PDB: 47720 resultsInfo pagesStatus searchChemie searchBIRD

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1O9C	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex Descriptor: 14-3-3-LIKE PROTEIN C, CHLORIDE ION, CITRATE ANION Authors: Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. Deposit date: 2002-12-12 Release date: 2003-03-06 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
1O9E	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex Descriptor: 14-3-3-LIKE PROTEIN C, CITRATE ANION, FUSICOCCIN Authors: Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. Deposit date: 2002-12-12 Release date: 2003-03-06 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
5LU2	Human 14-3-3 sigma complexed with long HSPB6 phosphopeptide Descriptor: 14-3-3 protein sigma, Heat shock protein beta-6 Authors: Sluchanko, N.N, Beelen, S, Kulikova, A.A, Weeks, S.D, Antson, A.A, Gusev, N.B, Strelkov, S.V. Deposit date: 2016-09-07 Release date: 2017-02-01 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator. Structure, 25, 2017
6Y4K	Crystal structure of human 14-3-3 gamma in complex with CaMKK2 14-3-3 binding motif Ser100 and Fusicoccin A Descriptor: 14-3-3 protein gamma, Calcium/calmodulin-dependent protein kinase kinase 2, FUSICOCCIN Authors: Lentini Santo, D, Obsilova, V, Obsil, T. Deposit date: 2020-02-21 Release date: 2021-01-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3 Å) Cite: Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins. Acs Chem.Biol., 15, 2020
6BZD	Structure of 14-3-3 gamma R57E mutant bound to GlcNAcylated peptide Descriptor: 14-3-3 protein gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose, GlcNAcylated peptide Authors: Schumacher, M.A. Deposit date: 2017-12-22 Release date: 2018-05-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.67 Å) Cite: Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5MYC	Crystal structure of human 14-3-3 sigma in complex with LRRK2 peptide pS910 Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Stevers, L.M, de Vries, R.M.J.M, Ottmann, C. Deposit date: 2017-01-26 Release date: 2017-03-01 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.459 Å) Cite: Structural interface between LRRK2 and 14-3-3 protein. Biochem. J., 474, 2017
5MY9	Crystal structure of human 14-3-3 sigma in complex with LRRK2 peptide pS935 Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Stevers, L.M, de Vries, R.M.J.M, Ottmann, C. Deposit date: 2017-01-26 Release date: 2017-03-01 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.327 Å) Cite: Structural interface between LRRK2 and 14-3-3 protein. Biochem. J., 474, 2017
4ZQ0	crystal structure of Giardia 14-3-3 in complex with the phosphopeptide A8Ap Descriptor: 14-3-3 protein, A8Ap phosphopeptide, PHOSPHATE ION Authors: Fiorillo, A, Ilari, A. Deposit date: 2015-05-08 Release date: 2016-03-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions. J.Chem.Inf.Model., 55, 2015
3UAL	Crystal Structure of 14-3-3 epsilon with Mlf1 peptide Descriptor: 14-3-3 protein epsilon, Myeloid leukemia factor 1, TERTIARY-BUTYL ALCOHOL Authors: Weyand, M, Ottmann, C. Deposit date: 2011-10-21 Release date: 2012-01-25 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural insights of the MLF1/14-3-3 interaction. Febs J., 279, 2012
3IQU	Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) Descriptor: 14-3-3 protein sigma, 6-mer from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... Authors: Ottmann, C, Weyand, M. Deposit date: 2009-08-21 Release date: 2010-09-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.05 Å) Cite: Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol.Cell.Biol., 30, 2010
3E6Y	Structure of 14-3-3 in complex with the differentiation-inducing agent Cotylenin A Descriptor: 14-3-3-like protein C, CHLORIDE ION, Cotylenin A, ... Authors: Ottmann, C, Weyand, M, Wittinghofer, A, Oecking, C. Deposit date: 2008-08-17 Release date: 2009-03-10 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A J.Mol.Biol., 386, 2009
3IQV	Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) and stabilisator Fusicoccin Descriptor: 14-3-3 protein sigma, 6-mer peptide from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... Authors: Ottmann, C, Weyand, M. Deposit date: 2009-08-21 Release date: 2010-09-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol.Cell.Biol., 30, 2010
5BY9	The crystal structure of polyglycilated 14-3-3 protein from Giardia intestinalis Descriptor: 14-3-3 protein Authors: Fiorillo, A, Ilari, A, Lalle, M. Deposit date: 2015-06-10 Release date: 2016-04-27 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (4 Å) Cite: Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions. J.Chem.Inf.Model., 55, 2015
