6GCY
Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (saccharin-sugar conjugate complex)
Summary for 6GCY
| Entry DOI | 10.2210/pdb6gcy/pdb |
| Related | 6fji 6fjj |
| Descriptor | Carbonic anhydrase 2, ZINC ION, [1-(1,1-dioxido-3-oxo-2,3-dihydro-1,2-benzothiazol-6-yl)-1H-1,2,3-triazol-4-yl]methyl alpha-L-idopyranoside, ... (4 entities in total) |
| Functional Keywords | proton transfer, carbonic anhydrase, lyase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 29708.70 |
| Authors | Fisher, S.Z.,Koruza, K. (deposition date: 2018-04-20, release date: 2019-02-06, Last modification date: 2019-03-06) |
| Primary citation | Koruza, K.,Mahon, B.P.,Blakeley, M.P.,Ostermann, A.,Schrader, T.E.,McKenna, R.,Knecht, W.,Fisher, S.Z. Using neutron crystallography to elucidate the basis of selective inhibition of carbonic anhydrase by saccharin and a derivative. J. Struct. Biol., 205:147-154, 2019 Cited by PubMed: 30639924DOI: 10.1016/j.jsb.2018.12.009 PDB entries with the same primary citation |
| Experimental method | NEUTRON DIFFRACTION (2 Å) X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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