6KZO
| membrane protein | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Yan, N. | Deposit date: | 2019-09-25 | Release date: | 2019-12-18 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures of apo and antagonist-bound human Cav3.1. Nature, 576, 2019
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6J8H
| Structure of human voltage-gated sodium channel Nav1.7 in complex with auxiliary beta subunits, huwentoxin-IV and saxitoxin (Y1755 down) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein type 9 subunit alpha, ... | Authors: | Shen, H, Liu, D, Lei, J, Yan, N. | Deposit date: | 2019-01-19 | Release date: | 2019-02-27 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins. Science, 363, 2019
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5T4D
| Cryo-EM structure of Polycystic Kidney Disease protein 2 (PKD2), residues 198-703 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, hPKD:198-703, Polycystin-2 | Authors: | Shen, P.S, Yang, X, DeCaen, P.G, Liu, X, Bulkley, D, Clapham, D.E, Cao, E. | Deposit date: | 2016-08-29 | Release date: | 2016-11-02 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs. Cell, 167, 2016
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6JUH
| structure of CavAb in complex with efonidipine | Descriptor: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-[phenyl-(phenylmethyl)amino]ethyl (4~{R})-5-(5,5-dimethyl-2-oxidanylidene-1,3,2$l^{5}-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate, ... | Authors: | Tang, L, Xu, F. | Deposit date: | 2019-04-13 | Release date: | 2019-11-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for efonidipine block of a voltage-gated Ca2+channel. Biochem.Biophys.Res.Commun., 513, 2019
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6LQA
| voltage-gated sodium channel Nav1.5 with quinidine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Quinidine, Sodium channel protein type 5 subunit alpha | Authors: | Yan, N, Li, Z, Pan, X, Huang, G. | Deposit date: | 2020-01-13 | Release date: | 2021-03-24 | Last modified: | 2021-05-19 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Na v 1.5 by the Antiarrhythmic Drug Quinidine*. Angew.Chem.Int.Ed.Engl., 60, 2021
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5TJ6
| Ca2+ bound aplysia Slo1 | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CALCIUM ION, High conductance calcium-activated potassium channel, ... | Authors: | MacKinnon, R, Tao, X, Hite, R.K. | Deposit date: | 2016-10-03 | Release date: | 2016-12-14 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structure of the open high-conductance Ca(2+)-activated K(+) channel. Nature, 541, 2017
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5TJI
| Ca2+ bound aplysia Slo1 | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, High conductance calcium-activated potassium channel | Authors: | MacKinnon, R, Tao, X, Hite, R.K. | Deposit date: | 2016-10-04 | Release date: | 2016-12-28 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural basis for gating the high-conductance Ca(2+)-activated K(+) channel. Nature, 541, 2017
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6MVW
| NavAb voltage-gated sodium channel, I217C/F203W | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein, PHOSPHATE ION | Authors: | Lenaeus, M.J, Catterall, W.A. | Deposit date: | 2018-10-28 | Release date: | 2018-12-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.198 Å) | Cite: | Fenestrations control resting-state block of a voltage-gated sodium channel. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6MWB
| NavAb Voltage-gated Sodium Channel, residues 1-239 with mutation T206A | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein, ... | Authors: | Lenaeus, M.J, Catterall, W.A. | Deposit date: | 2018-10-29 | Release date: | 2018-12-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Molecular dissection of multiphase inactivation of the bacterial sodium channel NaVAb. J. Gen. Physiol., 151, 2019
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6MJ2
| Human TRPM2 ion channel in a calcium- and ADPR-bound state | Descriptor: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 2 | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | Deposit date: | 2018-09-20 | Release date: | 2018-12-12 | Last modified: | 2019-01-02 | Method: | ELECTRON MICROSCOPY (6.36 Å) | Cite: | Structures and gating mechanism of human TRPM2. Science, 362, 2018
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6MU2
| Structure of full-length IP3R1 channel in the Apo-state | Descriptor: | Inositol 1,4,5-trisphosphate receptor type 1 | Authors: | Serysheva, I.I, Fan, G, Baker, M.R, Wang, Z, Seryshev, A, Ludtke, S.J, Baker, M.L. | Deposit date: | 2018-10-22 | Release date: | 2018-12-05 | Last modified: | 2019-11-27 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating. Cell Res., 28, 2018
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6MWD
| NavAb Voltage-gated Sodium Channel, residues 1-239 with mutation T206S | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ACETATE ION, ... | Authors: | Lenaeus, M.J, Catterall, W.A. | Deposit date: | 2018-10-29 | Release date: | 2018-12-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.327 Å) | Cite: | Molecular dissection of multiphase inactivation of the bacterial sodium channel NaVAb. J. Gen. Physiol., 151, 2019
