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1FLJ	CRYSTAL STRUCTURE OF S-GLUTATHIOLATED CARBONIC ANHYDRASE III Descriptor: CARBONIC ANHYDRASE III, GLUTATHIONE, ZINC ION Authors: Mallis, R.J, Poland, B.W, Chatterjee, T.K, Fisher, R.A, Darmawan, S, Honzatko, R.B, Thomas, J.A. Deposit date: 2000-08-14 Release date: 2000-09-04 Last modified: 2017-10-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of S-glutathiolated carbonic anhydrase III. FEBS Lett., 482, 2000
1YO1	Proton Transfer from His200 in Human Carbonic Anhydrase II Descriptor: Carbonic anhydrase II, SULFATE ION, ZINC ION Authors: Bhatt, D, Tu, C, Fisher, S.Z, Hernandez Prada, J.A, McKenna, R, Silverman, D.N. Deposit date: 2005-01-26 Release date: 2005-09-20 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Proton transfer in a Thr200His mutant of human carbonic anhydrase II Proteins, 61, 2005
3DV7	Role of Hydrophilic Residues in Proton Transfer During Catalysis by Human Carbonic Anhydrase II (N62A) Descriptor: Carbonic anhydrase 2, ZINC ION Authors: Avvaru, B.S. Deposit date: 2008-07-18 Release date: 2008-11-11 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II. Biochemistry, 47, 2008
1YO2	Proton Transfer from His200 in Human Carbonic Anhydrase II Descriptor: Carbonic anhydrase II, ZINC ION Authors: Bhatt, D, Tu, C, Fisher, S.Z, Hernandez Prada, J.A, McKenna, R, Silverman, D.N. Deposit date: 2005-01-26 Release date: 2005-09-20 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Proton transfer in a Thr200His mutant of human carbonic anhydrase II Proteins, 61, 2005
4E3G	Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors Descriptor: Carbonic anhydrase 2, GLYCEROL, MERCURIBENZOIC ACID, ... Authors: Cohen, S.M, Martin, D.P. Deposit date: 2012-03-09 Release date: 2012-06-27 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors Chem.Commun.(Camb.), 48, 2012
4E3H	Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors Descriptor: Carbonic anhydrase 2, MERCURIBENZOIC ACID, ZINC ION, ... Authors: Cohen, S.M, Martin, D.P. Deposit date: 2012-03-09 Release date: 2012-06-27 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors Chem.Commun.(Camb.), 48, 2012
4E49	Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors Descriptor: Carbonic anhydrase 2, MERCURIBENZOIC ACID, RESORCINOL, ... Authors: Cohen, S.M, Martin, D.P. Deposit date: 2012-03-12 Release date: 2012-06-27 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors Chem.Commun.(Camb.), 48, 2012
4CNR	Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture Descriptor: CARBONIC ANHYDRASE 2, ZINC ION Authors: Warden, A, Newman, J, Peat, T.S, Seabrook, S, Williams, M, Dojchinov, G, Haritos, V. Deposit date: 2014-01-24 Release date: 2015-02-04 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.29 Å) Cite: Rational Engineering of a Mesohalophilic Carbonic Anhydrase to an Extreme Halotolerant Biocatalyst. Nat.Commun., 6, 2015
4CNX	Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture Descriptor: CARBONIC ANHYDRASE 2, DI(HYDROXYETHYL)ETHER, ZINC ION Authors: Warden, A, Newman, J, Peat, T.S, Seabrook, S, Williams, M, Dojchinov, G, Haritos, V. Deposit date: 2014-01-25 Release date: 2015-02-04 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.23 Å) Cite: Rational Engineering of a Mesohalophilic Carbonic Anhydrase to an Extreme Halotolerant Biocatalyst. Nat.Commun., 6, 2015
4CNV	Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture Descriptor: CARBONIC ANHYDRASE 2, GLYCEROL, ZINC ION Authors: Warden, A, Newman, J, Peat, T.S, Seabrook, S, Williams, M, Dojchinov, G, Haritos, V. Deposit date: 2014-01-25 Release date: 2015-02-04 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Rational Engineering of a Mesohalophilic Carbonic Anhydrase to an Extreme Halotolerant Biocatalyst. Nat.Commun., 6, 2015
1Z97	Human Carbonic Anhydrase III: Structural and Kinetic Study of Catalysis and Proton Transfer. Descriptor: Carbonic anhydrase III, ZINC ION Authors: Duda, D.M, Tu, C, Fisher, S.Z, An, H, Yoshioka, C, Govindasamy, L, Laipis, P.J, Agbandje-McKenna, M, Silverman, D.N, McKenna, R. Deposit date: 2005-03-31 Release date: 2005-08-09 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Human Carbonic Anhydrase III: Structural and Kinetic Study of Catalysis and Proton Transfer Biochemistry, 44, 2005
1Z93	Human Carbonic Anhydrase III:Structural and Kinetic study of Catalysis and Proton Transfer. Descriptor: Carbonic anhydrase III, ZINC ION Authors: Duda, D.M, Tu, C, Fisher, S.Z, An, H, Yoshioka, C, Govindasamy, L, Laipis, P.J, Agbandje-McKenna, M, Silverman, D.N, McKenna, R. Deposit date: 2005-03-31 Release date: 2005-08-09 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Human Carbonic Anhydrase III: Structural and Kinetic Study of Catalysis and Proton Transfer Biochemistry, 44, 2005
