9EN2
| Crystal structure of the metalloproteinase enhancer PCPE-1 complexed with nanobodies VHH-H4 and VHH-I5 | Descriptor: | CALCIUM ION, GLYCEROL, Procollagen C-endopeptidase enhancer 1, ... | Authors: | Lagoutte, P, Gueguen-Chaignon, V, Bourhis, J.-M, Vadon-Le Goff, S. | Deposit date: | 2024-03-12 | Release date: | 2024-07-03 | Last modified: | 2024-07-17 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mono- and Bi-specific Nanobodies Targeting the CUB Domains of PCPE-1 Reduce the Proteolytic Processing of Fibrillar Procollagens. J.Mol.Biol., 436, 2024
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9EMV
| SARS-CoV-2 nsp10-16 methyltransferase in complex with Sangivamycin and m7GpppA (Cap0-analog)/m7GpppAm (Cap1-analog) | Descriptor: | 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | Authors: | Kremling, V, Sprenger, J, Oberthuer, D, Scheer, T.E.S. | Deposit date: | 2024-03-11 | Release date: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug development To Be Published
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9EML
| SARS-CoV-2 methyltransferase nsp10-16 in complex with SAM and m7GpppA (Cap0-analog)/m7GpppAm (Cap1-analog) | Descriptor: | 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | Authors: | Kremling, V, Sprenger, J, Oberthuer, D, Kiene, A. | Deposit date: | 2024-03-08 | Release date: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug development To Be Published
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9EMJ
| SARS-CoV-2 methyltransferase nsp10-16 in complex with Toyocamycin and m7GpppA (Cap0-analog) | Descriptor: | 1,2-ETHANEDIOL, 2'-O-methyltransferase nsp16, 4-amino-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, ... | Authors: | Kremling, V, Sprenger, J, Oberthuer, D, Kiene, A. | Deposit date: | 2024-03-08 | Release date: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug development To Be Published
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9EME
| AL amyloid fibril from the FOR103 light chain | Descriptor: | lambda 3 immunoglobulin light chain fragment, residues 2-116 | Authors: | Pfeiffer, P.B, Karimi-Farsijani, S, Kupfer, N, Schmidt, M, Faendrich, M. | Deposit date: | 2024-03-08 | Release date: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | Light chain mutations contribute to defining the fibril morphology in systemic AL amyloidosis. Nat Commun, 15, 2024
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9EMC
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9EMB
| Structure of KefC Asp156Asn variant | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE MONOPHOSPHATE, Glutathione-regulated potassium-efflux system protein KefC | Authors: | Gulati, A, Kokane, S, Drew, D. | Deposit date: | 2024-03-07 | Release date: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structure of KefC Asp156Asn variant To Be Published
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9EMA
| RUVBL1/2 in complex with ATP and CB-6644 inhibitor | Descriptor: | 5-chloranyl-2-ethoxy-4-fluoranyl-~{N}-[4-[[3-(methoxymethyl)-1-oxidanylidene-6,7-dihydro-5~{H}-pyrazolo[1,2-a][1,2]benzodiazepin-2-yl]amino]-2,2-dimethyl-4-oxidanylidene-butyl]benzamide, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Lopez-Perrote, A, Llorca, O, Garcia-Martin, C. | Deposit date: | 2024-03-07 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Mechanism of allosteric inhibition of RUVBL1-RUVBL2 by the small-molecule CB-6644 Cell Rep Phys Sci, 2024
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9EM1
| Human pyridoxal phosphatase in complex with 7,8-dihydroxyflavone and phosphate | Descriptor: | 7,8-bis(oxidanyl)-2-phenyl-chromen-4-one, Chronophin, GLYCEROL, ... | Authors: | Brenner, M, Gohla, A, Schindelin, H. | Deposit date: | 2024-03-07 | Release date: | 2024-06-12 | Last modified: | 2024-06-26 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | 7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase. Elife, 13, 2024
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9DNA
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9CKV
| Cryo-EM structure of alpha5beta1 integrin in complex with NeoNectin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Werther, R, Nguyen, A, Estrada Alamo, K.A, Wang, X, Campbell, M.G. | Deposit date: | 2024-07-09 | Release date: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | De Novo Design of Integrin alpha5beta1 Modulating Proteins for Regenerative Medicine To Be Published
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9CK0
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9CJA
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9CGT
| STRUCTURE OF CYCLODEXTRIN GLYCOSYLTRANSFERASE COMPLEXED WITH A THIO-MALTOPENTAOSE | Descriptor: | CALCIUM ION, PROTEIN (CYCLODEXTRIN-GLYCOSYLTRANSFERASE), alpha-D-glucopyranose-(1-4)-4-thio-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-4-thio-alpha-D-glucopyranose-(1-4)-1-thio-alpha-D-glucopyranose | Authors: | Schmidt, A.K, Schulz, G.E. | Deposit date: | 1998-09-27 | Release date: | 1998-10-14 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Substrate binding to a cyclodextrin glycosyltransferase and mutations increasing the gamma-cyclodextrin production. Eur.J.Biochem., 255, 1998
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9CGM
| The Structure of Spiroplasma Virus 4 | Descriptor: | Capsid protein VP1, DNA binding protein ORF8 | Authors: | Mietzsch, M, McKenna, R. | Deposit date: | 2024-06-30 | Release date: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.52 Å) | Cite: | The Structure of Spiroplasma Virus 4: Exploring the Capsid Diversity of the Microviridae Viruses, 2024
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9CEQ
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9CE9
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9CBE
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9CA2
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9CA1
| Human TOP3B-TDRD3 core complex in DNA religation state | Descriptor: | DNA (5'-D(*AP*TP*T)-3'), DNA (5'-D(P*TP*AP*CP*TP*AP*AP*A)-3'), DNA topoisomerase 3-beta-1, ... | Authors: | Yang, X, Chen, X, Yang, W, Pommier, Y. | Deposit date: | 2024-06-16 | Release date: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Structural Insights into human Topoisomerase 3-beta DNA and RNA catalytic cycles and topo-gate dynamics To Be Published
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9CA0
| Human TOP3B-TDRD3 core complex in DNA pre-cleavage state | Descriptor: | DNA (5'-D(*AP*TP*T)-3'), DNA (5'-D(P*TP*AP*CP*TP*AP*AP*A)-3'), DNA topoisomerase 3-beta-1, ... | Authors: | Yang, X, Chen, X, Yang, W, Pommier, Y. | Deposit date: | 2024-06-16 | Release date: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.48 Å) | Cite: | Structural Insights into human Topoisomerase 3-beta DNA and RNA catalytic cycles and topo-gate dynamics To Be Published
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9C9Y
| Human TOP3B-TDRD3 core complex in DNA pre-cleavage state | Descriptor: | DNA (5'-D(P*AP*CP*TP*AP*AP*AP*AP*T)-3'), DNA topoisomerase 3-beta-1, MANGANESE (II) ION, ... | Authors: | Yang, X, Chen, X, Yang, W, Pommier, Y. | Deposit date: | 2024-06-16 | Release date: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Structural Insights into human Topoisomerase 3-beta DNA and RNA catalytic cycles and topo-gate dynamics To Be Published
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9C8S
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9C8R
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9C8J
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