8R3V
 
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8G8G
 
 | Interaction of H3 tail in LIN28B nucleosome with Oct4 | Descriptor: | Histone H2A, Histone H2B, Histone H3, ... | Authors: | Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M. | Deposit date: | 2023-02-17 | Release date: | 2023-03-22 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Histone modifications regulate pioneer transcription factor cooperativity. Nature, 619, 2023
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2V22
 
 | REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors | Descriptor: | CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, N~2~-{[1-(4-CHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOL-3-YL]CARBONYL}-N~5~-(DIAMINOMETHYLIDENE)-L-ORNITHYL-L-LEUCYL-L-ISOLEUCYL-4-FLUORO-L-PHENYLALANINAMIDE | Authors: | Andrews, M.J, Kontopidis, G, McInnes, C, Plater, A, Innes, L, Cowan, A, Jewsbury, P, Fischer, P.M. | Deposit date: | 2007-05-31 | Release date: | 2008-01-29 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Replace: A Strategy for Iterative Design of Cyclin- Binding Groove Inhibitors Chembiochem, 7, 2006
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8PEG
 
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5QS6
 
 | PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z44592329 | Descriptor: | N-phenyl-N'-pyridin-3-ylurea, T-box transcription factor T | Authors: | Newman, J.A, Gavard, A.E, Sherestha, L, Fernandez-Cid, A, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | Deposit date: | 2019-06-19 | Release date: | 2019-08-21 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | PanDDA analysis group deposition To Be Published
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8G88
 
 | Human Oct4 bound to nucleosome with human nMatn1 sequence | Descriptor: | Histone H2A, Histone H2B, Histone H3, ... | Authors: | Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M. | Deposit date: | 2023-02-17 | Release date: | 2023-03-22 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | Histone modifications regulate pioneer transcription factor cooperativity. Nature, 619, 2023
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8G8B
 
 | Nucleosome with human nMatn1 sequence in complex with Human Oct4 | Descriptor: | Histone H2A, Histone H2B, Histone H3, ... | Authors: | Sinha, K.K, Bilokapic, S, Du, Y, Malik, D, Halic, M. | Deposit date: | 2023-02-17 | Release date: | 2023-03-22 | Last modified: | 2025-05-14 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Histone modifications regulate pioneer transcription factor cooperativity. Nature, 619, 2023
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8AT6
 
 | Cryo-EM structure of yeast Elp456 subcomplex | Descriptor: | Elongator complex protein 4, Elongator complex protein 5, Elongator complex protein 6 | Authors: | Jaciuk, M, Scherf, D, Kaszuba, K, Gaik, M, Koscielniak, A, Krutyholowa, R, Rawski, M, Indyka, P, Biela, A, Dobosz, D, Lin, T.-Y, Abbassi, N, Hammermeister, A, Chramiec-Glabik, A, Kosinski, J, Schaffrath, R, Glatt, S. | Deposit date: | 2022-08-22 | Release date: | 2022-12-07 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM structure of the fully assembled Elongator complex. Nucleic Acids Res., 51, 2023
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7WU0
 
 | Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-B3 | Descriptor: | 18S rRNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | Authors: | Cheng, J, Lau, B, Thoms, M, Ameismeier, M, Berninghausen, O, Hurt, E, Beckmann, R. | Deposit date: | 2022-02-05 | Release date: | 2022-10-19 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | The nucleoplasmic phase of pre-40S formation prior to nuclear export. Nucleic Acids Res., 50, 2022
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7WTZ
 
 | Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-B2 | Descriptor: | 18S rRNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | Authors: | Cheng, J, Lau, B, Thoms, M, Ameismeier, M, Berninghausen, O, Hurt, E, Beckmann, R. | Deposit date: | 2022-02-05 | Release date: | 2022-10-19 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | The nucleoplasmic phase of pre-40S formation prior to nuclear export. Nucleic Acids Res., 50, 2022
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7WTX
 
 | Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-B1 | Descriptor: | 18S rRNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | Authors: | Cheng, J, Lau, B, Thoms, M, Ameismeier, M, Berninghausen, O, Hurt, E, Beckmann, R. | Deposit date: | 2022-02-05 | Release date: | 2022-10-19 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | The nucleoplasmic phase of pre-40S formation prior to nuclear export. Nucleic Acids Res., 50, 2022
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4UUS
 
 | CRYSTAL STRUCTURE OF A UBX-EXD-DNA COMPLEX INCLUDING THE UBDA MOTIF | Descriptor: | 5'-D(*AP*CP*GP*TP*GP*AP*TP*TP*TP*AP*TP*GP*GP*CP*G)-3', 5'-D(*GP*TP*CP*GP*CP*CP*AP*TP*AP*AP*AP*TP*CP*AP*C)-3', HOMEOTIC PROTEIN EXTRADENTICLE, ... | Authors: | Foos, N, Mate, M.J, Ortiz-Lombardia, M. | Deposit date: | 2014-07-31 | Release date: | 2015-02-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | A Flexible Extension of the Drosophila Ultrabithorax Homeodomain Defines a Novel Hox/Pbc Interaction Mode. Structure, 23, 2015
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4UUT
 
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9N3R
 
 | Crystal structure of PRMT5:MEP50 in complex with MTA and TNG462 | Descriptor: | 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, ... | Authors: | Whittington, D.A. | Deposit date: | 2025-01-31 | Release date: | 2025-03-12 | Last modified: | 2025-03-19 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion. J.Med.Chem., 68, 2025
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9N3N
 
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9N3O
 
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9N3Q
 
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9N3P
 
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8R1G
 
 | Dimeric ternary structure of E6AP-E6-p53 | Descriptor: | Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... | Authors: | Sandate, C.R, Chakrabory, D, Kater, L, Kempf, G, Thoma, N.H. | Deposit date: | 2023-11-01 | Release date: | 2023-12-06 | Last modified: | 2025-07-09 | Method: | ELECTRON MICROSCOPY (3.99 Å) | Cite: | Structural insights into viral hijacking of p53 by E6 and E6AP Biorxiv, 2023
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9MRE
 
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3DDQ
 
 | Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor roscovitine | Descriptor: | Cell division protein kinase 2, Cyclin-A2, MONOTHIOGLYCEROL, ... | Authors: | Echalier, A, Endicott, J.A. | Deposit date: | 2008-06-06 | Release date: | 2008-07-22 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene, 27, 2008
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8R1F
 
 | Monomeric E6AP-E6-p53 ternary complex | Descriptor: | Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... | Authors: | Sandate, C.R, Chakraborty, D, Kater, L, Kempf, G, Thoma, N.H. | Deposit date: | 2023-11-01 | Release date: | 2023-12-06 | Last modified: | 2025-07-09 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | Structural insights into viral hijacking of p53 by E6 and E6AP Biorxiv, 2023
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5XQM
 
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8REV
 
 | Structure of XPD stalled at a Y-fork DNA containing a interstrand crosslink | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase CHL1, DNA (46-MER), ... | Authors: | Kuper, J, Hove, T, Kisker, C. | Deposit date: | 2023-12-12 | Release date: | 2024-05-29 | Last modified: | 2024-10-30 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | XPD stalled on cross-linked DNA provides insight into damage verification. Nat.Struct.Mol.Biol., 31, 2024
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8VG1
 
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