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6MIX
| Human TRPM2 ion channel in apo state | Descriptor: | Transient receptor potential cation channel subfamily M member 2 | Authors: | Wang, L, Fu, T.M, Xia, S, Wu, H. | Deposit date: | 2018-09-20 | Release date: | 2018-12-12 | Last modified: | 2019-01-02 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures and gating mechanism of human TRPM2. Science, 362, 2018
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6MVY
| NavAb voltage-gated sodium channel, residues 1-226, crystallized in the presence of Class 1B Anti-arrhythmic drug Lidocaine | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein, SULFATE ION | Authors: | Lenaeus, M.J, Catterall, W.A. | Deposit date: | 2018-10-28 | Release date: | 2018-12-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.002 Å) | Cite: | Fenestrations control resting-state block of a voltage-gated sodium channel. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6MWA
| NavAb Voltage-gated Sodium Channel, residues 1-239 | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein, ... | Authors: | Lenaeus, M.J, Catterall, W.A. | Deposit date: | 2018-10-29 | Release date: | 2018-12-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Molecular dissection of multiphase inactivation of the bacterial sodium channel NaVAb. J. Gen. Physiol., 151, 2019
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6MIZ
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6MVX
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6MVV
| NavAb voltage-gated sodium channel, I217C/F203A | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein, PHOSPHATE ION | Authors: | Lenaeus, M.J, Catterall, W.A. | Deposit date: | 2018-10-28 | Release date: | 2018-12-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Fenestrations control resting-state block of a voltage-gated sodium channel. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6MWG
| NavAb Voltage-gated Sodium Channel, residues 1-239, with mutation T206V | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ACETATE ION, ... | Authors: | Lenaeus, M.J, Catterall, W.A. | Deposit date: | 2018-10-29 | Release date: | 2018-12-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Molecular dissection of multiphase inactivation of the bacterial sodium channel NaVAb. J. Gen. Physiol., 151, 2019
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6N4Q
| CryoEM structure of Nav1.7 VSD2 (actived state) in complex with the gating modifier toxin ProTx2 | Descriptor: | Beta/omega-theraphotoxin-Tp2a, Fab heavy chain, Fab light chain, ... | Authors: | Xu, H, Rohou, A, Arthur, C.P, Estevez, A, Ciferri, C, Payandeh, J, Koth, C.M. | Deposit date: | 2018-11-20 | Release date: | 2019-01-23 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin. Cell, 176, 2019
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6MU1
| Structure of full-length IP3R1 channel bound with Adenophostin A | Descriptor: | Adenophostin A, Inositol 1,4,5-trisphosphate receptor type 1 | Authors: | Serysheva, I.I, Fan, G, Baker, M.R, Wang, Z, Seryshev, A, Ludtke, S.J, Baker, M.L. | Deposit date: | 2018-10-22 | Release date: | 2018-12-05 | Last modified: | 2019-11-27 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating. Cell Res., 28, 2018
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6N4R
| CryoEM structure of Nav1.7 VSD2 (deactived state) in complex with the gating modifier toxin ProTx2 | Descriptor: | Beta/omega-theraphotoxin-Tp2a, Fab heavy chain, Fab light chain, ... | Authors: | Xu, H, Rohou, A, Arthur, C.P, Estevez, A, Ciferri, C, Payandeh, J, Koth, C.M. | Deposit date: | 2018-11-20 | Release date: | 2019-01-23 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin. Cell, 176, 2019
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6NFV
| Structure of the KcsA-G77C mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter. | Descriptor: | (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, NONAN-1-OL, POTASSIUM ION, ... | Authors: | Tilegenova, C, Cortes, D.M, Jahovic, N, Hardy, E, Parameswaran, H, Guan, L, Cuello, L.G. | Deposit date: | 2018-12-20 | Release date: | 2019-08-07 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Structure, function, and ion-binding properties of a K+channel stabilized in the 2,4-ion-bound configuration. Proc.Natl.Acad.Sci.USA, 116, 2019
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6NT3
| Cryo-EM structure of a human-cockroach hybrid Nav channel. | Descriptor: | (7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9Z,12E)-octadeca-9,12-dienoate, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Clairfeuille, T, Rohou, A, Payandeh, J. | Deposit date: | 2019-01-28 | Release date: | 2019-02-20 | Last modified: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structures of a human-cockroach hybrid Nav channel in the presence and absence of the alpha-scorpion toxin AaH2. Science, 2019
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6ND0
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