6GCY
Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (saccharin-sugar conjugate complex)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Carbonic anhydrase 2 | polymer | 260 | 29200.9 | 1 | UniProt (P00918) Pfam (PF00194) | Homo sapiens (Human) | Carbonate dehydratase II,Carbonic anhydrase C,CAC,Carbonic anhydrase II,CA-II |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | [1-(1,1-dioxido-3-oxo-2,3-dihydro-1,2-benzothiazol-6-yl)-1H-1,2,3-triazol-4-yl]methyl alpha-L-idopyranoside | non-polymer | 442.4 | 1 | Chemie (3QR) | |||
| 4 | D (A) | water | water | 18.0 | 208 | Chemie (DOD) |
Sequence modifications
A: 1 - 260 (UniProt: P00918)
| PDB | External Database | Details |
|---|---|---|
| Ser 65 | Ala 65 | engineered mutation |
| Gln 67 | Asn 67 | engineered mutation |
| Thr 69 | Glu 69 | engineered mutation |
| Leu 91 | Ile 91 | engineered mutation |
| Val 130 | Phe 130 | engineered mutation |
| Glu 169 | Lys 169 | engineered mutation |
| Ala 203 | Leu 203 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29200.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 507.8 | |
| All* | Total formula weight | 29708.7 |
