6GCY
Joint neutron and x-ray crystal structure of human carbonic anhydrase IX mimic (saccharin-sugar conjugate complex)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Carbonic anhydrase 2 | polymer | 260 | 29200.9 | 1 | UniProt (P00918) Pfam (PF00194) In PDB | Homo sapiens (Human) | Carbonate dehydratase II,Carbonic anhydrase C,CAC,Carbonic anhydrase II,CA-II |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | [1-(1,1-dioxido-3-oxo-2,3-dihydro-1,2-benzothiazol-6-yl)-1H-1,2,3-triazol-4-yl]methyl alpha-L-idopyranoside | non-polymer | 442.4 | 1 | Chemie (3QR) | |||
4 | water | water | 18.0 | 208 | Chemie (DOD) |
Sequence modifications
A: 1 - 260 (UniProt: P00918)
PDB | External Database | Details |
---|---|---|
Ser 65 | Ala 65 | engineered mutation |
Gln 67 | Asn 67 | engineered mutation |
Thr 69 | Glu 69 | engineered mutation |
Leu 91 | Ile 91 | engineered mutation |
Val 130 | Phe 130 | engineered mutation |
Glu 169 | Lys 169 | engineered mutation |
Ala 203 | Leu 203 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 29200.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 507.8 | |
All* | Total formula weight | 29708.7 |