9ARE
| Rat GluN1-GluN2B NMDA receptor channel in complex with glycine, glutamate, and EU-1622-A, in open-channel conformation | Descriptor: | GLUTAMIC ACID, GLYCINE, Glutamate receptor ionotropic, ... | Authors: | Chou, T.-H, Furukawa, H. | Deposit date: | 2024-02-23 | Release date: | 2024-07-31 | Last modified: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.72 Å) | Cite: | Molecular mechanism of ligand gating and opening of NMDA receptor. Nature, 632, 2024
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9ARF
| Rat GluN1-GluN2B NMDA receptor channel in complex with glycine, glutamate, and EU-1622-A, in nonactive1 conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | Authors: | Chou, T.-H, Furukawa, H. | Deposit date: | 2024-02-23 | Release date: | 2024-07-31 | Last modified: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | Molecular mechanism of ligand gating and opening of NMDA receptor. Nature, 632, 2024
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9B6A
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9B67
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9BIB
| Rat GluN1-GluN2B NMDA receptor channel in complex with glycine, glutamate, and EU-1622-A, in open-channel conformation, C1 symmetry | Descriptor: | GLUTAMIC ACID, GLYCINE, Glutamate receptor, ... | Authors: | Chou, T.-H, Furukawa, H. | Deposit date: | 2024-04-23 | Release date: | 2024-07-31 | Last modified: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.81 Å) | Cite: | Molecular mechanism of ligand gating and opening of NMDA receptor. Nature, 632, 2024
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9ARH
| Rat GluN1-GluN2B NMDA receptor channel in complex with glycine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, ... | Authors: | Chou, T.-H, Furukawa, H. | Deposit date: | 2024-02-23 | Release date: | 2024-07-31 | Last modified: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.69 Å) | Cite: | Molecular mechanism of ligand gating and opening of NMDA receptor. Nature, 632, 2024
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9B69
| GluA2 flip Q in complex with TARPgamma2 at pH8, class12, structure of NTD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform Flip of Glutamate receptor 2, ... | Authors: | Nakagawa, T, Greger, I.H. | Deposit date: | 2024-03-23 | Release date: | 2024-07-31 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.69 Å) | Cite: | Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization. Nat.Struct.Mol.Biol., 2024
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9B68
| GluA2 flip Q in complex with TARPgamma2 at pH8, class1, structure of NTD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform Flip of Glutamate receptor 2, ... | Authors: | Nakagawa, T, Greger, I.H. | Deposit date: | 2024-03-23 | Release date: | 2024-07-31 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization. Nat.Struct.Mol.Biol., 2024
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8USX
| Glycine-bound GluN1a-3A NMDA receptor | Descriptor: | Glutamate receptor ionotropic, NMDA 1, NMDA 3A | Authors: | Michalski, K, Furukawa, H. | Deposit date: | 2023-10-30 | Release date: | 2024-04-17 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structure and function of GluN1-3A NMDA receptor excitatory glycine receptor channel. Sci Adv, 10, 2024
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8UUE
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3H06
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8VJ7
| GluA2 bound to GYKI-52466 and Glutamate, Inhibited State 2 | Descriptor: | 4-[(5S,8R)-8-methyl-6,7,8,9-tetrahydro-2H,5H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl]aniline, GLUTAMIC ACID, Isoform Flip of Glutamate receptor 2 | Authors: | Hale, W.D, Montano Romero, A, Huganir, R.L, Twomey, E.C. | Deposit date: | 2024-01-05 | Release date: | 2024-06-05 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4.85 Å) | Cite: | Allosteric competition and inhibition in AMPA receptors. Nat.Struct.Mol.Biol., 2024
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8VJ6
| GluA2 bound to GYKI-52466 and Glutamate, Inhibited State 1 | Descriptor: | 4-[(5S,8R)-8-methyl-6,7,8,9-tetrahydro-2H,5H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl]aniline, Isoform Flip of Glutamate receptor 2 | Authors: | Hale, W.D, Montano Romero, A, Huganir, R.L, Twomey, E.C. | Deposit date: | 2024-01-05 | Release date: | 2024-06-05 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Allosteric competition and inhibition in AMPA receptors. Nat.Struct.Mol.Biol., 2024
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3H03
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3H6W
| Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5217 at 1.50 A resolution | Descriptor: | (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ... | Authors: | Hald, H, Gajhede, M, Kastrup, J.S. | Deposit date: | 2009-04-24 | Release date: | 2009-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J.Mol.Biol., 391, 2009
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3IL1
| Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, IDRA-21 | Descriptor: | (3S)-7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... | Authors: | Ahmed, A.H, Ptak, C.P, Oswald, R.E. | Deposit date: | 2009-08-06 | Release date: | 2009-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.998 Å) | Cite: | Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
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3ILT
| Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, trichlormethiazide | Descriptor: | 6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE, GLUTAMIC ACID, Glutamate receptor 2, ... | Authors: | Ahmed, A.H, Ptak, C.P, Oswald, R.E. | Deposit date: | 2009-08-07 | Release date: | 2009-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.107 Å) | Cite: | Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
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3IK6
| Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, chlorothiazide | Descriptor: | 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... | Authors: | Ptak, C.P, Ahmed, A.H, Oswald, R.E. | Deposit date: | 2009-08-05 | Release date: | 2009-09-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.101 Å) | Cite: | Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
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3IJO
| Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, althiazide | Descriptor: | (3S)-6-chloro-3-[(prop-2-en-1-ylsulfanyl)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ... | Authors: | Ptak, C.P, Ahmed, A.H, Oswald, R.E. | Deposit date: | 2009-08-04 | Release date: | 2009-09-15 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.003 Å) | Cite: | Probing the allosteric modulator binding site of GluR2 with thiazide derivatives Biochemistry, 48, 2009
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8VUN
| Human GluN1-2A With Fab 008-218 | Descriptor: | 008-218 Heavy, 008-218 Light, Glutamate receptor ionotropic, ... | Authors: | Michalski, K, Furukawa, H. | Deposit date: | 2024-01-29 | Release date: | 2024-09-11 | Last modified: | 2024-09-18 | Method: | ELECTRON MICROSCOPY (4.01 Å) | Cite: | Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis. Nat.Struct.Mol.Biol., 2024
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8VUH
| Human GluN1-2A IgG 003-102 splayed conformation | Descriptor: | 003-102 Heavy, 003-102 Light, Glutamate receptor ionotropic, ... | Authors: | Michalski, K, Furukawa, H. | Deposit date: | 2024-01-29 | Release date: | 2024-09-11 | Last modified: | 2024-09-18 | Method: | ELECTRON MICROSCOPY (4.42 Å) | Cite: | Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis. Nat.Struct.Mol.Biol., 2024
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8VUJ
| Human GluN1-2A with Fab 003-102 | Descriptor: | 003-102 Heavy, 003-102 Light, Glutamate receptor ionotropic, ... | Authors: | Michalski, K, Furukawa, H. | Deposit date: | 2024-01-29 | Release date: | 2024-09-11 | Last modified: | 2024-09-18 | Method: | ELECTRON MICROSCOPY (3.92 Å) | Cite: | Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis. Nat.Struct.Mol.Biol., 2024
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8VUU
| Human GluN1-2B with Fab 007-168 | Descriptor: | 007-168 Heavy, 007-168 Light, Glutamate receptor ionotropic, ... | Authors: | Michalski, K, Furukawa, H. | Deposit date: | 2024-01-29 | Release date: | 2024-09-11 | Last modified: | 2024-09-18 | Method: | ELECTRON MICROSCOPY (4.05 Å) | Cite: | Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis. Nat.Struct.Mol.Biol., 2024
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8VUR
| Human GluN1-2A with IgG 003-102 WT conformation | Descriptor: | 003-102 Heavy, 003-102 Light, Glutamate receptor ionotropic, ... | Authors: | Michalski, K, Furukawa, H. | Deposit date: | 2024-01-29 | Release date: | 2024-09-11 | Last modified: | 2024-09-18 | Method: | ELECTRON MICROSCOPY (3.84 Å) | Cite: | Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis. Nat.Struct.Mol.Biol., 2024
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8VUT
| Human GluN1-2A with IgG 008-218 | Descriptor: | 008-218 Heavy, 008-218 Light, Glutamate receptor ionotropic, ... | Authors: | Michalski, K, Furukawa, H. | Deposit date: | 2024-01-29 | Release date: | 2024-09-11 | Last modified: | 2024-09-18 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis. Nat.Struct.Mol.Biol., 2024
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