8VJ7

GluA2 bound to GYKI-52466 and Glutamate, Inhibited State 2

This is a non-PDB format compatible entry.

Summary for 8VJ7

• Entry DOI: 10.2210/pdb8vj7/pdb
• EMDB information: 43276
• Descriptor: Isoform Flip of Glutamate receptor 2, GLUTAMIC ACID, 4-[(5S,8R)-8-methyl-6,7,8,9-tetrahydro-2H,5H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl]aniline (3 entities in total)
• Functional Keywords: ligand gated ion channel, ionotropic glutamate receptor, allosteric inhibition, membrane protein, membrane protein-inhibitor complex, membrane protein/inhibitor
• Biological source: Rattus norvegicus (Norway rat)
• Total number of polymer chains: 4
• Total formula weight: 358693.64

Authors

Hale, W.D.,Montano Romero, A.,Huganir, R.L.,Twomey, E.C. (deposition date: 2024-01-05, release date: 2024-06-05, Last modification date: 2024-06-19)

• Primary citation: Hale, W.D.,Montano Romero, A.,Gonzalez, C.U.,Jayaraman, V.,Lau, A.Y.,Huganir, R.L.,Twomey, E.C.; Allosteric competition and inhibition in AMPA receptors.; Nat.Struct.Mol.Biol., 2024; PubMed: 38834914; DOI: 10.1038/s41594-024-01328-0

Experimental method

ELECTRON MICROSCOPY (4.85 Å)