8QT5	Crystal structure of Arabidopsis thaliana 14-3-3 isoform lambda in complex with a phosphopeptide from the transcription factor BZR1. Descriptor: 14-3-3-like protein G-BOX factor 14 lambda,Protein BRASSINAZOLE-RESISTANT 1, ACETATE ION Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-12 Release date: 2023-10-25 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
7AZ2	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1014 Descriptor: 1-[4-methyl-2-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ... Authors: Wolter, M, Dijck, L.v, Ottmann, C. Deposit date: 2020-11-14 Release date: 2021-06-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.081 Å) Cite: Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7AZ1	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1013 Descriptor: 1-[4-methyl-3-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ... Authors: Wolter, M, Dijck, L.v, Ottmann, C. Deposit date: 2020-11-14 Release date: 2021-06-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.15 Å) Cite: Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
6YOS	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 pS617 peptide Descriptor: 14-3-3 protein zeta/delta, Glucocorticoid receptor,Glucocorticoid receptor Authors: Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. Deposit date: 2020-04-15 Release date: 2021-03-24 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
2O8P	Crystal structure of a putative 14-3-3 protein from Cryptosporidium parvum, cgd7_2470 Descriptor: 14-3-3 domain containing protein Authors: Dong, A, Lew, J, Wasney, G, Lin, L, Hassanali, A, Zhao, Y, Vedadi, M, Kozieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Walker, J.R, Bochkarev, A, Hui, R, Brokx, S.J, Structural Genomics Consortium (SGC) Deposit date: 2006-12-12 Release date: 2007-01-09 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Characterization of 14-3-3 proteins from Cryptosporidium parvum. Plos One, 6, 2011
8QTC	Crystal structure of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the transcription factor BZR1. Descriptor: 14-3-3-like protein GF14 omega, COBALT (II) ION, Protein BRASSINAZOLE-RESISTANT 1, ... Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-12 Release date: 2023-11-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
7QI1	Crystal structure of human 14-3-3 protein beta in complex with CFTR peptide pS753pS768 and PPI stabilizer CY007424 Descriptor: 14-3-3 protein theta, ARGININE, Cystic fibrosis transmembrane conductance regulator, ... Authors: Stevers, L.M, Ottmann, C. Deposit date: 2021-12-14 Release date: 2022-05-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR. Nat Commun, 13, 2022
6YO8	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 peptide Descriptor: 14-3-3 protein zeta/delta, Glucocorticoid receptor Authors: Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. Deposit date: 2020-04-14 Release date: 2021-03-24 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
6YMO	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pS617 peptide Descriptor: 14-3-3 protein zeta/delta, 2-HYDROXYBENZOIC ACID, Glucocorticoid receptor, ... Authors: Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. Deposit date: 2020-04-09 Release date: 2021-03-24 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
2O98	Structure of the 14-3-3 / H+-ATPase plant complex Descriptor: 14-3-3-like protein C, FUSICOCCIN, Plasma membrane H+ ATPase, ... Authors: Ottmann, C, Weyand, M, Wittinghofer, A, Oecking, C. Deposit date: 2006-12-13 Release date: 2007-04-03 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy Mol.Cell, 25, 2007
4F7R	Crystal structure of 14-3-3 protein from Giardia intestinalis Descriptor: 14-3-3 protein, SULFATE ION Authors: Fiorillo, A, Ilari, A, Lalle, M. Deposit date: 2012-05-16 Release date: 2013-05-22 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.2 Å) Cite: The Crystal Structure of Giardia duodenalis 14-3-3 in the Apo Form: When Protein Post-Translational Modifications Make the Difference. Plos One, 9, 2014
6F09	Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide Descriptor: 14-3-3 protein zeta/delta, Ubiquitin carboxyl-terminal hydrolase 8 Authors: Centorrino, F, Ballone, A, Ottmann, C, Guo, S, Leysen, S. Deposit date: 2017-11-17 Release date: 2018-03-07 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.594 Å) Cite: Biophysical and structural insight into the USP8/14-3-3 interaction. FEBS Lett., 592, 2018

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