5A6H

Synthesis, carbonic anhydrase inhibition and protein X-ray structure of the unusual natural product primary sulfonamide Psammaplin C

Summary for 5A6H

Entry DOI	10.2210/pdb5a6h/pdb
Descriptor	CARBONIC ANHYDRASE 2, ZINC ION, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywords	lyase, carbonic anhydrase inhibitor, natural product
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	30573.25
Authors	Mujumdar, P.,Supuran, C.T.,Peat, T.S.,Poulsen, S. (deposition date: 2015-06-26, release date: 2016-05-25, Last modification date: 2024-01-10)
Primary citation	Mujumdar, P.,Teruya, K.,Tonissen, K.F.,Vullo, D.,Supuran, C.T.,Peat, T.S.,Poulsen, S. An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition and Protein X-Ray Structures of Psammaplin C. J.Med.Chem., 59:5462-, 2016 Cited by PubMed: 27172398 DOI: 10.1021/ACS.JMEDCHEM.6B00443 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.57 Å)

Structure validation