5OB1
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6SII
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5O9F
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![BU of 5o9f by Molmil](/molmil-images/mine/5o9f) | Crystal structure of R. ruber ADH-A, mutant Y294F, W295A, Y54F, F43S, H39Y | Descriptor: | (2~{S})-2-methylpentanedioic acid, Alcohol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Dobritzsch, D, Maurer, D, Hamnevik, E, Enugala, T.R, Widersten, M. | Deposit date: | 2017-06-19 | Release date: | 2017-10-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Relaxation of nonproductive binding and increased rate of coenzyme release in an alcohol dehydrogenase increases turnover with a nonpreferred alcohol enantiomer. FEBS J., 284, 2017
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6SIS
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![BU of 6sis by Molmil](/molmil-images/mine/6sis) | Crystal structure of macrocyclic PROTAC 1 in complex with the second bromodomain of human Brd4 and pVHL:ElonginC:ElonginB | Descriptor: | Bromodomain-containing protein 4, Elongin-B, Elongin-C, ... | Authors: | Hughes, S.J, Testa, A, Ciulli, A. | Deposit date: | 2019-08-10 | Release date: | 2019-12-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structure-Based Design of a Macrocyclic PROTAC. Angew.Chem.Int.Ed.Engl., 59, 2020
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5OCM
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![BU of 5ocm by Molmil](/molmil-images/mine/5ocm) | Imine Reductase from Streptosporangium roseum in complex with NADP+ and 2,2,2-trifluoroacetophenone hydrate | Descriptor: | 2,2,2-trifluoromethyl acetophenone hydrate, MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Sharma, M, Nestl, B, Grogan, G. | Deposit date: | 2017-07-03 | Release date: | 2018-05-16 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | New imine-reducing enzymes from beta-hydroxyacid dehydrogenases by single amino acid substitutions. Protein Eng. Des. Sel., 31, 2018
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6SLG
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![BU of 6slg by Molmil](/molmil-images/mine/6slg) | HUMAN ERK2 WITH ERK1/2 INHIBITOR, AZD0364. | Descriptor: | (6~{R})-7-[[3,4-bis(fluoranyl)phenyl]methyl]-6-(methoxymethyl)-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-5,6-dihydroimidazo[1,2-a]pyrazin-8-one, 1,2-ETHANEDIOL, ERK-tide, ... | Authors: | Breed, J, Phillips, C. | Deposit date: | 2019-08-19 | Release date: | 2019-11-20 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC). J.Med.Chem., 62, 2019
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7CNX
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![BU of 7cnx by Molmil](/molmil-images/mine/7cnx) | Crystal structure of Apo PSD from E. coli (2.63 A) | Descriptor: | Phosphatidylserine decarboxylase alpha chain, Phosphatidylserine decarboxylase beta chain | Authors: | Kim, J, Cho, G. | Deposit date: | 2020-08-03 | Release date: | 2021-03-24 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Structural insights into phosphatidylethanolamine formation in bacterial membrane biogenesis. Sci Rep, 11, 2021
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5OE0
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![BU of 5oe0 by Molmil](/molmil-images/mine/5oe0) | CRYSTAL STRUCTURE OF THE BETA-LACTAMASE OXA-181 | Descriptor: | Beta-lactamase, CHLORIDE ION, SULFATE ION | Authors: | Lund, B.A, Carlsen, T.J.O, Leiros, H.K.S, Thomassen, A.M. | Deposit date: | 2017-07-07 | Release date: | 2017-08-02 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.0500083 Å) | Cite: | Structure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysis. Acta Crystallogr F Struct Biol Commun, 73, 2017
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7CNY
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![BU of 7cny by Molmil](/molmil-images/mine/7cny) | Crystal structure of 8PE bound PSD from E. coli (2.12 A) | Descriptor: | 1,2-Dioctanoyl-SN-Glycero-3-Phosphoethanolamine, DODECYL-BETA-D-MALTOSIDE, Phosphatidylserine decarboxylase alpha chain, ... | Authors: | Kim, J, Cho, G. | Deposit date: | 2020-08-03 | Release date: | 2021-03-24 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Structural insights into phosphatidylethanolamine formation in bacterial membrane biogenesis. Sci Rep, 11, 2021
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6SFG
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![BU of 6sfg by Molmil](/molmil-images/mine/6sfg) | CRYSTAL STRUCTURE OF DHQ1 FROM SALMONELLA TYPHI COVALENTLY MODIFIED BY COMPOUND 9 | Descriptor: | (1~{R},3~{S},4~{R},5~{R})-3-methyl-4,5-bis(hydroxyl)cyclohexane-1-carboxylic acid, (1~{S},3~{R},4~{S},5~{R})-3-methyl-3,4,5-tris(hydroxyl)cyclohexane-1-carboxylic Acid, 3-dehydroquinate dehydratase | Authors: | Sanz-Gaitero, M, Lence, E, Maneiro, M, Thompson, R, Hawkins, A.R, Gonzalez-Bello, C, van Raaij, M.J. | Deposit date: | 2019-08-01 | Release date: | 2020-04-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.23 Å) | Cite: | Self-Immolation of a Bacterial Dehydratase Enzyme by its Epoxide Product. Chemistry, 26, 2020
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5OE6
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7CNZ
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![BU of 7cnz by Molmil](/molmil-images/mine/7cnz) | Crystal structure of 10PE bound PSD from E. coli (2.70 A) | Descriptor: | 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, PHOSPHATE ION, Phosphatidylserine decarboxylase alpha chain, ... | Authors: | Kim, J, Cho, G. | Deposit date: | 2020-08-03 | Release date: | 2021-03-24 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural insights into phosphatidylethanolamine formation in bacterial membrane biogenesis. Sci Rep, 11, 2021
