2017-06-07
Release date:2017-11-08
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural and functional analysis of SMO-1, the SUMO homolog in Caenorhabditis elegans
PLoS ONE, 12, 2017
8REV
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BU of 8rev by Molmil
Structure of XPD stalled at a Y-fork DNA containing a interstrand crosslink
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase CHL1, DNA (46-MER), ...
Authors:Kuper, J, Hove, T, Kisker, C.
Deposit date:2023-12-12
Release date:2024-05-29
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:XPD stalled on cross-linked DNA provides insight into damage verification.
Nat.Struct.Mol.Biol., 31, 2024
8VG1
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BU of 8vg1 by Molmil
Cryo-EM structure of FoxA1 and GATA4 in complex with ALBN1 nucleosome
Descriptor: DNA (171-MER), Hepatocyte nuclear factor 3-alpha, Histone H2A type 1-B/E, ...
Authors:Zhou, B.R, Bai, Y.
Deposit date:2023-12-22
Release date:2024-08-07
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (2.48 Å)
Cite:Structural insights into the cooperative nucleosome recognition and chromatin opening by FOXA1 and GATA4.
Mol.Cell, 84, 2024

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數據於2025-07-09公開中

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