3FE4	Crystal Structure of Human Carbonic Anhydrase vi Descriptor: Carbonic anhydrase 6, GLYCEROL, MAGNESIUM ION Authors: Pilka, E.S, Kochan, G, Krysztofinska, E, Muniz, J, Yue, W.W, Roos, A.K, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, Oppermann, U, Structural Genomics Consortium (SGC) Deposit date: 2008-11-27 Release date: 2008-12-16 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor development Biochem.Biophys.Res.Commun., 419, 2012
6HWZ	Selenols: a new class of Carbonic Anhydrase inhibitors Descriptor: Carbonic anhydrase 1, ZINC ION, benzeneselenol Authors: Angeli, A, Ferraroni, M. Deposit date: 2018-10-15 Release date: 2018-12-26 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Selenols: a new class of carbonic anhydrase inhibitors. Chem. Commun. (Camb.), 55, 2019
5CXK	Crystal structure of beta carbonic anhydrase from Vibrio cholerae Descriptor: BICARBONATE ION, Carbonic anhydrase, ZINC ION Authors: Ferraroni, M, Supuran, C. Deposit date: 2015-07-29 Release date: 2015-12-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure and kinetic studies of a tetrameric type II beta-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae. Acta Crystallogr.,Sect.D, 71, 2015
6Y04	Crystal structure of beta-carbonic anhydrase isoform I (TvaCA1) from the Trichomonas vaginalis protozoan. Descriptor: Carbonic anhydrase, ZINC ION Authors: Di Fiore, A, De Simone, G. Deposit date: 2020-02-06 Release date: 2020-07-08 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.48 Å) Cite: Biochemical and structural characterisation of a protozoan beta-carbonic anhydrase fromTrichomonas vaginalis. J Enzyme Inhib Med Chem, 35, 2020
1HEB	STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Nair, S.K, Christianson, D.W. Deposit date: 1992-07-16 Release date: 1992-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II. Biochemistry, 32, 1993
1HEC	STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Nair, S.K, Christianson, D.W. Deposit date: 1992-07-16 Release date: 1992-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II. Biochemistry, 32, 1993
1HED	STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Nair, S.K, Christianson, D.W. Deposit date: 1992-07-16 Release date: 1992-10-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II. Biochemistry, 32, 1993
5EIJ	Carbonic Anhydrase II in complex with Sulfonamide Inhibitor Descriptor: 1-(3-iodanylphenyl)-3-(4-sulfamoylphenyl)thiourea, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... Authors: Lomelino, C.L, Mahon, B.P, McKenna, R. Deposit date: 2015-10-29 Release date: 2016-11-09 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111. Bioorg. Med. Chem., 24, 2016
4M2W	Genetically engineered Carbonic Anhydrase IX in complex with Dorzolamide Descriptor: (4S-TRANS)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE, Carbonic anhydrase 2, ZINC ION Authors: Pinard, M.P, Boone, C.D, Rife, B.D, Supuran, C.T, McKenna, R. Deposit date: 2013-08-05 Release date: 2013-11-06 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.658 Å) Cite: Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases. Bioorg.Med.Chem., 21, 2013
4M2V	Genetically engineered Carbonic Anhydrase IX in complex with Brinzolamide Descriptor: (+)-4-ETHYLAMINO-3,4-DIHYDRO-2-(METHOXY)PROPYL-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE, Carbonic anhydrase 2, ZINC ION Authors: Pinard, M.P, Boone, C.D, Rife, B.D, Supuran, C.T, Mckenna, R. Deposit date: 2013-08-05 Release date: 2013-11-06 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.718 Å) Cite: Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases. Bioorg.Med.Chem., 21, 2013
3DAZ	Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties Descriptor: Carbonic anhydrase 2, N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide, ZINC ION Authors: Genis, C, Sippel, K.H, Case, N, Govindasamy, L, Agbandje-Mckenna, M, Mckenna, R. Deposit date: 2008-05-30 Release date: 2009-03-03 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties Biochemistry, 48, 2009
3E24	H. influenzae beta-carbonic anhydrase, variant W39F Descriptor: Carbonic anhydrase 2, PHOSPHATE ION, ZINC ION Authors: Rowlett, R.S, Lee, J. Deposit date: 2008-08-05 Release date: 2009-06-02 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.301 Å) Cite: Allosteric site variants of Haemophilus influenzae beta-carbonic anhydrase. Biochemistry, 48, 2009
3E3G	H. influenzae beta-carbonic anhydrase, variant G41A Descriptor: Carbonic anhydrase 2, SULFATE ION, ZINC ION Authors: Rowlett, R.S, Failing, H. Deposit date: 2008-08-07 Release date: 2009-08-18 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Evidence for a bicarbonate "escort" site in Haemophilus influenzae beta-carbonic anhydrase . Biochemistry, 49, 2010

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