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6SMF
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5OF6
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![BU of 5of6 by Molmil](/molmil-images/mine/5of6) | Cu nitrite reductase serial data at varying temperatures 190K 0.48MGy | Descriptor: | ACETATE ION, COPPER (II) ION, Copper-containing nitrite reductase, ... | Authors: | Horrell, S, Kekilli, D, Strange, R.W, Hough, M.A. | Deposit date: | 2017-07-10 | Release date: | 2018-05-23 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | Enzyme catalysis captured using multiple structures from one crystal at varying temperatures. IUCrJ, 5, 2018
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7CNW
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![BU of 7cnw by Molmil](/molmil-images/mine/7cnw) | Crystal structure of Apo PSD from E. coli (1.90 A) | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Phosphatidylserine decarboxylase alpha chain, Phosphatidylserine decarboxylase beta chain, ... | Authors: | Kim, J, Cho, G. | Deposit date: | 2020-08-03 | Release date: | 2021-03-24 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural insights into phosphatidylethanolamine formation in bacterial membrane biogenesis. Sci Rep, 11, 2021
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5OFG
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![BU of 5ofg by Molmil](/molmil-images/mine/5ofg) | Cu nitrite reductase serial data at varying temperatures RT 0.06MGy | Descriptor: | ACETATE ION, COPPER (II) ION, Copper-containing nitrite reductase, ... | Authors: | Horrell, S, Kekilli, D, Strange, R.W, Hough, M.A. | Deposit date: | 2017-07-11 | Release date: | 2018-05-23 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Enzyme catalysis captured using multiple structures from one crystal at varying temperatures. IUCrJ, 5, 2018
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7CNB
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5OHE
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![BU of 5ohe by Molmil](/molmil-images/mine/5ohe) | Globin sensor domain of AfGcHK (FeIII form) in complex with cyanide | Descriptor: | CHLORIDE ION, CYANIDE ION, Globin-coupled histidine kinase, ... | Authors: | Skalova, T, Kolenko, P, Dohnalek, J, Stranava, M, Martinkova, M. | Deposit date: | 2017-07-16 | Release date: | 2017-11-08 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Coordination and redox state-dependent structural changes of the heme-based oxygen sensor AfGcHK associated with intraprotein signal transduction. J. Biol. Chem., 292, 2017
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5O5X
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![BU of 5o5x by Molmil](/molmil-images/mine/5o5x) | Crystal structure of Thermococcus litoralis ADP-dependent glucokinase (GK) | Descriptor: | ADP-dependent glucokinase,ADP-dependent glucokinase,ADP-dependent glucokinase, GLYCEROL, SULFATE ION | Authors: | Herrera-Morande, A, Castro-Fernandez, V, Merino, F, Ramirez-Sarmiento, C.A, Fernandez, F.J, Guixe, V, Vega, M.C. | Deposit date: | 2017-06-02 | Release date: | 2018-10-24 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.148 Å) | Cite: | Protein topology determines substrate-binding mechanism in homologous enzymes. Biochim Biophys Acta Gen Subj, 1862, 2018
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7CKG
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![BU of 7ckg by Molmil](/molmil-images/mine/7ckg) | Crystal structure of TMSiPheRS complexed with TMSiPhe | Descriptor: | 4-(trimethylsilyl)-L-phenylalanine, Tyrosine--tRNA ligase | Authors: | Sun, J.P, Wang, J.Y, Zhu, Z.L, He, Q.T, Xiao, P. | Deposit date: | 2020-07-17 | Release date: | 2021-03-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.053 Å) | Cite: | DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1 H-NMR probe. Nat Commun, 11, 2020
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6SKS
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5OJJ
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![BU of 5ojj by Molmil](/molmil-images/mine/5ojj) | Crystal structure of the Zn-bound ubiquitin-conjugating enzyme Ube2T | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, Ubiquitin-conjugating enzyme E2 T, ... | Authors: | Morreale, F.E, Testa, A, Chaugule, V.K, Bortoluzzi, A, Ciulli, A, Walden, H. | Deposit date: | 2017-07-21 | Release date: | 2017-10-04 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements. J. Med. Chem., 60, 2017
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7CKH
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![BU of 7ckh by Molmil](/molmil-images/mine/7ckh) | Crystal structure of TMSiPheRS | Descriptor: | Tyrosine--tRNA ligase | Authors: | Sun, J.P, Wang, J.Y, Zhu, Z.L, He, Q.T, Xiao, P. | Deposit date: | 2020-07-17 | Release date: | 2021-03-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.79492676 Å) | Cite: | DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1 H-NMR probe. Nat Commun, 11, 2020
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5O6M
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7CE2
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![BU of 7ce2 by Molmil](/molmil-images/mine/7ce2) | The Crystal structure of TeNT Hc complexed with neutralizing antibody | Descriptor: | Tetanus toxin, neutralizing antibody heavy chain, neutralizing antibody light chain | Authors: | Wang, X, Wang, Y, Wu, C, Yu, J, Liao, H. | Deposit date: | 2020-06-21 | Release date: | 2021-04-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structural basis of tetanus toxin neutralization by native human monoclonal antibodies. Cell Rep, 35, 2021
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